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JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1371 - 1381
The BRAF mutant, BRAF(V600E), is expressed in nearly half of melanomas, and oral BRAF inhibitors induce substantial tumor regression in patients with... 
MEDICINE, RESEARCH & EXPERIMENTAL | METASTATIC MELANOMA | THERAPY | RESISTANCE | TUMOR-ASSOCIATED MACROPHAGES | ANTIBODY | MICE | CANCER-IMMUNOTHERAPY | ANTITUMOR IMMUNITY | ESTABLISHED TUMORS | BRAF(V600E) | Chemokine CCL2 - immunology | Humans | Drug Resistance, Neoplasm | Male | Antineoplastic Agents - administration & dosage | Mutation, Missense | Molecular Targeted Therapy | Indoles - administration & dosage | T-Lymphocytes, Regulatory - immunology | Immunotherapy | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Chemokine CCL2 - metabolism | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Chemokine CCL2 - genetics | Melanoma - pathology | Down-Regulation - drug effects | Sulfonamides - pharmacology | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Receptors, CCR2 - metabolism | Animals | Antibodies, Monoclonal - administration & dosage | Melanoma - immunology | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Mice | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | Sulfonamides - administration & dosage | Care and treatment | Melanoma | Physiological aspects | Genetic aspects | Research | Chemokine receptors | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 30, pp. 12425 - 12430
Recent evidence has unveiled the critical role of tumor cells with stem cell activities in tumorigenicity and drug resistance, but how tumor microenvironments... 
Myeloid cells | Stem cells | Antineoplastics | Medical genetics | Mice | Tumor stem cells | Macrophages | Drug resistance | Tumors | Cancer | Chemoresistance | Tumor progression | STEM-CELLS | METASTASIS | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | IDENTIFICATION | LUNG-CANCER | MAINTENANCE | chemoresistance | tumor progression | INFLAMMATION | APOPTOTIC CELLS | MYELOID-LEUKEMIA | PROGRESSION | RNA, Small Interfering - genetics | Neoplastic Stem Cells - drug effects | Humans | Neoplastic Stem Cells - immunology | Drug Resistance, Neoplasm | Adoptive Transfer | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Signal Transduction - immunology | Milk Proteins - immunology | Neoplasms - genetics | Neoplastic Stem Cells - pathology | Macrophages - immunology | STAT3 Transcription Factor - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Antigens, Surface - genetics | Milk Proteins - genetics | Mice, SCID | Mice, Knockout | Neoplasms - drug therapy | Tumor Microenvironment - immunology | Models, Immunological | Animals | Neoplasms - immunology | Interleukin-6 - immunology | Cell Line, Tumor | RNA, Neoplasm - genetics | Mice, Inbred NOD | STAT3 Transcription Factor - immunology | Hedgehog Proteins - immunology | Neoplasms - pathology | STAT3 Transcription Factor - antagonists & inhibitors | Antigens, Surface - immunology | Antimitotic agents | Cancer cells | Physiological aspects | Genetic aspects | Antineoplastic agents | Health aspects | Signal transduction | Cell growth | Rodents | Cells | Index Medicus | Transcription | Tumor cells | Stat3 protein | Inflammation | Tumorigenicity | Interleukin 6 | Antitumor agents | Hedgehog protein | Bone marrow | Microenvironments | Biological Sciences
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 09/2011, Volume 121, Issue 9, pp. 3645 - 3656
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2011, Volume 108, Issue 17, pp. 7142 - 7147
Trastuzumab, a monoclonal antibody targeting human epidermal growth factor receptor-2 (HER2/ErbB-2), has become the mainstay of treatment for HER2-positive... 
T lymphocytes | Inoculation | Medical treatment | Antibodies | Cytotoxicity | Breast cancer | Adaptive immunity | Natural killer cells | Tumors | Cancer | Natural killer cell | Innate | Adaptive | Tumor immunology | tumor immunology | TRASTUZUMAB | MECHANISM | MULTIDISCIPLINARY SCIENCES | innate | OVEREXPRESSING HER2 | COMBINATION | HER2-POSITIVE BREAST-CANCER | ADAPTIVE IMMUNITY | adaptive | IMMUNOTHERAPY | MICE | natural killer cell | PHASE-I | ESTABLISHED TUMORS | Receptor, ErbB-2 - genetics | Receptors, Interleukin-1 Type I - immunology | CD8-Positive T-Lymphocytes - transplantation | Humans | Receptors, Interleukin-17 - immunology | Receptors, Interleukin-17 - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | Adoptive Transfer | Interferon Type I - immunology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Antibodies, Monoclonal, Humanized | Receptor, ErbB-2 - immunology | Interferon-gamma - genetics | Antibodies, Monoclonal - immunology | Mammary Neoplasms, Animal - genetics | Mammary Neoplasms, Animal - immunology | Antibodies, Monoclonal - pharmacology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Mice, Transgenic | Antineoplastic Combined Chemotherapy Protocols - immunology | Mice, SCID | Animals | Apoptosis Regulatory Proteins | Interferon-gamma - immunology | Receptors, Interleukin-1 Type I - genetics | Cell Line, Tumor | Interferon Type I - genetics | Programmed Cell Death 1 Receptor | Antigens, Surface | Mammary Neoplasms, Animal - drug therapy | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Trastuzumab | Proteins | Cytokines | Monoclonal antibodies | Interferon | Gene expression | Cells | Index Medicus | Biological Sciences
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2007, Volume 13, Issue 7, pp. 2151 - 2157
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2015, Volume 125, Issue 7, pp. 2877 - 2890
Journal Article
Immunity, ISSN 1074-7613, 04/2012, Volume 36, Issue 4, pp. 623 - 634
Interleukin 9 (IL-9) is a pleiotropic cytokine that can regulate autoimmune responses by enhancing regulatory CD4 FoxP3 T regulatory (Treg) cell survival and T... 
EFFECTOR | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ACTIVATION | TGF-BETA | IL-9 PRODUCTION | MAST-CELLS | IN-VIVO | GATA3 EXPRESSION | DIFFERENTIATION | IMMUNOLOGY | INTRACELLULAR DOMAIN | T-Lymphocytes, Regulatory - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Encephalomyelitis, Autoimmune, Experimental - immunology | Receptor, Notch2 - genetics | Smad3 Protein - metabolism | T-Lymphocytes, Regulatory - immunology | Interleukin-9 - biosynthesis | Th17 Cells - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Interleukin-9 - metabolism | Jagged-2 Protein | Female | Cell Differentiation | Membrane Proteins - metabolism | Transforming Growth Factor beta | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Signal Transduction | Mice, Inbred C57BL | Receptor, Notch2 - metabolism | Cell Communication | Receptor, Notch1 - metabolism | Animals | Receptors, Interleukin-9 - genetics | Th17 Cells - immunology | Mice | Mice, Inbred BALB C | Receptor, Notch1 - genetics | Autoimmunity | Medical colleges | Antigens | Nervous system diseases | Interleukins | Analysis | Oncology, Experimental | Research | Transforming growth factors | T cells | Protein binding | Cancer | Ligands | Transcription factors | Mutagenesis | Mammals | Gene expression | Deoxyribonucleic acid--DNA | Index Medicus | Immunization | Cell survival | Immune response | Helper cells | Intracellular signalling | Lymphocytes T | Smad3 protein | Transforming growth factor- beta | Experimental allergic encephalomyelitis | Promoters | CD4 antigen | Signal transduction | Foxp3 protein | Notch protein | Interleukin 9
Journal Article