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index medicus (7) 7
animals (4) 4
usage (4) 4
cell biology (3) 3
mice (3) 3
oncology (3) 3
stroke (3) 3
cancer research (2) 2
cell transformation, neoplastic - genetics (2) 2
clinical neurology (2) 2
dabigatran (2) 2
diagnosis (2) 2
genetic aspects (2) 2
humans (2) 2
idarucizumab (2) 2
intracranial hemorrhage (2) 2
mutation (2) 2
pancreatic neoplasms - genetics (2) 2
pancreatic neoplasms - pathology (2) 2
peripheral vascular disease (2) 2
research (2) 2
tool (2) 2
tumorigenesis (2) 2
3-phosphoinositide-dependent protein kinases (1) 1
acute ischemic-stroke (1) 1
adenocarcinoma - genetics (1) 1
adenocarcinoma - metabolism (1) 1
adenocarcinoma - pathology (1) 1
amino acid sequence (1) 1
analysis (1) 1
antagonizing dabigatran (1) 1
anticoagulant (1) 1
anticoagulants (1) 1
antidote (1) 1
aphasia (1) 1
arterial-occlusion (1) 1
article (1) 1
atrial fibrillation (1) 1
autoradiography (1) 1
binding sites (1) 1
blood (1) 1
braf (1) 1
brain (1) 1
bronchi - metabolism (1) 1
c-raf (1) 1
cancer (1) 1
carbon isotopes (1) 1
carcinoma, pancreatic ductal - genetics (1) 1
carcinoma, pancreatic ductal - metabolism (1) 1
carcinoma, pancreatic ductal - pathology (1) 1
cardiology (1) 1
care and treatment (1) 1
case report (1) 1
cell proliferation (1) 1
cell transformation, neoplastic (1) 1
cell transformation, neoplastic - metabolism (1) 1
cerebral amyloid angiopathy (1) 1
chromosomal transposition (1) 1
colorectal neoplasms - drug therapy (1) 1
colorectal neoplasms - etiology (1) 1
colorectal-cancer (1) 1
cpnp foundation strategic goals award finalists (1) 1
cyclin-dependent kinase inhibitor p16 (1) 1
cyclin-dependent kinase inhibitor p16 - genetics (1) 1
cyclin-dependent kinase inhibitor p16 - metabolism (1) 1
dabigatran etexilate (1) 1
deoxyribonucleic acid--dna (1) 1
design (1) 1
discovery (1) 1
dna transposable elements - genetics (1) 1
door-to-needle time (1) 1
dosage and administration (1) 1
drug screening assays, antitumor (1) 1
drug therapy (1) 1
ductal adenocarcinoma (1) 1
dura mater (1) 1
early neoplastic progression (1) 1
egf receptor (1) 1
embolism (1) 1
embolization (1) 1
enzyme activation (1) 1
epithelial cells (1) 1
epithelium - metabolism (1) 1
expression (1) 1
extrapontine myelinolysis (1) 1
fibrillation (1) 1
fidgetin (1) 1
forkhead transcription factors - analysis (1) 1
forkhead transcription factors - antagonists & inhibitors (1) 1
forkhead transcription factors - genetics (1) 1
freeze drying (1) 1
gene expression profiling (1) 1
gene expression regulation (1) 1
gene knock-in techniques (1) 1
gene regulatory networks (1) 1
genes (1) 1
genes, p16 (1) 1
genes, synthetic (1) 1
genetic research (1) 1
genetic screening (1) 1
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FRONTIERS IN NEUROLOGY, ISSN 1664-2295, 03/2019, Volume 10, p. 230
We report a case of intravenous thrombolysis in acute ischemic stroke of anterior choroidal artery following the antagonization of dabigatran with... 
intravenous thrombolysis | PLASMINOGEN-ACTIVATOR | ANTAGONIZING DABIGATRAN | door-to-needle time | ACUTE ISCHEMIC-STROKE | dabigatran | idarucizumab | case report | ANTICOAGULANT | NEUROSCIENCES | CLINICAL NEUROLOGY | Neuroimaging | Stroke (Disease) | Usage | Dabigatran etexilate | Dosage and administration | Research | Drug therapy
Journal Article
Deutsches Aerzteblatt Online, ISSN 1866-0452, 09/2019
Journal Article
Clinical Neurology and Neurosurgery, ISSN 0303-8467, 03/2020, Volume 190, p. 105655
Journal Article
by Rad, Roland and Rad, Roland and Rad, Lena and Rad, Lena and Wang, Wei and Wang, Wei and Strong, Alexander and Strong, Alexander and Ponstingl, Hannes and Ponstingl, Hannes and Bronner, Iraad F and Bronner, Iraad F and Mayho, Matthew and Mayho, Matthew and Steiger, Katja and Steiger, Katja and Weber, Julia and Weber, Julia and Hieber, Maren and Hieber, Maren and Veltkamp, Christian and Veltkamp, Christian and Eser, Stefan and Eser, Stefan and Geumann, Ulf and Geumann, Ulf and Öllinger, Rupert and Öllinger, Rupert and Zukowska, Magdalena and Zukowska, Magdalena and Barenboim, Maxim and Barenboim, Maxim and Maresch, Roman and Maresch, Roman and Cadiñanos, Juan and Cadiñanos, Juan and Friedrich, Mathias and Friedrich, Mathias and Varela, Ignacio and Varela, Ignacio and Constantino-Casas, Fernando and Constantino-Casas, Fernando and Sarver, Aaron and Sarver, Aaron and Ten Hoeve, Jelle and Ten Hoeve, Jelle and Prosser, Haydn and Prosser, Haydn and Seidler, Barbara and Seidler, Barbara and Bauer, Judith and Bauer, Judith and Heikenwälder, Mathias and Heikenwälder, Mathias and Metzakopian, Emmanouil and Metzakopian, Emmanouil and Krug, Anne and Krug, Anne and Ehmer, Ursula and Ehmer, Ursula and Schneider, Gönter and Schneider, Günter and Knösel, Thomas and Knösel, Thomas and Römmele, Petra and Rümmele, Petra and Aust, Daniela and Aust, Daniela and Grützmann, Robert and Grötzmann, Robert and Pilarsky, Christian and Pilarsky, Christian and Ning, Zemin and Ning, Zemin and Wessels, Lodewyk and Wessels, Lodewyk and M Schmid, Roland and Schmid, Roland M and A Quail, Michael and Quail, Michael A and Vassiliou, George and Vassiliou, George and Esposito, Irene and Esposito, Irene and Liu, Pentao and Liu, Pentao and Saur, Dieter and Saur, Dieter and Bradley, Allan and Bradley, Allan
Nature Genetics, ISSN 1061-4036, 01/2015, Volume 47, Issue 1, pp. 47 - 56
Here we describe a conditional piggyBac transposition system in mice and report the discovery of large sets of new cancer genes through a pancreatic... 
PATHWAYS | FIDGETIN | SOMATIC MUTAGENESIS | LANDSCAPE | CHROMOSOMAL TRANSPOSITION | GENETICS & HEREDITY | SLEEPING-BEAUTY | PROTEINS | EXPRESSION | DISCOVERY | TOOL | Pancreatic Neoplasms - chemistry | Humans | Molecular Sequence Data | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Gene Regulatory Networks | Repressor Proteins - analysis | Repressor Proteins - antagonists & inhibitors | Moths - genetics | Proton-Translocating ATPases - genetics | Cell Transformation, Neoplastic - genetics | Transposases - genetics | DNA Transposable Elements - genetics | Forkhead Transcription Factors - antagonists & inhibitors | Neoplasm Proteins - genetics | Transgenes | Amino Acid Sequence | Pancreatic Neoplasms - pathology | RNA, Small Interfering - pharmacology | Gene Expression Regulation | Genes, Synthetic | Repressor Proteins - genetics | Mice, Transgenic | Pancreatic Neoplasms - genetics | Forkhead Transcription Factors - genetics | Genes, p16 | Gene Knock-In Techniques | Transposases - physiology | Animals | Forkhead Transcription Factors - analysis | Mice | Mutagenesis, Insertional | Noncoding DNA | Usage | Pancreatic cancer | Genetic aspects | Diagnosis | Research | Genetic screening | Studies | Medical research | Vertebrates | Mutagenesis | Genes | Genomes | Tumorigenesis | Mutation | Binding sites | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Neurology: Clinical Practice, ISSN 2163-0402, 12/2019, p. 10
Journal Article
Journal of Thrombosis and Thrombolysis, ISSN 0929-5305, 7/2018, Volume 46, Issue 1, pp. 12 - 15
Journal Article
Cancer Cell, ISSN 1535-6108, 03/2013, Volume 23, Issue 3, pp. 406 - 420
Oncogenic Kras activates a plethora of signaling pathways, but our understanding of critical Ras effectors is still very limited. We show that cell-autonomous... 
RAS ONCOGENE | PI3K | ONCOLOGY | DUCTAL ADENOCARCINOMA | MOUSE MODEL | IN-VIVO | C-RAF | TUMOR-SUPPRESSOR | MICE | TUMORIGENESIS | EGF RECEPTOR | CELL BIOLOGY | Neoplasm Transplantation | Proto-Oncogene Proteins p21(ras) | Adenocarcinoma - pathology | Cell Proliferation | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | ras Proteins - metabolism | Transplantation, Heterologous | Phosphatidylinositol 3-Kinases - metabolism | Carcinoma, Pancreatic Ductal - genetics | Lithostathine - metabolism | Adenocarcinoma - metabolism | Cell Transformation, Neoplastic - genetics | Adenocarcinoma - genetics | Tumor Cells, Cultured | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Signal Transduction | Pancreatic Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Pancreatic Neoplasms - genetics | TNF Receptor-Associated Factor 3 - metabolism | Sulfonamides - pharmacology | Carcinoma, Pancreatic Ductal - pathology | Cell Transformation, Neoplastic - metabolism | Indazoles - pharmacology | Metaplasia | Animals | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Mice, Inbred NOD | Mice | Enzyme Activation | Analysis | Genomics | Genetic research | Genetic aspects | Livestock | Lung cancer, Non-small cell | Health aspects | Cancer
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2013, Volume 24, Issue 1, pp. 15 - 29
We show that BRAF initiates an alternative pathway to colorectal cancer (CRC), which progresses through a hyperplasia/adenoma/carcinoma sequence. This pathway... 
Journal Article
Journal Article
DEUTSCHES ARZTEBLATT INTERNATIONAL, ISSN 1866-0452, 09/2019, Volume 116, Issue 35-36, pp. 600 - 600
Background: Osmotic demyelination syndrome (ODS), which embraces central pontine myelinolysis (CPM) and extrapontine myelinosis (EPM), is often underdiagnosed... 
DIAGNOSIS | MEDICINE, GENERAL & INTERNAL | EXTRAPONTINE MYELINOLYSIS | HYPONATREMIA | Review
Journal Article
Stroke, ISSN 0039-2499, 10/2018, Volume 49, Issue 10, pp. 2323 - 2329
BACKGROUND AND PURPOSE—To date, no clinical score has become widely accepted as an eligible prehospital marker for large vessel occlusion (LVO) and the need of... 
Aphasia | Intracranial hemorrhage | Stroke | Thrombectomy | Neglect | aphasia | DESIGN | thrombectomy | VALIDATION | VISUAL NEGLECT | stroke | CLINICAL NEUROLOGY | PREDICTION | ARTERIAL-OCCLUSION | intracranial hemorrhage | PERIPHERAL VASCULAR DISEASE | SCALE | neglect | TOOL | Stroke (Disease) | Care and treatment | Usage | Surgery | Embolism
Journal Article
Clinical neurology and neurosurgery, 12/2019, Volume 190, p. 105655
Cerebral amyloid angiopathy (CAA) is an important cause of intracerebral hemorrhage (ICH). However, data on surgical intervention in CAA-related ICH is very... 
Journal Article
Stroke, 10/2018, Volume 49, Issue 10, p. 2323
Background and Purpose- To date, no clinical score has become widely accepted as an eligible prehospital marker for large vessel occlusion (LVO) and the need... 
Journal Article
by Kermer, Pawel and Eschenfelder, Christoph C and Diener, Hans-Christoph and Grond, Martin and Abdalla, Yasser and Abraham, Alexej and Althaus, Katharina and Becks, Gebhard and Berrouschot, Jörg and Berthel, Jörg and Bode, Felix J and Burghaus, Lothar and Cangür, Hakan and Daffertshofer, Michael and Edelbusch, Sebastian and Eggers, Jürgen and Gerlach, Rüdiger and Gröschel, Klaus and Große-Dresselhaus, Florian and Günther, Albrecht and Haase, Claus G and Haensch, Carl-Albrecht and Harloff, Andreas and Heckmann, Joseph G and Held, Valentin and Hieber, Maren and Kauert, Andreas and Kern, Rolf and Kerz, Thomas and Köhrmann, Martin and Kraft, Peter and Kühnlein, Peter and Latta, Jan and Leinisch, Elke and Lenz, Arne and Leithner, Christoph and Neumann-Haefelin, Tobias and Mäurer, Mathias and Müllges, Wolfgang and Nolte, Christian H and Obermann, Mark and Partowi, Someieh and Patzschke, Peer and Poli, Sven and Pulkowski, Ulrich and Purrucker, Jan and Rehfeldt, Torsten and Ringleb, Peter A and Röther, Joachim and Rossi, Raluca and El-Sabassy, Hazem and Sauer, Oliver and Schackert, Gabriele and Schäfer, Niklas and Schellinger, Peter D and Schneider, Andreas and Schuppner, Ramona and Schwab, Stefan and Schwarte, Olav and Seitz, Rüdiger J and Senger, Sebastian and Shah, Yogesh P and Sindern, Eckhart and Sparenberg, Paul and Steiner, Thorsten and Szabo, Kristina and Urbanek, Christian and Sarnowksi, Bettina von and Weissenborn, Karin and Wienecke, Peter and Witt, Karsten and Wruck, Robert and Wunderlich, Silke
International Journal of Stroke, ISSN 1747-4930, 01/2020, p. 174749301989565
Background Idarucizumab is a monoclonal antibody fragment with high affinity for dabigatran reversing its anticoagulant effects within minutes. Thereby,... 
Journal Article
by Kermer, Pawel and Eschenfelder, Christoph C and Diener, Hans-Christoph and Grond, Martin and Abdalla, Yasser and Abraham, Alexej and Althaus, Katharina and Becks, Gebhard and Berrouschot, Jörg and Berthel, Jörg and Bode, Felix J and Burghaus, Lothar and Cangür, Hakan and Daffertshofer, Michael and Edelbusch, Sebastian and Eggers, Jürgen and Gerlach, Rüdiger and Gröschel, Klaus and Große-Dresselhaus, Florian and Günther, Albrecht and Haase, Claus G and Haensch, Carl-Albrecht and Harloff, Andreas and Heckmann, Joseph G and Held, Valentin and Hieber, Maren and Kauert, Andreas and Kern, Rolf and Kerz, Thomas and Köhrmann, Martin and Kraft, Peter and Kühnlein, Peter and Latta, Jan and Leinisch, Elke and Lenz, Arne and Leithner, Christoph and Neumann-Haefelin, Tobias and Mäurer, Mathias and Müllges, Wolfgang and Nolte, Christian H and Obermann, Mark and Partowi, Someieh and Patzschke, Peer and Poli, Sven and Pulkowski, Ulrich and Purrucker, Jan and Rehfeldt, Torsten and Ringleb, Peter A and Röther, Joachim and Rossi, Raluca and El-Sabassy, Hazem and Sauer, Oliver and Schackert, Gabriele and Schäfer, Niklas and Schellinger, Peter D and Schneider, Andreas and Schuppner, Ramona and Schwab, Stefan and Schwarte, Olav and Seitz, Rüdiger J and Senger, Sebastian and Shah, Yogesh P and Sindern, Eckhart and Sparenberg, Paul and Steiner, Thorsten and Szabo, Kristina and Urbanek, Christian and Sarnowksi, Bettina von and Weissenborn, Karin and Wienecke, Peter and Witt, Karsten and Wruck, Robert and Wunderlich, Silke
International journal of stroke : official journal of the International Stroke Society, 01/2020, p. 1747493019895654
Idarucizumab is a monoclonal antibody fragment with high affinity for dabigatran reversing its anticoagulant effects within minutes. Thereby, patients with... 
Journal Article
The mental health clinician, ISSN 2168-9709, 05/2019, Volume 9, Issue 3, pp. 141 - 257
Journal Article
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