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1. Full Text Pruning cancer’s evolutionary tree with lesion-directed therapy
by Hiley, Crispin T and Swanton, Charles
Cancer Discovery, ISSN 2159-8274, 02/2016, Volume 6, Issue 2, pp. 122 - 124
Next generation sequencing of spatially and temporally separated biopsies and circulating tumour DNA directs therapy in response to tumor evolution and... 
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2. Full Text Cognitive impairment in survivors of irradiated brain tumors is multifactorial: Implications of polypharmacy with antiepileptics?
by Hiley, Crispin T
Journal of Clinical Oncology, ISSN 0732-183X, 12/2015, Volume 33, Issue 34, pp. 4122 - 4122
ONCOLOGY | Piperidines - therapeutic use | Humans | Female | Male | Brain Neoplasms - drug therapy | Brain Neoplasms - radiotherapy | Cognition Disorders - drug therapy | Indans - therapeutic use
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3. Full Text Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
by McGranahan, Nicholas and Furness, Andrew J.S and Rosenthal, Rachel and Ramskov, Sofie and Lyngaa, Rikke and Saini, Sunil Kumar and Jamal-Hanjani, Mariam and Wilson, Gareth A and Birkbak, Nicolai J and Hiley, Crispin T and Watkins, Thomas B.K and Shafi, Seema and Murugaesu, Nirupa and Mitter, Richard and Akarca, Ayse U and Linares, Joseph and Marafioti, Teresa and Henry, Jake Y and Van Allen, Eliezer M and Miao, Diana and Schilling, Bastian and Schadendorf, Dirk and Garraway, Levi A and Makarov, Vladimir and Rizvi, Naiyer A and Snyder, Alexandra and Hellmann, Matthew D and Merghoub, Taha and Wolchok, Jedd D and Shukla, Sachet A and Wu, Catherine J and Peggs, Karl S and Chan, Timothy A and Hadrup, Sine R and Quezada, Sergio A and Swanton, Charles
Science, ISSN 0036-8075, 03/2016, Volume 351, Issue 6280, pp. 1463 - 1469
As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored... 
ANALYSIS REVEALS | CTLA-4 BLOCKADE | CANCER | MULTIDISCIPLINARY SCIENCES | Immunologic Surveillance | Lung Neoplasms - drug therapy | Adenocarcinoma of Lung | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | CD4-Positive T-Lymphocytes - immunology | Aged, 80 and over | Female | Adenocarcinoma - genetics | Cell Cycle Checkpoints - immunology | Lung Neoplasms - genetics | Antigens, Neoplasm - genetics | Skin Neoplasms - immunology | Antigens, Neoplasm - immunology | Carcinoma, Non-Small-Cell Lung - genetics | Adenocarcinoma - immunology | CTLA-4 Antigen - immunology | Adenocarcinoma - drug therapy | Carcinoma, Non-Small-Cell Lung - immunology | Lung Neoplasms - immunology | Melanoma - immunology | Aged | Mutation | Programmed Cell Death 1 Receptor - immunology | Lymphocytes, Tumor-Infiltrating - immunology | Tumor antigens | Cancer cells | Genetic aspects | Cancer invasiveness | T cells | Lung cancer, Non-small cell | Diseases | Antigens | Cellular biology | Lymphocytes | Cancer
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4. Full Text Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease
by Hiley, Crispin T, MD and Le Quesne, John, FRCPath and Santis, George, Prof and Sharpe, Rowena, PhD and de Castro, David Gonzalez, Prof and Middleton, Gary, Prof and Swanton, Charles, Prof
Lancet, The, ISSN 0140-6736, 2016, Volume 388, Issue 10048, pp. 1002 - 1011
Summary Lung cancer diagnostics have progressed greatly in the previous decade. Development of molecular testing to identify an increasing number of... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | CIRCULATING TUMOR-CELLS | FACTOR RECEPTOR MUTATIONS | TYROSINE KINASE | PD-L1 EXPRESSION | EML4-ALK FUSION GENE | PHASE-III | INTRATUMOR HETEROGENEITY | ACQUIRED-RESISTANCE | TRANSBRONCHIAL NEEDLE ASPIRATION | PREVIOUSLY TREATED PATIENTS | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Severity of Illness Index | Receptor, Epidermal Growth Factor - genetics | Biomarkers, Tumor - analysis | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Lung Neoplasms - pathology | Receptor, Epidermal Growth Factor - analysis | Receptor Protein-Tyrosine Kinases - genetics | Biomarkers, Tumor - genetics | Mutation | High-Throughput Nucleotide Sequencing - methods | Medical colleges | Care and treatment | Therapeutics | Respiratory agents | Lung cancer, Non-small cell | Homeopathy | Materia medica and therapeutics | Ultrasonic imaging | Biomedical research | Histopathology | Immunotherapy | Lung cancer | Diagnostic tests | Tumors
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5. Full Text Evolutionary Precision Medicine: A Role for Repeat Epidermal Growth Factor Receptor Analysis inALK-Rearranged Lung Adenocarcinoma?
by Birkbak, Nicolai Juul and Hiley, Crispin T and Swanton, Charles
Journal of Clinical Oncology, ISSN 0732-183X, 11/2015, Volume 33, Issue 32, pp. 3681 - 3683
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6. Full Text Tracking the Evolution of Non–Small-Cell Lung Cancer
by Jamal-Hanjani, Mariam and Wilson, Gareth A and McGranahan, Nicholas and Birkbak, Nicolai J and Watkins, Thomas B.K and Veeriah, Selvaraju and Shafi, Seema and Johnson, Diana H and Mitter, Richard and Rosenthal, Rachel and Salm, Max and Horswell, Stuart and Escudero, Mickael and Matthews, Nik and Rowan, Andrew and Chambers, Tim and Moore, David A and Turajlic, Samra and Xu, Hang and Lee, Siow-Ming and Forster, Martin D and Ahmad, Tanya and Hiley, Crispin T and Abbosh, Christopher and Falzon, Mary and Borg, Elaine and Marafioti, Teresa and Lawrence, David and Hayward, Martin and Kolvekar, Shyam and Panagiotopoulos, Nikolaos and Janes, Sam M and Thakrar, Ricky and Ahmed, Asia and Blackhall, Fiona and Summers, Yvonne and Shah, Rajesh and Joseph, Leena and Quinn, Anne M and Crosbie, Phil A and Naidu, Babu and Middleton, Gary and Langman, Gerald and Trotter, Simon and Nicolson, Marianne and Remmen, Hardy and Kerr, Keith and Chetty, Mahendran and Gomersall, Lesley and Fennell, Dean A and Nakas, Apostolos and Rathinam, Sridhar and Anand, Girija and Khan, Sajid and Russell, Peter and Ezhil, Veni and Ismail, Babikir and Irvin-Sellers, Melanie and Prakash, Vineet and Lester, Jason F and Kornaszewska, Malgorzata and Attanoos, Richard and Adams, Haydn and Davies, Helen and Dentro, Stefan and Taniere, Philippe and O’Sullivan, Brendan and Lowe, Helen L and Hartley, John A and Iles, Natasha and Bell, Harriet and Ngai, Yenting and Shaw, Jacqui A and Herrero, Javier and Szallasi, Zoltan and Schwarz, Roland F and Stewart, Aengus and Quezada, Sergio A and Le Quesne, John and Van Loo, Peter and Dive, Caroline and Hackshaw, Allan and Swanton, Charles and TRACERx Consortium
The New England Journal of Medicine, ISSN 0028-4793, 06/2017, Volume 376, Issue 22, pp. 2109 - 2121
Distinct genes are mutated in different regions of a single patient’s tumor. Point mutations seem to have less adverse effect on relapse-free survival than... 
HETEROGENEITY | WIDESPREAD | MUTATIONAL PROCESSES | MEDICINE, GENERAL & INTERNAL | ADENOCARCINOMAS | PATTERNS | CHROMOSOMAL INSTABILITY | Lung Neoplasms - genetics | Prognosis | Prospective Studies | Carcinoma, Non-Small-Cell Lung - genetics | Lung Neoplasms - mortality | Humans | Risk Factors | Male | Phylogeny | Carcinoma, Non-Small-Cell Lung - mortality | Genetic Heterogeneity | DNA Copy Number Variations | Exome | Disease-Free Survival | Female | Neoplasm Recurrence, Local - genetics | Mutation | Chromosomal Instability | Sequence Analysis, DNA - methods | Evolution, Molecular | Lung cancer, Non-small cell | Chromosomes | Research | Medical research | Chromatin | Epidermal growth factor receptors | Transcription | p53 Protein | Lung cancer | DNA damage | Non-small cell lung carcinoma | Oncology | Genomes | Multivariate analysis | DNA repair | Survival | Cyclin-dependent kinase 4 | Genomic instability | Pathology | Census | Lungs | Evolution | Death | Tumors | Index Medicus | Abridged Index Medicus
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7. Full Text Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution
by McGranahan, Nicholas and Rosenthal, Rachel and Hiley, Crispin and Hiley, Crispin T and Rowan, Andrew and Rowan, Andrew J and Watkins, Thomas B.K and Wilson, Gareth and Wilson, Gareth A and Birkbak, Nicolai J and Veeriah, Selvaraju and Van Loo, Peter and Herrero, Javier and Swanton, Charles and Jamal-Hanjani, Mariam and Shafi, Seema and Czyzewska-Khan, Justyna and Johnson, Benjamin and Johnson, Diana and Laycock, Joanne and Bosshard-Carter, Leticia and Gorman, Pat and Hynds, Robert E and Horswell, Stuart and Mitter, Richard and Escudero, Mickael and Stewart, Aengus and Xu, Hang and Turajlic, Samra and Abbosh, Christopher and Goldman, Jacki and Stone, Richard Kevin and Denner, Tamara and Matthews, Nik and Matthews, Sue and Elgar, Greg and Ward, Sophia and Costa, Marta and Begum, Sharmin and Phillimore, Ben and Chambers, Tim and Nye, Emma and Graca, Sofia and Al Bakir, Maise and Joshi, Kroopa and Furness, Andrew and Ben Aissa, Assma and Wong, Yien Ning Sophia and Georgiou, Andy and Quezada, Sergio and Hartley, John A and Lowe, Helen L and Lawrence, David and Hayward, Martin and Panagiotopoulos, Nikolaos and Kolvekar, Shyam and Falzon, Mary and Borg, Elaine and Marafioti, Teresa and Simeon, Celia and Hector, Gemma and Smith, Amy and Smith, Sean and Smith, Elaine and Aranda, Marie and Novelli, Marco and Oukrif, Dahmane and Janes, Sam M and Thakrar, Ricky and Forster, Martin and Ahmad, Tanya and Lee, Siow Ming and Papadatos-Pastos, Dionysis and Carnell, Dawn and Mendes, Ruheena and George, Jeremy and Navani, Neal and Ahmed, Asia and Taylor, Paul and Taylor, Magali and Choudhary, Junaid and Summers, Yvonne and Califano, Raffaele and Shah, Rajesh and Krysiak, Piotr and Rammohan, Kendadai and Fontaine, Eustace and Booton, Richard and Evison, Matthew and Crosbie, Phil and Moss, Stuart and Idries, Faiza and Joseph, Leena and Bishop, Paul and Chaturved, Anshuman and Quinn, Anne Marie and Doran, Helen and Leek, Angela and Harrison, Phil and Moore, Katrina and ... and TRACERx Consortium
Cell, ISSN 0092-8674, 11/2017, Volume 171, Issue 6, pp. 1259 - 1271.e11
Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion.... 
neoantigen | lung cancer | chromosomal instability | bioinformatics | cancer evolution | immune-editing | copy number | loss of heterozygosity | immune-escape | heterogeneity | MUTATIONAL PROCESSES | CTLA-4 BLOCKADE | CELLS | PD-1 BLOCKADE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COPY NUMBER | DOWN-REGULATION | SENSITIVITY | RESISTANCE | NEOANTIGENS | DISCOVERY | CELL BIOLOGY | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Tumor Escape | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Middle Aged | HLA Antigens - immunology | Lung Neoplasms - pathology | Male | Lung Neoplasms - therapy | HLA Antigens - genetics | Loss of Heterozygosity | Carcinoma, Non-Small-Cell Lung - immunology | Carcinoma, Non-Small-Cell Lung - therapy | Lung Neoplasms - immunology | Antigen Presentation | Aged, 80 and over | Adult | Female | Aged | Polymorphism, Single Nucleotide | Mutation | Cohort Studies | Histocompatibility antigens | Lung cancer, Non-small cell | Analysis | Immunotherapy | Tumor antigens | HLA histocompatibility antigens
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8. Full Text Spatial and temporal cancer evolution: causes and consequences of tumour diversity
by Hiley, Crispin T and Swanton, Charles
Clinical medicine (London, England), ISSN 1470-2118, 12/2014, Volume 14, Issue Suppl_6, pp. s33 - s37
evolution | heterogeneity | resistance | Cancer
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9. Full Text Evolutionary precision medicine: A role for repeat epidermal growth factor receptor analysis in ALK-rearranged lung adenocarcinoma?
by Birkbak, Nicolai Juul and Hiley, Crispin T and Swanton, Charles
Journal of Clinical Oncology, ISSN 0732-183X, 11/2015, Volume 33, Issue 32, pp. 3681 - 3683
ONCOLOGY | Lung Neoplasms - genetics | Receptor, Epidermal Growth Factor - genetics | Adenocarcinoma - pathology | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Gene Rearrangement | Humans | Female | Lung Neoplasms - pathology | Male | Adenocarcinoma - genetics | Mutation
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10. Spatial and temporal cancer evolution: causes and consequences of tumour diversity
by Hiley, Crispin T and Swanton, Charles
Clinical medicine (London, England), 12/2014, Volume 14 Suppl 6, p. s33
Our knowledge of the morphological heterogeneity of cancer has recently been augmented by the genomic heterogeneity revealed by the use of next-generation... 
Neoplasms - chemistry | Neoplastic Processes | Drug Resistance, Neoplasm - genetics | Neoplasms - genetics | Humans | Spatio-Temporal Analysis | Phylogeny | Neoplasms - pathology | Sequence Analysis, DNA | Disease Progression | Evolution, Molecular
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11. Full Text Pruning Cancer's Evolutionary Tree with Lesion-Directed Therapy
by Hiley, CT and Swanton, C
CANCER DISCOVERY, ISSN 2159-8274, 02/2016, Volume 6, Issue 2, pp. 122 - 124
Next-generation sequencing of spatially and temporally separated biopsies and circulating tumor DNA directs therapy in response to tumor evolution and acquired... 
ACQUIRED-RESISTANCE | CLONAL EVOLUTION | MUTATIONS | ONCOLOGY | COLORECTAL-CANCER | Colorectal Neoplasms | High-Throughput Nucleotide Sequencing | DNA, Neoplasm - genetics | Humans
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12. Full Text Association of the imbalance between early and late differentiated intra-tumor CD4 T cells with mutational burden in non-small cell lung cancer
by Ghorani, Ehsan and Reading, James L and Henry, Jake Y and Robert De Massy, Marc and Rosenthal, Rachel and Furness, Andrew J.S and Ben Aissa, Assma and Jamal-Hanjani, Mariam and Birkbak, Nicolai and Wilson, Gareth and Salgado, Roberto and Lund, Tom and Hiley, Crispin T and Loi, Sherene and Hackshaw, Allan and McGranahan, Nicholas and Chain, Benjamin M and Peggs, Karl S and Swanton, Charles and Quezada, Sergio A
Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. 2590 - 2590
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13. Full Text A clonal expression biomarker associates with lung cancer mortality
by Biswas, Dhruva and Birkbak, Nicolai J and Rosenthal, Rachel and Hiley, Crispin T and Lim, Emilia L and Papp, Krisztian and Boeing, Stefan and Krzystanek, Marcin and Djureinovic, Dijana and La Fleur, Linnea and Greco, Maria and Döme, Balázs and Fillinger, János and Brunnström, Hans and Wu, Yin and Moore, David A and Skrzypski, Marcin and Abbosh, Christopher and Litchfield, Kevin and Al Bakir, Maise and Watkins, Thomas B. K and Veeriah, Selvaraju and Wilson, Gareth A and Jamal-Hanjani, Mariam and Moldvay, Judit and Botling, Johan and Chinnaiyan, Arul M and Micke, Patrick and Hackshaw, Allan and Bartek, Jiri and Csabai, Istvan and Szallasi, Zoltan and Herrero, Javier and McGranahan, Nicholas and Swanton, Charles and TRACERx Consortium
Nature Medicine, ISSN 1078-8956, 10/2019, Volume 25, Issue 10, pp. 1540 - 1548
An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes predictive of outcome, improving diagnostic precision beyond clinical... 
RNA sequencing | Care and treatment | Usage | Lung cancer | Genetic aspects | Research | Genetic transcription | Biological markers | Cell proliferation | Small cell lung carcinoma | Bias | Biological evolution | Non-small cell lung carcinoma | Ribonucleic acid--RNA | Risk analysis | Gene expression | Risk factors | Gene sequencing | Genomic instability | Heterogeneity | Biomarkers | Bioindicators | Diagnostic systems | Sampling | Deoxyribonucleic acid--DNA | Tumors
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14. Full Text Neoantigen-directed immune escape in lung cancer evolution
by Rosenthal, Rachel and Cadieux, Elizabeth Larose and Salgado, Roberto and Bakir, Maise Al and Moore, David A and Hiley, Crispin T and Lund, Tom and Tanić, Miljana and Reading, James L and Joshi, Kroopa and Henry, Jake Y and Ghorani, Ehsan and Wilson, Gareth A and Birkbak, Nicolai J and Jamal-Hanjani, Mariam and Veeriah, Selvaraju and Szallasi, Zoltan and Loi, Sherene and Hellmann, Matthew D and Feber, Andrew and Chain, Benny and Herrero, Javier and Quezada, Sergio A and Demeulemeester, Jonas and Van Loo, Peter and Beck, Stephan and McGranahan, Nicholas and Swanton, Charles and Swanton, Charles and Jamal-Hanjani, Mariam and Veeriah, Selvaraju and Czyzewska-Khan, Justyna and Johnson, Diana and Laycock, Joanne and Rosenthal, Rachel and Gorman, Pat and Hynds, Robert E and Wilson, Gareth and Birkbak, Nicolai J and Watkins, Thomas B. K and McGranahan, Nicholas and Escudero, Mickael and Stewart, Aengus and Van Loo, Peter and Rowan, Andrew and Hiley, Crispin T and Abbosh, Christopher and Goldman, Jacki and Stone, Richard Kevin and Denner, Tamara and Ward, Sophia and Nye, Emma and Joshi, Kroopa and Ben Aissa, Assma and Wong, Yien Ning Sophia and Georgiou, Andy and Quezada, Sergio and Hartley, John A and Lowe, Helen L and Herrero, Javier and Lawrence, David and Hayward, Martin and Panagiotopoulos, Nikolaos and Falzon, Mary and Borg, Elaine and Marafioti, Teresa and Janes, Sam M and Forster, Martin and Ahmad, Tanya and Lee, Siow Ming and Papadatos-Pastos, Dionysis and Carnell, Dawn and Mendes, Ruheena and George, Jeremy and Ahmed, Asia and Taylor, Magali and Choudhary, Junaid and Summers, Yvonne and Califano, Raffaele and Taylor, Paul and Shah, Rajesh and Krysiak, Piotr and Rammohan, Kendadai and Fontaine, Eustace and Booton, Richard and Evison, Matthew and Crosbie, Phil and Moss, Stuart and Joseph, Leena and Bishop, Paul and Quinn, Anne Marie and Doran, Helen and Leek, Angela and Harrison, Phil and Moore, Katrina and Waddington, Rachael and Novasio, Juliette and Blackhall, Fiona and Rogan, Jane and Smith, Elaine and ... and TRACERx Consortium and TRACERx consortium and The TRACERx consortium
Nature, ISSN 0028-0836, 03/2019, Volume 567, Issue 7749, pp. 479 - 485
The interplay between an evolving cancer and a dynamic immune microenvironment remains unclear. Here we analyse 258 regions from 88 early-stage, untreated... 
TUMOR-INFILTRATING LYMPHOCYTES | THERAPY | CELL | MULTIDISCIPLINARY SCIENCES | Causes of | Development and progression | Genetic aspects | Cellular immunity | Lung cancer | Working groups | Brain cancer | Editing | Genomes | Metastases | Gene sequencing | Histopathology | Lymphocytes | Evolution | Bioinformatics | Immune system | Antigens | T cell receptors | Ribonucleic acid--RNA | Estimates | Heterozygosity | White blood cells | Pathology | Depletion | Loss of heterozygosity | Epigenetics | Biomarkers | Ligands | Infiltration | Microenvironments | Mutation | Tumors | Cancer
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