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Acta Neuropathologica, ISSN 0001-6322, 4/2017, Volume 133, Issue 4, pp. 629 - 644
Mutations in codon 132 of isocitrate dehydrogenase (IDH) 1 are frequent in diffuse glioma, acute myeloid leukemia, chondrosarcoma and intrahepatic... 
Pathology | Therapy | Neurosciences | IDH-mutated glioma | Medicine & Public Health | IDH1R132 inhibitor | Pharmacology | Drug development | Mouse xenograft | SELECTIVE-INHIBITION | GLIOMAS | ISOCITRATE DEHYDROGENASE | PHENOTYPE | ACUTE MYELOID-LEUKEMIA | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | BRAIN-TUMORS | GLIOBLASTOMAS | TUMOR STEM-CELLS | MUTATIONS | DIFFERENTIATION | Benzimidazoles - toxicity | Colonic Neoplasms - genetics | Colonic Neoplasms - drug therapy | Escherichia coli | Humans | Sarcoma - enzymology | Benzimidazoles - chemistry | Isocitrate Dehydrogenase - antagonists & inhibitors | Antineoplastic Agents - toxicity | Sf9 Cells | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | Enzyme Inhibitors - toxicity | Astrocytoma - drug therapy | HEK293 Cells | Astrocytoma - enzymology | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Sarcoma - genetics | Cell Survival - physiology | Astrocytoma - genetics | Recombinant Proteins - metabolism | Cell Survival - drug effects | Brain Neoplasms - enzymology | Aniline Compounds - pharmacology | Enzyme Inhibitors - pharmacology | Benzimidazoles - pharmacokinetics | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Recombinant Proteins - genetics | Aniline Compounds - pharmacokinetics | Aniline Compounds - toxicity | Antineoplastic Agents - chemistry | Brain Neoplasms - drug therapy | Sarcoma - drug therapy | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cell Line, Tumor | Benzimidazoles - pharmacology | Isocitrate Dehydrogenase - metabolism | Colonic Neoplasms - enzymology | Glutarates - metabolism | Mice, Inbred BALB C | Aniline Compounds - chemistry | Mutation | Gliomas | Genetic aspects | Codon | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2019, Volume 116, Issue 7, pp. 2551 - 2560
Journal Article
ChemMedChem, ISSN 1860-7179, 12/2015, Volume 10, Issue 12, pp. 2116 - 2116
The back cover picture shows our modular approach in reassembling previously described building blocks of inhibitors for the mitogen‐activated protein kinase... 
inhibitors | structure-based drug design | MEK | kinases | feedback activation | oncology
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 10, pp. 4578 - 4600
Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 12/2019, Volume 62, Issue 24, pp. 11194 - 11217
The P2X4 receptor is a ligand-gated ion channel that is expressed on a variety of cell types, especially those involved in inflammatory and immune processes.... 
MEDICINAL CHEMISTRY | DYNAMIC WEIGHT-BEARING | CHEMISTRY, MEDICINAL | ANTAGONIST | PROTEIN | ABDOMINAL-PAIN | MICROGLIA | P2X RECEPTORS | INFLAMMATION | MODEL | DERIVATIVES
Journal Article
ChemMedChem, ISSN 1860-7179, 12/2015, Volume 10, Issue 12, pp. 2004 - 2013
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 01/2020, Volume 63, Issue 2, pp. 601 - 612
The serine/threonine kinase TBK1 (TANK-binding kinase 1) and its homologue IKK epsilon are noncanonical members of the inhibitor of the nuclear factor kappa B... 
POTENT | ACTIVATION | CHEMISTRY, MEDICINAL | TBK1 | CANCERS | IN-VIVO EFFICACY | THERAPEUTIC TARGET | GENES | BINDING KINASE 1 | AUTOPHAGY | IDENTIFICATION
Journal Article
The EMBO Journal, ISSN 0261-4189, 05/2002, Volume 21, Issue 9, pp. 2095 - 2106
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2016, Volume 113, Issue 17, p. 4711
  Cancerous cells have an acutely increased demand for energy, leading to increased levels of human glucose transporter 1 (hGLUT1). This up-regulation suggests... 
Proteins | Glucose | Cells | Binding sites | Cancer
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2016, Volume 26, Issue 1, pp. 186 - 193
Journal Article
Expert Opinion on Drug Discovery, ISSN 1746-0441, 04/2008, Volume 3, Issue 4, pp. 391 - 401
Journal Article
Molecular Cell, ISSN 1097-2765, 1999, Volume 3, Issue 6, pp. 781 - 791
Journal Article