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1. Full Text Functional genetics - an approach to mechanisms in Alzheimer's disease
by Hiltunen, Mikko
Molecular Neurodegeneration, ISSN 1750-1326, 09/2013, Volume 8 Suppl 1, pp. O3 - O3
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2. Full Text DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
by Martiskainen, Henna and Paldanius, Kaisa M.A and Natunen, Teemu and Takalo, Mari and Marttinen, Mikael and Leskelä, Stina and Huber, Nadine and Mäkinen, Petra and Bertling, Enni and Dhungana, Hiramani and Huuskonen, Mikko and Honkakoski, Paavo and Hotulainen, Pirta and Rilla, Kirsi and Koistinaho, Jari and Soininen, Hilkka and Malm, Tarja and Haapasalo, Annakaisa and Hiltunen, Mikko
Journal of Neuroinflammation, ISSN 1742-2094, 11/2017, Volume 14, Issue 1, pp. 215 - 215
Background: DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be... 
Neuroprotection | Neuroinflammation | Alzheimer's disease | DHCR24/Seladin-1 | SELADIN-1 | CELLS | APP | OXIDATIVE STRESS | ACTIVATION | ALZHEIMERS-DISEASE | IMMUNOLOGY | SYNAPTIC PLASTICITY | NEUROSCIENCES | MOUSE MODEL | GENERATION | CHOLESTEROL-BIOSYNTHESIS | Genetic aspects | Neural circuitry | Gene expression | Cell death | Health aspects | Brain | Cell culture | Pathogenesis | Lipids | Lipopolysaccharides | Proteins | Dendritic spines | Ischemia | Rodents | Cell adhesion | Neostriatum | Aging | Microglial cells | Growth conditions | Immunoglobulins | Neurons | Cortex | Inflammation | Embryos | Cholesterol | Magnetic resonance imaging | γ-Interferon | Brain injury | Hippocampus | Index Medicus | Alzheimer’s disease
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3. A report from the 8th Kuopio Alzheimer Symposium
by Haapasalo, Annakaisa and Hiltunen, Mikko
Neurodegenerative disease management, 10/2018, Volume 8, Issue 5, p. 289
The international Kuopio Alzheimer Symposium was organized by the University of Eastern Finland in Kuopio, Finland on June 6-8, 2018 for the 8th time.... 
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4. Full Text Letter by Hiltunen and Jolkkonen Regarding Article, “Secondary Neurodegeneration in Remote Regions After Focal Cerebral Infarction: A New Target for Stroke Management?”
by Hiltunen, Mikko and Jolkkonen, Jukka
Stroke, ISSN 0039-2499, 09/2012, Volume 43, Issue 9
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5. Full Text Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
by Lambert, Jean-Charles and Ibrahim-Verbaas, Carla A and Harold, Denise and Naj, Adam C and Sims, Rebecca and Bellenguez, Céline and Jun, Gyungah and DeStefano, Anita L and Bis, Joshua C and Beecham, Gary W and Grenier-Boley, Benjamin and Russo, Giancarlo and Thornton-Wells, Tricia A and Jones, Nicola and Smith, Albert V and Chouraki, Vincent and Thomas, Charlene and Ikram, M. Arfan and Zelenika, Diana and Vardarajan, Badri N and Kamatani, Yoichiro and Lin, Chiao-Feng and Gerrish, Amy and Schmidt, Helena and Kunkle, Brian and Fiévet, Nathalie and Amouyel, Philippe and Pasquier, Florence and Deramecourt, Vincent and De Bruijn, Renee F.A.G and Amin, Najaf and Hofman, Albert and Van Duijn, Cornelia M and Dunstan, Melanie L and Hollingworth, Paul and Owen, Michael J and O'Donovan, Michael C and Jones, Lesley and Holmans, Peter A and Moskvina, Valentina and Williams, Julie and Baldwin, Clinton and Farrer, Lindsay A and Choi, Seung-Hoan and Lunetta, Kathryn L and Fitzpatrick, Annette L and Harris, Tamara B and Psaty, Bruce M and Gilbert, John R and Hamilton-Nelson, Kara L and Martin, Eden R and Kunkle, Brian and Haines, Jonathan L and Gudnason, Vilmundur and Jonsson, Palmi V and Eiriksdottir, Gudny and Bihoreau, Marie-Thérèse and Lathrop, Mark and Valladares, Otto and Cantwell, Laura B and Wang, Li-San and Schellenberg, Gerard D and Ruiz, Agustin and Boada, Mercè and Reitz, Christiane and Mayeux, Richard and Ramirez, Alfredo and Maier, Wolfgang and Hanon, Olivier and Kukull, Walter A and Buxbaum, Joseph D and Campion, Dominique and Wallon, David and Hannequin, Didier and Crane, Paul K and Larson, Eric B and Becker, Tim and Cruchaga, Carlos and Goate, Alison M and Craig, David and Johnston, Janet A and Mc-Guinness, Bernadette and Todd, Stephen and Passmore, Peter and Berr, Claudine and Ritchie, Karen and Lopez, Oscar L and De Jager, Philip L and Evans, Denis and Lovestone, Simon and Proitsi, Petroula and Powell, John F and Letenneur, Luc and Barberger-Gateau, Pascale and Dufouil, Carole and Dartigues, Jean-François and Morón, Francisco J and Rubinsztein, David C and St. George-Hyslop, Peter and Sleegers, Kristel and ... and EADI and CHARGE and ADGC and GERAD and Cohorts for Heart and Aging Research in Genomic Epidemiology and Genetic and Environmental Risk in Alzheimer's Disease and Alzheimer's Disease Genetic Consortium and European Alzheimer's Disease Initiative (EADI) and Alzheimer's Disease Genetic Consortium (ADGC) and Genetic and Environmental Risk in Alzheimer's Disease (GERAD) and Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) and Stockholms universitet and Centrum för forskning om äldre och åldrande (ARC), (tills m KI) and Samhällsvetenskapliga fakulteten
Nature Genetics, ISSN 1061-4036, 12/2013, Volume 45, Issue 12, pp. 1452 - 1458
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this... 
GENOTYPES | COMMON VARIANTS | IMPUTATION | GENETIC RISK | SEQUENCE | GENETICS & HEREDITY | NEURONS | RECEPTOR | MUTATIONS | CD33 | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease | Humans | Middle Aged | Male | Genetic Loci | Genome-Wide Association Study - statistics & numerical data | Case-Control Studies | Age of Onset | Aged, 80 and over | Alzheimer Disease - epidemiology | Female | Aged | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Cohort Studies | Quantitative trait loci | Genetic aspects | Research | Genetic susceptibility | Alzheimer's disease | Identification and classification | Genealogy | Genomics | Genes | Quality control | Aging | Genomes | Alzheimers disease | Health risk assessment | Meta-analysis | Index Medicus | Genetik | Biological Sciences | Genetics | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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6. Full Text Molecular Epidemiology of Charcot-Marie-Tooth Disease in Northern Ost
by Marttila, Maria and Kytövuori, Laura and Helisalmi, Seppo and Kallio, Mika and Laitinen, Marjo and Hiltunen, Mikko and Kärppä, Mikko and Majamaa, Kari
Neuroepidemiology, ISSN 0251-5350, 10/2017, Volume 49, Issue 1-2, pp. 34 - 39
Hereditary sensory and motor neuropathy | Neuromuscular diseases | Epidemiology Charcot-Marie-Tooth disea | Genetics | Peripheral nervous system diseases
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7. Full Text Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease
by Steinberg, Stacy and Stefansson, Hreinn and Jonsson, Thorlakur and Johannsdottir, Hrefna and Ingason, Andres and Helgason, Hannes and Sulem, Patrick and Magnusson, Olafur Th and Gudjonsson, Sigurjon A and Unnsteinsdottir, Unnur and Kong, Augustine and Helisalmi, Seppo and Soininen, Hilkka and Lah, James J and Aarsland, Dag and Fladby, Tormod and Ulstein, Ingun D and Djurovic, Srdjan and Sando, Sigrid B and White, Linda R and Knudsen, Gun-Peggy and Westlye, Lars T and Selbæk, Geir and Giegling, Ina and Hampel, Harald and Hiltunen, Mikko and Levey, Allan I and Andreassen, Ole A and Rujescu, Dan and Jonsson, Palmi V and Bjornsson, Sigurbjorn and Snaedal, Jon and Stefansson, Kari and DemGene
Nature Genetics, ISSN 1061-4036, 05/2015, Volume 47, Issue 5, pp. 445 - 447
We conducted a search for rare, functional variants altering susceptibility to Alzheimer's disease that exploited knowledge of common variants associated with... 
DIAGNOSIS | PHAGOCYTOSIS | GENE | CELLULAR CHOLESTEROL | AMYLOID-BETA | MUTATION | GENETICS & HEREDITY | ASSOCIATION | BINDING | EXPRESSION | APOLIPOPROTEIN-E | Haplotypes | Genetic Predisposition to Disease | ATP-Binding Cassette Transporters - genetics | Genetic Association Studies | Humans | Risk | Mutation | Alzheimer Disease - genetics | Sequence Analysis, DNA | Case-Control Studies | Genetic variation | Genetic aspects | Properties | Alzheimer's disease | Health aspects | Risk factors | Membrane proteins | Studies | Alzheimers disease | Rodents | Cholesterol | Index Medicus
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8. Full Text Associations of Genetic Susceptibility to Alzheimer’s Disease with Adiposity and Cardiometabolic Risk Factors among Children in a 2-Year Follow-up Study
by Haapala, Eero A and Paananen, Jussi and Hiltunen, Mikko and Lakka, Timo A
Journal of Alzheimer's Disease, ISSN 1387-2877, 06/2018, Volume 64, Issue 2, pp. 587 - 595
We investigated the associations of genetic risk score (GRS) for Alzheimer’s disease and apolipoprotein E (APOE) ɛ variant with cardiometabolic risk factors... 
Lipoproteins (low density) | Adipose tissue | Body fat | Health risks | Triglycerides | Glucose | Risk analysis | Apolipoproteins | Insulin | Density | Low density lipoprotein | Cholesterol | Girls | Risk factors | Children & youth | Genotyping | Apolipoprotein E | Blood pressure | Children | Health risk assessment | Lipoproteins (high density)
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9. Full Text Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
by Jaillard, Céline and Bettens, Karolien and Alpérovitch, Annick and Van Broeckhoven, Christine and Ritchie, Karen and Mancuso, Michelangelo and Fiévet, Nathalie and Annoni, Giorgio and Galimberti, Daniela and Alvarez, Victoria and Tzourio, Christophe and Gut, Ivo and Leveillard, Thierry and Licastro, Federico and Zelenika, Diana and Panza, Francesco and Soininen, Hilkka and Barberger-Gateau, Pascale and Pasquier, Florence and Lendon, Corinne and De Deyn, Peter and Bullido, Maria J and Hiltunen, Mikko and Dufouil, Carole and Piccardi, Paola and Lambert, Jean-Charles and Blanché, Hélène and Seripa, Davide and Dartigues, Jean-François and Nacmias, Benedetta and de Pancorbo, Marian M and Lathrop, Mark and Hannequin, Didier and Franck, Ana and Heath, Simon and Hanon, Olivier and Tavernier, Béatrice and Bosco, Paolo and Porcellini, Elisa and Letenneur, Luc and Engelborghs, Sebastiaan and Even, Gael and Berr, Claudine and Amouyel, Philippe and Campion, Dominique and Mateo, Ignacio and Combarros, Onofre and Helisalmi, Seppo and Sleegers, Kristel and Bossù, Paola and European Alzheimers Dis Initiative and European Alzheimer's Disease Initiative Investigators and the European Alzheimer's Disease Initiative Investigators
Nature Genetics, ISSN 1061-4036, 10/2009, Volume 41, Issue 10, pp. 1094 - 1099
The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other... 
COMPLEMENT | APOLIPOPROTEIN-J | AMYLOID-BETA-PEPTIDE | MOUSE MODEL | IN-VIVO | GENETICS & HEREDITY | A-BETA | GENETIC-HETEROGENEITY | PLAQUE-FORMATION | CLUSTERIN | CEREBROSPINAL-FLUID | Haplotypes | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Clusterin - genetics | Humans | Polymorphism, Single Nucleotide | Receptors, Complement 3b - genetics | Alzheimer Disease - genetics | Care and treatment | Demographic aspects | Physiological aspects | Genetic aspects | Disease susceptibility | Research | Single nucleotide polymorphisms | Apolipoproteins | Alzheimer's disease | Health aspects | Risk factors | Data collection | Medical research | Data analysis | Grants | Alzheimers disease | Neurological disorders | Index Medicus
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10. A report from the 8th Kuopio Alzheimer Symposium
by Haapasalo, Annakaisa and Hiltunen, Mikko
Neurodegenerative disease management, 10/2018, Volume 8, Issue 5, pp. 289 - 299
Alzheimer's disease | risk factors | biomarkers
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11. Full Text Supervised pathway analysis of blood gene expression profiles in Alzheimer’s disease
by Moradi, Elaheh and Marttinen, Mikael and Häkkinen, Tomi and Hiltunen, Mikko and Nykter, Matti
Neurobiology of Aging, ISSN 0197-4580, 07/2019
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12. Full Text Common Variants at Abca7, Ms4A6A/Ms4A4E, Epha1, Cd33 and Cd2Ap Are Associated with Alzheimer'S Disease
by Hollingworth, P and Harold, D and Sims, R and Gerrish, A and Lambert, J.C and Carrasquillo, M.M and Abraham, R and Hamshere, M.L and Pahwa, J.S and Moskvina, V and Dowzell, K and Jones, N and Stretton, A and Thomas, C and Richards, A and Ivanov, D and Widdowson, C and Chapman, J and Lovestone, S and Powell, J and Proitsi, P and Lupton, M.K and Brayne, C and Rubinsztein, D.C and Gill, M and Lawlor, B and Lynch, A and Brown, K.S and Passmore, P.A and Craig, D and McGuinness, B and Todd, S and Holmes, C and Mann, D and Smith, A.D and Beaumont, H and Warden, D and Wilcock, G and Love, S and Kehoe, P.G and Hooper, N.M and Vardy, E.R.L.C and Hardy, J and Mead, S and Fox, N.C and Rossor, M and Collinge, J and Maier, W and Jessen, F and Ruther, E and Schurmann, B and Heun, R and Kolsch, H and van den Bussche, H and Heuser, I and Kornhuber, J and Wiltfang, J and Dichgans, M and Frolich, L and Hampel, H and Gallacher, J and Hull, M and Rujescu, D and Giegling, I and Goate, A.M and Kauwe, J.S.K and Cruchaga, C and Nowotny, P and Morris, J.C and Mayo, K and Sleegers, K and Bettens, K and Engelborghs, S and de Deyn, P.P and Van Broeckhoven, C and Livingston, G and Bass, N.J and Gurling, H and McQuillin, A and Gwilliam, R and Deloukas, P and Al-Chalabi, A and Shaw, C.E and Tsolaki, M and Singleton, A.B and Guerreiro, R and Muhleisen, T. W and Nothen, M. M and Moebus, S and Jockel, K.H and Klopp, N and Wichmann, H. E and Pankratz, V.S and Sando, S.B and Aasly, J.O and Barcikowska, M and Wszolek, Z.K and Dickson, D.W and Graff-Radford, N.R. and others and Alzheimer's Dis Neuroimaging and EADI1 Consortium and CHARGE Consortium and Alzheimer's Disease Neuroimaging Initiative and EADI1 consortium and CHARGE consortium and the Alzheimer's Disease Neuroimaging Initiative
Nature Genetics, ISSN 1061-4036, 2011, Volume 43, Issue 5, pp. 429 - 435
We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by... 
IDENTIFIES VARIANTS | GENETICS & HEREDITY | GENE-EXPRESSION | RISK | LOCI | APOE | CR-1 | CLU | RECEPTOR TYROSINE KINASE | GENOME-WIDE ASSOCIATION | PICALM | Genetic Predisposition to Disease | Genome-Wide Association Study | Multigene Family | Cytoskeletal Proteins - genetics | Membrane Proteins - genetics | Humans | Databases, Genetic | Male | Antigens, CD - genetics | Antigens, Differentiation, Myelomonocytic - genetics | Case-Control Studies | Genetic Variation | ATP-Binding Cassette Transporters - genetics | Receptor, EphA1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Aged, 80 and over | Female | Aged | Polymorphism, Single Nucleotide | Sialic Acid Binding Ig-like Lectin 3 | Alzheimer Disease - genetics | Usage | Genetic aspects | Disease susceptibility | Research | Single nucleotide polymorphisms | Drug therapy | Alzheimer's disease | Health aspects | Risk factors | Genomes | Medical imaging | Biomedical research | Alzheimers disease | Genes | Index Medicus
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13. Full Text Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
by Sims, Rebecca and Van Der Lee, Sven J and Naj, Adam C and Bellenguez, Céline and Badarinarayan, Nandini and Jakobsdottir, Johanna and Kunkle, Brian W and Boland, Anne and Raybould, Rachel and Bis, Joshua C and Martin, Eden R and Grenier-Boley, Benjamin and Heilmann-Heimbach, Stefanie and Chouraki, Vincent and Kuzma, Amanda B and Sleegers, Kristel and Vronskaya, Maria and Ruiz, Agustin and Graham, Robert R and Olaso, Robert and Hoffmann, Per and Grove, Megan L and Vardarajan, Badri N and Hiltunen, Mikko and Nöthen, Markus M and White, Charles C and Hamilton-Nelson, Kara L and Epelbaum, Jacques and Maier, Wolfgang and Choi, Seung-Hoan and Beecham, Gary W and Dulary, Cécile and Herms, Stefan and Smith, Albert V and Funk, Cory C and Derbois, Céline and Forstner, Andreas J and Ahmad, Shahzad and Li, Hongdong and Bacq, Delphine and Harold, Denise and Satizabal, Claudia L and Valladares, Otto and Squassina, Alessio and Thomas, Rhodri and Brody, Jennifer A and Qu, Liming and Sánchez-Juan, Pascual and Morgan, Taniesha and Wolters, Frank J and Zhao, Yi and Garcia, Florentino Sanchez and Denning, Nicola and Fornage, Myriam and Malamon, John and Naranjo, Maria Candida Deniz and Majounie, Elisa and Mosley, Thomas H and Dombroski, Beth and Wallon, David and Lupton, Michelle K and Dupuis, Josée and Whitehead, Patrice and Fratiglioni, Laura and Medway, Christopher and Jian, Xueqiu and Mukherjee, Shubhabrata and Keller, Lina and Brown, Kristelle and Lin, Honghuang and Cantwell, Laura B and Panza, Francesco and McGuinness, Bernadette and Moreno-Grau, Sonia and Burgess, Jeremy D and Solfrizzi, Vincenzo and Proitsi, Petra and Adams, Hieab H and Allen, Mariet and Seripa, Davide and Pastor, Pau and Cupples, L Adrienne and Price, Nathan D and Hannequin, Didier and Frank-García, Ana and Levy, Daniel and Chakrabarty, Paramita and Caffarra, Paolo and Giegling, Ina and Beiser, Alexa S and Giedraitis, Vilmantas and Hampel, Harald and Garcia, Melissa E and Wang, Xue and Lannfelt, Lars and Mecocci, Patrizia and Eiriksdottir, Gudny and Crane, Paul K and Pasquier, Florence and Boccardi, Virginia and ... and EADI and GERAD PERADES and ARUKConsortium and CHARGE and ADGC and GERAD/PERADES, CHARGE, ADGC, EADI and ARUK Consortium and Stockholms universitet and Centrum för forskning om äldre och åldrande (ARC), (tills m KI) and Samhällsvetenskapliga fakulteten
Nature Genetics, ISSN 1061-4036, 09/2017, Volume 49, Issue 9, pp. 1373 - 1384
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174... 
COMMON VARIANTS | IDENTIFIES VARIANTS | METAANALYSIS | GENOTYPE IMPUTATION | LOW-FREQUENCY | SUSCEPTIBILITY | GENETICS & HEREDITY | RISK | LOCI | WAVE2 COMPLEX | GENOME-WIDE ASSOCIATION | Amino Acid Sequence | Microglia - metabolism | Genetic Predisposition to Disease - genetics | Gene Frequency | Humans | Immunity, Innate - genetics | Genotype | Gene Expression Profiling | Case-Control Studies | Linkage Disequilibrium | Membrane Glycoproteins - genetics | Sequence Homology, Amino Acid | Exome - genetics | Protein Interaction Maps - genetics | Adaptor Proteins, Signal Transducing - genetics | Phospholipase C gamma - genetics | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Odds Ratio | Receptors, Immunologic - genetics | Immune response | Genetic variation | Physiological aspects | Development and progression | Genetic aspects | Research | Alzheimer's disease | Neurodegenerative diseases | Genes | Genomics | Health risks | Innate immunity | Genomes | Disease control | Immunity | Microglia | Proteins | Immune systems | Studies | Consortia | DNA microarrays | Genotyping | Gene frequency | DNA methylation | Alzheimers disease | Protein interaction | Bioinformatics | Genotypes | Index Medicus | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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