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1. Full Text L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia
by Huttunen, Johanna and Peltokangas, Soile and Gynther, Mikko and Natunen, Teemu and Hiltunen, Mikko and Auriola, Seppo and Ruponen, Marika and Vellonen, Kati-Sisko and Huttunen, Kristiina M
Scientific reports, ISSN 2045-2322, 09/2019, Volume 9, Issue 1, pp. 12860 - 12
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Drugs | Brain | Phenotypes | Prodrugs | Astrocytes | L-leucine | Amino acids | Drug delivery | Cell membranes | Leucine | Microglia | Blood-brain barrier | Protein transport | Index Medicus
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2. Full Text Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process
by Salminen, Antero and Kaarniranta, Kai and Hiltunen, Mikko and Kauppinen, Anu
Journal of molecular medicine (Berlin, Germany), ISSN 0946-2716, 10/2014, Volume 92, Issue 10, pp. 1035 - 1043
Human Genetics | JMJD3 | NF-κB | Biomedicine | Cellular senescence | Aging | Epigenetics | Internal Medicine | Molecular Medicine | Methylation | Genetics & Heredity | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Cellular Senescence - physiology | Inflammation - metabolism | Animals | Jumonji Domain-Containing Histone Demethylases - metabolism | Epigenesis, Genetic | Humans | Epigenetic inheritance | Physiological aspects | Development and progression | Inflammation | Genetic aspects | Research | Gene expression | Index Medicus
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3. Full Text AMP‐activated protein kinase: a potential player in Alzheimer’s disease
by Salminen, Antero and Kaarniranta, Kai and Haapasalo, Annakaisa and Soininen, Hilkka and Hiltunen, Mikko
Journal of neurochemistry, ISSN 0022-3042, 08/2011, Volume 118, Issue 4, pp. 460 - 474
AMPK | tauopathy | autophagy | aging | Alzheimer’s disease | inflammation | Alzheimer's disease | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Organic mental disorders. Neuropsychology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Psychopathology. Psychiatry | Biological and medical sciences | Medical sciences | Inflammation - pathology | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Calcium - metabolism | Humans | Metformin - pharmacology | tau Proteins - metabolism | Autophagy - physiology | Alzheimer Disease - enzymology | Enzyme Activation - drug effects | Leptin - physiology | AMP-Activated Protein Kinases - physiology | Inflammation - metabolism | Animals | Amyloid - biosynthesis | Neurons - physiology | Alzheimer Disease - genetics | AMP-Activated Protein Kinases - genetics | Glucose metabolism | Neurons | Amyloidosis | Glucose | Protein kinases | Risk factors | Dextrose | Neurochemistry | Signal transduction | Alzheimers disease | Kinases | Protein synthesis | Index Medicus
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4. Full Text Molecular Epidemiology of Charcot-Marie-Tooth Disease in Northern Ostrobothnia, Finland: A Population-Based Study
by Marttila, Maria and Kytovuori, Laura and Helisalmi, Seppo and Kallio, Mika and Laitinen, Marjo and Hiltunen, Mikko and Karppa, Mikko and Majamaa, Kari
Neuroepidemiology, ISSN 0251-5350, 01/2017, Volume 49, Issue 1-2, pp. 34 - 39
Public, Environmental & Occupational Health | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Point Mutation | Phenotype | Health Surveys | Molecular Epidemiology | Gene Deletion | Humans | Finland | Female | Male | Charcot-Marie-Tooth Disease - epidemiology | Myelin Proteins - genetics | Charcot-Marie-Tooth Disease - genetics | Nervous system diseases | Gene mutations | Charcot-Marie-Tooth disease | Development and progression | Genetic aspects | Epidemiology | Neurophysiology | Index Medicus
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5. Full Text DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
by Martiskainen, Henna and Paldanius, Kaisa M.A and Natunen, Teemu and Takalo, Mari and Marttinen, Mikael and Leskelä, Stina and Huber, Nadine and Mäkinen, Petra and Bertling, Enni and Dhungana, Hiramani and Huuskonen, Mikko and Honkakoski, Paavo and Hotulainen, Pirta and Rilla, Kirsi and Koistinaho, Jari and Soininen, Hilkka and Malm, Tarja and Haapasalo, Annakaisa and Hiltunen, Mikko
Journal of neuroinflammation, ISSN 1742-2094, 11/2017, Volume 14, Issue 1, pp. 215 - 215
Neuroprotection | Neuroinflammation | Alzheimer's disease | DHCR24/Seladin-1 | Neurosciences | Immunology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Genetic aspects | Neural circuitry | Gene expression | Cell death | Health aspects | Growth conditions | Brain | Cell culture | Immunoglobulins | Neurons | Pathogenesis | Lipids | Inflammation | Embryos | Cholesterol | Lipopolysaccharides | Proteins | Dendritic spines | Magnetic resonance imaging | Ischemia | Rodents | γ-Interferon | Cell adhesion | Neostriatum | Aging | Microglial cells | Brain injury | Hippocampus | Index Medicus | Alzheimer’s disease
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6. Full Text Functional genetics – an approach to mechanisms in Alzheimer’s disease
by Hiltunen, Mikko
Molecular neurodegeneration, ISSN 1750-1326, 09/2013, Volume 8, Issue S1, pp. O3 - O3
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7. Full Text Age-related macular degeneration (AMD): Alzheimer's disease in the eye?
by Kaarniranta, Kai and Salminen, Antero and Haapasalo, Annakaisa and Soininen, Hilkka and Hiltunen, Mikko
Journal of Alzheimer's disease, ISSN 1387-2877, 2011, Volume 24, Issue 4, pp. 615 - 631
proteasome | autophagy | Age-related macular degeneration (AMD) | aggregation | aging | Alzheimer's disease | lysosome | oxidative stress | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Alzheimer Disease - complications | Macular Degeneration - physiopathology | Eye Diseases - complications | Humans | Macular Degeneration - complications | Aging - pathology | Alzheimer Disease - pathology | Animals | Aging - genetics | Alzheimer Disease - genetics | Eye Diseases - pathology | Eye Diseases - physiopathology | Aging - metabolism | Macular Degeneration - pathology | Index Medicus
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8. Full Text Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome
by Salminen, Antero and Kaarniranta, Kai and Kauppinen, Anu and Ojala, Johanna and Haapasalo, Annakaisa and Soininen, Hilkka and Hiltunen, Mikko
Progress in neurobiology, ISSN 0301-0082, 07/2013, Volume 106-107, pp. 33 - 54
Vps34 | Mitophagy | Alzheimer's disease | Autophagy | Ageing | Beclin 1 | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Beclin-1 | Membrane Proteins - genetics | Humans | Autophagy - physiology | Apoptosis Regulatory Proteins - metabolism | Animals | Alzheimer Disease - metabolism | Amyloid beta-Protein Precursor - metabolism | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Apoptosis - physiology | Autophagy - genetics | Alzheimer Disease - genetics | Proteome - metabolism | Genetic engineering | Ophthalmology | Amyloid beta-protein | Index Medicus
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