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1. Full Text c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-β inhibits c-Maf-induced IL-21 production in CD4+ T cells
by Yukiko Hiramatsu and Akira Suto and Daisuke Kashiwakuma and Hiroko Kanari and Shin-ichiro Kagami and Kei Ikeda and Koichi Hirose and Norihiko Watanabe and Michael J. Grusby and Itsuo Iwamoto and Hiroshi Nakajima
Journal of leukocyte biology, ISSN 0741-5400, 04/2010, Volume 87, Issue 4, pp. 703 - 712
Foxp3 | Tfh cells | Tregs | Th17 cells | Immunology | Life Sciences & Biomedicine | Hematology | Science & Technology | Cell Biology | Forkhead Transcription Factors - immunology | STAT6 Transcription Factor | CD4-Positive T-Lymphocytes - immunology | Interleukins - genetics | Autocrine Communication - immunology | Forkhead Transcription Factors - metabolism | Interleukins - immunology | Interleukins - biosynthesis | Proto-Oncogene Proteins c-maf - immunology | Transforming Growth Factor beta - immunology | Interleukin-6 - genetics | Interleukin-4 - metabolism | Proto-Oncogene Proteins c-maf - genetics | CD4-Positive T-Lymphocytes - metabolism | Forkhead Transcription Factors - genetics | Interleukin-4 - immunology | Animals | Promoter Regions, Genetic - physiology | Up-Regulation - immunology | Interleukin-6 - immunology | Interleukin-6 - biosynthesis | Proto-Oncogene Proteins c-maf - metabolism | Enhancer Elements, Genetic - physiology | Mice | Mice, Inbred BALB C | Transforming Growth Factor beta - metabolism | Index Medicus
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2. Full Text CD14+ monocyte‐derived galectin‐9 induces natural killer cell cytotoxicity in chronic hepatitis C
by Nishio, Akira and Tatsumi, Tomohide and Nawa, Takatoshi and Suda, Takahiro and Yoshioka, Teppei and Onishi, Yoshiki and Aono, Satoshi and Shigekawa, Minoru and Hikita, Hayato and Sakamori, Ryotaro and Okuzaki, Daisuke and Fukuhara, Takasuke and Matsuura, Yoshiharu and Hiramatsu, Naoki and Takehara, Tetsuo
Hepatology (Baltimore, Md.), ISSN 0270-9139, 01/2017, Volume 65, Issue 1, pp. 18 - 31
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Antibody-Dependent Cell Cytotoxicity | Lymphocyte Activation | Humans | Middle Aged | Male | Monocytes - immunology | Killer Cells, Natural - physiology | Lipopolysaccharide Receptors | Galectins - physiology | Hepatitis C, Chronic - immunology | Aged, 80 and over | Adult | Female | Aged | Alanine | Liver | Chronic infection | Cytotoxicity | Leukocytes (mononuclear) | Infections | T cell receptors | Lymphocytes T | Hepatoma | CD14 antigen | Galectin-9 | Hepatitis | Monocytes | Cell activation | Clonal deletion | Hepatocytes | Persistent infection | Alanine transaminase | Peripheral blood mononuclear cells | Natural killer cells | Hepatitis C | Phosphatidylserine | Apoptosis | Index Medicus
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3. Full Text Human blood dendritic cell antigen 3 (BDCA3)+ dendritic cells are a potent producer of interferon‐λ in response to hepatitis C virus
by Yoshio, Sachiyo and Kanto, Tatsuya and Kuroda, Shoko and Matsubara, Tokuhiro and Higashitani, Koyo and Kakita, Naruyasu and Ishida, Hisashi and Hiramatsu, Naoki and Nagano, Hiroaki and Sugiyama, Masaya and Murata, Kazumoto and Fukuhara, Takasuke and Matsuura, Yoshiharu and Hayashi, Norio and Mizokami, Masashi and Takehara, Tetsuo
Hepatology (Baltimore, Md.), ISSN 0270-9139, 05/2013, Volume 57, Issue 5, pp. 1705 - 1715
Leukocytes, Mononuclear - metabolism | Liver - pathology | Humans | Dendritic Cells - pathology | Male | Interferon-gamma - metabolism | Interleukins - metabolism | Immunity, Innate - physiology | Antigens, Surface - metabolism | Adult | Dendritic Cells - drug effects | Female | Hepacivirus - physiology | Liver Neoplasms - pathology | Dendritic Cells - metabolism | Poly I-C - pharmacology | Liver - metabolism | Cells, Cultured | Genotype | Leukocytes, Mononuclear - pathology | Phenotype | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Carcinoma, Hepatocellular - metabolism | Index Medicus
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4. Full Text Growth of c‑Axis-Oriented Superconducting KFe2As2 Thin Films
by Hiramatsu, Hidenori and Matsuda, Shogo and Sato, Hikaru and Kamiya, Toshio and Hosono, Hideo
ACS applied materials & interfaces, ISSN 1944-8244, 08/2014, Volume 6, Issue 16, pp. 14293 - 14301
iron-based superconductors | thermal annealing | potassium | pulsed laser deposition | air-sensitive materials | thin films | Science & Technology - Other Topics | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology
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5. Full Text Suppression of hepatocellular carcinoma development in hepatitis C patients given interferon‐based antiviral therapy
by Hiramatsu, Naoki and Oze, Tsugiko and Takehara, Tetsuo
Hepatology research, ISSN 1386-6346, 02/2015, Volume 45, Issue 2, pp. 152 - 161
interferon therapy | hepatocellular carcinoma | sustained virological response | Interferon therapy | Hepatocellular carcinoma | Sustained virological response | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Glucose metabolism | Care and treatment | Interferon | Hepatoma | Hepatitis C | Biological response modifiers | Hepatitis C virus
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6. Full Text NOD/SCID/gamma(null)(c) mouse: an excellent recipient mouse model for engraftment of human cells
by Ito, M and Hiramatsu, H and Kobayashi, K and Suzue, K and Kawahata, M and Hioki, K and Ueyama, Y and Koyanagi, Y and Sugamura, K and Tsuji, K and Heike, T and Nakahata, T
Blood, ISSN 0006-4971, 11/2002, Volume 100, Issue 9, pp. 3175 - 3182
Life Sciences & Biomedicine | Hematology | Science & Technology | Humans | Antigens, Bacterial - immunology | Male | G(M1) Ganglioside - antagonists & inhibitors | Killer Cells, Natural - pathology | Listeria monocytogenes - immunology | Receptors, Interleukin-7 - genetics | G(M1) Ganglioside - immunology | Female | Models, Animal | Cell Differentiation | Interferon-gamma - deficiency | Spleen - pathology | Cells, Cultured - immunology | Lymphocyte Subsets - pathology | Infant, Newborn | Transplantation, Heterologous - immunology | Antibodies, Monoclonal - pharmacology | Interferon-gamma - secretion | Mice, Inbred C57BL | Graft Survival | Mice, SCID | Transplantation Chimera | Cord Blood Stem Cell Transplantation | Mice, Knockout | beta 2-Microglobulin - deficiency | Cell Lineage | Dendritic Cells - secretion | Animals | Receptors, Interleukin-7 - deficiency | Mice, Inbred NOD | Mice | Interleukin Receptor Common gamma Subunit | Ascites | beta 2-Microglobulin - genetics | Crosses, Genetic | Index Medicus | Abridged Index Medicus
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7. Full Text Real-world efficacy of glecaprevir plus pibrentasvir for chronic hepatitis C patient with previous direct-acting antiviral therapy failures
by Osawa, Mitsutaka and Osawa, Mitsutaka and Imamura, Michio and Imamura, Michio and Teraoka, Yuji and Teraoka, Yuji and Uchida, Takuro and Uchida, Takuro and Morio, Kei and Morio, Kei and Fujino, Hatsue and Fujino, Hatsue and Nakahara, Takashi and Nakahara, Takashi and Ono, Atsushi and Ono, Atsushi and Murakami, Eisuke and Murakami, Eisuke and Kawaoka, Tomokazu and Kawaoka, Tomokazu and Miki, Daiki and Miki, Daiki and Tsuge, Masataka and Tsuge, Masataka and Hiramatsu, Akira and Hiramatsu, Akira and Aikata, Hiroshi and Aikata, Hiroshi and Hayes, C Nelson and Hayes, C Nelson and Chayama, Kazuaki and Chayama, Kazuaki and Hiroshima Liver Study Grp and Hiroshima Liver Study Group
Journal of gastroenterology, ISSN 0944-1174, 3/2019, Volume 54, Issue 3, pp. 291 - 296
Pibrentasvir | NS5A RAVs | Medicine & Public Health | Glecaprevir | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | NS5A-P32 deletion | Surgical Oncology | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Quinoxalines - adverse effects | Recurrence | Antiviral Agents - therapeutic use | Humans | Japan | Middle Aged | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Genotype | Male | Treatment Outcome | Hepatitis C, Chronic - drug therapy | Retreatment | Sulfonamides - therapeutic use | Antiviral Agents - adverse effects | Treatment Failure | Aged, 80 and over | Sulfonamides - adverse effects | Female | Aged | Benzimidazoles - therapeutic use | Quinoxalines - therapeutic use | Care and treatment | Analysis | Liver | Drug resistance | Hepatitis C virus | Hepatitis C | Health aspects | Genotype & phenotype | Hepatitis | Fibrosis | Interferon | Patients | Genotypes | Index Medicus
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8. Full Text Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
by Zinman, Bernard and Wanner, Christoph and Lachin, John M and Fitchett, David and Bluhmki, Erich and Hantel, Stefan and Mattheus, Michaela and Devins, Theresa and Johansen, Odd Erik and Woerle, Hans J and Broedl, Uli C and Inzucchi, Silvio E and EMPA-REG OUTCOME Investigators
The New England journal of medicine, ISSN 0028-4793, 11/2015, Volume 373, Issue 22, pp. 2117 - 2128
Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Risk Factors | Kaplan-Meier Estimate | Hospitalization - statistics & numerical data | Male | Cause of Death | Benzhydryl Compounds - adverse effects | Diabetes Mellitus, Type 2 - mortality | Intention to Treat Analysis | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Female | Glucosides - therapeutic use | Aged | Diabetes Mellitus, Type 2 - drug therapy | Benzhydryl Compounds - therapeutic use | Hypoglycemic Agents - adverse effects | Glucosides - adverse effects | Type 2 diabetes | Treatment outcome | Care and treatment | Patient outcomes | Analysis | Cardiovascular diseases | Risk factors | Myocardial infarction | Cerebral infarction | Inhibitor drugs | Mortality | Diabetes mellitus | Cardiovascular disease | Angina | Glucose | Morbidity | Sodium | Death | Diabetes | Health risk assessment | Drug therapy | Diabetes mellitus (non-insulin dependent) | Heart diseases | Index Medicus | Abridged Index Medicus
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9. Full Text Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes
by Wanner, Christoph and Inzucchi, Silvio E and Lachin, John M and Fitchett, David and von Eynatten, Maximilian and Mattheus, Michaela and Johansen, Odd Erik and Woerle, Hans J and Broedl, Uli C and Zinman, Bernard and EMPA-REG OUTCOME Investigators
The New England journal of medicine, ISSN 0028-4793, 07/2016, Volume 375, Issue 4, pp. 323 - 334
Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Glomerular Filtration Rate | Kidney - blood supply | Humans | Middle Aged | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Diabetic Nephropathies - drug therapy | Microvessels - drug effects | Male | Albuminuria | Disease Progression | Benzhydryl Compounds - adverse effects | Intention to Treat Analysis | Female | Glucosides - therapeutic use | Aged | Diabetes Mellitus, Type 2 - drug therapy | Benzhydryl Compounds - therapeutic use | Hypoglycemic Agents - adverse effects | Diabetes Mellitus, Type 2 - complications | Glucosides - adverse effects | Type 2 diabetes | Complications and side effects | Kidney diseases | Cardiovascular diseases | Risk factors | Creatinine | Kidneys | Mortality | Diabetes mellitus | Glomerular filtration rate | Side effects | Nephropathy | Sodium | Microvasculature | Diabetes | Health risk assessment | Drug therapy | Diabetes mellitus (non-insulin dependent) | Index Medicus | Abridged Index Medicus
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10. Full Text Advanced liver fibrosis effects on the response to sofosbuvir‐based antiviral therapies for chronic hepatitis C
by Morio, Kei and Imamura, Michio and Kawakami, Yoshiiku and Nakamura, Yuki and Hatooka, Masahiro and Morio, Reona and Fujino, Hatsue and Nakahara, Takashi and Murakami, Eisuke and Kawaoka, Tomokazu and Tsuge, Masataka and Hiramatsu, Akira and Aikata, Hiroshi and Hayes, C. Nelson and Miki, Daiki and Ochi, Hidenori and Katamura, Yoshio and Arataki, Keiko and Moriya, Takashi and Ito, Hiroyuki and Tsuji, Keiji and Kohno, Hiroshi and Waki, Koji and Tamura, Toru and Nakamura, Toshio and Chayama, Kazuaki and Hiroshima Liver Study Grp and Hiroshima Liver Study Group
Journal of medical virology, ISSN 0146-6615, 12/2018, Volume 90, Issue 12, pp. 1834 - 1840
direct‐acting antiviral | sofosbuvir | liver fibrosis | chronic hepatitis C | direct-acting antiviral | Life Sciences & Biomedicine | Science & Technology | Virology | Age Factors | Humans | Japan | Middle Aged | Male | Treatment Outcome | Hepatitis C, Chronic - complications | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Young Adult | Drug Therapy, Combination - methods | Sofosbuvir - administration & dosage | Adolescent | Aged, 80 and over | Liver Cirrhosis - pathology | Adult | Female | Aged | Sustained Virologic Response | Child | Antiviral agents | Care and treatment | Analysis | Liver | Fibrosis | Hepatitis C virus | Hepatitis C | Health aspects | Therapy | Ritonavir | Chronic infection | Viruses | Regression analysis | Age factors | Patients | Ribavirin | Hepatitis | Interferon | Index Medicus
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