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JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 05/2019, Volume 129, Issue 5, pp. 1833 - 1835
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2019, Volume 10, Issue 1, pp. 1 - 18
Journal Article
Cancers, ISSN 2072-6694, 07/2019, Volume 11, Issue 8, p. 1091
This special issue is dedicated to glioblastoma and elucidates this disease from different perspectives [...] 
n/a
Journal Article
Journal Article
Science, ISSN 0036-8075, 01/2015, Volume 347, Issue 6219, pp. 273 - 277
Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination... 
GLIOBLASTOMA | REPEAT-CONTAINING RNA | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | POLYMERASE | CHROMOSOME ENDS | SINGLE-STRANDED-DNA | HOMOLOGOUS RECOMBINATION | MUTATIONS | TUMORS | DISCOVERY | Osteosarcoma - drug therapy | Ataxia Telangiectasia Mutated Proteins - metabolism | RNA, Untranslated - metabolism | Humans | Homologous Recombination | X-linked Nuclear Protein | Telomere - drug effects | Sulfones - pharmacology | RNA, Untranslated - genetics | Gene Knockdown Techniques | Glioma - genetics | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Telomerase - metabolism | Antineoplastic Agents - pharmacology | Telomere - metabolism | Nuclear Proteins - genetics | DNA Helicases - genetics | Telomere - genetics | Tumor Suppressor Proteins - metabolism | Nuclear Proteins - metabolism | Replication Protein A - metabolism | Telomere Homeostasis | Transcription Factors - metabolism | DNA Helicases - metabolism | Cell Cycle | Cell Line, Tumor | Telomeric Repeat Binding Protein 2 - metabolism | HeLa Cells | Osteosarcoma - genetics | Pyrazines - pharmacology | Glioma - drug therapy | Promyelocytic Leukemia Protein | Apoptosis | Telomeres | Protein research | Cell research | Cancer cells | Cell cycle | Genetic aspects | Research | Health aspects | Enzymes | Deoxyribonucleic acid--DNA | Cancer | Index Medicus | Proteins | Inhibitors | Deoxyribonucleic acid | Kinases | Chromosomes | Telomerase | Tumors
Journal Article
Science, ISSN 0036-8075, 03/2017, Volume 355, Issue 6332, pp. eaai8478 - eaai8478
Journal Article
International Journal of Cancer, ISSN 0020-7136, 10/2017, Volume 141, Issue 8, pp. 1671 - 1681
Temozolomide (TMZ) chemotherapy, in combination with maximal safe resection and radiotherapy, is the current standard of care for patients with glioblastoma... 
recurrence | temozolomide | TNF‐related apoptosis inducing ligand (TRAIL) | glioblastoma | oncolytic herpes simplex virus | TNF-related apoptosis inducing ligand (TRAIL) | GLIOMA-CELLS | CATALYTIC SUBUNIT | ACTIVATION | DEPENDENT PROTEIN-KINASE | MODEL | EGFR | ADJUVANT TEMOZOLOMIDE | ONCOLOGY | IN-VIVO | RADIOTHERAPY | TUMOR MICROENVIRONMENT | Simplexvirus - physiology | Neoplastic Stem Cells - drug effects | Humans | Neoplasm Recurrence, Local - virology | Neoplasm Recurrence, Local - drug therapy | Drug Resistance, Neoplasm | TNF-Related Apoptosis-Inducing Ligand - biosynthesis | Dacarbazine - pharmacology | Dacarbazine - analogs & derivatives | HEK293 Cells | Neoplastic Stem Cells - pathology | Neoplasm Recurrence, Local - therapy | Simplexvirus - genetics | Glioblastoma - virology | Neoplastic Stem Cells - virology | Brain Neoplasms - drug therapy | Glioblastoma - therapy | Oncolytic Virotherapy - methods | Animals | Brain Neoplasms - therapy | Cell Line, Tumor | Mice | Apoptosis - physiology | Brain Neoplasms - virology | Glioblastoma - drug therapy | TNF-Related Apoptosis-Inducing Ligand - genetics | Cohort Studies | Immunohistochemistry | Medical research | Relapse | Herpes simplex | Transplantation | Glioblastoma multiforme | Herpes simplex virus | Diseases | Chemotherapy | Stem cells | Medicine, Experimental | Health aspects | Apoptosis | Cancer | Neuroimaging | Brain | Animal models | DNA damage | Glioblastoma | Stem cell transplantation | Viruses | Anticancer properties | Allografts | Pathways | Oncolysis | Genetic modification | Deoxyribonucleic acid--DNA | Cell survival | Therapeutic applications | Tumor cells | Mortality | MAP kinase | Cures | Radiation therapy | Survival | Herpes viruses | In vivo methods and tests | Temozolomide | In vitro methods and tests | Tumors | Index Medicus | Recurrence | Oncolytic herpes simplex virus
Journal Article
Expert Opinion on Biological Therapy, ISSN 1471-2598, 08/2019, Volume 19, Issue 8, pp. 845 - 854
Introduction: With the approval of talimogene laherparepvec (T-VEC) for advanced malignant melanoma, virotherapy using oncolytic herpes simplex virus (oHSV) is... 
clinical trial | high grade glioma | Glioblastoma | oncolytic herpes simplex virus | MEDICINE, RESEARCH & EXPERIMENTAL | GLIOBLASTOMA-MULTIFORME | EXPRESSING IL-12 | MACROPHAGE | CANCER STEM-CELLS | VIROTHERAPY | HSV-1 | REPLICATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | INHIBITORS | HIGH-GRADE GLIOMA | ANTITUMOR EFFICACY
Journal Article
Molecular Therapy, ISSN 1525-0016, 01/2015, Volume 23, Issue 1, pp. 108 - 118
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2016, Volume 113, Issue 16, pp. 4476 - 4481
Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve overall survival of patients with glioblastoma (GBM). We previously... 
Anti-angiogenic therapy | Macrophage polarization | Tumor microenvironment | Microglia reprogramming | Anti-tumor immunity | anti-angiogenic therapy | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | macrophage polarization | RANDOMIZED-TRIAL | ANGIOPOIETIN-2 | CANCER | THERAPY | microglia reprogramming | TIE2-EXPRESSING MONOCYTES | BLOOD-VESSELS | TUMOR-ASSOCIATED MACROPHAGES | tumor microenvironment | NORMALIZATION | anti-tumor immunity | ENDOTHELIAL GROWTH-FACTOR | Macrophages - pathology | Antibodies, Bispecific - pharmacology | Vesicular Transport Proteins - metabolism | Humans | Neoplasm Proteins - antagonists & inhibitors | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neoplasms, Experimental - pathology | Xenograft Model Antitumor Assays | Macrophages - metabolism | Vesicular Transport Proteins - antagonists & inhibitors | Animals | Antibodies, Neoplasm - pharmacology | Ribonuclease, Pancreatic - metabolism | Glioblastoma - pathology | Cell Line, Tumor | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Mice | Neoplasms, Experimental - metabolism | Glioblastoma - drug therapy | Ribonuclease, Pancreatic - antagonists & inhibitors | Neoplasms, Experimental - drug therapy | Viral antibodies | Care and treatment | Antibodies | Physiological aspects | Models | Macrophages | Vascular endothelial growth factor | Health aspects | Glioblastoma multiforme | Genotype & phenotype | Survival analysis | Protein expression | Cells | Tumors | Cancer | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2009, Volume 106, Issue 12, pp. 4822 - 4827
Journal Article