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Cardiovascular and Hematological Disorders - Drug Targets, ISSN 1871-529X, 01/2015, Volume 15, Issue 1, pp. 29 - 40
Sepsis is a state of infection with serious systemic manifestations, and if severe enough, can be associated with multiple organ dysfunction and systemic... 
Chemokine | NF-κB | Cytokine | Hypoxia-inducible factor | Hypoxia | Sepsis | Inflammation | Cell Hypoxia - physiology | Animals | Humans | Gene Expression Regulation | Homeostasis | Sepsis - physiopathology | Hypoxia-Inducible Factor 1 - metabolism | Oxygen - metabolism | Sepsis - genetics | Hypoxia-Inducible Factor 1 - genetics | Inflammation - physiopathology
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 03/2019, Volume 133, pp. 118 - 129
Journal Article
Anesthesiology, ISSN 0003-3022, 06/2014, Volume 120, Issue 6, pp. 1523 - 1523
Journal Article
Free radical biology & medicine, 07/2018
Oxygen and iron are among the most abundant elements and have significant roles in human biology. Iron is essential for oxygen transport and is a component of... 
Journal Article
Nitric Oxide, ISSN 1089-8603, 05/2014, Volume 39, p. S8
Hydrogen sulfide (H.sub.2S) is an endogenously synthesized gasous moleclule and acts as an important signaling molecule in the living body. The transcription... 
Mitochondrial DNA | Cells
Journal Article
Nitric Oxide, ISSN 1089-8603, 05/2014, Volume 39, pp. S8 - S8
Journal Article
Cardiovascular and Hematological Disorders, ISSN 1871-529X, 03/2015, Volume 15, Issue 1, pp. 29 - 40
Sepsis is a state of infection with serious systemic manifestations, and if severe enough, can be associated with multiple organ dysfunction and systemic... 
Journal Article
FEBS Open Bio, 11/2017, Volume 7, Issue 11, pp. 1768 - 1777
Numerous secretory and membrane proteins undergo post‐translational modifications in the endoplasmic reticulum (ER), and the formation of disulfide bonds is a... 
Enzymes | Disulfide bonds | Brefeldin A | Homeostasis | Thioredoxin | Membrane proteins | Signal transduction | Protein folding | Chemical bonds | Oxidation | Endoplasmic reticulum | Glutathione | Adaptation
Journal Article
FEBS Letters, ISSN 0014-5793, 12/2015, Volume 589, Issue 24, p. 4097
* Targeting cholesterol with bCD disrupted the signal transduction between PI3K and AKT. * In mice, the absence of activated AKT was only for a few hours. * In... 
Cellular signal transduction | Cyclodextrins | Cholesterol | Cancer | Apoptosis | Tyrosine | Cytochrome c | Oligomers | Medical colleges | Epidermal growth factor | Pancreatic cancer | Cancer cells
Journal Article
Scientific Reports, ISSN 2045-2322, 09/2016, Volume 6, Issue 1, p. 34424
Cigarette smoke (CS) is a major contributor to the development of a large number of fatal and debilitating disorders. However, the precise molecular mechanisms... 
Hypoxia-inducible factors | Hypoxia-inducible factor 1 | Reactive oxygen species | DNA damage | Lung diseases | MAP kinase | Gene expression | Kinases | Respiratory tract | Proteins | Molecular modelling | Protein kinase | Hypoxia | Vascular endothelial growth factor | Cigarette smoke | Cellular stress response | Smoking
Journal Article
IEEE Transactions on Industrial Informatics, ISSN 1551-3203, 11/2018, Volume 14, Issue 11, pp. 5178 - 5186
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e82930
Background: Glial cells, including microglia and astrocytes, are considered the primary source of proinflammatory cytokines in the brain. Immune insults... 
INNATE IMMUNE-RESPONSES | INFLAMMATORY RESPONSES | MULTIDISCIPLINARY SCIENCES | LIPOPOLYSACCHARIDE | INDUCED SICKNESS BEHAVIOR | CENTRAL-NERVOUS-SYSTEM | ACTIVATED MICROGLIAL CELLS | NF-KAPPA-B | ASTROCYTES | CNS INFLAMMATION | BRAIN | Cell Line | Lipopolysaccharides - toxicity | Hypothalamo-Hypophyseal System - pathology | Neuroglia - pathology | Pituitary-Adrenal System - metabolism | Pituitary-Adrenal System - pathology | Hypothalamo-Hypophyseal System - metabolism | Up-Regulation - drug effects | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Anesthetics, General - pharmacology | Interleukin-6 - biosynthesis | Neuroglia - metabolism | Interleukin-1beta - biosynthesis | Mice | Phosphorylation - drug effects | Tumor Necrosis Factor-alpha - biosynthesis | Brain | Phosphorylation | Interleukin | Nervous system | Infections | Activation | Hypothalamus | Glial cells | Lipopolysaccharides | Interleukin 6 | Proteins | Rodents | Anesthesia | Tumor necrosis factor-TNF | Propofol | Medical research | Cytokines | Astrocytes | Activator protein 1 | Extracellular signal-regulated kinase | Hypothalamic-pituitary-adrenal axis | Inflammation | Tumor necrosis factor-α | Anesthetics | Gene expression | Isoflurane | Fever | Microglia | Studies | Adrenocorticotropic hormone | Ketamine | Pituitary | Pentobarbital | Anesthesiology | Midazolam | Brain injury
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2002, Volume 277, Issue 41, pp. 38205 - 38211
Stimulation of human colon cancer cells with insulin-like growth factor 1 (IGF-1) induces expression of the VEGF gene, encoding vascular endothelial growth... 
FACTOR 1-ALPHA HIF-1-ALPHA | CAP-BINDING PROTEIN | TRANSCRIPTIONAL ACTIVITY | ACTIVATED PROTEIN-KINASE | PROLYL HYDROXYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | TUMOR-SUPPRESSOR PROTEIN | TRANSLATION INITIATION | UP-REGULATION | HIF-ALPHA | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | MAP Kinase Signaling System - physiology | Protein-Tyrosine Kinases - metabolism | Vascular Endothelial Growth Factors | Humans | Ubiquitin - metabolism | Eukaryotic Initiation Factor-4E - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphoproteins - metabolism | MAP Kinase Kinase 2 | Colonic Neoplasms - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit | Hypoxia - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Lymphokines - genetics | Lymphokines - metabolism | Repressor Proteins - metabolism | Enzyme Inhibitors - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Adaptor Proteins, Signal Transducing | Animals | Carrier Proteins - metabolism | Endothelial Growth Factors - genetics | Carcinoma - metabolism | Insulin-Like Growth Factor I - metabolism
Journal Article
Japanese Journal of Anesthesiology, ISSN 0021-4892, 11/2011, Volume 60, Issue NOVEMBER, pp. S183 - S188
Journal Article