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1. Full Text Spotlight: Emilio Hirsch, PhD, FESC Aiming to Prove the Benefits of Treating Some Cardiac Diseases With PI3 Kinase gamma Inhibitors
by Taylor, J and Hirsch, E
CIRCULATION, ISSN 0009-7322, 03/2009, Volume 119, Issue 12, pp. F67 - F69
CARDIAC & CARDIOVASCULAR SYSTEMS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY
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2. Full Text Guido Tarone (1951-2015)
by Hirsch, Emilio
Cardiovascular research, ISSN 0008-6363, 07/2015, Volume 107, Issue 1, pp. 1 - 2
History, 21st Century | History, 20th Century | Cell Biology
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3. Full Text Salvage pathways in heart rejuvenation
by Hirsch, Emilio
Cardiovascular Research, ISSN 0008-6363, 2016, Volume 111, Issue 2, pp. 123 - 124
CARDIAC & CARDIOVASCULAR SYSTEMS | Cardiovascular Physiological Phenomena | Animals | Aging - physiology | Signal Transduction | Humans | Translational Medical Research
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4. Full Text Insight GPI-anchored uPAR relies on two partners to trigger selected signal transduction events: Two signalling hands for uPAR
by Hirsch, Emilio
Thrombosis and Haemostasis, ISSN 0340-6245, 01/2012, Volume 109, Issue 2, p. 179
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5. Full Text Regulating neutrophil apoptosis: new players enter the game
by Witko-Sarsat, Véronique and Pederzoli-Ribeil, Magali and Hirsh, Emilio and Sozzani, Silvano and Cassatella, Marco A
Trends in Immunology, ISSN 1471-4906, 2011, Volume 32, Issue 3, pp. 117 - 124
Recently, unexpected biological features of polymorphonuclear neutrophils have been revealed. In addition to their pivotal role in the defence against... 
Allergy and Immunology | ACTIVATION | NK CELLS | INFLAMMATION | IN-VIVO | DRUG DISCOVERY | BONE-MARROW | GENE-EXPRESSION | DOWN-REGULATION | IMMUNOLOGY | CELL-DEATH | POLYMORPHONUCLEAR NEUTROPHILS | Cell Nucleus - immunology | Neutrophils - cytology | Animals | Cytoplasm - immunology | Humans | Neutrophils - immunology | Proliferating Cell Nuclear Antigen - immunology | Inflammation - immunology | Apoptosis | Proteins | Rodents | Cyclin-dependent kinases | Rheumatoid arthritis | Bone marrow | Gene expression | Chemokines | Immune system
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6. Full Text Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking
by Campa, Carlo Cosimo and Hirsch, Emilio
Advances in Biological Regulation, ISSN 2212-4926, 01/2017, Volume 63, pp. 132 - 139
Rab11 and phosphoinositides are signal transducers able to direct the delivery of membrane components to the cell surface. Rab11 is a small GTPase that, by... 
rab GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Humans | Gene Expression Regulation | rab GTP-Binding Proteins - genetics | Guanosine Triphosphate - metabolism | GTPase-Activating Proteins - metabolism | Animals | Protein Isoforms - metabolism | Biological Transport | Guanine Nucleotide Exchange Factors - metabolism | Cytoplasmic Vesicles - metabolism | Phosphatidylinositols - metabolism | GTPase-Activating Proteins - genetics | Guanosine Diphosphate - metabolism | Protein Isoforms - genetics
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7. Full Text Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial
by Gerstein, Hertzel C and Colhoun, Helen M and Dagenais, Gilles and Dagenais, Gilles R and Diaz, Rafael and Diaz, Sarahy and Lakshmanan, Mark and Pais, Prem and Probstfield, Jeffrey and Riesmeyer, Jeffrey S and Riddle, Matthew C and Rydén, Lars and Xavier, Denis and Atisso, Charles Messan and Dyal, Leanne and Hall, Stephanie and Hall, Charles and Rao-Melacini, Purnima and Wong, Gloria and Avezum, Alvaro and Basile, Jan and Chung, Ming-Min and Chung, Namsik and Chung, Jin-Wook and Conget, Ignacio and Cushman, William C and Franek, Edward and Hancu, Nicolae and Hanefeld, Christoph and Hanefeld, Markolf and Holt, Shaun and Jansky, Petr and Keltai, Matyas and Keltai, Katalin and Lanas, Fernando and Leiter, Lawrence A and Lopez-Jaramillo, Patricio and Cardona Munoz, Ernesto German and Pirags, Valdis and Pogosova, Nana and Raubenheimer, Peter J and Shaw, Jonathan E and Sheu, Wayne H-H and Temelkova-Kurktschiev, Theodora and Abella, Mercedes and Alebuena, Andrea and Almagro, Sandra and Amoroso, Eduardo and Anadon, Paula and Andreu, Elizabeth and Aristimuño, Guillermo and Arzadun, Maria and Barbieri, Maria and Barcudi, Raul and Bartolacci, Ines and Bolobanich, Gabriel and Bordonava, Anselmo and Bustamante Labarta, Miguel and Bustos, Betina and Caccavo, Alberto and Camino, Alejandra and Cantero, Maria and Carignano, Maria and Cartasegna, Luis and Cipullo, Marcela and Commendatore, Víctor and Conosciuto, Victoria and Costamagna, Osvaldo and Crespo, Claudia and Cuello, Jose and Cuneo, Carlos and Cusimano, Sandra and Dean, Sofia and Dituro, Claudio and Dominguez, Andrea and Farah, Miguel and Fernandez, Alberto and Fernandez, Florencia and Ferrari, Adriana and Flammia, Patricia and Fuentealba, Jose and Gallardo, Karina Beatriz and Garcia, Mar and Garcia, Celso and Garcia, Maria and Garcia Duran, Ruben and Garrido, Marcelo and Gavicola, Rodolfo and Gerbaudo, Claudio and Gilli, Graciela and Giotto, Ana Paula and Godoy Bolzán, Pedro and Gomez Vilamajo, Oscar and Guerlloy, Fernando and Guridi, Cristian and Gutierrez Garrido, Narcisa and Hasbani, Eduardo and Hermida, Sonia and Hominal, Miguel and Hrabar, Adrian and ... and REWIND Investigators
The Lancet, ISSN 0140-6736, 07/2019, Volume 394, Issue 10193, pp. 121 - 130
Three different glucagon-like peptide-1 (GLP-1) receptor agonists reduce cardiovascular outcomes in people with type 2 diabetes at high cardiovascular risk... 
MEDICINE, GENERAL & INTERNAL | BASE-LINE | EVENTS | EFFICACY | SAFETY | PEPTIDE-1 RECEPTOR AGONISTS | Myocardial infarction | Heart attacks | Peptides | Control methods | Glucagon | Clinical trials | Cardiovascular disease | Population studies | Cancer therapies | Risk factors | Incidence | Randomization | Motivation | Hemoglobin | Blood pressure | Diabetes mellitus (non-insulin dependent) | Drug dosages | Glucagon-like peptide 1 | Women | Cerebral infarction | Enzymes | Stroke | Middle age | Diabetes mellitus | Health risks | Hypoglycemia | Risk analysis | Angina pectoris | Disease control | Cholesterol | Thyroid cancer | Agonists | Diabetes | Cardiovascular diseases | Health risk assessment | Elderly
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8. Full Text PI3K and Calcium Signaling in Cardiovascular Disease
by Ghigo, Alessandra and Laffargue, Muriel and Li, Mingchuan and Hirsch, Emilio
Circulation Research, ISSN 0009-7330, 07/2017, Volume 121, Issue 3, pp. 282 - 292
Receptor signaling relays on intracellular events amplified by secondary and tertiary messenger molecules. In cardiomyocytes and smooth muscle cells, cyclic... 
myocytes, cardiac | myocytes, smooth muscle | calcium | hypertrophy | signal transduction | PROTEIN-KINASE-A | CA2+ ENTRY | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | CALPAIN | MAST-CELLS | ANGIOTENSIN-II | SARCOPLASMIC-RETICULUM | PHOSPHOINOSITIDE 3-KINASE | KEY ROLE | PERIPHERAL VASCULAR DISEASE | PI3K-GAMMA | HEMATOLOGY | Myocytes, Cardiac - pathology | Animals | Cardiovascular Diseases - metabolism | Calcium Signaling - physiology | Humans | Myocytes, Smooth Muscle - pathology | Myocytes, Cardiac - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Cardiovascular Diseases - pathology | Myocytes, Smooth Muscle - metabolism | Metabolic rate | Cardiovascular system | Phosphatidylinositol 3,4,5-triphosphate | Contractility | Cyclic AMP | Cardiomyocytes | Intracellular signalling | Smooth muscle | Metabolism | Muscle contraction | 1-Phosphatidylinositol 3-kinase | Calcium signalling | Phosphatidylinositol | Signal transduction | Molecular modelling | Intracellular | Hypertrophy
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9. Full Text Spatiotemporal control of endocytosis by phosphatidylinositol-3,4- bisphosphate
by Posor, York and Eichhorn-Gruenig, Marielle and Puchkov, Dmytro and Schöneberg, Johannes and Ullrich, Alexander and Lampe, André and Müller, Rainer and Zarbakhsh, Sirus and Gulluni, Federico and Hirsch, Emilio and Krauss, Michael and Schultz, Carsten and Schmoranzer, Jan and Noé, Frank and Haucke, Volker
Nature, ISSN 0028-0836, 2013, Volume 499, Issue 7457, pp. 233 - 237
Phosphoinositides serve crucial roles in cell physiology, ranging from cell signalling to membrane traffic(1,2). Among the seven eukaryotic phosphoinositides... 
HOMOLOGY-DOMAIN | CLATHRIN-MEDIATED ENDOCYTOSIS | CELLS | COATED VESICLES | MULTIDISCIPLINARY SCIENCES | KINASE | PROTEINS | IDENTIFICATION | PHOSPHOINOSITIDE 3-KINASE | PHOSPHOINOSITIDE-3-KINASE-C2-ALPHA | 4,5-BISPHOSPHATE | Amino Acid Sequence | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Humans | Cercopithecus aethiops | Molecular Sequence Data | Clathrin-Coated Vesicles - metabolism | Endocytosis | Animals | Time Factors | HEK293 Cells | HeLa Cells | Sorting Nexins - metabolism | Phosphoric Monoester Hydrolases - metabolism | COS Cells | Physiological aspects | Phosphoinositides | Research | Proteins | Plasma | Epidermal growth factor | Rodents | Lipids | Kinases
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10. Full Text Targeting PI3K in cancer: Any good news?
by Martini, Miriam and Ciraolo, Elisa and Gulluni, Federico and Hirsch, Emilio
Frontiers in Oncology, ISSN 2234-943X, 2013, Volume 3, p. 108
The phosphatidylinositol 3-kinase (PI3K) signaling pathway regulates several cellular processes and it's one of the most frequently deregulated pathway in... 
Genetic determinants | Class II phosphatidylinositol 3-kinase | PI3K | Therapeutics | Cancer | Class II Phosphatidylinositol 3-Kinases | genetic determinants
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11. Full Text Natural-born killers unleashed
by Hirsch, Emilio and Novelli, Francesco
Nature, ISSN 0028-0836, 06/2014, Volume 510, Issue 7505, pp. 342 - 343
Ali and colleagues show that the growth and metastatic spread of different types of tumour transplanted into mice in which PI(3)Kδ is genetically inactivated... 
Physiological aspects | Immune response | Cancer cells | Medical research | Kinases | Immune system | Cancer
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12. Full Text Cytokinetic Abscission: Phosphoinositides and ESCRTs Direct the Final Cut
by Gulluni, Federico and Martini, Miriam and Hirsch, Emilio
Journal of Cellular Biochemistry, ISSN 0730-2312, 11/2017, Volume 118, Issue 11, pp. 3561 - 3568
ABSTRACT Cytokinetic abscission involves the fine and regulated recruitment of membrane remodeling proteins that participate in the abscission of the...