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science & technology (28) 28
life sciences & biomedicine (22) 22
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rna processing, post-transcriptional (3) 3
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tristetraprolin - metabolism (3) 3
tumor necrosis factor-alpha - genetics (3) 3
tumor necrosis factor-alpha - metabolism (3) 3
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intracellular signaling peptides and proteins - physiology (2) 2
lipopolysaccharide (2) 2
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messenger rna (2) 2
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neurons (2) 2
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1. Full Text Post-Transcriptional Inflammatory Response to Intracellular Bacterial c-di-AMP
by Mahmoud, Linah and Abdulkarim, Alaa S and Kutbi, Shaima and Moghrabi, Walid and Altwijri, Sulaiman and Khabar, Khalid S. A and Hitti, Edward G
Frontiers in immunology, ISSN 1664-3224, 01/2020, Volume 10, pp. 3050 - 3050
Life Sciences & Biomedicine | Immunology | Science & Technology | Index Medicus | c-di-AMP | p38 MAPK | AU-rich element | post-transcriptional regulation | tristetraprolin/zink finger protein 36
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2. Full Text Bi-phased regulation of the post-transcriptional inflammatory response by Tristetraprolin levels
by Mahmoud, Linah and Moghrabi, Walid and Khabar, Khalid S. A and Hitti, Edward G
RNA biology, ISSN 1547-6286, 03/2019, Volume 16, Issue 3, pp. 309 - 319
Tristetraprolin | AU-rich elements | ZFP36 | post-transcriptional | TNF | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | RNA Processing, Post-Transcriptional | Down-Regulation | Humans | Tristetraprolin - chemistry | RNA Stability | AU Rich Elements | Gene Knockdown Techniques | Inflammation - metabolism | Animals | Tristetraprolin - genetics | Inflammation - genetics | Tristetraprolin - metabolism | Mice | 3' Untranslated Regions | Chemokine CXCL2 - metabolism | RNA, Messenger | Genes, Reporter | Index Medicus
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3. Full Text Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Regulates Tumor Necrosis Factor mRNA Stability and Translation Mainly by Altering Tristetraprolin Expression, Stability, and Binding to Adenine/Uridine-Rich Element
by Edward Hitti and Tatiana Iakovleva and Matthew Brook and Stefanie Deppenmeier and Achim D. Gruber and Danuta Radzioch and Andrew R. Clark and Perry J. Blackshear and Alexey Kotlyarov and Matthias Gaestel
Molecular and Cellular Biology, ISSN 0270-7306, 03/2006, Volume 26, Issue 6, pp. 2399 - 2407
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Abnormalities, Multiple - pathology | Protein Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Protein Biosynthesis | Protein Kinases - genetics | Protein-Serine-Threonine Kinases | Tumor Necrosis Factor-alpha - genetics | RNA, Messenger - metabolism | Mice, Mutant Strains | Tristetraprolin - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | 3' Untranslated Regions | Abnormalities, Multiple - genetics | Macrophages - pathology | RNA Processing, Post-Transcriptional | Down-Regulation | RNA, Messenger - genetics | Cells, Cultured | Intracellular Signaling Peptides and Proteins | RNA Stability | Macrophages - metabolism | Animals | Tristetraprolin - genetics | Uridine - metabolism | Adenine - metabolism | Mice | Index Medicus
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4. Full Text Sustained stabilization of Interleukin-8 mRNA in human macrophages
by Mahmoud, Linah and Al-Enezi, Fatma and Al-Saif, Maher and Warsy, Arjumand and Khabar, Khalid SA and Hitti, Edward G
RNA biology, ISSN 1547-6286, 02/2014, Volume 11, Issue 2, pp. 124 - 133
monocytes | AU-rich elements | macrophages | IL-8 | CXCL-8 | mRNA stability | Monocytes | Macrophages | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | Interleukin-8 - genetics | Nucleic Acid Synthesis Inhibitors - pharmacology | Humans | Tumor Necrosis Factor-alpha - genetics | Monocytes - metabolism | RNA Stability | RNA, Messenger - metabolism | AU Rich Elements - physiology | Macrophages - metabolism | MAP Kinase Signaling System - drug effects | Cell Line, Tumor | Phorbol Esters - pharmacology | Cell Differentiation | HeLa Cells | Interleukin-8 - metabolism | Dactinomycin - pharmacology | Index Medicus | Research Paper
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5. Full Text Oligomerization activity of a double-stranded RNA-binding domain
by Hitti, Edward G and Sallacz, Nina B and Schoft, Vera K and Jantsch, Michael F
FEBS letters, ISSN 0014-5793, 2004, Volume 574, Issue 1, pp. 25 - 30
Xenopus laevis RNA-binding protein A | Protein–protein interaction | PACT | Double-stranded RNA-binding domain | Protein-protein interaction | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Amino Acid Sequence | Xenopus laevis | Molecular Sequence Data | DNA Primers | Biopolymers | Xenopus Proteins - chemistry | Sequence Homology, Amino Acid | Two-Hybrid System Techniques | Animals | Base Sequence | Cloning, Molecular | Xenopus Proteins - metabolism | RNA, Double-Stranded - metabolism | Index Medicus
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6. Full Text MAPKAP kinases MK2 and MK3 in inflammation: Complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin
by Ronkina, Natalia and Menon, Manoj B and Schwermann, Jessica and Tiedje, Christopher and Hitti, Edward and Kotlyarov, Alexey and Gaestel, Matthias
Biochemical pharmacology, ISSN 0006-2952, 2010, Volume 80, Issue 12, pp. 1915 - 1920
mRNA translation | transcription | lipopolysaccharide | Protein kinase | mRNA stability | Lipopolysaccharide | MRNA stability | Transcription | MRNA translation | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | RNA, Messenger - biosynthesis | Inflammation - metabolism | Phosphorylation | Animals | Mitogen-Activated Protein Kinase 14 - metabolism | Protein-Serine-Threonine Kinases - physiology | Humans | Tumor Necrosis Factor-alpha - genetics | Tristetraprolin - biosynthesis | Transcription, Genetic | Intracellular Signaling Peptides and Proteins - physiology | Tumor Necrosis Factor-alpha - biosynthesis | Physiological aspects | Messenger RNA | Tumor necrosis factor | Phosphotransferases | Mitogens | Index Medicus
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7. Full Text ARED-Plus: an updated and expanded database of AU-rich element-containing mRNAs and pre-mRNAs
by Bakheet, Tala and Hitti, Edward and Khabar, Khalid S A
Nucleic acids research, ISSN 0305-1048, 01/2018, Volume 46, Issue D1, pp. D218 - D220
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Database Issue
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8. Full Text MAPKAP kinase 2‐deficiency prevents neurons from cell death by reducing neuroinflammation – relevance in a mouse model of Parkinson’s disease
by Thomas, Tobias and Timmer, Marco and Cesnulevicius, Konstantin and Hitti, Edward and Kotlyarov, Alexey and Gaestel, Matthias
Journal of neurochemistry, ISSN 0022-3042, 06/2008, Volume 105, Issue 5, pp. 2039 - 2052
neurodegeneration | protein kinases | inflammation | Parkinson’s disease | ablation | Inflammation | Parkinson's disease | Neurodegeneration | Ablation | Protein kinases | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Biological and medical sciences | Nervous system as a whole | Medical sciences | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Nervous system (semeiology, syndromes) | Inflammation - pathology | Neurons - pathology | Protein-Serine-Threonine Kinases - deficiency | Parkinson Disease - pathology | Protein-Serine-Threonine Kinases - physiology | Mice, Inbred C57BL | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Parkinson Disease - genetics | Mice, Knockout | Intracellular Signaling Peptides and Proteins - deficiency | Animals | Cell Death - genetics | Neurons - enzymology | Parkinson Disease - enzymology | Inflammation - genetics | Mice | Intracellular Signaling Peptides and Proteins - physiology | Inflammation - enzymology | Intracellular Signaling Peptides and Proteins - genetics | Disease Models, Animal | Prevention | Tumor necrosis factor | Cell death | Neurons | Analysis | Biochemistry | Brain | Cell culture | Neurotransmitters | Index Medicus
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9. Full Text Clinical and Genetic Determinants of Plasma Nevirapine Exposure Following an Intrapartum Dose to Prevent Mother-to-Child HIV Transmission
by Saran Vardhanabhuti and Edward P. Acosta and Heather J. Ribaudo and Patrice Severe and Umesh Lalloo and Nagalingeshwaran Kumarasamy and Frank Taulo and Joseph Kabanda and Olola Oneko and Prudence Ive and Pradeep Sambarey and Ellen S. Chan and Jane Hitti and Francis Hong and Deborah McMahon and David W. Haas and A5207 ACTG Study Team
The Journal of infectious diseases, ISSN 0022-1899, 8/2013, Volume 208, Issue 4, pp. 662 - 671
HIV/AIDS | Body mass index | Quantification | Ancestry | Genetics | AIDS | Pharmacokinetics | Inhibitory concentration 50 | Dosage | Genotypes | HIV 1 | Pregnancy | Pharmacogenetics | CYP2B6 | Nevirapine | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Miscellaneous | Infectious diseases | Biological and medical sciences | Medical sciences | Virology | HIV Infections - prevention & control | Oxidoreductases, N-Demethylating - genetics | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Male | Metabolic Clearance Rate | Polymorphism, Genetic | Anti-HIV Agents - administration & dosage | Young Adult | Time Factors | Anti-HIV Agents - pharmacokinetics | Plasma - chemistry | Inhibitory Concentration 50 | Adult | Female | Nevirapine - administration & dosage | Nevirapine - pharmacokinetics | Infectious Disease Transmission, Vertical - prevention & control | Cytochrome P-450 CYP2B6 | Infant, Newborn | Chemoprevention - methods | Prevention | Perinatal infection | Prenatal drug exposure | Dosage and administration | Genetic aspects | Research | HIV infection | Index Medicus | Abridged Index Medicus | pharmacokinetics | Major and Brief Reports | nevirapine | pharmacogenetics | pregnancy
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10. Full Text The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages
by Tudor, Corina and Marchese, Francesco P and Hitti, Edward and Aubareda, Anna and Rawlinson, Lesley and Gaestel, Matthias and Blackshear, Perry J and Clark, Andrew R and Saklatvala, Jeremy and Dean, Jonathan L.E
FEBS letters, ISSN 0014-5793, 2009, Volume 583, Issue 12, pp. 1933 - 1938
Tristetraprolin | p38 Mitogen-activated protein kinase | Interleukin-10 | COX-2 | glutathione-S-transferase | CXCL1 | BMDM | TNF | LPS | mitogen-activated protein kinase | TTP | UTR | chemokine (C-X-C motif) ligand 1 | Act D | bone marrow-derived macrophages | foetal calf serum | glyceraldehyde-3-phosphate dehydrogenase | interleukin | tristetraprolin | actinomycin D | IL | untranslated region | GST | MAPK | ARE | AU-rich element | FCS | tumour necrosis factor | lipopolysaccharide | GAPDH | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Mice, Inbred C57BL | RNA, Messenger - genetics | RNA Stability | RNA, Messenger - metabolism | MAP Kinase Signaling System | Mice, Knockout | Tristetraprolin - deficiency | Macrophages - metabolism | Animals | Tristetraprolin - genetics | Base Sequence | Interleukin-10 - antagonists & inhibitors | Interleukin-10 - genetics | Inflammation Mediators - metabolism | Interleukin-6 - biosynthesis | Tristetraprolin - metabolism | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | In Vitro Techniques | Interleukin-12 Subunit p40 - biosynthesis | Phosphates | Messenger RNA | Interleukins | Glutathione transferase | Macrophages | Protein kinases | Mitogens | Sugars | Monosaccharides | Index Medicus
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