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1. Genetics and molecular biology
by Scott, James and Hobbs, Helen H
1995, Volume 6, no. 2., 67-114.
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2. Full Text Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
by Smagris, Eriks and BasuRay, Soumik and Li, John and Huang, Yongcheng and Lai, Ka‐man V and Gromada, Jesper and Cohen, Jonathan C and Hobbs, Helen H
Hepatology, ISSN 0270-9139, 01/2015, Volume 61, Issue 1, pp. 108 - 118
A sequence polymorphism (rs738409, I148M) in patatin‐like phospholipid domain containing protein 3 ( PNPLA3 ) is strongly associated with nonalcoholic fatty... 
OVEREXPRESSION | HEPATOCELLULAR-CARCINOMA | COMMON VARIANT | FATTY LIVER-DISEASE | NONALCOHOLIC STEATOHEPATITIS | I148M | GASTROENTEROLOGY & HEPATOLOGY | ADIPONUTRIN | Sucrose | Membrane Proteins - genetics | Humans | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Lipid Metabolism | Male | Mice, Transgenic | Lipase - metabolism | Gene Knock-In Techniques | 1-Acylglycerol-3-Phosphate O-Acyltransferase - metabolism | Animals | Female | Membrane Proteins - metabolism | Lipid Droplets - metabolism | Fatty Acids - metabolism | Fatty Liver - etiology | Lipase - genetics | Lipids | Rodents | Physiology | Index Medicus | Steatohepatitis | Metabolic Liver Disease
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3. Full Text Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease
by Cohen, Jonathan C and Boerwinkle, Eric and Mosley, Thomas H and Hobbs, Helen H
The New England Journal of Medicine, ISSN 0028-4793, 03/2006, Volume 354, Issue 12, pp. 1264 - 1272
This study demonstrates a strong protective effect of three variants of PCSK9 against coronary heart disease. Two of the variants were found predominantly in... 
MEDICINE, GENERAL & INTERNAL | PLASMA-CHOLESTEROL | SERUM-CHOLESTEROL | MOUSE | RECEPTOR | COMMUNITIES | LIPOPROTEIN CHOLESTEROL | STATINS | ATHEROSCLEROSIS RISK | Coronary Disease - blood | European Continental Ancestry Group - genetics | United States | Gene Frequency | Humans | Middle Aged | Proportional Hazards Models | Coronary Disease - epidemiology | Genotype | Male | Risk | Codon, Nonsense | Hypolipoproteinemias - genetics | Incidence | Genetic Variation | Coronary Disease - genetics | Serine Endopeptidases - genetics | Carotid Arteries - anatomy & histology | Cholesterol, LDL - blood | Female | African Continental Ancestry Group - genetics | Proprotein Convertases | Cohort Studies | Proprotein Convertase 9 | Cardiovascular disease | Low density lipoprotein | Coronary vessels | Deoxyribonucleic acid--DNA | Index Medicus | Abridged Index Medicus
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4. Full Text Science, serendipity, and the single degree
by Hobbs, HH
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 10/2018, Volume 128, Issue 10, pp. 4218 - 4223
Hobbs' 2018 Association of American Physicians George M Kober Lecture on science, serendipity, and the single degree is presented. Among other things, she... 
CONFERS SUSCEPTIBILITY | MEDICINE, RESEARCH & EXPERIMENTAL | TANGIER-DISEASE | SCAVENGER RECEPTOR | FATTY LIVER-DISEASE | CASSETTE TRANSPORTER 1 | DIETARY-CHOLESTEROL | LIPID ACYL-HYDROLASE | AUTOSOMAL RECESSIVE HYPERCHOLESTEROLEMIA | HEPATIC STEATOSIS | DENSITY-LIPOPROTEIN RECEPTOR | Proteins | Liver diseases | Fatty liver | Laboratories | Hepatology | Cloning | Careers | Lipids | Metabolism | Cholesterol
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5. Full Text 2018 association of American physicians George M. Kober lecture science, serendipity, and the single degree
by Hobbs, Helen H
Journal of Clinical Investigation, ISSN 0021-9738, 10/2018, Volume 128, Issue 10, pp. 4218 - 4223
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6. Full Text Chronic overexpression of PNPLA3 I148M in mouse liver causes hepatic steatosis
by Li, John Zhong and Huang, Yongcheng and Karaman, Ruchan and Ivanova, Pavlina T and Brown, H. Alex and Roddy, Thomas and Castro-Perez, Jose and Cohen, Jonathan C and Hobbs, Helen H
Journal of Clinical Investigation, ISSN 0021-9738, 11/2012, Volume 122, Issue 11, pp. 4130 - 4144
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7. Full Text PNPLA3, CGI‐58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice
by Wang, Yang and Kory, Nora and BasuRay, Soumik and Cohen, Jonathan C and Hobbs, Helen H
Hepatology, ISSN 0270-9139, 06/2019, Volume 69, Issue 6, pp. 2427 - 2441
A variant (148M) in patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) is a major risk factor for fatty liver disease. Despite its clinical... 
PROTEIN | LIPOLYSIS | FATTY LIVER-DISEASE | I148M | GASTROENTEROLOGY & HEPATOLOGY | LIPID DROPLETS | DEFICIENCY | Hydrolysis | Phospholipase | Liver diseases | Immunoprecipitation | Fatty liver | Hepatoma | Lipase | Steatosis | Original
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8. Full Text Inactivation of Tm6sf2, a gene defective in fatty liver disease, impairs lipidation but not secretion of very low density lipoproteins
by Smagris, Eriks and Gilyard, Shenise and BasuRay, Soumik and Cohen, Jonathan C and Hobbs, Helen H
Journal of Biological Chemistry, ISSN 0021-9258, 05/2016, Volume 291, Issue 20, pp. 10659 - 10676
A missense mutation (E167K) in TM6SF2 (transmembrane 6 superfamily member 2), a polytopic protein of unknown function, is associated with the full spectrum of... 
TRIGLYCERIDE TRANSFER PROTEIN | CONFERS SUSCEPTIBILITY | SUPERFAMILY MEMBER 2 | HEPATOCELLULAR-CARCINOMA | CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | RISK | WIDE ASSOCIATION | PNPLA3 RS738409 | HEPATIC STEATOSIS | VARIANT | Fatty Liver - genetics | Fatty Liver - metabolism | Endoplasmic Reticulum - genetics | Lipoylation | Fatty Liver - pathology | Membrane Proteins - genetics | Endoplasmic Reticulum - metabolism | Lipid Droplets - pathology | Golgi Apparatus - pathology | Mutation, Missense | Mice, Knockout | Triglycerides - metabolism | Endoplasmic Reticulum - pathology | Animals | Lipoproteins, VLDL - secretion | Golgi Apparatus - metabolism | Membrane Proteins - metabolism | Mice | Triglycerides - genetics | Lipid Droplets - metabolism | Golgi Apparatus - genetics | Index Medicus | lipid droplet | Lipids | liver injury | triacylglycerol | lipoprotein | cholesterol metabolism
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9. Full Text HSD17B13 and Chronic Liver Disease in Blacks and Hispanics
by Stender, Stefan and Hobbs, Helen H and Kozlitina, Julia and Cohen, Jonathan C
The New England Journal of Medicine, ISSN 0028-4793, 11/2018, Volume 379, Issue 19, pp. 1876 - 1877
The established association between variant HSD17B13 and protection against chronic liver disease has been replicated. A newly discovered, probably damaging... 
POPULATION | MEDICINE, GENERAL & INTERNAL | Gene frequency | Hispanics | Liver diseases | Index Medicus | Abridged Index Medicus
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10. Full Text Relative roles of ABCG5/ABCG8 in liver and intestine
by Wang, Jin and Mitsche, Matthew A and Lütjohann, Dieter and Cohen, Jonathan C and Xie, Xiao-Song and Hobbs, Helen H
Journal of Lipid Research, ISSN 0022-2275, 02/2015, Volume 56, Issue 2, pp. 319 - 330
ABCG5 (G5) and ABCG8 (G8) form a sterol transporter that acts in liver and intestine to prevent accumulation of dietary sterols. Mutations in either G5 or G8... 
Cholesterol/absorption | Sterols | Transport | Bile | ABCG5 | absorption | DIETARY-CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | SITOSTEROLEMIA | X-RECEPTOR | sterols | transport | DEFICIENT MICE | bile | BILIARY STEROL SECRETION | PLASMA-CHOLESTEROL | REVERSE CHOLESTEROL TRANSPORT | cholesterol | SITOSTANOL | Enterocytes - metabolism | Lipoproteins - genetics | Liver - metabolism | Male | Intestines - metabolism | Cholesterol - metabolism | Mutation - genetics | Mice, Knockout | Animals | Feces - chemistry | ATP-Binding Cassette Transporters - genetics | Lipoproteins - metabolism | Phytosterols - metabolism | ATP-Binding Cassette Transporters - metabolism | Female | ATP Binding Cassette Transporter, Sub-Family G, Member 8 | Biological Transport - physiology | Mice | ATP Binding Cassette Transporter, Sub-Family G, Member 5 | Index Medicus
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11. Full Text Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis
by BasuRay, S and Wang, Y and Smagris, E and Cohen, JC and Hobbs, HH
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 05/2019, Volume 116, Issue 19, pp. 9521 - 9526
Fatty liver disease (FLD) is a disorder in which accumulation of triglycerides (TGs) in the liver can lead to inflammation, fibrosis, and cirrhosis.... 
lipid droplet | proteasome | autophagy | FATTY LIVER-DISEASE | MULTIDISCIPLINARY SCIENCES | fatty liver disease | TM6SF2 | CONFERS SUSCEPTIBILITY | OVEREXPRESSION | GENE VARIANT | INHIBITION | PROTEIN-DEGRADATION | PNPLA3 | MICE | WIDE ASSOCIATION | Ubiquitin | Inflammation | Proteolysis | Liver cirrhosis | Liver | Liver diseases | Deactivation | Sucrose | Hydrolase | Lipids | Triglycerides | Inactivation | Accumulation | Steatosis | Proteins | Cirrhosis | Phospholipase | Fatty liver | Enzymatic activity | Fibrosis | Mice | Droplets | Sugars | Biological Sciences
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12. Full Text Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets
by Mitsche, Michael A and Hobbs, Helen H and Cohen, Jonathan C
The Journal of Biological Chemistry, ISSN 0021-9258, 6/2018, Volume 293, Issue 24, pp. 9232 - 9232
Additions and s
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13. Full Text Reply
by Smagris, Eriks and BasuRay, Soumik and Gromada, Jesper and Cohen, Jonathan C and Hobbs, Helen H
Hepatology, ISSN 0270-9139, 02/2016, Volume 63, Issue 2, pp. 677 - 677
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14. Full Text Reply
by Smagris, Eriks and Basuray, Soumik and Gromada, Jesper and Cohen, Jonathan C and Hobbs, Helen H
Hepatology, ISSN 0270-9139, 02/2016, Volume 63, Issue 2, p. 677
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15. Full Text Reply
by Eriks Smagris and Soumik BasuRay and Jesper Gromada and Jonathan C Cohen and Helen H Hobbs
Hepatology, ISSN 0270-9139, 02/2016, Volume 63, Issue 2, p. 677
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16. Full Text The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation
: Basuray et al
by BasuRay, Soumik and Smagris, Eriks and Cohen, Jonathan C and Hobbs, Helen H
Hepatology, ISSN 0270-9139, 10/2017, Volume 66, Issue 4, pp. 1111 - 1124
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17. Full Text Patatin-like phospholipase domain-containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets (vol 293, pg 6958, 2018)
by Mitsche, MA and Hobbs, HH and Cohen, JC
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 06/2018, Volume 293, Issue 24, pp. 9232 - 9232
BIOCHEMISTRY & MOLECULAR BIOLOGY
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18. Full Text Genetic Variation at PPP1R3B and Changes in Levels of Liver Glycogen and Triglyceride
by Stender, Stefan and Smagris, Eriks and Lauridsen, Bo K and Kofoed, Klaus F and Nordestgaard, Børge G and Tybjærg-Hansen, Anne and Pennacchio, Len A and Dickel, Diane E and Cohen, Jonathan C and Hobbs, Helen H
Hepatology (Baltimore, Md.), ISSN 0270-9139, 6/2018, Volume 67, Issue 6, pp. 2182 - 2195
Genetic variation at rs4240624 on chromosome 8 is associated with an attenuated signal on hepatic computerized tomography (CT), which has been attributed to... 
liver injury | metabolism | hepatic glycogen | hepatic steatosis
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19. Full Text Reply
: HEPATOLOGY, Vol. XX, No. X, 2015 CORRESPONDENCE
by Smagris, Eriks and BasuRay, Soumik and Gromada, Jesper and Cohen, Jonathan C and Hobbs, Helen H
Hepatology, ISSN 0270-9139, 02/2016, Volume 63, Issue 2, pp. 677 - 677
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20. Full Text Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis
by Yan Wang and Fabiana Quagliarini and Viktoria Gusarova and Jesper Gromada and David M. Valenzuela and Jonathan C. Cohen and Helen H. Hobbs
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 40, pp. 16109 - 16114
Angiopoietin-like protein (ANGPTL)8 (alternatively called TD26, RIFL, Lipasin, and Betatrophin) is a newly recognized ANGPTL family member that has been... 
Adipose tissues | Lipoproteins | Fasting | Refeeding | Mice | Triglycerides | Lipid metabolism | Insulin | Fatty acids | Blood plasma | FATTY-ACID SYNTHESIS | LIPID-METABOLISM | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | LIVER | ELEMENT-BINDING PROTEIN | ANGIOPOIETIN-LIKE PROTEIN-4 | TARGET GENE | LIPOPROTEIN-LIPASE | DEFICIENCY | TRANSGENIC MICE | Dyslipidemias - drug therapy | Mice, Inbred C57BL | Immunoblotting | Male | Peptide Hormones - deficiency | Calorimetry, Indirect | Cholesterol, VLDL - blood | Peptide Hormones - genetics | Sequence Analysis, DNA | Mice, Knockout | Triglycerides - metabolism | Adipose Tissue - metabolism | Animals | Angiopoietin-like Proteins | Homeostasis - physiology | Triglycerides - blood | Dyslipidemias - metabolism | Glucose - metabolism | Biological Transport - physiology | Real-Time Polymerase Chain Reaction | Homeostasis | Physiological aspects | Glucose metabolism | Research | Membrane proteins | Tissue | Rodents | Glucose | Metabolism | Gene expression | Low density lipoprotein | Index Medicus | Biological Sciences
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