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1. Full Text A conversation with Helen Hobbs
by Neill, Ushma S
The Journal of clinical investigation, ISSN 0021-9738, 10/2015, Volume 125, Issue 10, pp. 3725 - 3726
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Cardiovascular Diseases - ethnology | History, 21st Century | Humans | Serine Endopeptidases - physiology | Genetics, Population - history | Genetics, Medical - history | Coronary Disease - ethnology | Cardiovascular Diseases - genetics | Proprotein Convertases - genetics | Genetic Variation | Founder Effect | Lipoproteins, LDL - deficiency | Receptors, LDL - deficiency | Serine Endopeptidases - genetics | Texas - epidemiology | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Hispanic Americans - genetics | Serine Endopeptidases - deficiency | History, 20th Century | African Americans - genetics | California | Codon, Nonsense | Proprotein Convertases - deficiency | Proprotein Convertases - physiology | Coronary Disease - genetics | Hyperlipoproteinemia Type II - epidemiology | Mutation | Lipoproteins, LDL - blood | Cohort Studies | Hyperlipoproteinemia Type II - genetics | Proprotein Convertase 9 | Interviews | Geneticists | Hobbs, Helen Haskell | Studies | Low density lipoprotein | Cholesterol | Index Medicus | Abridged Index Medicus | Hobbs | Conversations with Giants in Medicine
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2. Full Text Human Fatty Liver Disease: Old Questions and New Insights
by Jonathan C. Cohen and Jay D. Horton and Helen H. Hobbs
Science (American Association for the Advancement of Science), ISSN 0036-8075, 6/2011, Volume 332, Issue 6037, pp. 1519 - 1523
Cirrhosis | Obesity | Hepatocytes | Liver | Nonesterified fatty acids | Insulin resistance | Lipids | REVIEW | Insulin | Fatty acids | Human genetics | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Medical sciences | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Other diseases. Semiology | Fatty Liver - genetics | Liver Cirrhosis - etiology | Genetic Predisposition to Disease | Liver - pathology | Fatty Liver - metabolism | Fatty Liver - pathology | Humans | Liver - metabolism | Insulin Resistance | Male | Disease Progression | Triglycerides - metabolism | Liver Neoplasms - etiology | Animals | Dietary Fats - administration & dosage | Non-alcoholic Fatty Liver Disease | Female | Disease Models, Animal | Fatty Liver - etiology | Physiological aspects | Development and progression | Genetic aspects | Fatty liver | Disease management | Index Medicus | Human | Pathogenesis | Focusing | Genetics | Aberration | Cancer
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3. Full Text Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease
by Cohen, Jonathan C and Boerwinkle, Eric and Mosley, Thomas H and Hobbs, Helen H
The New England journal of medicine, ISSN 0028-4793, 03/2006, Volume 354, Issue 12, pp. 1264 - 1272
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Cardiology. Vascular system | Heart | Biological and medical sciences | General aspects | Medical sciences | Coronary heart disease | Coronary Disease - blood | European Continental Ancestry Group - genetics | United States | Gene Frequency | Humans | Middle Aged | Proportional Hazards Models | Coronary Disease - epidemiology | Genotype | Male | Risk | Codon, Nonsense | Hypolipoproteinemias - genetics | Incidence | Genetic Variation | Coronary Disease - genetics | Serine Endopeptidases - genetics | Carotid Arteries - anatomy & histology | Cholesterol, LDL - blood | Female | African Continental Ancestry Group - genetics | Proprotein Convertases | Cohort Studies | Proprotein Convertase 9 | Cardiovascular disease | Low density lipoprotein | Coronary vessels | Deoxyribonucleic acid--DNA | Index Medicus | Abridged Index Medicus
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4. Full Text Science, serendipity, and the single degree
by Hobbs, Helen H
The Journal of clinical investigation, ISSN 0021-9738, 10/2018, Volume 128, Issue 10, pp. 4218 - 4223
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | History, 21st Century | History, 20th Century | Humans | Biomedical Research - history | Proteins | Liver diseases | Fatty liver | Laboratories | Hepatology | Cloning | Careers | Lipids | Metabolism | Cholesterol | Index Medicus | Abridged Index Medicus | Hobbs
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5. Full Text Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
by Romeo, Stefano and Cox, David and Pertsemlidis, Alexander and Hobbs, Helen H and Pennacchio, Len A and Cohen, Jonathan C and Xing, Chao and Boerwinkle, Eric and Kozlitina, Julia and Joint Genome Institute (JGI)
Nature genetics, ISSN 1061-4036, 12/2008, Volume 40, Issue 12, pp. 1461 - 1465
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Gastroenterology. Liver. Pancreas. Abdomen | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Biological and medical sciences | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Other diseases. Semiology | Fatty Liver - genetics | Genetic Variation | Genetic Predisposition to Disease | Membrane Proteins - genetics | Humans | Female | Male | Fatty Liver - epidemiology | Fatty Liver - ethnology | Lipase - genetics | Genetic aspects | Fatty liver | Research | Single nucleotide polymorphisms | Genetic susceptibility | Risk factors | African Americans | Plasma | Liver diseases | Diet | Hispanics | Index Medicus
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6. Full Text Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4): an unmasked randomised controlled trial
by McManus, Richard J and Mant, Jonathan and Franssen, Marloes and Nickless, Alecia and Schwartz, Claire and Hodgkinson, James and Bradburn, Peter and Farmer, Andrew and Grant, Sabrina and Greenfield, Sheila M and Heneghan, Carl and Jowett, Susan and Martin, Una and Milner, Siobhan and Monahan, Mark and Mort, Sam and Ogburn, Emma and Perera-Salazar, Rafael and Shah, Syed Ahmar and Yu, Ly-Mee and Tarassenko, Lionel and Hobbs, F D Richard and Bradley, Brendan and Lovekin, Chris and Judge, David and Castello, Luis and Dawson, Maureen and Brice, Rebecca and Dunbabin, Bethany and Maslen, Sophie and Rutter, Heather and Norris, Mary and French, Lauren and Loynd, Michael and Whitbread, Pippa and Saldana Ortaga, Luisa and Noel, Irene and Madronal, Karen and Timmins, Julie and Bradburn, Peter and Hughes, Lucy and Hinks, Beth and Bailey, Sheila and Read, Sue and Weston, Andrea and Spannuth, Somi and Maiden, Sue and Chermahini, Makiko and McDonald, Ann and Rajan, Shelina and Allen, Sue and Deboys, Brenda and Fell, Kim and Johnson, Jenny and Jung, Helen and Lister, Rachel and Osborne, Ruth and Secker, Amy and Qasim, Irene and William, Kirsty and Harris, Abi and Zhao, Susan and Butcher, Elaine and Darbyshire, Pauline and Joshi, Sarah and Davies, Jon and Talbot, Claire and Hoverd, Eleanor and Field, Linda and Adcock, Tracey and Rooney, Julia and Cooter, Nina and Butler, Aaron and Allen, Naomi and Abdul-Wahab, Maria and McNicholas, Kathryn and Peniket, Lara and Dodd, Kate and Mugurza, Julie and Baskerville, Richard and Syed, Rakshan and Bailey, Clare and Adams, Jill and Uglow, Paul and Townsend, Neil and Macleod, Alison and Hawkins, Charlotte and Behura, Suparna and Crawshaw, Jonathan and Fox, Robin and Doski, Waleed and Aylward, Martin and A'Court, Christine and Rapley, David and Walsh, Jo and Batra, Paul and Seoane, Ana and Mukherjee, Sluti and Dixon, Jonathan and Arthur, Peter and ... and TASMINH4 investigators and TASMINH4 Investigators
The Lancet (British edition), ISSN 0140-6736, 03/2018, Volume 391, Issue 10124, pp. 949 - 959
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Humans | Middle Aged | Hypertension - drug therapy | Male | United Kingdom | Antihypertensive Agents - therapeutic use | Telemedicine | General Practice | Female | Aged | Primary Health Care | Hypertension - diagnosis | Self Care | Blood Pressure Determination | Hypertension | Antihypertensive drugs | Family medicine | Blood pressure | Patient monitoring equipment | Analysis | Health care | Automation | Physicians | Antihypertensives | Cardiovascular disease | Systematic review | Primary care | Evidence-based medicine | Family physicians | Studies | Titration | Kidney diseases | Drugs | Leadership | Sensitivity analysis | Patients | Blood | Randomization | Mercury | Remote monitoring | Index Medicus | Abridged Index Medicus
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7. Full Text The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation
by BasuRay, Soumik and Smagris, Eriks and Cohen, Jonathan C and Hobbs, Helen H
Hepatology (Baltimore, Md.), ISSN 0270-9139, 10/2017, Volume 66, Issue 4, pp. 1111 - 1124
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Fatty Liver - genetics | Genetic Predisposition to Disease | Phospholipases A2, Calcium-Independent - metabolism | Adenine - analogs & derivatives | Fatty Liver - metabolism | Oxidation-Reduction | Caloric Restriction | Lipid Metabolism | Mice, Transgenic | Triglycerides - metabolism | Ubiquitination | Animals | Dietary Sucrose | Proteasome Endopeptidase Complex - metabolism | Lipid Droplets - metabolism | Phospholipases A2, Calcium-Independent - genetics | Ubiquitin | Proteins | Phospholipase | Bortezomib | Liver diseases | Fatty liver | Sucrose | Secretion | Rodents | Proteasomes | Index Medicus | Original
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8. Full Text 2018 association of American physicians George M. Kober lecture science, serendipity, and the single degree
by Hobbs, Helen H
The Journal of clinical investigation, ISSN 0021-9738, 10/2018, Volume 128, Issue 10, pp. 4218 - 4223
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9. Full Text Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
by Kozlitina, Julia and Smagris, Eriks and Stender, Stefan and Nordestgaard, Børge G and Zhou, Heather H and Tybjærg-Hansen, Anne and Vogt, Thomas F and Hobbs, Helen H and Cohen, Jonathan C
Nature genetics, ISSN 1061-4036, 2014, Volume 46, Issue 4, pp. 352 - 356
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Humans | Molecular Sequence Data | Alanine Transaminase - blood | Mutation, Missense - genetics | Gene Knockdown Techniques | Adipose Tissue - metabolism | Base Sequence | Lipoproteins, VLDL - secretion | Non-alcoholic Fatty Liver Disease | Chromatography, Liquid | Real-Time Polymerase Chain Reaction | Fatty Liver - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Genetic Predisposition to Disease - genetics | Genetic Association Studies | Membrane Proteins - genetics | Liver - metabolism | Recombinant Proteins - genetics | Dependovirus | Sequence Analysis, DNA | Triglycerides - metabolism | Exome - genetics | Sequence Alignment | Animals | Hepatocytes | Mice | Fatty liver | Genetic susceptibility | Exome sequencing | Genetic research | Genetic aspects | Research | Methods | Studies | Lipoproteins | Hypotheses | Genealogy | Rodents | African Americans | Lipids | Triglycerides | Cholesterol | Hispanics | Index Medicus
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10. Full Text A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
by Abul-Husn, Noura S and Cheng, Xiping and Li, Alexander H and Xin, Yurong and Schurmann, Claudia and Stevis, Panayiotis and Liu, Yashu and Kozlitina, Julia and Stender, Stefan and Wood, G. Craig and Stepanchick, Ann N and Still, Matthew D and Still, Christopher D and McCarthy, Shane and O’Dushlaine, Colm and Packer, Jonathan S and Balasubramanian, Suganthi and Gosalia, Nehal and Esopi, David and Kim, Sun Y and Mukherjee, Semanti and Lopez, Alexander E and Fuller, Erin D and Penn, John and Chu, Xin and Luo, Jonathan Z and Mirshahi, Tooraj and Mirshahi, Uyenlinh L and Carey, David J and Feldman, Michael D and Small, Aeron and Damrauer, Scott M and Rader, Daniel J and Zambrowicz, Brian and Olson, William and Murphy, Andrew J and Borecki, Ingrid B and Shuldiner, Alan R and Reid, Jeffrey G and Overton, John D and Yancopoulos, George D and Hobbs, Helen H and Cohen, Jonathan C and Gottesman, Omri and Teslovich, Tanya M and Baras, Aris and Gromada, Jesper and Dewey, Frederick E
The New England journal of medicine, ISSN 0028-4793, 03/2018, Volume 378, Issue 12, pp. 1096 - 1106
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Fatty Liver - genetics | Genetic Predisposition to Disease | Liver - pathology | Liver Diseases - genetics | Loss of Function Mutation | Humans | Liver Diseases - pathology | Genotype | Linear Models | Male | Alanine Transaminase - blood | Biomarkers - blood | Disease Progression | Whole Exome Sequencing | Genetic Variation | Sequence Analysis, RNA | Aspartate Aminotransferases - blood | 17-Hydroxysteroid Dehydrogenases - genetics | Female | 17-Hydroxysteroid Dehydrogenases - metabolism | Chronic Disease | Genetic aspects | Liver diseases | Research | Genetic variation | Risk factors | Alternative splicing | Heterozygotes | Lipids | Electronic medical records | Proteins | Fatty liver | Enzymatic activity | Genetics | Genetic factors | Localization | Deoxyribonucleic acid--DNA |