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1. Full Text Ancient human genomes suggest three ancestral populations for present-day Europeans
by Lazaridis, Iosif and Lazaridis, Iosif and Patterson, Nick and Patterson, Nick and Mittnik, Alissa and Mittnik, Alissa and Renaud, Gabriel and Renaud, Gabriel and Mallick, Swapan and Mallick, Swapan and Kirsanow, Karola and Kirsanow, Karola and Sudmant, Peter H and Sudmant, Peter H and Schraiber, Joshua G and Schraiber, Joshua G and Castellano, Sergi and Castellano, Sergi and Lipson, Mark and Lipson, Mark and Berger, Bonnie and Berger, Bonnie and Economou, Christos and Economou, Christos and Bollongino, Ruth and Bollongino, Ruth and Fu, Qiaomei and Fu, Qiaomei and Bos, Kirsten I and Bos, Kirsten I and Nordenfelt, Susanne and Nordenfelt, Susanne and Li, Heng and Li, Heng and de Filippo, Cesare and De Filippo, Cesare and Prüfer, Kay and Prüfer, Kay and Sawyer, Susanna and Sawyer, Susanna and Posth, Cosimo and Posth, Cosimo and Haak, Wolfgang and Haak, Wolfgang and Hallgren, Fredrik and Hallgren, Fredrik and Fornander, Elin and Fornander, Elin and Rohland, Nadin and Rohland, Nadin and Delsate, Dominique and Delsate, Dominique and Francken, Michael and Francken, Michael and Guinet, Jean-Michel and Guinet, Jean-Michel and Wahl, Joachim and Wahl, Joachim and Ayodo, George and Ayodo, George and Babiker, Hamza A and Babiker, Hamza A and Bailliet, Graciela and Bailliet, Graciela and Balanovska, Elena and Balanovska, Elena and Balanovsky, Oleg and Balanovsky, Oleg and Barrantes, Ramiro and Barrantes, Ramiro and Bedoya, Gabriel and Bedoya, Gabriel and Ben-Ami, Haim and Ben-Ami, Haim and Bene, Judit and Bene, Judit and Berrada, Fouad and Berrada, Fouad and Bravi, Claudio M and Bravi, Claudio M and Brisighelli, Francesca and Brisighelli, Francesca and Busby, George B J and Busby, George B.J and Cali, Francesco and Cali, Francesco and Churnosov, Mikhail and Churnosov, Mikhail and Cole, David E C and Cole, David E.C and Corach, Daniel and Corach, Daniel and Damba, Larissa and Damba, Larissa and Van Driem, George and van Driem, George and Dryomov, Stanislav and Dryomov, Stanislav and Dugoujon, Jean-Michel and Dugoujon, Jean-Michel and ... and Humanistiska fakulteten and Stockholms universitet and Institutionen för arkeologi och antikens kultur and Arkeologiska forskningslaboratoriet
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7518, pp. 409 - 413
We sequenced the genomes of a similar to 7,000-year-old farmer from Germany and eight similar to 8,000-year-old hunter-gatherers from Luxembourg and Sweden. We... 
GENETIC DIVERSITY | AFRICA | CAVE | FARMERS | MULTIDISCIPLINARY SCIENCES | NEANDERTHAL | WIDE ASSOCIATION | DNA-SEQUENCING DATA | ADMIXTURE | HUNTER-GATHERERS | HISTORY | Europeans | Human genome | Genetic research | Genetic aspects | Research | Population genetics | Natural history | Population | Genomes | Genealogy | Index Medicus | Quantitative Biology - Populations and Evolution | Genètica de poblacions humanes | Genoma humà | Arkeologi | Humanities | Archaeology | Historia och arkeologi | History and Archaeology | Humaniora
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2. Full Text The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
by Mallick, Swapan and Li, Heng and Lipson, Mark and Mathieson, Iain and Gymrek, Melissa and Racimo, Fernando and Zhao, Mengyao and Chennagiri, Niru and Nordenfelt, Susanne and Tandon, Arti and Skoglund, Pontus and Lazaridis, Iosif and Sankararaman, Sriram and Fu, Qiaomei and Rohland, Nadin and Renaud, Gabriel and Erlich, Yaniv and Willems, Thomas and Gallo, Carla and Spence, Jeffrey P and Song, Yun S and Poletti, Giovanni and Balloux, Francois and Van Driem, George and De Knijff, Peter and Romero, Irene Gallego and Jha, Aashish R and Behar, Doron M and Bravi, Claudio M and Capelli, Cristian and Hervig, Tor and Moreno-Estrada, Andres and Posukh, Olga L and Balanovska, Elena and Balanovsky, Oleg and Karachanak-Yankova, Sena and Sahakyan, Hovhannes and Toncheva, Draga and Yepiskoposyan, Levon and Tyler-Smith, Chris and Xue, Yali and Abdullah, M. Syafiq and Ruiz-Linares, Andres and Beall, Cynthia M and Di Rienzo, Anna and Jeong, Choongwon and Starikovskaya, Elena B and Metspalu, Ene and Parik, Jüri and Villems, Richard and Henn, Brenna M and Hodoglugil, Ugur and Mahley, Robert and Sajantila, Antti and Stamatoyannopoulos, George and Wee, Joseph T. S and Khusainova, Rita and Khusnutdinova, Elza and Litvinov, Sergey and Ayodo, George and Comas, David and Hammer, Michael F and Kivisild, Toomas and Klitz, William and Winkler, Cheryl A and Labuda, Damian and Bamshad, Michael and Jorde, Lynn B and Tishkoff, Sarah A and Watkins, W. Scott and Metspalu, Mait and Dryomov, Stanislav and Sukernik, Rem and Singh, Lalji and Thangaraj, Kumarasamy and Paäbo, Svante and Kelso, Janet and Patterson, Nick and Reich, David
Nature, ISSN 0028-0836, 2016, Volume 538, Issue 7624, pp. 201 - 206
Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at... 
DISPERSAL | AFRICA | MUTATION-RATE | MODERN HUMANS | MULTIDISCIPLINARY SCIENCES | SEQUENCE | NEANDERTHAL | ADMIXTURE | INFERENCE | ANCESTRY | HISTORY | Genetics, Population | History, Ancient | Datasets as Topic | Species Specificity | Genomics | Humans | Mutation Rate | Neanderthals - genetics | Continental Population Groups - genetics | Phylogeny | Sequence Analysis, DNA | Genome, Human - genetics | Human Migration - history | New Guinea | Animals | Time Factors | Genetic Variation - genetics | African Continental Ancestry Group - genetics | Australia | Oceanic Ancestry Group - genetics | Genetic research | Genomes | Research | Biological diversity | Datasets | Demography | Population | Genetic diversity | Mutation | Hominids | Index Medicus | Genètica | Filogènia | Genoma humà | Genòmica
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3. Full Text A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components
by Chiefari, Eusebio and Tanyolaç, Sinan and Iiritano, Stefania and Sciacqua, Angela and Capula, Carmelo and Arcidiacono, Biagio and Nocera, Aurora and Possidente, Katiuscia and Baudi, Francesco and Ventura, Valeria and Brunetti, Giuseppe and Brunetti, Francesco S and Vero, Raffaella and Maio, Raffaele and Greco, Manfredi and Pavia, Maria and Hodoglugil, Ugur and Durlach, Vincent and Pullinger, Clive R and Goldfine, Ira D and Perticone, Francesco and Foti, Daniela and Brunetti, Antonio
Scientific Reports, ISSN 2045-2322, 2013, Volume 3, Issue 1, pp. 1491 - 1491
The metabolic syndrome (MetS) is a common disorder, where systemic insulin-resistance is associated with increased risk for type 2 diabetes (T2D) and... 
Genetic Predisposition to Disease | HMGA1a Protein - genetics | Demography | Genetic Association Studies | Humans | Middle Aged | Risk Factors | Male | Case-Control Studies | Turkey | Metabolic Syndrome - genetics | Insulin Resistance - genetics | Polymorphism, Single Nucleotide - genetics | Female | Italy | Hyperglycemia | Diabetes mellitus | Metabolic syndrome | Insulin | Lipoproteins (high density) | Cholesterol | Metabolic disorders | Index Medicus
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4. Full Text Turkish Population Structure and Genetic Ancestry Reveal Relatedness among Eurasian Populations
by Hodoğlugil, Uğur and Mahley, Robert W
Annals of Human Genetics, ISSN 0003-4800, 03/2012, Volume 76, Issue 2, pp. 128 - 141
Turkey has experienced major population movements. Population structure and genetic relatedness of samples from three regions of Turkey, using over 500,000 SNP... 
population genetics | ancestry | population structure | admixture | Human Genome Diversity Panel | Kyrgyz | Turks | Admixture | Ancestry | Population structure | Population genetics | WHOLE-GENOME | ELEVATED HEPATIC LIPASE | GENOME-WIDE PATTERNS | MITOCHONDRIAL-DNA | PLASMA TRIGLYCERIDE | HIGH-DENSITY-LIPOPROTEIN | GENOTYPE DATA | CHOLESTEROL LEVELS | GENETICS & HEREDITY | DIVERSITY | Genetics, Population | Asian Continental Ancestry Group | Turkey | Humans | European Continental Ancestry Group | Population Groups | Polymorphism, Single Nucleotide | Phylogeny | Emigration and Immigration | Genetic research | Universities and colleges | Analysis | Evolution | Population | Genealogy | Subpopulations | Genetic structure | Migration | Data processing | Genomes | Single-nucleotide polymorphism | Sampling | Genotypes | Index Medicus
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5. Full Text Disruption of a novel krüppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus
by Bonnefond, Amélie and Lomberk, Gwen and Buttar, Navtej and Busiah, Kanetee and Vaillant, Emmanuel and Lobbens, Stéphane and Yengo, Loïc and Dechaume, Aurélie and Mignot, Brigitte and Simon, Albane and Scharfmann, Raphaël and Neve, Bernadette and Tanyolaç, Sinan and Hodoglugil, Ugur and Pattou, François and Cavé, Hélène and Iovanna, Juan and Stein, Roland and Polak, Michel and Vaxillaire, Martine and Froguel, Philippe and Urrutia, Raul
Journal of Biological Chemistry, ISSN 0021-9258, 08/2011, Volume 286, Issue 32, pp. 28414 - 28424
Kruppel-like transcription factors (KLFs) have elicited significant attention because of their regulation of essential biochemical pathways and, more recently,... 
FINGER | GLUCOSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR KLF11 | MICE | GROWTH-REGULATION | CELL-GROWTH | EXPRESSION | GENE-TRANSCRIPTION | FAMILY | PDX-1 | Diabetes Mellitus - genetics | Humans | Infant, Newborn, Diseases - pathology | Child, Preschool | Infant | Male | Insulin - biosynthesis | DNA-Binding Proteins - metabolism | Insulin-Secreting Cells - metabolism | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Adult | Female | Infant, Newborn, Diseases - genetics | Response Elements - genetics | Insulin - genetics | Infant, Newborn | Repressor Proteins - metabolism | Cell Line | Cell Cycle Proteins - metabolism | Diabetes Mellitus - metabolism | Rats | Repressor Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mice, Knockout | Transcription Factors - metabolism | Animals | Trans-Activators - metabolism | Infant, Newborn, Diseases - metabolism | Mice | Mutagenesis, Insertional | Insulin-Secreting Cells - pathology | Index Medicus | Pancreatic Islet | Molecular Bases of Disease | Transcription Regulation | Genetic Diseases | KLF | Glucose Metabolism | Diabetes
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6. Full Text Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population
by Hodolugil, Uur and Williamson, David W and Mahley, Robert W
Journal of Lipid Research, ISSN 0022-2275, 02/2010, Volume 51, Issue 2, pp. 422 - 430
We investigated the effects of single nucleotide polymorphisms (SNPs) of the hepatic lipase gene (LIPC) on plasma HDL-cholesterol (HDL-C) levels in Turks, a... 
Lipoprotein metabolism | Heart disease risk | Single nucleotide polymorphisms | PROMOTER ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOME | heart disease risk | HIGH-DENSITY-LIPOPROTEIN | HEART-DISEASE | ATHEROGENIC DYSLIPIDEMIA | C-514T POLYMORPHISM | LINKAGE ANALYSES | lipoprotein metabolism | CARDIOVASCULAR-DISEASE | single nucleotide polymorphisms | TRANSCRIPTIONAL REGULATION | CORONARY-ARTERY-DISEASE | Transcription Factors - metabolism | Turkey | Genomics | Humans | Cholesterol, HDL - blood | Adult | Female | Genotype | Male | Polymorphism, Single Nucleotide | Lipase - metabolism | Lipase - genetics | Index Medicus | Patient-Oriented and Epidemiological Research
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7. Full Text Pierpont syndrome associated with the p.Tyr446Cys missense mutation in TBL1XR1
by Slavotinek, Anne and Pua, Heather and Hodoglugil, Ugur and Abadie, Jude and Shieh, Joseph and Van Ziffle, Jessica and Kvale, Mark and Lee, Hane and Kwok, Pui-Yan and Risch, Neil and Sabbadini, Marta
European Journal of Medical Genetics, ISSN 1769-7212, 10/2017, Volume 60, Issue 10, pp. 504 - 508
We present a 7-year old male with severe delays, hypotonia and dysmorphic features who had striking, deep palmar and plantar creases and pillowing of the soft... 
Pierpont syndrome | Syndromic intellectual disability | WD40 repeat domain | TBL1XR1 | REANALYSIS | ACTIVATION | COMPLEX | TBLR1 | DISORDERS | DEVELOPMENTAL DELAY | PLANTAR LIPOMATOSIS | DELETION | INTELLECTUAL DISABILITY | GENETICS & HEREDITY | Repressor Proteins - chemistry | Muscle Hypotonia - genetics | Humans | Repressor Proteins - genetics | Male | Nuclear Proteins - metabolism | Developmental Disabilities - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Mutation, Missense | Nuclear Proteins - chemistry | Syndrome | Muscle Hypotonia - diagnosis | Phenotype | Arnold-Chiari Malformation - diagnosis | Arnold-Chiari Malformation - genetics | Receptors, Cytoplasmic and Nuclear - chemistry | Protein Binding | Protein Domains | Nuclear Proteins - genetics | Child | Developmental Disabilities - diagnosis | Repressor Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Medicine, Experimental | Autism | Medical research | Genetic aspects | Kidney diseases | Medical genetics | Index Medicus
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8. Full Text Glucuronic Acid Epimerase is Associated with Plasma Triglyceride and High‐Density Lipoprotein Cholesterol Levels in Turks
by Hodoğlugil, Uğur and Williamson, David W and Yu, Yi and Farrer, Lindsay A and Mahley, Robert W
Annals of Human Genetics, ISSN 0003-4800, 05/2011, Volume 75, Issue 3, pp. 398 - 417
We narrowed chromosome 15q21–23 linkage to plasma high‐density lipoprotein cholesterol (HDL‐C) levels in Turkish families by fine mapping, then focused on... 
triglyceride | GLCE | apolipoprotein E | HDL‐C | heparan sulfate proteoglycans | single nucleotide polymorphisms | Turks | HDL-C | Apolipoprotein E | Heparan sulfate proteoglycans | Single nucleotide polymorphisms | Triglyceride | INBRED MOUSE STRAINS | LIPID CONCENTRATIONS | QUANTITATIVE TRAIT LOCI | ATHEROGENIC DYSLIPIDEMIA | JAPANESE POPULATION | LINKAGE ANALYSES | GENETICS & HEREDITY | CARDIOVASCULAR-DISEASE | MILLION SNPS | HEPARAN-SULFATE PROTEOGLYCANS | HDL-CHOLESTEROL | Animals | Turkey | Humans | Mice, Inbred C57BL | Triglycerides - blood | Cholesterol, HDL - blood | Female | Male | Mice | Carbohydrate Epimerases - genetics | Microsatellite Repeats | Enzymes | Nervous system diseases | Analysis | Physiological aspects | Triglycerides | Sulfates | Apolipoproteins | Population genetics | Cholesterol | Index Medicus
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9. Full Text Gender Differences in the Relationship of ENPP1/PC-1 Variants to Obesity in a Turkish Population
by Tanyolaç, Sinan and Mahley, Robert W and Hodoglugil, Uǧur and Goldfine, Ira D
Obesity, ISSN 1930-7381, 11/2008, Volume 16, Issue 11, pp. 2468 - 2471
The ectoenzyme ENPP1 (also termed membrane glycoprotein PC-1 or ENPP1/PC-1) is an inhibitor of insulin-induced activation of the insulin receptor. There is... 
NUTRITION & DIETETICS | ABNORMALITIES | INSULIN-RESISTANCE | GLUCOSE-INTOLERANCE | ENDOCRINOLOGY & METABOLISM | RECEPTOR | RISK | GLYCOPROTEIN PC-1 GENE | K121Q POLYMORPHISM | WEIGHT | ASSOCIATION | REGION | Gene Frequency - genetics | Genetic Predisposition to Disease - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Obesity - ethnology | Pyrophosphatases - genetics | Male | Phosphoric Diester Hydrolases - genetics | Sex Characteristics | Obesity - genetics | Haplotypes - genetics | Diabetes Mellitus, Type 2 - ethnology | Turkey | Adult | Female | Genetic Predisposition to Disease - ethnology | Genetic Variation - genetics | Index Medicus | ENPP1 | PC-1 | polymorphism | Turkish population | obesity
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10. Full Text Apolipoprotein A-V: A potential modulator of plasma triglyceride levels in Turks
by Hodoǧlugil, Uǧur and Tanyolaç, Sinan and Williamson, David W and Huang, Yadong and Mahley, Robert W
Journal of Lipid Research, ISSN 0022-2275, 01/2006, Volume 47, Issue 1, pp. 144 - 153
The apolipoprotein A-V gene (APOA5) plays an important role in determining plasma triglyceride levels. We studied the effects of APOA5 polymorphisms on plasma... 
Turkish population | High density lipoprotein cholesterol | Haplotype | Polymorphism | haplotype | RISK-FACTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROMOTER POLYMORPHISM | polymorphism | high density lipoprotein cholesterol | DENSITY-LIPOPROTEIN CHOLESTEROL | APOA5 GENE VARIANTS | HEART-DISEASE | ATHEROGENIC DYSLIPIDEMIA | CARDIOVASCULAR-DISEASE | HDL CHOLESTEROL | CORONARY-ARTERY-DISEASE | LIPIDS | Haplotypes | Apolipoprotein A-V | European Continental Ancestry Group - genetics | Cross-Sectional Studies | United States | Apolipoproteins A | Gene Frequency | Humans | Middle Aged | Male | Coronary Artery Disease - blood | Linkage Disequilibrium | Turkey | Apolipoproteins - genetics | Alleles | Coronary Artery Disease - genetics | Triglycerides - blood | Arabs - genetics | Cholesterol, HDL - blood | Adult | Female | Polymorphism, Single Nucleotide | Triglycerides - genetics | Index Medicus
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11. Full Text Ancient human genomes suggest three ancestral populations for present-day Europeans
by Lazaridis, Iosif and Patterson, Nick and Mittnik, Alissa and Renaud, Gabriel and Mallick, Swapan and Kirsanow, Karola and Sudmant, Peter H and Schraiber, Joshua G and Castellano, Sergi and Lipson, Mark and Berger, Bonnie and Economou, Christos and Bollongino, Ruth and Fu, Qiaomei and Bos, Kirsten I and Nordenfelt, Susanne and Li, Heng and de Filippo, Cesare and Prüfer, Kay and Sawyer, Susanna and Posth, Cosimo and Haak, Wolfgang and Hallgren, Fredrik and Fornander, Elin and Rohland, Nadin and Delsate, Dominique and Francken, Michael and Guinet, Jean-Michel and Wahl, Joachim and Ayodo, George and Babiker, Hamza A and Bailliet, Graciela and Balanovska, Elena and Balanovsky, Oleg and Barrantes, Ramiro and Bedoya, Gabriel and Ben-Ami, Haim and Bene, Judit and Berrada, Fouad and Bravi, Claudio M and Brisighelli, Francesca and Busby, George B J and Cali, Francesco and Churnosov, Mikhail and Cole, David E C and Corach, Daniel and Damba, Larissa and van Driem, George and Dryomov, Stanislav and Dugoujon, Jean-Michel and Fedorova, Sardana A and Gallego Romero, Irene and Gubina, Marina and Hammer, Michael and Henn, Brenna M and Hervig, Tor and Hodoglugil, Ugur and Jha, Aashish R and Karachanak-Yankova, Sena and Khusainova, Rita and Khusnutdinova, Elza and Kittles, Rick and Kivisild, Toomas and Klitz, William and Kučinskas, Vaidutis and Kushniarevich, Alena and Laredj, Leila and Litvinov, Sergey and Loukidis, Theologos and Mahley, Robert W and Melegh, Béla and Metspalu, Ene and Molina, Julio and Mountain, Joanna and Näkkäläjärvi, Klemetti and Nesheva, Desislava and Nyambo, Thomas and Osipova, Ludmila and Parik, Jüri and Platonov, Fedor and Posukh, Olga and Romano, Valentino and Rothhammer, Francisco and Rudan, Igor and Ruizbakiev, Ruslan and Sahakyan, Hovhannes and Sajantila, Antti and Salas, Antonio and Starikovskaya, Elena B and Tarekegn, Ayele and Toncheva, Draga and Turdikulova, Shahlo and Uktveryte, Ingrida and Utevska, Olga and Vasquez, René and Villena, Mercedes and Voevoda, Mikhail and Winkler, Cheryl A and Yepiskoposyan, Levon and Zalloua, Pierre and ...
Nature, 09/2014, Volume 513, Issue 7518, p. 409
We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and... 
European Continental Ancestry Group - classification | History, Ancient | European Continental Ancestry Group - genetics | Agriculture - manpower | Agriculture - history | Europe | Humans | Asia - ethnology | Principal Component Analysis | Genome, Human - genetics | Population Dynamics
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