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Neuron, ISSN 0896-6273, 2007, Volume 56, Issue 1, pp. 66 - 78
Mutations in the amyloid precursor protein (APP) cause early-onset Alzheimer's disease (AD), but the only genetic risk factor for late-onset AD is the ɛ4... 
CELLBIO | MOLNEURO | SIGNALING | BETA-SECRETASE | PRESENILIN | APP | DEGRADING ENZYME NEPRILYSIN | INTRAMEMBRANE PROTEOLYSIS | ALZHEIMERS-DISEASE | GENE-EXPRESSION | DEPENDENT TRANSCRIPTIONAL CONTROL | NEUROSCIENCES | INTRACELLULAR DOMAINS | MICE LACKING | Enzyme-Linked Immunosorbent Assay - methods | Humans | Gene Expression Regulation, Developmental - genetics | Nuclear Proteins - pharmacology | Apolipoproteins E - metabolism | Brain - metabolism | RNA, Messenger - biosynthesis | Transfection - methods | Chromatin Immunoprecipitation | Tumor Suppressor Proteins - deficiency | Reverse Transcriptase Polymerase Chain Reaction - methods | Nerve Tissue Proteins - pharmacology | Receptors, LDL - deficiency | Lysine Acetyltransferase 5 | Amyloid beta-Protein Precursor - physiology | Gene Expression Regulation, Developmental - physiology | Animals, Newborn | Amyloid beta-Protein Precursor - deficiency | Cricetinae | Histone Acetyltransferases - pharmacology | Trans-Activators | Cholesterol - metabolism | Mice, Knockout | Tumor Suppressor Proteins - physiology | Amyloid Precursor Protein Secretases - metabolism | Animals | Cytidine Deaminase - metabolism | Mice | Receptors, LDL - physiology | Cell Line, Transformed | Proteins | Brain | Lipoproteins | Pathogenesis | Neurons | Rodents | Alzheimers disease | Metabolism | Apolipoproteins | Cholesterol | Deoxyribonucleic acid--DNA
Journal Article
Neuron, ISSN 0896-6273, 10/2014, Volume 84, Issue 1, pp. 63 - 77
Journal Article
Nature Biotechnology, ISSN 1087-0156, 06/2010, Volume 28, Issue 6, pp. 617 - 623
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2015, Volume 35, Issue 32, pp. 11346 - 11357
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 01/2018, Volume 119, Issue 1, pp. 300 - 313
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 12/2017, Volume 118, Issue 12, pp. 4672 - 4685
ABSTRACT Histone deacetylase inhibitors (HDACIs) have emerged as potential anticancer agents for the treatment of solid and hematopoietic cancers. Several... 
HDAC INHIBITOR | INVASION | CELL MIGRATION | BRAIN CANCER | HDAC | HYDROXAMIC ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHASE-II | CANCER | VORINOSTAT | TEMOZOLOMIDE | CELL BIOLOGY | MATRIX METALLOPROTEINASES | RESISTANCE | FOCAL ADHESION KINASE | PROMOTES | MOLECULAR-MECHANISMS | Focal Adhesion Kinase 1 - genetics | Thioacetamide - pharmacology | Neoplasm Invasiveness | Humans | Neoplasm Proteins - metabolism | Glioma - metabolism | Glioma - genetics | Cell Movement - drug effects | MAP Kinase Signaling System - drug effects | Glioma - pathology | Thioacetamide - analogs & derivatives | Cell Line, Tumor | Histone Deacetylase Inhibitors - pharmacology | Neoplasm Proteins - genetics | Focal Adhesion Kinase 1 - metabolism | Glioma - drug therapy | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Cell differentiation | Gliomas | Metastasis | Histone deacetylase | Phosphorylation | Leukocyte migration | Brain tumors | AKT protein | Matrix metalloproteinase | Cell adhesion & migration | Anticancer properties | Antitumor agents | Glioma cells | Metalloproteinase | Inhibition | Translocation | Stat3 protein | Extracellular signal-regulated kinase | JNK protein | Nuclear transport | 1-Phosphatidylinositol 3-kinase | Hemopoiesis | Gelatinase A | Inhibitors | Nuclei (cytology) | Cell migration | Tumors | Cancer | Apoptosis
Journal Article
Journal of Neuroinflammation, ISSN 1742-2094, 09/2018, Volume 15, Issue 1, pp. 271 - 22
Background: The FDA-approved small-molecule drug ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib... 
Neuroinflammation | AKT | LPS | STAT3 | Microglia | KAPPA-B ACTIVATION | INFLAMMATORY RESPONSES | PHOSPHORYLATION | MACROPHAGES | INDUCED TNF-ALPHA | IMMUNOLOGY | NEUROSCIENCES | INHIBITION | PATHWAY | TOLL-LIKE RECEPTORS | Inflammation - chemically induced | Pyrazoles - therapeutic use | Heterocyclic Compounds, 3-Ring - pharmacology | Male | Lipopolysaccharides - adverse effects | Pyrimidines - chemistry | Pyrazoles - chemistry | Cyclooxygenase 2 - genetics | Inflammation - drug therapy | Anti-Inflammatory Agents - therapeutic use | Culture Media, Serum-Free - pharmacology | Cytokines - genetics | Wound Healing - drug effects | Disease Models, Animal | Animals, Newborn | Microglia - cytology | Cytokines - metabolism | Microglia - drug effects | Mice, Inbred C57BL | Cells, Cultured | Rats | Animals | Signal Transduction - drug effects | Pyrimidines - therapeutic use | Cyclooxygenase 2 - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Cell Line, Transformed | Nervous system diseases | Care and treatment | Research | Lipopolysaccharides | Immunohistochemistry | Phosphorylation | Immunocytochemistry | Leukemia | AKT protein | Kinases | Experiments | Neurodegeneration | Rodents | Toll-like receptors | Microglial cells | Tumor necrosis factor-TNF | Protein-tyrosine kinase | Tyrosine | Automation | Chronic lymphatic leukemia | Cytokines | Astrocytes | Stat3 protein | Inflammation | TLR4 protein | Lymphatic leukemia | IL-1β | Bruton's tyrosine kinase | Polymerase chain reaction | Brain research | Researchers | Lymphocytes B | Nitric oxide | Software | Cyclooxygenase-2 | Cell migration
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 38, pp. 63949 - 63962
Isothiocyanates, which are present as glucosinolate precursors in cruciferous vegetables, have strong activity against various cancers. Here, we compared the... 
Cancer invasion | FAK | Metastasis | Isothiocyanates | MMP-9 | MIGRATION | MMP-9 EXPRESSION | CARCINOMA CELLS | isothiocyanates | CELL BIOLOGY | BREAST-CANCER CELLS | MATRIX METALLOPROTEINASES | cancer invasion | metastasis | SIGNALING PATHWAY | GENE-EXPRESSION | ANTICANCER DRUGS | FOCAL ADHESION KINASE | NF-KAPPA-B
Journal Article