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Journal of Clinical Oncology, ISSN 0732-183X, 05/2017, Volume 35, Issue 15_suppl, pp. 11619 - 11619
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2017, Volume 35, Issue 15_suppl, pp. 11620 - 11620
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2016, Volume 34, Issue 15_suppl, pp. 11527 - 11527
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2016, Volume 34, Issue 4_suppl, pp. 254 - 254
254 Background: 5 year (yr) overall survival (OS) for resected PDAC is typically 20%. To test the potential for molecular prediction of > 5 yr OS in such... 
Journal Article
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2015, Volume 33, Issue 15_suppl, pp. 517 - 517
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2015, Volume 33, Issue 15_suppl, pp. e12073 - e12073
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 2010, Volume 182, Issue 5, pp. 652 - 660
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e45243
Background: Insulin resistance impairs nitric oxide (NO) bioavailability and obesity promotes a state of chronic inflammation and damages the vascular... 
ISCHEMIA-REPERFUSION INJURY | METABOLIC SYNDROME | MYOCARDIAL INFARCT SIZE | NITRIC-OXIDE SYNTHASE | K-ATP CHANNELS | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | CARDIAC MYOCYTES | PHOSPHODIESTERASE-5 INHIBITOR | ENDOTHELIAL FUNCTION | ERECTILE DYSFUNCTION | Necrosis - drug therapy | Phosphodiesterase Inhibitors - therapeutic use | Diabetes Mellitus, Experimental - drug therapy | Obesity - drug therapy | Receptors, Leptin - genetics | Apoptosis - drug effects | Myocardial Reperfusion Injury - complications | Tumor Necrosis Factor-alpha - blood | Body Weight - drug effects | Male | Interleukin-1beta - blood | Diabetes Mellitus, Experimental - complications | Myocardial Reperfusion Injury - drug therapy | Diabetes Mellitus, Experimental - metabolism | Carbolines - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Fasting | Drug Administration Schedule | Obesity - complications | Necrosis - complications | Phosphodiesterase Inhibitors - pharmacology | Necrosis - metabolism | Myocardial Infarction - metabolism | Mice, Knockout | Obesity - metabolism | Myocardial Infarction - complications | Myocardial Reperfusion Injury - metabolism | Tadalafil | Animals | Myocardial Infarction - drug therapy | Myocytes, Cardiac - drug effects | Triglycerides - blood | Myocytes, Cardiac - metabolism | Mice | Blood Glucose - metabolism | Carbolines - pharmacology | Heart | Oxidative stress | Body weight | Interleukin | Cardiovascular disease | Biosynthesis | Glucose | Kinases | Proteins | Hyperglycemia | Reperfusion | Ischemia | Rodents | Atherosclerosis | Cardiology | Phosphodiesterase | Hypertension | Obesity | Computer simulation | Cytokines | Diabetes mellitus | Cardiomyocytes | Triglycerides | Inflammation | Bioavailability | FDA approval | Tumor necrosis factor-α | Metabolism | Insulin | Fatty acids | Endothelium | Medicine | Studies | Signaling | Injury prevention | Nitric oxide | Coronary vessels | Weight reduction | Insulin resistance | Ventricle | Morphometry | Chemokines | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 42, pp. 18202 - 18207
We have shown that the potent phosphodiesterase-5 (PDE-5) inhibitor sildenafil (Viagra) induces a powerful effect on reduction of infarct size following... 
Heart | Tumor burden | Cell growth | Reactive oxygen species | Cell death | Medical treatment | Cell lines | Prostate cancer | Apoptosis | Tumors | Phosphodiesterase-5 | INDUCED APOPTOSIS | CYCLIN D1 | K-ATP CHANNELS | MULTIDISCIPLINARY SCIENCES | apoptosis | phosphodiesterase-5 | CELL-LINES | RADIATION-THERAPY | DOCETAXEL TREATMENT | reactive oxygen species | METASTATIC BREAST-CANCER | EXISULIND | PHOSPHODIESTERASE-5 INHIBITION | HYDROGEN-PEROXIDE | Doxorubicin - therapeutic use | Neoplasm Transplantation | Phosphodiesterase Inhibitors - therapeutic use | Prostatic Neoplasms - metabolism | Sulfones - therapeutic use | Phosphorylation | Caspase 9 - metabolism | Reactive Oxygen Species - metabolism | Humans | Caspase 3 - metabolism | Male | Antineoplastic Agents - therapeutic use | Sildenafil Citrate | Antineoplastic Agents - adverse effects | Echocardiography, Doppler | bcl-Associated Death Protein - metabolism | Purines - therapeutic use | Prostatic Neoplasms - drug therapy | Piperazines - therapeutic use | Drug Synergism | Animals | Mice, Nude | Heart - drug effects | Prostatic Neoplasms - enzymology | Mice | Mice, Inbred BALB C | bcl-X Protein - metabolism | Doxorubicin - adverse effects | Chemotherapy | Dosage and administration | Sildenafil | Drug therapy | Doxorubicin | Heart diseases | Methods | Cancer | Biological Sciences
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 06/2011, Volume 300, Issue 6, pp. 2272 - 2279
Chronic inhibition of phosphodiesterase-5 with sildenafil immediately after permanent occlusion of the left anterior descending coronary artery was shown to... 
Ischemia-reperfusion injury | Protein kinase G | Echocardiography | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MYOCARDIAL-INFARCTION | PULMONARY-HYPERTENSION | NITRIC-OXIDE SYNTHASE | K-ATP CHANNELS | echocardiography | RHO-KINASE | VASCULAR SMOOTH-MUSCLE | OXYGEN-UPTAKE | ischemia-reperfusion injury | CYCLIC-GMP | PERIPHERAL VASCULAR DISEASE | protein kinase G | PHOSPHODIESTERASE-5 INHIBITION | LEFT-VENTRICULAR FUNCTION | Sulfones - therapeutic use | Apoptosis - drug effects | Heart Failure - physiopathology | Male | rhoA GTP-Binding Protein - physiology | Hemodynamics - physiology | Sulfones - pharmacology | rho-Associated Kinases - antagonists & inhibitors | Heart Failure - prevention & control | Sildenafil Citrate | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cyclic GMP-Dependent Protein Kinases - physiology | Models, Animal | Phosphodiesterase 5 Inhibitors - therapeutic use | Purines - therapeutic use | Phosphodiesterase 5 Inhibitors - pharmacology | rho-Associated Kinases - physiology | Purines - pharmacology | bcl-2-Associated X Protein - metabolism | Cardiomegaly - physiopathology | rhoA GTP-Binding Protein - antagonists & inhibitors | Piperazines - therapeutic use | Heart Failure - pathology | Piperazines - pharmacology | Mice, Inbred ICR | Ventricular Dysfunction, Left - physiopathology | Animals | Signal Transduction - drug effects | Signal Transduction - physiology | Mice | Apoptosis - physiology | Heart failure | Prevention | Physiological aspects | Genetic aspects | Sildenafil | Health aspects | Phosphotransferases | Integrative Cardiovascular Physiology and Pathophysiology
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 03/2008, Volume 294, Issue 3, pp. 1398 - 1406
Journal Article
STEM CELLS, ISSN 1066-5099, 02/2012, Volume 30, Issue 2, pp. 326 - 335
The rationale of this article is enhancing the therapeutic potential of stem cells in ischemic microenvironments by novel preconditioning strategies is... 
Myocardial infarction | Angiogenesis | Paracrine factors | Adipose‐derived stem cells | Echocardiography | Adipose-derived stem cells | SILDENAFIL | POSTNATAL NEOVASCULARIZATION | VENTRICULAR-FUNCTION | K-ATP CHANNELS | CARDIAC MYOCYTES | TRANSPLANTATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | ENHANCED SURVIVAL | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | HEART FUNCTION | STROMAL CELLS | HEMATOLOGY | Sulfones - therapeutic use | Humans | Adipose Tissue - cytology | Male | Sulfones - pharmacology | Cyclic GMP-Dependent Protein Kinases - metabolism | Cardiotonic Agents - therapeutic use | Sildenafil Citrate | Stem Cell Transplantation | Intercellular Signaling Peptides and Proteins - metabolism | Myocardial Infarction - therapy | Stem Cells - enzymology | Myocardium - metabolism | Phosphodiesterase 5 Inhibitors - therapeutic use | Purines - therapeutic use | Intercellular Signaling Peptides and Proteins - secretion | Fibrosis - prevention & control | Phosphodiesterase 5 Inhibitors - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Coronary Vessels - drug effects | Signal Transduction | Cell Survival | Purines - pharmacology | Cells, Cultured | Myocardium - pathology | Combined Modality Therapy | Piperazines - therapeutic use | Cardiotonic Agents - pharmacology | Piperazines - pharmacology | Animals | Cyclic GMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Stem Cells - drug effects | Mice | Myocardial Reperfusion Injury - prevention & control | Apoptosis
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 03/2012, Volume 302, Issue 6, pp. 1347 - 1354
Cinaciguat (BAY 58–2667) is a novel nitric oxide (NO)-independent activator of soluble guanylate cyclase (sGC), which induces cGMP-generation and vasodilation... 
Bay 58-2667 | Infarction | Cystathione-γ-lysase | Protein kinase g | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | SILDENAFIL | K-ATP CHANNELS | CARDIAC MYOCYTES | infarction | RABBITS | cystathione-gamma-lysase | PERIPHERAL VASCULAR DISEASE | protein kinase G | PHOSPHODIESTERASE-5 INHIBITION | RAT-HEART | CARDIOPROTECTION | EXPRESSION | BAY 58-2667 | Enzyme Activators - pharmacology | Hydrogen Sulfide - metabolism | Up-Regulation | Apoptosis - drug effects | Cystathionine gamma-Lyase - metabolism | Male | Myocardial Infarction - diagnostic imaging | RNA, Messenger - metabolism | Cyclic GMP-Dependent Protein Kinases - metabolism | Myocardial Reperfusion Injury - enzymology | Necrosis | Myocytes, Cardiac - enzymology | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Ultrasonography | Myocardial Infarction - physiopathology | Cystathionine gamma-Lyase - genetics | Myocardial Reperfusion Injury - drug therapy | Disease Models, Animal | Myocardial Infarction - enzymology | Cell Survival - drug effects | Rabbits | Ventricular Function, Left - drug effects | Enzyme Inhibitors - pharmacology | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Cystathionine gamma-Lyase - antagonists & inhibitors | Mice, Inbred ICR | Myocardial Reperfusion Injury - physiopathology | Myocardial Reperfusion Injury - diagnostic imaging | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Cyclic GMP - metabolism | Benzoates - pharmacology | Mice | Myocardial Infarction - prevention & control | Enzyme Activation | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Dosage and administration | Research | Drug therapy | Protein kinases | Reperfusion injury | Risk factors | Cardiovascular agents | cystathione-γ-lysase | Integrative Cardiovascular Physiology and Pathophysiology | BAY 58–2667
Journal Article
AJP - Heart and Circulatory Physiology, ISSN 0363-6135, 03/2008, Volume 294, Issue 3, pp. H1398 - H1406
Journal Article
Journal Article
Journal Article
Basic Research in Cardiology, ISSN 0300-8428, 07/2015, Volume 110, Issue 4, p. 1
Cyclic GMP-dependent protein kinase (PKG) is a serine-threonine kinase that mediates the cardioprotective effect of ischemic and pharmacologic preconditioning.... 
Hydrogen sulfide | Genetic research | Enzymes | Gene therapy | Analysis | Genes
Journal Article