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1. Full Text Survival-related profile, pathways, and transcription factors in ovarian cancer
by Crijns, Anne P G and Fehrmann, Rudolf S N and de Jong, Steven and Gerbens, Frans and Meersma, Gert Jan and Klip, Harry G and Hollema, Harry and Hofstra, Robert M W and te Meerman, Gerard J and de Vries, Elisabeth G. E and van der Zee, Ate G J and te Meerman, Gerhardus
PLOS MEDICINE, ISSN 1549-1277, 02/2009, Volume 6, Issue 2, pp. 181 - 193
BACKGROUND: Ovarian cancer has a poor prognosis due to advanced stage at presentation and either intrinsic or acquired resistance to classic cytotoxic drugs... 
CELLS | MEDICINE, GENERAL & INTERNAL | INDUCED APOPTOSIS | E2F FAMILY | POOR-PROGNOSIS | GENE-EXPRESSION PROFILES | BINDING-PROTEIN | MOLECULAR-CLONING | 2-COLOR MICROARRAYS | GENOMIC SIGNATURES | CLINICAL-RELEVANCE | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Kaplan-Meier Estimate | Gene Expression Profiling | Ovarian Neoplasms - mortality | Transcription Factors - genetics | Ovarian Neoplasms - genetics | Metabolic Networks and Pathways - genetics | Survival Analysis | Aged, 80 and over | Adult | Female | Aged | Patient outcomes | Outcome and process assessment (Health Care) | Development and progression | Genetic aspects | Cellular signal transduction | Research | DNA binding proteins | Ovarian cancer | Genetics and Genomics | Oncology | Proteins | Studies | Womens health
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2. Full Text An oncological view on the blood–testis barrier
by Bart, Joost and Groen, Harry JM and van der Graaf, Winette TA and Hollema, Harry and Hendrikse, N Harry and Vaalburg, Willem and Sleijfer, Dirk T and de Vries, Elisabeth GE
Lancet Oncology, ISSN 1470-2045, 2002, Volume 3, Issue 6, pp. 357 - 363
The function of the blood–testis barrier is to protect germ cells from harmful influences; thus, it also impedes the delivery of chemotherapeutic drugs to the... 
GERM-CELL CANCER | CISPLATIN-BASED CHEMOTHERAPY | BRAIN-BARRIER | ORGANIC ANION TRANSPORTER | ONCOLOGY | MDR1A P-GLYCOPROTEIN | ACUTE LYMPHOBLASTIC-LEUKEMIA | ENDOTHELIAL-CELLS | TESTICULAR CANCER | RESISTANCE-ASSOCIATED PROTEIN | MULTIDRUG-RESISTANCE | Blood-Testis Barrier - immunology | Testicular Neoplasms - drug therapy | Humans | Male | Testis - anatomy & histology | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - physiology | Testicular Neoplasms - pathology | Blood-Testis Barrier - physiology | Chemotherapy | Cancer
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3. Full Text CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma
by Workel, Hagma H and Komdeur, Fenne L and Wouters, Maartje C.A and Plat, Annechien and Klip, Harry G and Eggink, Florine A and Wisman, G. Bea A and Arts, Henriette J.G and Oonk, Maaike H.M and Mourits, Marian J.E and Yigit, Refika and Versluis, Marco and Duiker, Evelien W and Hollema, Harry and de Bruyn, Marco and Nijman, Hans W
European Journal of Cancer, ISSN 0959-8049, 2016, Volume 60, pp. 1 - 11
Abstract Introduction Intraepithelial CD8+ tumour-infiltrating T-lymphocytes (TIL) are associated with a prolonged survival in endometrial cancer (EC). By... 
Hematology, Oncology and Palliative Medicine | Adenocarcinoma | Endometrial cancer | CD103 | Survival | Tumour-infiltrating lymphocytes | CELLS | LYTIC GRANULE POLARIZATION | E-CADHERIN | TUMOR-INFILTRATING LYMPHOCYTES | ADHESION | ONCOLOGY | ENGAGEMENT | T-LYMPHOCYTES | T-Lymphocyte Subsets - immunology | Prognosis | Adenocarcinoma - immunology | Humans | Middle Aged | Integrin alpha Chains - metabolism | Integrins - metabolism | Antigens, CD - metabolism | Endometrial Neoplasms - immunology | Phenotype | Adenocarcinoma - therapy | Endometrial Neoplasms - therapy | Adult | Female | Aged | CD8-Positive T-Lymphocytes - immunology | Lymphocytes, Tumor-Infiltrating - immunology | T cells | Analysis | Tumors | Integrins | Antigens | Immunotherapy
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4. Full Text Management of extracolonic tumours in patients with Lynch syndrome
by Koornstra, Jan J, Dr and Mourits, Marian JE, Prof and Sijmons, Rolf H, MD and Leliveld, Annemarie M, MD and Hollema, Harry, Prof and Kleibeuker, Jan H, Prof
Lancet Oncology, ISSN 1470-2045, 2009, Volume 10, Issue 4, pp. 400 - 408
Summary Hereditary nonpolyposis colorectal cancer, or Lynch syndrome, is responsible for 2–3% of all colorectal cancers. Lynch syndrome is also associated with... 
Hematology, Oncology and Palliative Medicine | SMALL-BOWEL CANCER | URINARY-TRACT CANCER | ONCOLOGY | NONPOLYPOSIS COLORECTAL-CANCER | MUIR-TORRE-SYNDROME | GASTRIC-CANCER | TRANSITIONAL-CELL CARCINOMA | MSH6 GERMLINE MUTATIONS | SYNDROME FAMILIES | SYNDROME-II | ENDOMETRIAL CANCER | Colorectal Neoplasms, Hereditary Nonpolyposis - therapy | Neoplasms - therapy | Neoplasms - genetics | Pedigree | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Humans | Female | Male | Care and treatment | Endometrial cancer | Colorectal cancer | Hysterectomy | Health aspects | Ovarian cancer | Skin cancer
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5. Full Text Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study
by Oonk, Maaike H, MD and van Hemel, Bettien M, MD and Hollema, Harry, Prof and de Hullu, Joanne A, PhD and Ansink, Anca C, PhD and Vergote, Ignace, Prof and Verheijen, René H, Prof and Maggioni, Angelo, MD and Gaarenstroom, Katja N, PhD and Baldwin, Peter J, PhD and van Dorst, Eleonora B, MD and van der Velden, Jacobus, PhD and Hermans, Ralph H, PhD and van der Putten, Hans W, PhD and Drouin, Pierre, MD and Runnebaum, Ingo B, PhD and Sluiter, Wim J, PhD and van der Zee, Ate G, Prof
Lancet Oncology, The, ISSN 1470-2045, 2010, Volume 11, Issue 7, pp. 646 - 652
Summary Background Currently, all patients with vulvar cancer with a positive sentinel node undergo inguinofemoral lymphadenectomy, irrespective of the size of... 
Hematology, Oncology and Palliative Medicine | BREAST-CANCER | SQUAMOUS-CELL CARCINOMA | MICROMETASTASES | MELANOMA | ONCOLOGY | LYMPH-NODES | Vulvar Neoplasms - surgery | Prognosis | Neoplasm Recurrence, Local - prevention & control | Humans | Proportional Hazards Models | Lymphatic Metastasis | Secondary Prevention | Disease-Free Survival | Vulvar Neoplasms - pathology | Groin | Survival Analysis | Female | Aged | Sentinel Lymph Node Biopsy | Research | Metastasis | Oncology, Experimental | Cancer
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6. Full Text Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)
by McCluggage, W. Glenn and Judge, Meagan J and Clarke, Blaise A and Davidson, Ben and Gilks, C. Blake and Hollema, Harry and Ledermann, Jonathan A and Matias-Guiu, Xavier and Mikami, Yoshiki and Stewart, Colin J. R and Vang, Russell and Hirschowitz, Lynn and International Collaboration on Cancer Reporting
Modern Pathology, ISSN 0893-3952, 08/2015, Volume 28, Issue 8, pp. 1101 - 1122
A comprehensive pathological report is essential for optimal patient management, cancer staging and prognostication. In many countries, proforma reports are... 
PATHOLOGY | Predictive Value of Tests | Humans | Ovarian Neoplasms - pathology | Immunohistochemistry - standards | Carcinoma - chemistry | Peritoneal Neoplasms - chemistry | Ovarian Neoplasms - genetics | Peritoneal Neoplasms - drug therapy | Neoplasm Grading | Fallopian Tube Neoplasms - chemistry | Fallopian Tube Neoplasms - genetics | Female | Molecular Diagnostic Techniques - standards | Neoadjuvant Therapy | Chemotherapy, Adjuvant | Carcinoma - pathology | Ovarian Neoplasms - drug therapy | Fallopian Tube Neoplasms - drug therapy | Carcinoma - drug therapy | Peritoneal Neoplasms - pathology | Pathology, Clinical - standards | Diagnosis, Differential | Ovarian Neoplasms - chemistry | Biopsy - standards | Biomarkers, Tumor - analysis | Carcinoma - surgery | Peritoneal Neoplasms - surgery | Fallopian Tube Neoplasms - pathology | Fallopian Tube Neoplasms - surgery | Peritoneal Neoplasms - genetics | Carcinoma - genetics | Research Design - standards | Biomarkers, Tumor - genetics | Neoplasm Staging | Ovarian Neoplasms - surgery
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7. Full Text Adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): final results of an international, open-label, multicentre, randomised, phase 3 trial
by de Boer, Stephanie M and Powell, Melanie E and Mileshkin, Linda and Katsaros, Dionyssios and Bessette, Paul and Haie-Meder, Christine and Ottevanger, Petronella B and Ledermann, Jonathan A and Khaw, Pearly and Colombo, Alessandro and Fyles, Anthony and Baron, Marie-Helene and Jürgenliemk-Schulz, Ina M and Kitchener, Henry C and Nijman, Hans W and Wilson, Godfrey and Brooks, Susan and Carinelli, Silvestro and Provencher, Diane and Hanzen, Chantal and Lutgens, Ludy C H W and Smit, Vincent T H B M and Singh, Naveena and Do, Viet and D'Amico, Romerai and Nout, Remi A and Feeney, Amanda and Verhoeven-Adema, Karen W and Putter, Hein and Creutzberg, Carien L and McCormack, Mary and Whitmarsh, Karen and Allerton, Rozenn and Gregory, Deborah and Symonds, Paul and Hoskin, Peter J and Adusumalli, Madhavi and Anand, Anjana and Wade, Robert and Stewart, Alexandra and Taylor, Wendy and Kruitwagen, Roy F.P.M and Hollema, Harry and Pras, Elizabeth and Snyers, An and Stalpers, Lukas and Jobsen, Jan J and Slot, Annerie and Mens, Jan-Willem M and Stam, Tanja C and Van Triest, Baukelien and Van der Steen - Banasik, Elzbieta M and De Winter, Karin A.J and Quinn, Michael A and Kolodziej, Ilka and Pyman, Jan and Johnson, Carol and Capp, Anne and Fossati, Roldano and Gribaudo, Sergio and Lissoni, Andrea A and Ferrero, Annamaria and Artioli, Grazia and Davidson, Cathy and McLachlin, C. Meg and Ghatage, Prafull and Rittenberg, Paula V.C and Souhami, Luis and Thomas, Gillian and Duvillard, Pierre and Berton-Rigaud, Dominique and Tubiana-Mathieu, Nicole and PORTEC Study Grp and PORTEC study group
The Lancet Oncology, ISSN 1470-2045, 03/2018, Volume 19, Issue 3, pp. 295 - 309
Although women with endometrial cancer generally have a favourable prognosis, those with high-risk disease features are at increased risk of recurrence. The... 
CARCINOMA PATIENTS | GYNECOLOGIC-ONCOLOGY-GROUP | ONCOLOGY | PROGNOSIS | CLINICAL-TRIALS | RECURRENCE | QUALITY-OF-LIFE | STAGE-I | III TRIAL | CHEMOTHERAPY | RADIATION-THERAPY | Lymph Node Excision | Endometrial Neoplasms - mortality | Gynecologic Surgical Procedures - adverse effects | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Chemoradiotherapy, Adjuvant - adverse effects | Carcinoma, Endometrioid - therapy | Chemoradiotherapy, Adjuvant - mortality | Cisplatin - administration & dosage | Neoplasm Grading | Time Factors | Female | Paclitaxel - administration & dosage | Radiotherapy, Adjuvant | Gynecologic Surgical Procedures - mortality | Europe | Risk Factors | Carboplatin - administration & dosage | Treatment Outcome | New Zealand | Canada | Dose Fractionation, Radiation | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Carcinoma, Endometrioid - mortality | Endometrial Neoplasms - therapy | Endometrial Neoplasms - pathology | Aged | Australia | Carcinoma, Endometrioid - radiotherapy | Neoplasm Staging | Carcinoma, Endometrioid - pathology
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8. Full Text Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer
by Leffers, Ninke and Gooden, Marloes J. M and de Jong, Renske A and Hoogeboom, Baukje-Nynke and ten Hoor, Klaske A and Hollema, Harry and Boezen, H. Marieke and van der Zee, Ate G. J and Daemen, Toos and Nijman, Hans W
Cancer Immunology Immunotherapy, ISSN 0340-7004, 03/2009, Volume 58, Issue 3, pp. 449 - 459
PURPOSE: Ovarian cancer patients with intra-tumoral CD3(+) T-lymphocytes in primary tumor tissue have a better prognosis. This study aims to analyze the... 
Memory T-lymphocytes | Biomedicine | Immunology | Cancer Research | Oncology | Omental metastasis | Ovarian cancer | SURVIVAL | LOCATION | HEAD | STATISTICS | TISSUE MICROARRAYS | IMMUNOLOGY | FOXP3 | CELL CARCINOMA | MELANOMA | ONCOLOGY | COLORECTAL-CANCER | LYMPHOMA | Immunohistochemistry | Prognosis | Follow-Up Studies | Ovarian Neoplasms - diagnosis | Humans | Middle Aged | Ovarian Neoplasms - pathology | Treatment Outcome | Neoplasm Metastasis | Forkhead Transcription Factors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | Immunologic Memory | Aged | Lymphocytes, Tumor-Infiltrating - immunology | Ovarian Neoplasms - immunology | Analysis | Immunotherapy | Metastasis | T cells | Health aspects
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9. Full Text Digital image analysis of Ki67 proliferation index in breast cancer using virtual dual staining on whole tissue sections: clinical validation and inter-platform agreement
by Koopman, Timco and Buikema, Henk J and Hollema, Harry and de Bock, Geertruida H and van der Vegt, Bert
Breast Cancer Research and Treatment, ISSN 0167-6806, 5/2018, Volume 169, Issue 1, pp. 33 - 42
The Ki67 proliferation index is a prognostic and predictive marker in breast cancer. Manual scoring is prone to inter- and intra-observer variability. The aims... 
Ki67 proliferation index | Medicine & Public Health | Immunohistochemistry (IHC) | Virtual dual staining | Inter-platform agreement | Oncology | Breast cancer | Digital image analysis (DIA) | BIOMARKER | QUANTIFICATION | REPRODUCIBILITY | ACCURACY | METHODOLOGY | KI-67 | ONCOLOGY | LABELING INDEX | INTERNATIONAL KI67 | Immunohistochemistry | Breast Neoplasms, Male - diagnosis | Breast Neoplasms, Male - genetics | Cell Proliferation - genetics | Prognosis | Humans | Male | Molecular Imaging | Mitotic Index | Breast Neoplasms - genetics | Image Processing, Computer-Assisted | Ki-67 Antigen - genetics | Breast Neoplasms - pathology | Adult | Female | Aged | Biomarkers, Tumor - genetics | Breast Neoplasms - diagnosis | Breast Neoplasms, Male - pathology | Keratin | Preclinical Study
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10. Full Text Genome-wide methylation profiling identifies hypermethylated biomarkers in high-grade cervical intraepithelial neoplasia
by Lendvai, Ágnes and Johannes, Frank and Grimm, Christina and Eijsink, Jasper J.H and Wardenaar, René and Volders, Haukeline H and Klip, Harry G and Hollema, Harry and Jansen, Ritsert C and Schuuring, Ed and Wisman, G. Bea A and van der Zee, Ate G.J
Epigenetics, ISSN 1559-2294, 11/2012, Volume 7, Issue 11, pp. 1268 - 1278
Epigenetic modifications, such as aberrant DNA promoter methylation, are frequently observed in cervical cancer. Identification of hypermethylated regions... 
DNA methylation | MeDIP-chip | cervical scraping | cervical precancerous lesion | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Cervical scraping | Cervical precancerous lesion | CANCEROUS LESIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MARKERS | RANDOMIZED CONTROLLED-TRIAL | CYTOLOGY | HUMAN-PAPILLOMAVIRUS DNA | HYPOMETHYLATION | CHROMOSOME | GENE PROMOTER METHYLATION | GENETICS & HEREDITY | DIFFERENTIATION | Uterine Cervical Neoplasms - diagnosis | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Non-Fibrillar Collagens - genetics | Adenosine Triphosphatases - metabolism | Cervical Intraepithelial Neoplasia - diagnosis | Uterine Cervical Neoplasms - genetics | Sequence Analysis, DNA | Case-Control Studies | Non-Fibrillar Collagens - metabolism | DNA Methylation | Uterine Cervical Neoplasms - metabolism | Aged, 80 and over | Adult | Cervical Intraepithelial Neoplasia - metabolism | Female | Katanin | Adenosine Triphosphatases - genetics | Aged | Biomarkers, Tumor - genetics | Cervical Intraepithelial Neoplasia - genetics | Genome, Human | Research Paper
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11. Full Text Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma
by Qi, Liqiang and Bart, Joost and Tan, Lu Ping and Platteel, Inge and van der Sluis, Tineke and Huitema, Sippie and Harms, Geert and Fu, Li and Hollema, Harry and van den Berg, Anke
BMC CANCER, ISSN 1471-2407, 05/2009, Volume 9, Issue 1, pp. 163 - 163
Background: Flat epithelial atypia (FEA) of the breast is characterised by a few layers of mildly atypical luminal epithelial cells. Genetic changes found in... 
CANCER-CELLS | TRANSFORMATION | CAENORHABDITIS-ELEGANS | SMALL RNAS | METASTASIS | PROTEIN | ONCOLOGY | TUMOR-SUPPRESSOR GENE | TROPOMYOSIN-1 | MICRORNA-21 TARGETS | COLUMNAR CELL LESIONS | Carcinoma, Ductal, Breast - genetics | PTEN Phosphohydrolase - genetics | RNA-Binding Proteins - genetics | Tropomyosin - genetics | Gene Expression | Epithelium - metabolism | Neoplasm Invasiveness | Humans | PTEN Phosphohydrolase - metabolism | MicroRNAs - metabolism | Apoptosis Regulatory Proteins - metabolism | Breast Neoplasms - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Apoptosis Regulatory Proteins - genetics | Carcinoma, Ductal, Breast - pathology | Female | MicroRNAs - genetics | Carcinoma, Ductal, Breast - metabolism | RNA-Binding Proteins - metabolism | Tropomyosin - metabolism | RNA | Physiological aspects | Breast cancer | Genetic aspects | Research | Gene expression | Risk factors | Index Medicus
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