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PLoS One, ISSN 1932-6203, 2013, Volume 8, Issue 2, p. e55571
BACKGROUND: Gene-based vaccination using prime/boost regimens protects animals and humans against malaria, inducing cell-mediated responses that in animal... 
APICAL MEMBRANE ANTIGEN-1 | SPOROZOITE INOCULATION | VIRUS ANKARA | IMMUNIZATION | NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | CIRCUMSPOROZOITE PROTEIN | DOUBLE-BLIND | NAIVE ADULTS | CYTOTOXIC T-LYMPHOCYTES | PHASE 2A TRIAL | Vaccines, DNA - genetics | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Humans | Middle Aged | Vaccines, DNA - immunology | Male | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Young Adult | Malaria Vaccines - adverse effects | Plasmodium falciparum - genetics | Malaria Vaccines - immunology | Adult | Female | Antigens, Protozoan - genetics | Malaria Vaccines - therapeutic use | Membrane Proteins - genetics | Adenoviruses, Human - immunology | Membrane Proteins - immunology | Vaccines, DNA - therapeutic use | Malaria, Falciparum - parasitology | Interferon-gamma - immunology | Vaccines, DNA - adverse effects | Adolescent | Malaria, Falciparum - immunology | Adenoviruses, Human - genetics | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | Protozoan Proteins - immunology | Malaria Vaccines - genetics | Antigens | Wildlife conservation | Malaria | Liver | Vaccination | Malaria vaccine | Vaccines | T cells | Plasmodium falciparum | Advertising executives | Mosquitoes | Control | Analysis | Adenoviruses | DNA | Bites and stings | Genetic aspects | Health aspects | Enzyme-linked immunosorbent assay | Flow cytometry | Animal models | Goats | CD8 antigen | Antibodies | Leukocytes (mononuclear) | Lymphocytes T | Parasites | Aquatic insects | Immunity | Immunity (cell-mediated) | Replicating | Acquired immune deficiency syndrome--AIDS | Sporozoites | Peripheral blood mononuclear cells | Deoxyribonucleic acid--DNA | Circumsporozoite protein | Expression vectors | Vector-borne diseases | Medical research | Immunization | Statistical analysis | Diarrhea | Membrane proteins | Cytometry | Plasmids | γ-Interferon | Interferon | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e106241
Background: Fifteen volunteers were immunized with three doses of plasmid DNA encoding P. falciparum circumsporozoite protein (CSP) and apical membrane... 
APICAL MEMBRANE ANTIGEN-1 | RESPONSES | IMMUNOGENICITY | PROTEIN | PROTECTION | LIVER STAGES | SAFETY | MULTIDISCIPLINARY SCIENCES | VACCINE | CANDIDATE | CD8(+) T-CELLS | Antigens, Protozoan - immunology | DNA - immunology | Humans | Malaria, Falciparum - pathology | DNA - administration & dosage | Membrane Proteins - immunology | Plasmodium falciparum - immunology | Epitopes - immunology | Membrane Proteins - administration & dosage | Malaria, Falciparum - parasitology | Interleukin-2 - immunology | Malaria Vaccines - administration & dosage | Interferon-gamma - immunology | Antigens, Protozoan - administration & dosage | Malaria Vaccines - immunology | Malaria, Falciparum - immunology | Tumor Necrosis Factor-alpha - immunology | Plasmodium falciparum - pathogenicity | Adult | Immunologic Memory | Protozoan Proteins - administration & dosage | Adenoviridae - immunology | CD8-Positive T-Lymphocytes - immunology | Protozoan Proteins - immunology | Infection | Plasmodium falciparum | Immunization | Malaria | Adenoviruses | DNA | Interferon | T cells | Health aspects | Antigenic determinants | CD8 antigen | Liver | Effector cells | Lymphocytes T | Infections | Vaccines | Immunity | Proteins | Immunology | Interleukin 2 | Lymphocytes | Plasmid DNA | Volunteers | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Circumsporozoite protein | Vector-borne diseases | Antigens | Medical research | Immunological memory | Memory cells | Priming | Epitopes | Tumor necrosis factor-α | Vectors (Biology) | Membrane proteins | Plasmids | γ-Interferon | Comparative analysis | Deoxyribonucleic acid
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2011, Volume 6, Issue 10, p. e25868
Background: A protective malaria vaccine will likely need to elicit both cell-mediated and antibody responses. As adenovirus vaccine vectors induce both these... 
APICAL MEMBRANE ANTIGEN-1 | NATURAL IMMUNE-RESPONSES | T-CELL RESPONSES | RHESUS-MONKEYS | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | CIRCUMSPOROZOITE PROTEIN | SEQUENTIAL IMMUNIZATION | NAIVE ADULTS | CANDIDATE MALARIA VACCINE | PHASE 2A TRIAL | Protozoan Proteins - adverse effects | Antigens, Protozoan - immunology | Dose-Response Relationship, Immunologic | Humans | Membrane Proteins - adverse effects | Middle Aged | Male | Plasmodium falciparum - cytology | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Sporozoites - immunology | Young Adult | Malaria Vaccines - adverse effects | Malaria Vaccines - immunology | Adenoviridae - genetics | Adult | Female | Antigens, Protozoan - adverse effects | Antigens, Protozoan - genetics | Gene Expression | Membrane Proteins - genetics | Membrane Proteins - immunology | Genetic Vectors - genetics | Adolescent | Protozoan Proteins - immunology | Malaria Vaccines - genetics | Antigens | Plasmodium falciparum | Advertising executives | Malaria | Adenoviruses | Malaria vaccine | Vaccines | Drug therapy | Vector-borne diseases | Immunization | Goats | CD8 antigen | Antibodies | Dosage | Aquatic insects | CD4 antigen | Mosquitoes | Immunogenicity | Coding | Plasmids | Infectivity | Adults | Safety | Enzyme-linked immunosorbent assay | Circumsporozoite protein | Viral infections | Expression vectors
Journal Article
Pathogens and disease, ISSN 2049-632X, 06/2017, Volume 75, Issue 4
Background: Plasmid DNA encoding Plasmodium yoelii circumsporozoite protein (PyCSP) followed by boosting with recombinant vaccinia virus containing the PyCSP... 
protection | malaria | T cells | vaccines | mechanisms | INFECTIOUS DISEASES | BLOOD-STAGE | EXOERYTHROCYTIC ANTIGENS | NITRIC-OXIDE SYNTHASE | CIRCUMSPOROZOITE PROTEIN | GAMMA-INTERFERON | MICROBIOLOGY | IMMUNOLOGY | CD8(+) T-CELLS | SPOROZOITE VACCINE | PROTECTIVE IMMUNITY | MALARIA LIVER STAGES | STAGE MALARIA | Vaccines, DNA - genetics | Cell Survival | Coculture Techniques | Vaccines, Synthetic - genetics | Vaccines, DNA - immunology | Malaria - therapy | Plasmodium yoelii - immunology | Vaccines, Synthetic - immunology | Protozoan Proteins - genetics | Plasmodium yoelii - genetics | Vaccines, DNA - administration & dosage | Vaccinia virus - genetics | Drug Carriers | Hepatocytes - parasitology | Animals | Malaria Vaccines - administration & dosage | Malaria Vaccines - immunology | Mice | Vaccines, Synthetic - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | Protozoan Proteins - immunology | Disease Models, Animal | Malaria Vaccines - genetics | Cell culture | CD8 antigen | Liver | Antibodies | Viruses | Lymphocytes T | Activation | DNA vaccines | Parasites | Vaccines | Immunity | Developmental stages | Rodents | Inhibition | Plasmid DNA | Deoxyribonucleic acid--DNA | Circumsporozoite protein | Recombinant | Immune system | Spleen | Vector-borne diseases | NF-κB protein | Immunization | Immune response | Malaria | Intercellular adhesion molecule 1 | Caspase | Cultures | Nitric-oxide synthase | Inhibitors | Hepatocytes | Nitric oxide | γ-Interferon | Interferon
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, p. e0136109
Background Nearly 100% protection against malaria infection can be achieved in humans by immunization with P. falciparum radiation-attenuated sporozoites... 
T-CELLS RECOGNIZE | IMMUNIZATION | PROTECTIVE IMMUNITY | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | CIRCUMSPOROZOITE PROTEIN | MALARIA | SPOROZOITES | INFECTION | IDENTIFICATION | EXPRESSION | Erythrocytes - immunology | Rabbits | Immunization | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Malaria Vaccines - pharmacology | Humans | T-Lymphocytes - parasitology | Leukocytes, Mononuclear - parasitology | Plasmodium falciparum - immunology | Sporozoites - immunology | Malaria, Falciparum - blood | Animals | Leukocytes, Mononuclear - immunology | Malaria Vaccines - immunology | Malaria, Falciparum - immunology | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Erythrocytes - parasitology | Protozoan Proteins - immunology | Antigens | Complications and side effects | Plasmodium falciparum | Care and treatment | Malaria | Analysis | Physiological aspects | Research | Vaccines | Health aspects | Military medicine | Peptides | Liver | Radiation | Lymphocytes T | Identification | Micronemes | Parasites | Nuclei | Proteins | Immunology | Lymphocytes | Sporozoites | Peripheral blood mononuclear cells | Bioinformatics | Enzyme-linked immunosorbent assay | Recombinant | Vector-borne diseases | Medical research | Wheat germ | Medicine | Mosquitoes | Reagents | Endoplasmic reticulum | Wheat | Cytoplasm
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, p. e0163026
A DNA prime/adenovirus boost malaria vaccine encoding Plasmodium falciparum strain 3D7 CSP and AMA1 elicited sterile clinical protection associated with CD8+ T... 
IMMUNIZATION | PROTEIN | ORIENTATION | MULTIDISCIPLINARY SCIENCES | CLASS-I SUPERTYPES | MALARIA | PREDICTIONS | T-CELL RECEPTOR | BINDING | AFFINITIES | ALTERED PEPTIDE LIGANDS | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Humans | HLA-B Antigens - immunology | HLA Antigens - immunology | Membrane Proteins - immunology | Plasmodium falciparum - immunology | Epitopes - immunology | Flow Cytometry | CD8-Positive T-Lymphocytes - drug effects | Malaria Vaccines - immunology | Malaria, Falciparum - immunology | CD8-Positive T-Lymphocytes - immunology | Interferon-gamma - pharmacology | Protozoan Proteins - immunology | Plasmodium falciparum | Peptides | Malaria | Malaria vaccine | Amino acids | Interferon | Vaccines | Comparative analysis | Biological response modifiers | T cells | Antigenic determinants | Flow cytometry | Military medicine | CD8 antigen | Erythrocytes | Clinical trials | Lymphocytes T | Infections | Assaying | Proteins | T-cell receptor | Lymphocytes | Recall | Enzyme-linked immunosorbent assay | Deoxyribonucleic acid--DNA | Vector-borne diseases | Medical research | Antigens | T cell receptors | Epitopes | Strain | Medicine | Cytometry | Major histocompatibility complex | Acids | Adenoviruses | γ-Interferon | Histocompatibility antigen HLA | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2011, Volume 6, Issue 10, p. e24586
Background: Models of immunity to malaria indicate the importance of CD8+ T cell responses for targeting intrahepatic stages and antibodies for targeting... 
APICAL MEMBRANE ANTIGEN-1 | NATURAL IMMUNE-RESPONSES | PROTECTIVE IMMUNITY | MULTIDISCIPLINARY SCIENCES | CIRCUMSPOROZOITE PROTEIN | T-CELL EPITOPES | PRIME-BOOST REGIMENS | PLASMODIUM-BERGHEI SPOROZOITES | PHASE I/IIA SAFETY | VIRAL VECTORS | CANDIDATE MALARIA VACCINE | Protozoan Proteins - adverse effects | Antigens, Protozoan - immunology | Dose-Response Relationship, Immunologic | Immunity, Humoral - immunology | Humans | Membrane Proteins - adverse effects | Middle Aged | Male | Interferon-gamma - metabolism | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Malaria Vaccines - chemistry | CD4-Positive T-Lymphocytes - immunology | Young Adult | Malaria Vaccines - adverse effects | Peptide Fragments - immunology | Malaria Vaccines - immunology | Adenoviridae - genetics | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | Protozoan Proteins - chemistry | Antigens, Protozoan - adverse effects | Antigens, Protozoan - genetics | Gene Expression | Antigens, Protozoan - chemistry | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - metabolism | Membrane Proteins - immunology | Genetic Vectors - genetics | Immunity, Cellular - immunology | Membrane Proteins - chemistry | Adolescent | CD8-Positive T-Lymphocytes - immunology | Protozoan Proteins - immunology | Malaria Vaccines - genetics | Plasmodium falciparum | Antigens | Safety and security measures | Malaria | Adenoviruses | Malaria vaccine | Vaccines | T cells | Military medicine | Goats | CD8 antigen | Fluorescence | Antibodies | Lymphocytes T | Parasites | Immunity | Blood | Proteins | Interleukin 2 | Lymphocytes | Armed forces | Safety | Volunteers | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Circumsporozoite protein | Vector-borne diseases | Medical research | Dendritic cells | Tumor necrosis factor-α | Membrane proteins | CD4 antigen | Medicine | Immunogenicity | γ-Interferon | Interferon | Adults | Deoxyribonucleic acid | DNA
Journal Article