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by Vaara, Suvi T and Hollmén, Maija and Korhonen, Anna-Maija and Maksimow, Mikael and Ala-Kokko, Tero and Salmi, Marko and Jalkanen, Sirpa and Pettilä, Ville and Laru-Sompa, Raili and Pulkkinen, Anni and Saarelainen, Minna and Reilama, Mikko and Tolmunen, Sinikka and Rantalainen, Ulla and Miettinen, Marja and Suvela, Markku and Pesola, Katrine and Saastamoinen, Pekka and Kauppinen, Sirpa and Kaukonen, Kirsi-Maija and Nisula, Sara and Suojaranta-Ylinen, Raili and Mildh, Leena and Haapio, Mikko and Nurminen, Laura and Sutinen, Sari and Pettilä, Leena and Laitinen, Helinä and Syrjä, Heidi and Henttonen, Kirsi and Lappi, Elina and Boman, Hillevi and Varpula, Tero and Porkka, Päivi and Sivula, Mirka and Rahkonen, Mira and Tsurkka, Anne and Nieminen, Taina and Pirttinen, Niina and Alaspää, Ari and Salanto, Ville and Juntunen, Hanna and Sanisalo, Teija and Parviainen, Ilkka and Uusaro, Ari and Ruokonen, Esko and Bendel, Stepani and Rissanen, Niina and Lång, Maarit and Rahikainen, Sari and Rissanen, Saija and Ahonen, Merja and Halonen, Elina and Vaskelainen, Eija and Poukkanen, Meri and Lintula, Esa and Suominen, Sirpa and Heikkinen, Jorma and Lavander, Timo and Heinonen, Kirsi and Juopperi, Anne-Mari and Kaminski, Tadeusz and Gäddnäs, Fiia and Kuusela, Tuija and Roiko, Jane and Karlsson, Sari and Reinikainen, Matti and Surakka, Tero and Jyrkönen, Helena and Eiserbeck, Tanja and Kallinen, Jaana and Laurila, Jouko and Sälkiö, Sinikka and Lund, Vesa and Tuominen, Päivi and Perkola, Pauliina and Tuominen, Riikka and Hietaranta, Marika and Johansson, Satu and Hovilehto, Seppo and Kirsi, Anne and Tiainen, Pekka and Myllärinen, Tuija and Leino, Pirjo and Toropainen, Anne and Kuitunen, Anne and Tenhunen, Jyrki and Leppänen, Ilona and Levoranta, Markus and Hoppu, Sanna and Sauranen, Jukka and Kukkurainen, Atte and Kortelainen, Samuli and Varila, Simo and Inkinen, Outi and Koivuviita, Niina and Kotamäki, Jutta and Laine, Anu and Koivisto, Simo-Pekka and Hautamäki, Raku and ... and FINNAKI Study Grp and FINNAKI Study Group
PLoS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, p. e0164420
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2016, Volume 11, Issue 9, p. e0162353
Critical limb ischemia (CLI) is the advanced stage of peripheral artery disease (PAD) and associated with an extremely poor clinical outcome. In order to... 
MORTALITY | PATHWAYS | INFLAMMATION | CHEMOKINES | MULTIDISCIPLINARY SCIENCES | ATHEROSCLEROSIS | MARKERS | RISK | PERIPHERAL ARTERIAL-DISEASE | CANCER | Comorbidity | Humans | Middle Aged | Intermittent Claudication - etiology | Male | Ischemia - blood | Peripheral Arterial Disease - complications | Extremities - blood supply | Peripheral Arterial Disease - diagnosis | Ischemia - complications | Aged, 80 and over | Biomarkers | Female | Aged | Intermittent Claudication - blood | Cohort Studies | Cytokines - blood | Care and treatment | Chronic kidney failure | Cytokines | Ischemia | Fibroblast growth factors | Comparative analysis | Vascular endothelial growth factor | Laboratories | Cardiovascular disease | Interleukin 1 receptors | Family medical history | Interleukin 6 | Proteins | Interleukin 7 | Interleukin 4 | Vascular diseases | Immunology | Granulocytes | Interleukin 2 | Granulocyte colony-stimulating factor | Atherosclerosis | Tumor necrosis factor-TNF | Fibroblast growth factor 2 | Interleukin 2 receptors | Vascular surgery | Granulocyte-macrophage colony-stimulating factor | Interleukin 1 receptor antagonist | Invasiveness | Mortality | Medical treatment | Diabetes mellitus | Interleukin 12 | Inflammation | Interleukin 13 | Patients | Interleukin 17 | Studies | Hospitals | γ-Interferon | Interleukin 10 | Stem cells | Interferon | Cardiovascular diseases | Chemokines | Kidney transplantation | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2018, Volume 13, Issue 5, p. e0198262
Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family... 
INCREASED INTESTINAL PERMEABILITY | OBESITY | ACTIVATION | INSULIN-RESISTANCE | INFLAMMATION | GLUCOSE | MULTIDISCIPLINARY SCIENCES | NONALCOHOLIC STEATOHEPATITIS | GUT MICROBIOTA | STRESS | ADIPOSE-TISSUE | Hypertrophy - chemically induced | Toll-Like Receptor 5 - metabolism | Lipolysis - drug effects | Liver - metabolism | Mice, Inbred C57BL | Liver - microbiology | Diet, High-Fat - adverse effects | Enterobacter cloacae - physiology | Subcutaneous Fat - cytology | Subcutaneous Fat - pathology | Triglycerides - metabolism | Gene Expression Regulation - drug effects | Animals | Liver - drug effects | Hypertrophy - microbiology | Subcutaneous Fat - drug effects | Adiponectin - metabolism | Female | Receptor, Insulin - metabolism | Liver - cytology | Mice | Liver failure | Enterobacter | Rattus | Rats | Cellular signal transduction | Research | Food and nutrition | Health aspects | Ketogenic diet | Risk factors | Enterobacteriaceae | Health sciences | Enterobacter cloacae | Body fat | Laboratories | Liver | Infections | Adipocytes | High fat diet | Eutrophication | Proteins | Microbiota | Rodents | Damage accumulation | Obesity | Liver diseases | Glycerol | Inflammation | Histology | Permeability | Gene expression | Metabolism | Insulin | Lipolysis | Nutrition research | Weight control | Diet | Fibrosis | Insulin resistance | Females | Metabolic disorders
Journal Article
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2015, Volume 5, Issue 1, p. 9188
Journal Article
Future Oncology, ISSN 1479-6694, 2010, Volume 6, Issue 1, pp. 37 - 53
Antibodies targeting the extracellular domains of ErbB receptors have been extensively studied for cancer drug development. This work has led to clinical... 
alternative splicing | HUMAN-BREAST-CANCER | MESSENGER-RNA EXPRESSION | biomarkers | TYROSINE KINASE | HUMAN LUNG-CANCER | HUMAN MONOCLONAL-ANTIBODY | shedding | ALPHA-CONVERTING-ENZYME | therapeutic antibodies | EGFR | ESTROGEN-RECEPTOR | GROWTH-FACTOR RECEPTOR | ONCOLOGY | INTRACELLULAR DOMAIN 4ICD | SQUAMOUS-CELL CARCINOMA | tumor growth | HER4 | ELISA
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 06/2015, Volume 54, Issue 27, pp. 7815 - 7818
Noninvasive, real‐time pharmacokinetic (PK) monitoring of ketamine, propofol, and valproic acid, and their metabolites was achieved in mice, using secondary... 
pharmacokinetics | secondary electrospray ionization | breath analysis | ketamine | high‐resolution mass spectrometry | Secondary electrospray ionization | High-resolution mass spectrometry | Ketamine | Pharmacokinetics | Breath analysis | high-resolution mass spectrometry | METABOLITES | RATS | RECEPTOR | MICE | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | Valproic Acid - pharmacokinetics | Breath Tests - instrumentation | Analgesics - metabolism | Anticonvulsants - administration & dosage | Analgesics - pharmacokinetics | Anesthetics, Intravenous - metabolism | Equipment Design | Ketamine - administration & dosage | Spectrometry, Mass, Electrospray Ionization - instrumentation | Anesthetics, Intravenous - administration & dosage | Propofol - metabolism | Propofol - administration & dosage | Valproic Acid - metabolism | Anticonvulsants - pharmacokinetics | Administration, Oral | Injections, Intraperitoneal | Analgesics - administration & dosage | Anticonvulsants - metabolism | Animals | Valproic Acid - administration & dosage | Spectrometry, Mass, Electrospray Ionization - methods | Ketamine - pharmacokinetics | Anesthetics, Intravenous - pharmacokinetics | Propofol - pharmacokinetics | Ketamine - metabolism | Mice | Breath Tests - methods | Medical colleges | Divalproex | Metabolites | Ionization | Antidepressants | Analysis | Animal welfare | Valproic acid | Mass spectrometry | Rodents | Index Medicus | Drugs | Real time | Anaesthetics
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e39413
Journal Article
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A15998 - A15998
BackgroundIt has not been entirely explained why patients with stable coronary artery disease (CAD) have lower incidence of adverse events and mortality... 
Journal Article