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by Webb, Thomas R., PhD and Erdmann, Jeanette, PhD and Stirrups, Kathleen E., PhD and Stitziel, Nathan O., MD, PhD and Masca, Nicholas G.D., PhD and Jansen, Henning, MD and Kanoni, Stavroula, PhD and Nelson, Christopher P., PhD and Ferrario, Paola G., PhD and König, Inke R., PhD and Eicher, John D., PhD and Johnson, Andrew D., PhD and Hamby, Stephen E., PhD and Betsholtz, Christer, PhD and Ruusalepp, Arno, MD, PhD and Franzén, Oscar, PhD and Schadt, Eric E., MD, PhD and Björkegren, Johan L.M., MD, PhD and Weeke, Peter E., MD, PhD and Auer, Paul L., PhD and Schick, Ursula M., PhD and Lu, Yingchang, MD, PhD and Zhang, He, PhD and Dube, Marie-Pierre, PhD and Goel, Anuj, MSc and Farrall, Martin, MD and Peloso, Gina M., PhD and Won, Hong-Hee, PhD and Do, Ron, PhD and van Iperen, Erik, MSc and Kruppa, Jochen, PhD and Mahajan, Anubha, PhD and Scott, Robert A., PhD and Willenborg, Christina, PhD and Braund, Peter S., PhD and van Capelleveen, Julian C., MD and Doney, Alex S.F., MD, PhD and Donnelly, Louise A., PhD and Asselta, Rosanna, PhD and Merlini, Pier A., MD and Duga, Stefano, PhD and Marziliano, Nicola, PhD and Denny, Josh C., MD, MS and Shaffer, Christian, BS and El-Mokhtari, Nour Eddine, MD and Franke, Andre, PhD and Heilmann, Stefanie, PhD and Hengstenberg, Christian, MD and Hoffmann, Per, PhD and Holmen, Oddgeir L., MD and Hveem, Kristian, MD, PhD and Jansson, Jan-Håkan, MD, PhD and Jöckel, Karl-Heinz, PhD and Kessler, Thorsten, MD and Kriebel, Jennifer, PhD and Laugwitz, Karl L., MD and Marouli, Eirini, MSc and Martinelli, Nicola, MD, PhD and McCarthy, Mark I., MD and Van Zuydam, Natalie R., PhD and Meisinger, Christa, MD, MPH and Esko, Tõnu, PhD and Mihailov, Evelin, MSc and Escher, Stefan A., PhD and Alver, Maris, MSc and Moebus, Susanne, PhD and Morris, Andrew D., MD and Virtamo, Jarma, MD, PhD and Nikpay, Majid, PhD and Olivieri, Oliviero, MD and Provost, Sylvie, MSc and AlQarawi, Alaa, BSc and Robertson, Neil R., MSc and Akinsansya, Karen O., PhD and Reilly, Dermot F., PhD and Vogt, Thomas F., PhD and Yin, Wu, PhD and Asselbergs, Folkert W., MD, PhD and Kooperberg, Charles, PhD and Jackson, Rebecca D., MD and Stahl, Eli, PhD and Müller-Nurasyid, Martina, PhD and Strauch, Konstantin, PhD and Varga, Tibor V., PhD and Waldenberger, Melanie, PhD and Zeng, Lingyao, MSc and Chowdhury, Rajiv, MD, PhD and Salomaa, Veikko, MD, PhD and Ford, Ian, PhD and Jukema, J. Wouter, MD, PhD and Amouyel, Philippe, MD, PhD and Kontto, Jukka, MSSc and Nordestgaard, Børge G., MD, DMSc and Ferrières, Jean, MD and Saleheen, Danish, MBBS, PhD and Sattar, Naveed, PhD and Surendran, Praveen, PhD and Wagner, Aline, MD, PhD and Young, Robin, PhD and Howson, Joanna M.M., PhD and ... and Wellcome Trust Case Control and MORGAM Investigators and Myocardial Infarction Genetics and Wellcome Trust Case Control Consortium and Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Umeå universitet and Medicin
Journal of the American College of Cardiology, ISSN 0735-1097, 2017, Volume 69, Issue 7, pp. 823 - 836
Abstract Background Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show... 
Cardiovascular | Internal Medicine | expression quantitative trait loci | genetics | genome-wide association | single nucleotide polymorphism | cholesteryl ester transfer protein | SR-BI | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | CETP MASS | SUSCEPTIBILITY | RISK | PHOSPHOLIPASE A | VARIANT | SCAVENGER RECEPTOR | ABDOMINAL AORTIC-ANEURYSM | Genome-Wide Association Study | Gene Frequency | Humans | Coronary Artery Disease - genetics | Female | Male | Coronary Artery Disease - epidemiology | Genetic Pleiotropy | Polymorphism, Single Nucleotide | Genetic Loci | Odds Ratio | Case-Control Studies | Coronary heart disease | Analysis | Genealogy | Cardiovascular disease | Genomes | Metabolism | Gene expression | Blood | Risk factors | Studies | Celiac disease | Lipoproteins | Coronary vessels | Rheumatoid arthritis | Quality control | Calcification | Diabetes | Bioinformatics | LD, linkage disequilibrium | CETP, cholesteryl ester transfer protein | eQTL, expression quantitative trait locus | CAD, coronary artery disease | GWAS, genome-wide association study | BMI, body mass index | SNP, single nucleotide polymorphism | HDL, high-density lipoprotein | LDL, low-density lipoprotein | Original Investigation | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Kardiologi | Medical Genetics | Medicinsk genetik | Clinical Medicine | Cardiac and Cardiovascular Systems | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Journal Article
by Gusarova, Viktoria and O'Dushlaine, Colm and Teslovich, Tanya M and Benotti, Peter N and Mirshahi, Tooraj and Gottesman, Omri and Van Hout, Cristopher V and Murray, Michael F and Mahajan, Anubha and Nielsen, Jonas B and Fritsche, Lars and Wulff, Anders Berg and Gudbjartsson, Daniel F and Sjögren, Marketa and Emdin, Connor A and Scott, Robert A and Lee, Wen-Jane and Small, Aeron and Kwee, Lydia C and Dwivedi, Om Prakash and Prasad, Rashmi B and Bruse, Shannon and Lopez, Alexander E and Penn, John and Marcketta, Anthony and Leader, Joseph B and Still, Christopher D and Kirchner, H. Lester and Mirshahi, Uyenlinh L and Wardeh, Amr H and Hartle, Cassandra M and Habegger, Lukas and Fetterolf, Samantha N and Tusie-Luna, Teresa and Morris, Andrew P and Holm, Hilma and Steinthorsdottir, Valgerdur and Sulem, Patrick and Thorsteinsdottir, Unnur and Rotter, Jerome I and Chuang, Lee-Ming and Damrauer, Scott and Birtwell, David and Brummett, Chad M and Khera, Amit V and Natarajan, Pradeep and Orho-Melander, Marju and Flannick, Jason and Lotta, Luca A and Willer, Cristen J and Holmen, Oddgeir L and Ritchie, Marylyn D and Ledbetter, David H and Murphy, Andrew J and Borecki, Ingrid B and Reid, Jeffrey G and Overton, John D and Hansson, Ola and Groop, Leif and Shah, Svati H and Kraus, William E and Rader, Daniel J and Chen, Yii-Der I and Hveem, Kristian and Wareham, Nicholas J and Kathiresan, Sekar and Melander, Olle and Stefansson, Kari and Nordestgaard, Børge G and Tybjærg-Hansen, Anne and Abecasis, Goncalo R and Altshuler, David and Florez, Jose C and Boehnke, Michael and McCarthy, Mark I and Yancopoulos, George D and Carey, David J and Shuldiner, Alan R and Baras, Aris and Dewey, Frederick E and Gromada, Jesper and Diabetes - Cardiovascular Disease and Cardiovascular Research - Hypertension and Kardiovaskulär forskning - hypertoni and Diabetes - kardiovaskulär sjukdom and Lund University and Genomics, Diabetes and Endocrinology and EpiHealth: Epidemiology for Health and Genomik, diabetes och endokrinologi and Institutionen för kliniska vetenskaper, Malmö and Lunds universitet and Department of Clinical Sciences, Malmö
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2252 - 11
Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient... 
HEART-DISEASE | REMNANT CHOLESTEROL | PLASMA-LIPIDS | MULTIDISCIPLINARY SCIENCES | MICE | ANGIOPOIETIN-LIKE PROTEIN-4 | LIPOPROTEIN-LIPASE | HAN CHINESE | CHINESE POPULATION | GENOME-WIDE ASSOCIATION | ADIPOSE-TISSUE | Diabetes Mellitus, Type 2 - genetics | Humans | Homeostasis | Male | Diabetes Mellitus, Type 2 - metabolism | Case-Control Studies | Genetic Variation | Diabetes Mellitus, Type 2 - etiology | Female | Lipoprotein Lipase - metabolism | Genetic Association Studies | Mice, Inbred C57BL | Risk Factors | Gene Silencing | Angiopoietin-like 4 Protein - deficiency | Mice, Knockout | Whole Exome Sequencing | Animals | Insulin Resistance - genetics | Angiopoietin-like 4 Protein - metabolism | Heterozygote | Mice | Blood Glucose - metabolism | Amino Acid Substitution | Angiopoietin-like 4 Protein - genetics | Deactivation | Angiopoietin | Diabetes mellitus | Health risks | Risk reduction | Risk | Lipoprotein lipase | Glucose | Lipase | Inactivation | Insulin | Proteins | Confidence intervals | Sensitivity | Nutrient loss | Rodents | Arteriosclerosis | Atherosclerosis | Genetics | Diabetes | Diabetes mellitus (non-insulin dependent) | Medicinsk genetik | Basic Medicine | Medical Genetics | Clinical Medicine | Medical and Health Sciences | Endokrinologi och diabetes | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin | Endocrinology and Diabetes
Journal Article
by Locke, A.E and Kahali, B and Berndt, S.I and Justice, A.E and Pers, T.H and Day, F.R and Powell, C and Vedantam, S and Buchkovich, M.L and Yang, J and Croteau-Chonka, D.C and Esko, T and Fall, T and Ferreira, T and Gustafsson, S and Kutalik, Z and Luan, J and Magi, R and Randall, J.C and Winkler, T.W and Wood, A.R and Workalemahu, T and Faul, J.D and Smith, J.A and Zhao, J and Zhao, W and Chen, J and Fehrmann, R and Hedman, A.K and Karjalainen, J and Schmidt, E.M and Absher, D and Amin, N and Anderson, D and Beekman, M and Bolton, J.L and Bragg-Gresham, J.L and Buyske, S and Demirkan, A and Deng, G and Ehret, G.B and Feenstra, B and Feitosa, M.F and Fischer, K and Goel, A and Gong, J and Jackson, A.U and Kanoni, S and Kleber, M.E and Kristiansson, K and Lim, U and Lotay, V and Mangino, M and Leach, I. Mateo and Medina-Gomez, C and Medland, S.E and Nalls, M.A and Palmer, C.D and Pasko, D and Pechlivanis, S and Peters, M.J.W and Prokopenko, I and Shungin, D and Stancakova, A and Strawbridge, R.J and Sung, Y. Ju and Tanaka, T and Teumer, A and Trompet, S and Laan, S.W. van der and Setten, J. van and Vliet-Ostaptchouk, J.V. Van and Wang, Z and Yengo, L and Zhang, W and Isaacs, A and Albrecht, E and Arnlov, J and Arscott, G.M and Attwood, A.P and Bandinelli, S and Barrett, A and Bas, I.N and Bellis, C and Bennett, A.J and Berne, C and Blagieva, R and Bluher, M and Bohringer, S and Bonnycastle, L.L and Bottcher, Y and Boyd, H.A and Bruinenberg, M and Caspersen, I.H and Chen, Y.D and Clarke, R and Daw, E.W and Craen, A.J. de and Delgado, G and Dimitriou, M and ... and ADIPOGen Consortium and PAGE Consortium and LifeLines Cohort Study and MIGen Consortium and CARDIOGRAMplusC4D Consortium and MuTHER Consortium and ICBP and CKDGen Consortium and Int Endogene Consortium and GENIE Consortium and MAGIC Investigators and ReproGen Consortium and AGEN-BMI Working Grp and GLGC and International Endogene Consortium and AGEN-BMI Working Group and The PAGE Consortium and The International Endogene Consortium and The MAGIC Investigators and The ReproGen Consortium and The CKDGen Consortium and The ADIPOGen Consortium and The ICBP and The CARDIOGRAMplusC4D Consortium and The GLGC and The GENIE Consortium and The AGEN-BMI Working Group and The MIGen Consortium and The MuTHER Consortium and The LifeLines Cohort Study and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Medicinsk genetik och genomik and Geriatrik and Uppsala universitet and Klinisk diabetologi och metabolism and Institutionen för immunologi, genetik och patologi and Molekylär medicin and Kardiovaskulär epidemiologi and Institutionen för medicinska vetenskaper and Molekylär epidemiologi and Institutionen för folkhälso- och vårdvetenskap
Nature, ISSN 0028-0836, 2015, Volume 518, Issue 7538, pp. 197 - 206
Journal Article
by Shungin, Dmitry and Winkler, Thomas W and Croteau-Chonka, Damien C and Ferreira, Teresa and Locke, Adam E and Mägi, Reedik and Strawbridge, Rona J and Pers, Tune H and Fischer, Krista and Justice, Anne E and Workalemahu, Tsegaselassie and Wu, Joseph M. W and Buchkovich, Martin L and Heard-Costa, Nancy L and Roman, Tamara S and ng, Alexander W and Song, Ci and Gustafsson, Stefan and Day, Felix R and Esko, Tonu and Fall, Tove and Kutalik, Zoltán and Luan, Jian'an and Randall, Joshua C and Scherag, Ané and Vedantam, Sailaja and Wood, Anew R and Chen, Jin and Fehrmann, Rudolf and Karjalainen, Juha and Kahali, Bratati and Liu, Ching-Ti and Schmidt, Ellen M and Absher, Devin and Amin, Najaf and Anderson, Denise and Beekman, Marian and Bragg-Gresham, Jennifer L and Buyske, Steven and Demirkan, Ayse and Ehret, Georg B and Feitosa, Mary F and Goel, Anuj and Jackson, Anne U and Johnson, Toby and Kleber, Marcus E and Henneman, Peter and Hovingh, G. Kees and Kastelein, John J. P and Chen, Wei and PAGE Consortium and LifeLines Cohort Study and CARDIOGRAMplusC4D Consortium and MuTHER Consortium and ICBP and ADIPOGEN Consortium and CKDGen Consortium and GEFOS Consortium and Int Endogene Consortium and GENIE Consortium and MAGIC Investigators and ReproGen Consortium and GLGC and ADIPOGen Consortium and International Endogene Consortium and The PAGE Consortium and The International Endogene Consortium and The MAGIC Investigators and The ReproGen Consortium and The CKDGen Consortium and The ADIPOGen Consortium and The ICBP and The CARDIOGRAMplusC4D Consortium and The GENIE Consortium and The GLGC and The GEFOS Consortium and The MuTHER Consortium and The LifeLines Cohort Study and Högskolan Dalarna and Akademin Utbildning, hälsa och samhälle and Medicinsk vetenskap
Nature, ISSN 0028-0836, 2015, Volume 518, Issue 7538, pp. 187 - U378
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our... 
HUMAN HEIGHT | ABDOMINAL ADIPOSITY | MULTIDISCIPLINARY SCIENCES | COMMON SNPS | SUSCEPTIBILITY LOCI | GLYCEMIC TRAITS | FALSE DISCOVERY | MESENCHYMAL STEM-CELLS | GENOME-WIDE ASSOCIATION | ADIPOGENIC DIFFERENTIATION | SEXUAL-DIMORPHISM | Body Mass Index | Genome-Wide Association Study | Age Factors | Neovascularization, Physiologic - genetics | Epigenesis, Genetic | Humans | Male | Continental Population Groups - genetics | Sex Characteristics | Obesity - genetics | Europe - ethnology | Genome, Human - genetics | Adipose Tissue - metabolism | Insulin - metabolism | Models, Biological | Adipocytes - metabolism | Insulin Resistance - genetics | Polymorphism, Single Nucleotide - genetics | Female | Body Fat Distribution | Transcription, Genetic - genetics | Adipogenesis - genetics | Waist-Hip Ratio | Quantitative Trait Loci - genetics | Adipose tissues | Quantitative trait loci | Genetic research | Genetic aspects | Research | Metabolism | Health aspects | Studies | Body mass index | Genealogy | Body fat | Insulin resistance | Genetics | Genomes | Abdomen | Meta-analysis | Life Sciences | Adipocytes/metabolism Adipogenesis/genetics Adipose Tissue/metabolism Age Factors Body Fat Distribution Body Mass Index Continental Population Groups/genetics Epigenesis, Genetic Europe/ethnology Female Genome, Human/genetics Genome-Wide Association Study Humans Insulin/metabolism Insulin Resistance/genetics Male Models, Biological Neovascularization, Physiologic/genetics Obesity/genetics Polymorphism, Single Nucleotide/genetics Quantitative Trait Loci/genetics Sex Characteristics Transcription, Genetic/genetics Waist-Hip Ratio | Clinical Medicine | Hälsa och välfärd | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Health and Welfare
Journal Article