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PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e71323
Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade.... 
HIPPOCAMPUS | MESSENGER-RNA | ACETYLATION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | STRAIN DIFFERENCES | VALPROIC ACID | MICE | HISTONE DEACETYLASE INHIBITORS | LITHIUM | NUCLEUS-ACCUMBENS | Transcription, Genetic - drug effects | Male | Neurons - cytology | Promoter Regions, Genetic - drug effects | Promoter Regions, Genetic - genetics | Brain - metabolism | Mi-2 Nucleosome Remodeling and Deacetylase Complex - antagonists & inhibitors | Time Factors | Behavior, Animal - drug effects | Histone Deacetylase 1 - antagonists & inhibitors | Benzamides - pharmacology | Neurons - drug effects | Chromatin - drug effects | Benzamides - chemistry | Affect - drug effects | Brain - cytology | Reproducibility of Results | Histone Deacetylase 2 - antagonists & inhibitors | Lithium - pharmacology | Mice, Inbred C57BL | Histone Deacetylase Inhibitors - chemistry | Brain - drug effects | Gene Expression Regulation - drug effects | Acetylation - drug effects | Animals | Histone Deacetylase Inhibitors - pharmacology | Mice | Histones - metabolism | Chromatin - genetics | Epigenetic inheritance | Brain | Chromatin | Antidepressants | Genes | Depression, Mental | Schizophrenia | Gene expression | Drugs | Drug abuse | Histone deacetylase | Immunoprecipitation | Transcription | Mental disorders | Medical services | Disorders | Lithium | Bipolar disorder | Genomes | Mental depression | Compounds | Kinases | Benzamide | Psychotropic drugs | Plasticity (behavioral) | Rodents | Inhibition | Acetylation | HDAC2 protein | Locomotor activity | Binding | Cortex (prefrontal) | Hydroxamic acid | Pharmacology | Nucleus accumbens | Amphetamine | Mood | Inhibitors | Acids | In vivo methods and tests
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 06/2011, Volume 36, Issue 7, pp. 1397 - 1411
Bipolar disorder (BP) is a debilitating psychiatric disorder, affecting similar to 2% of the worldwide population, for which the etiological basis,... 
lithium | AKT | depression | TCF/LEF | behavior | mania | MOLECULAR-MECHANISM | ACTIVATION | PSYCHIATRY | GLYCOGEN-SYNTHASE KINASE-3 | BIPOLAR DISORDER | NEUROSCIENCES | IN-VIVO | PHARMACOLOGY & PHARMACY | DOPAMINE-RECEPTORS | UP-REGULATION | SIGNALING CASCADE | RODENT MODEL | Gene Expression Regulation, Enzymologic - drug effects | Mood Disorders - drug therapy | Humans | Glycogen Synthase Kinase 3 beta | Male | Corpus Striatum - metabolism | Proto-Oncogene Proteins c-akt - genetics | Drug Interactions | Transfection - methods | Lithium Chloride - pharmacology | Mice, Inbred DBA | Disease Models, Animal | Mood Disorders - chemically induced | Drug Administration Routes | Antimanic Agents - therapeutic use | Lithium Chloride - therapeutic use | Antimanic Agents - pharmacology | Drug Administration Schedule | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Amphetamine - adverse effects | Signal Transduction - genetics | Glycogen Synthase Kinase 3 - metabolism | Hippocampus - cytology | Animals | Analysis of Variance | Glycogen Synthase Kinase 3 - genetics | Signal Transduction - drug effects | Corpus Striatum - drug effects | Mice | Cell Line, Transformed | animal models | mood | stress disorders | LEF | LEF response | anxiety | TCF | neuropharmacology | mood-related behavior | psychiatry and behavioral sciences | Original
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e102684
Selective histone deacetylase (HDAC) inhibitors have emerged as a potential anti-latency therapy for persistent human immunodeficiency virus type 1 (HIV-1)... 
RECRUITMENT | THERAPY | LONG TERMINAL REPEAT | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | CD4(+) T-CELLS | HISTONE DEACETYLASE INHIBITORS | ESTABLISHMENT | IDENTIFICATION | NF-KAPPA-B | EXPRESSION | Anti-HIV Agents - pharmacology | RNA, Small Interfering - genetics | HIV-1 - pathogenicity | Virus Latency | Humans | HIV Infections - enzymology | CD4-Positive T-Lymphocytes - enzymology | HIV-1 - physiology | Gene Deletion | Histone Deacetylase 1 - antagonists & inhibitors | CD4-Positive T-Lymphocytes - virology | Histone Deacetylase 1 - genetics | Histone Deacetylase 2 - genetics | Promoter Regions, Genetic | Histone Deacetylases - genetics | Signal Transduction | HIV-1 - drug effects | Histone Deacetylase 2 - antagonists & inhibitors | HIV Infections - genetics | HIV Infections - virology | Gene Expression Regulation | Histone Deacetylases - deficiency | Host-Pathogen Interactions | Histone Deacetylase 2 - deficiency | Histone Deacetylase 1 - deficiency | HIV Infections - drug therapy | Histone Deacetylase Inhibitors - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Cell Line, Transformed | RNA, Small Interfering - metabolism | RNA | T cells | HIV (Viruses) | Health aspects | HIV infection | Analysis | Histone deacetylase | Transcription factors | Transcription | Viruses | Infections | Lymphocytes T | Kinases | Gene expression | Ribonucleic acid--RNA | CD4 antigen | Latency | Virology | Immunology | Depletion | Inhibitors | Lymphocytes | Antiretroviral agents | Human immunodeficiency virus--HIV | Cell cycle | Inhibition | HDAC2 protein | Ribonucleic acid | HIV | Human immunodeficiency virus
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2016, Volume 55, Issue 33, pp. 9601 - 9605
Glycogen synthase kinase‐3 (GSK‐3) regulates multiple cellular processes in diabetes, oncology, and neurology.... 
glycogen synthase kinase-3 | tau proteins | positron emission tomography | Alzheimer's disease | phosphorylation | VIVO | RADIOSYNTHESIS | ALZHEIMERS-DISEASE | GSK-3-BETA | RADIOTRACER | CHEMISTRY, MULTIDISCIPLINARY | TRANSGENIC MICE | Neuroimaging | Protein Kinase Inhibitors - chemical synthesis | Brain - diagnostic imaging | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Triazoles - chemistry | Humans | Models, Molecular | tau Proteins - metabolism | Crystallography, X-Ray | Positron-Emission Tomography | Glycogen Synthase Kinase 3 - metabolism | Oxazoles - chemistry | Brain - drug effects | Brain - metabolism | Dose-Response Relationship, Drug | Triazoles - pharmacology | Oxazoles - chemical synthesis | Protein Kinase Inhibitors - chemistry | Triazoles - chemical synthesis | Molecular Structure | Oxazoles - pharmacology | Protein Kinase Inhibitors - pharmacology | Phosphorylation - drug effects | tau Proteins - antagonists & inhibitors | Proteins | Synthesis | PET imaging | Oxazoles | Glycogen | Primates | Permeability | Kinases | Phosphorylation | Binding | Brain | Medical imaging | Diabetes mellitus | Central nervous system | Oxazole | Positron emission | Glycogen synthase kinase 3 | Antagonists | Pharmacology | Tissues | Chemical compounds | Neurology | Inhibitors | Tau protein | Tomography | Kinetics | Positron emission tomography | Alzheimer’s disease | Glycogen synthase kinase-3 | PF-367 | phosphorylation of tau protein
Journal Article
eLife, ISSN 2050-084X, 06/2016, Volume 5, Issue 2016
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2013, Volume 110, Issue 24, pp. 9806 - 9811
Cardiac hypertrophy is a strong predictor of morbidity and mortality in patients with heart failure. Small molecule histone deacetylase (HDAC) inhibitors have... 
Heart | Cardiomegaly | Phosphorylation | Phosphatases | Messenger RNA | Histone deacetylase inhibitors | Myocardium | Histones | Gene expression regulation | Hypertrophy | Lysine acetylation | Cardiac remodeling | Gene transcription | gene transcription | PROTEIN-KINASE-C | SPECIFICITY | lysine acetylation | ACETYLATION | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | HISTONE DEACETYLASE HDAC | INACTIVATION | cardiac remodeling | CARDIAC-HYPERTROPHY | DISEASE | LEFT-VENTRICULAR MASS | INHIBITORS | Immunoblotting | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Cell Nucleus - enzymology | RNA Interference | Dual-Specificity Phosphatases - genetics | Benzamides - pharmacology | Animals, Newborn | Dual-Specificity Phosphatases - metabolism | Cells, Cultured | Rats | Histone Deacetylases - metabolism | Signal Transduction - genetics | Pyrimidines - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Animals | Myocytes, Cardiac - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Myocytes, Cardiac - metabolism | Histone Deacetylase Inhibitors - pharmacology | Cardiomegaly - genetics | Cardiomegaly - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Physiological aspects | Heart enlargement | Phosphotransferases | Health aspects | Heart cells | Biological Sciences
Journal Article
Science Translational Medicine, ISSN 1946-6234, 03/2018, Volume 10, Issue 431, p. eaam8460
Glycogen synthase kinase 3 (GSK3), a key regulatory kinase in the wingless-type MMTV integration site family (WNT) pathway, is a therapeutic target of interest... 
Life Sciences | Cancer
Journal Article