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1. Full Text The authors reply
by Holst, Lars B and Wetterslev, Jørn and Perner, Anders
New England Journal of Medicine, ISSN 0028-4793, 01/2015, Volume 372, Issue 1, pp. 91 - 92
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2. Full Text Testing current practice is no mistake
by Perner, Anders and Haase, Nicolai and Wetterslev, Jørn and Holst, Lars B
Intensive Care Medicine, ISSN 0342-4642, 5/2015, Volume 41, Issue 5, pp. 960 - 960
Pediatrics | Pain Medicine | Emergency Medicine | Pneumology/Respiratory System | Medicine & Public Health | Intensive / Critical Care Medicine | Anesthesiology | BLOOD-CELL TRANSFUSION | TRIAL | SEPTIC SHOCK | ICU | CRITICAL CARE MEDICINE | Practice Patterns, Physicians' - statistics & numerical data | Critical Care - standards | Medical Errors | Humans | Practice | Critical care medicine | Forecasts and trends
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3. Full Text Lower versus Higher Hemoglobin Threshold for Transfusion in Septic Shock
by Holst, Lars B and Haase, Nicolai and Wetterslev, Jørn and Wernerman, Jan and Guttormsen, Anne B and Karlsson, Sari and Johansson, Pär I and Åneman, Anders and Vang, Marianne L and Winding, Robert and Nebrich, Lars and Nibro, Helle L and Rasmussen, Bodil S and Lauridsen, Johnny R.M and Nielsen, Jane S and Oldner, Anders and Pettilä, Ville and Cronhjort, Maria B and Andersen, Lasse H and Pedersen, Ulf G and Reiter, Nanna and Wiis, Jørgen and White, Jonathan O and Russell, Lene and Thornberg, Klaus J and Hjortrup, Peter B and Müller, Rasmus G and Møller, Morten H and Steensen, Morten and Tjäder, Inga and Kilsand, Kristina and Odeberg-Wernerman, Suzanne and Sjøbø, Brit and Bundgaard, Helle and Thyø, Maria A and Lodahl, David and Mærkedahl, Rikke and Albeck, Carsten and Illum, Dorte and Kruse, Mary and Winkel, Per and Perner, Anders and Scandinavian Critical Care Trials and TRISS Trial Grp and Scandinavian Critical Care Trials Group and TRISS Trial Group
The New England Journal of Medicine, ISSN 0028-4793, 10/2014, Volume 371, Issue 15, pp. 1381 - 1391
A large Scandinavian randomized trial showed no important outcome differences between hemoglobin levels of 7 g per deciliter and 9 g per deciliter as... 
BLOOD-CELL TRANSFUSION | MORTALITY | TRIAL | MEDICINE, GENERAL & INTERNAL | UNSELECTED PATIENTS | MULTICENTER COHORT | CLINICAL CHARACTERISTICS | CRITICALLY-ILL | ORGAN FAILURE | CRITICAL-CARE | SEVERE SEPSIS | Single-Blind Method | Intensive Care Units | Erythrocyte Transfusion - adverse effects | Humans | Middle Aged | Kaplan-Meier Estimate | Shock, Septic - complications | Male | Risk | Shock, Septic - mortality | Shock, Septic - therapy | Myocardial Ischemia - etiology | Shock, Septic - blood | Female | Aged | Hemoglobins - analysis | Ischemia - etiology | Hemoglobin | Septic shock | Development and progression | Research | Blood transfusion | Risk factors | Blood transfusions | Intervention | Shock | Intensive care | Mortality | Data processing | Cardiovascular disease | Angina pectoris | Patients | Studies | Hospitals | Ischemia | Consent | Sepsis
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4. Full Text Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis
by Perner, Anders and Haase, Nicolai and Guttormsen, Anne B and Tenhunen, Jyrki and Klemenzson, Gudmundur and Åneman, Anders and Madsen, Kristian R and Møller, Morten H and Elkjær, Jeanie M and Poulsen, Lone M and Bendtsen, Asger and Winding, Robert and Steensen, Morten and Berezowicz, Pawel and Søe-Jensen, Peter and Bestle, Morten and Strand, Kristian and Wiis, Jørgen and White, Jonathan O and Thornberg, Klaus J and Quist, Lars and Nielsen, Jonas and Andersen, Lasse H and Holst, Lars B and Thormar, Katrin and Kjældgaard, Anne-Lene and Fabritius, Maria L and Mondrup, Frederik and Pott, Frank C and Møller, Thea P and Winkel, Per and Wetterslev, Jørn and Scandinavian Critical Care Trials Group and 6S Trial Group
New England Journal of Medicine, ISSN 0028-4793, 07/2012, Volume 367, Issue 2, pp. 124 - 134
Hydroxyethyl starch (HES) [corrected] is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been... 
Isotonic Solutions - therapeutic use | Double-Blind Method | Humans | Middle Aged | Renal Replacement Therapy | Isotonic Solutions - adverse effects | Male | Sepsis - complications | Fluid Therapy - adverse effects | Sepsis - mortality | Kidney Failure, Chronic - therapy | Fluid Therapy - methods | Sepsis - therapy | Intention to Treat Analysis | Hydroxyethyl Starch Derivatives - therapeutic use | Female | Aged | Hemorrhage - chemically induced | Hydroxyethyl Starch Derivatives - adverse effects | Kidney Failure, Chronic - etiology | End-stage renal disease | Kidneys | Starch | Body weight | Fluid | Hydroxyethyl starch | Risk factors | Molecular weight | Intensive care units | Motivation | Consent | Renal failure | Sepsis | Death | Kidney diseases | Acetic acid
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5. Full Text Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis
by Holst, Lars B and Petersen, Marie W and Haase, Nicolai and Perner, Anders and Wetterslev, Jørn
BMJ : British Medical Journal, ISSN 0959-8138, 3/2015, Volume 350, Issue mar24 9, pp. h1354 - h1354
Objective To compare the benefit and harm of restrictive versus liberal transfusion strategies to guide red blood cell transfusions.Design Systematic review... 
RESEARCH | REQUIREMENTS | MEDICINE, GENERAL & INTERNAL | MANAGEMENT | PEDIATRIC CARDIAC-SURGERY | MYOCARDIAL-INFARCTION | PREMATURE-INFANTS | RISK | PRETERM INFANTS | HEMOGLOBIN THRESHOLD | CLINICAL-PRACTICE | CARE | Erythrocyte Transfusion - adverse effects | Erythrocyte Transfusion - mortality | Humans | Models, Statistical | Erythrocyte Transfusion - methods | Odds Ratio | Randomized Controlled Trials as Topic
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6. Full Text Hemoglobin threshold for transfusion in septic shock
by Gordillo-Escobar, Elena and Egea-Guerrero, Juan J and Leal-Noval, Santiago R
The New England journal of medicine, ISSN 0028-4793, 01/2015, Volume 372, Issue 1, pp. 91 - 91
MEDICINE, GENERAL & INTERNAL | BLOOD | Female | Male | Erythrocyte Transfusion | Shock, Septic - therapy | Humans | Hemoglobins
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7. Full Text Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a non-cardiac surgery setting: systematic review and meta-analysis
by Docherty, Annemarie B and O’Donnell, Rob and Brunskill, Susan and Trivella, Marialena and Doree, Carolyn and Holst, Lars and Parker, Martyn and Gregersen, Merete and Pinheiro de Almeida, Juliano and Walsh, Timothy S and Stanworth, Simon J
BMJ, ISSN 0959-8146, 3/2016, Volume 352, p. i1351
Objective To compare patient outcomes of restrictive versus liberal blood transfusion strategies in patients with cardiovascular disease not undergoing cardiac... 
BLOOD-CELL TRANSFUSION | HIP FRACTURE | REQUIREMENTS | MEDICINE, GENERAL & INTERNAL | THRESHOLD | MULTICENTER | MYOCARDIAL-INFARCTION | FEASIBILITY | RANDOMIZED CONTROLLED-TRIAL | ANEMIA | ELDERLY-PATIENTS | Blood Transfusion - mortality | Postoperative Complications - etiology | Surgical Procedures, Operative - mortality | Humans | Acute Coronary Syndrome - mortality | Treatment Outcome | Postoperative Complications - mortality | Randomized Controlled Trials as Topic | Cardiovascular Diseases - complications | Acute Coronary Syndrome - etiology | Cardiovascular Diseases - mortality | Adult | Surgical Procedures, Operative - methods | Blood Transfusion - methods
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8. Full Text Hydroxyethyl Starch 130/0.4 versus Ringer's Acetate in Severe Sepsis
by Perner, Anders and Haase, Nicolai and Guttormsen, Anne B and Tenhunen, Jyrki and Klemenzson, Gudmundur and Åneman, Anders and Madsen, Kristian R and Møller, Morten H and Møller, Thea P and Elkjær, Jeanie M and Poulsen, Lone M and Bendtsen, Asger and Winding, Robert and Steensen, Morten and Berezowicz, Pawel and Søe-Jensen, Peter and Bestle, Morten and Strand, Kristian and Wiis, Jørgen and White, Jonathan O and Thornberg, Klaus J and Quist, Lars and Nielsen, Jonas and Andersen, Lasse H and Holst, Lars B and Thormar, Katrin and Kjældgaard, Anne-Lene and Fabritius, Maria L and Mondrup, Frederik and Pott, Frank C and Winkel, Per and Wetterslev, Jørn and Scandinavian Critical Care Trials and 6S Trial Grp and Medicinska fakulteten and Anestesiologi och intensivvård and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för kirurgiska vetenskaper
The New England Journal of Medicine, ISSN 0028-4793, 07/2012, Volume 367, Issue 2, pp. 124 - 134
In this study, patients with severe sepsis were assigned to fluid resuscitation with starch (HES 130/0.4) or Ringer's acetate. The starch group had an... 
MORTALITY | TRIAL | MEDICINE, GENERAL & INTERNAL | MULTICENTER | IMPACT | THERAPY | SCORE | SAFETY | SEPTIC SHOCK | ACUTE-RENAL-FAILURE | RESUSCITATION | Drugs | Dose-response relationship (Biochemistry) | Hydration | Patient outcomes | Fluid therapy | Sepsis | Dosage and administration | Product/Service Evaluations | Comparative analysis | Drug therapy | Medical and Health Sciences | Medicin och hälsovetenskap
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9. Full Text Effects of shorter versus longer storage time of transfused red blood cells in adult ICU patients: a systematic review with meta-analysis and Trial Sequential Analysis
by Rygård, Sofie L and Jonsson, Andreas B and Madsen, Martin B and Perner, Anders and Holst, Lars B and Johansson, Pär I and Wetterslev, Jørn
Intensive Care Medicine, ISSN 0342-4642, 2/2018, Volume 44, Issue 2, pp. 204 - 217
Patients in the intensive care unit (ICU) are often transfused with red blood cells (RBC). During storage, the RBCs and storage medium undergo changes, which... 
Pediatrics | Pain Medicine | Emergency Medicine | Pneumology/Respiratory System | Storage | Medicine & Public Health | Intensive care unit and critical care | Intensive / Critical Care Medicine | Anesthesiology | Blood preservation | Erythrocyte transfusion | Blood transfusion | MORTALITY | QUALITY | RBCS | RISK | CRITICALLY-ILL | CARE | OUTCOMES | ANEMIA | DURATION | AGE | CRITICAL CARE MEDICINE | Specimen Handling | Intensive Care Units | Time Factors | Erythrocyte Transfusion | Humans | Erythrocytes | Adult | Critical Care | Randomized Controlled Trials as Topic | Physiological aspects | Methods | Medical research | Transfusion | Bias | Blood cells | Mortality | Clinical trials | Risk | Systematic review | Patients | Blood | Confidence intervals | Sequential analysis | Randomization | Red blood cells
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10. Full Text The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty
by Plamboeck, Astrid and Veedfald, Simon and Deacon, Carolyn F and Hartmann, Bolette and Wettergren, André and Svendsen, Lars B and Meisner, Søren and Hovendal, Claus and Vilsbøll, Tina and Knop, Filip K and Holst, Jens J
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 06/2013, Volume 304, Issue 12, pp. G1117 - G1127
Rapid degradation of glucagon-like peptide-1 (GLP-1) by dipeptidyl peptidase-4 suggests that endogenous GLP-1 may act locally before being degraded. Signaling... 
Degradation | Meal test | GLP-1 | DPP-4 | Vagus nerve | Vagotomy | Insulin and glucagon secretion | PHYSIOLOGY | DUODENAL-ULCER | PARACETAMOL ABSORPTION | vagotomy | insulin and glucagon secretion | HIGHLY SELECTIVE VAGOTOMY | GLYCEMIC EXCURSIONS | degradation | DIABETES-MELLITUS | vagus nerve | meal test | GLUCAGON-LIKE PEPTIDE-1 | GLUCOSE-METABOLISM | DEPENDENT INSULINOTROPIC POLYPEPTIDE | GASTRIC-INHIBITORY POLYPEPTIDE | GASTROENTEROLOGY & HEPATOLOGY | PROMOTES SATIETY | Duodenal Ulcer - surgery | Humans | Glucagon-Like Peptide 1 - pharmacology | Male | Pylorus - innervation | Pylorus - surgery | Eating - drug effects | Insulin - metabolism | Gastric Emptying - drug effects | Glucagon - metabolism | Aged | Meals | Insulin Secretion | Biomechanics | Physiological aspects | Research | Peptides | Food consumption | Health aspects
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11. Full Text Should red blood cell transfusion be individualized? No
by Holst, Lars B and Carson, Jeffrey L and Perner, Anders
Intensive Care Medicine, ISSN 0342-4642, 11/2015, Volume 41, Issue 11, pp. 1977 - 1979
Pediatrics | Pain Medicine | Emergency Medicine | Pneumology/Respiratory System | Medicine & Public Health | Intensive / Critical Care Medicine | Anesthesiology | REQUIREMENTS | THRESHOLD | MULTICENTER | MYOCARDIAL-INFARCTION | RESTRICTIVE TRANSFUSION | CARE | STRATEGIES | CRITICAL CARE MEDICINE | Cardiac Surgical Procedures - standards | Randomized Controlled Trials as Topic - statistics & numerical data | Critical Care - standards | Precision Medicine - standards | Humans | Critical Illness | Biomarkers - blood | Brain Injuries - therapy | Erythrocyte Transfusion - standards | Erythrocyte Transfusion - methods | Evidence-Based Practice - standards | Myocardial Ischemia - therapy | Hemoglobins - analysis | Precision Medicine - methods | Practice Guidelines as Topic
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12. Full Text Long-term outcomes in patients with septic shock transfused at a lower versus a higher haemoglobin threshold: the TRISS randomised, multicentre clinical trial
by Rygård, Sofie L and Holst, Lars B and Wetterslev, Jørn and Winkel, Per and Johansson, Pär I and Wernerman, Jan and Guttormsen, Anne B and Karlsson, Sari and Perner, Anders and Scandinavian Critical Care Trials and TRISS Trial Grp and Scandinavian Critical Care Trials Group and TRISS Trial Group and The Scandinavian Critical Care Trials Group and The TRISS Trial Group
Intensive Care Medicine, ISSN 0342-4642, 11/2016, Volume 42, Issue 11, pp. 1685 - 1694
We assessed the predefined long-term outcomes in patients randomised in the Transfusion Requirements in Septic Shock (TRISS) trial.In 32 Scandinavian ICUs, we... 
Red blood cell transfusion | Pediatrics | Emergency Medicine | Intensive / Critical Care Medicine | Critical care | Septic shock | Blood transfusion | Intensive care unit | Pain Medicine | Pneumology/Respiratory System | Medicine & Public Health | Hemoglobin | Anesthesiology | BLOOD-CELL TRANSFUSION | RINGERS ACETATE | METAANALYSIS | HYDROXYETHYL STARCH | FOLLOW-UP | CARDIAC-SURGERY | RESTRICTIVE TRANSFUSION | QUALITY-OF-LIFE | SEQUENTIAL-ANALYSIS | SEVERE SEPSIS | CRITICAL CARE MEDICINE | Anemia - mortality | Erythrocyte Transfusion - adverse effects | Follow-Up Studies | Humans | Middle Aged | Shock, Septic - complications | Anemia - therapy | Intensive Care Units - statistics & numerical data | Male | Risk | Erythrocyte Transfusion - methods | Shock, Septic - mortality | Shock, Septic - therapy | Anemia - complications | Time Factors | Shock, Septic - blood | Quality of Life | Female | Aged | Hemoglobins - analysis | Physiological aspects | Care and treatment | Patient outcomes
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13. Full Text The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity
by Christoffersen, Christina and Federspiel, Christine K and Borup, Anna and Christensen, Pernille M and Madsen, Andreas N and Heine, Markus and Nielsen, Carsten H and Nielsen, Lars B and Kjaer, Andreas and Holst, Birgitte and Heeren, Joerg
Cell Reports, ISSN 2211-1247, 01/2018, Volume 22, Issue 1, pp. 175 - 188
Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five... 
triglyceride | apoM | apolipoproteins | brown adipose tissue | sphingolipids | lipid metabolism | sphingosine-1-phosphate | lipoproteins | DIABETES-MELLITUS | MULTIPLE-SCLEROSIS | BARRIER | COLD | SITE-DIRECTED MUTAGENESIS | R-/-MICE | LIPOPROTEIN-LIPASE | SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 | SPHINGOSINE 1-PHOSPHATE | ADIPOSE-TISSUE | CELL BIOLOGY
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14. Full Text Characterisation of oral and i.v. glucose handling in truncally vagotomised subjects with pyloroplasty
by Plamboeck, Astrid and Veedfald, Simon and Deacon, Carolyn F and Hartmann, Bolette and Wettergren, Andre and Svendsen, Lars B and Meisner, Soren and Hovendal, Claus and Knop, Filip K and Vilsboll, Tina and Holst, Jens J
European Journal of Endocrinology, ISSN 0804-4643, 08/2013, Volume 169, Issue 2, pp. 187 - 201
Objective: Glucagon-like peptide 1 (GLP1) is rapidly inactivated by dipeptidyl peptidase 4 (DPP4), but may interact with vagal neurons at its site of... 
INTRAVENOUS GLUCOSE | TYPE-2 DIABETIC-PATIENTS | GLUCAGON-LIKE PEPTIDE-1 | PARACETAMOL ABSORPTION | ENDOCRINOLOGY & METABOLISM | HIGHLY SELECTIVE VAGOTOMY | DEPENDENT INSULINOTROPIC POLYPEPTIDE | NONDIABETIC SUBJECTS | GASTRIC-INHIBITORY POLYPEPTIDE | REACTIVE HYPOGLYCEMIA | BETA-CELL FUNCTION | Area Under Curve | Humans | Acetaminophen - administration & dosage | Pyrrolidines - administration & dosage | Male | Case-Control Studies | Glucose - administration & dosage | Nitriles - administration & dosage | Adamantane - administration & dosage | Vagotomy, Truncal - methods | Adamantane - analogs & derivatives | Insulin-Secreting Cells - physiology | Glucose Tolerance Test | Duodenal Ulcer - surgery | Glucagon-Like Peptide 1 - metabolism | Pylorus - surgery | Dipeptidyl-Peptidase IV Inhibitors - administration & dosage | Insulin-Secreting Cells - drug effects | Gastric Emptying - drug effects | Gastric Emptying - physiology | Glucose - metabolism | Glucagon - metabolism | Aged | Vildagliptin | Glucagon-Like Peptide 1 - antagonists & inhibitors | Clinical Study
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