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Journal Article
International Journal of Cancer, ISSN 0020-7136, 12/2015, Volume 137, Issue 12, pp. 2846 - 2857
Stratification of head and neck squamous cell carcinomas (HNSCC) based on HPV16 DNA and RNA status, gene expression patterns, and mutated candidate genes may... 
neck metastasis | consensus clustering | APC | human papillomavirus | TP53 | gene expression | head and neck squamous cell carcinoma | SURVIVAL | METHYLATION | SUBTYPES | INVOLVEMENT | PATTERNS | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | CERVICAL LESIONS | INFECTION | CLASS DISCOVERY | ACTIVE HUMAN-PAPILLOMAVIRUS | Head and Neck Neoplasms - virology | Prognosis | Carcinoma, Squamous Cell - virology | Humans | Immunity, Innate - genetics | Human papillomavirus 16 - immunology | Tumor Suppressor Protein p53 - genetics | Papillomavirus Infections - pathology | Carcinoma, Squamous Cell - mortality | RNA, Viral - genetics | Papillomavirus Infections - immunology | Transcription, Genetic | RNA, Viral - metabolism | Gene Frequency | Proportional Hazards Models | Gene Expression Regulation, Neoplastic - immunology | Lymphatic Metastasis | Papillomavirus Infections - mortality | Carcinoma, Squamous Cell - immunology | Human papillomavirus 16 - metabolism | Head and Neck Neoplasms - pathology | Head and Neck Neoplasms - immunology | Carcinoma, Squamous Cell - secondary | Head and Neck Neoplasms - mortality | Mutation | Human papillomavirus 16 - genetics | Squamous cell carcinoma | Immune response | RNA | Analysis | Genes | Genetic research | Genetic aspects | Diagnosis | Genetic transcription | Tumor proteins | Lymphatic system | Metastasis | Gene expression | Cervical cancer | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 09/2013, Volume 133, Issue 6, pp. 1389 - 1399
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2013, Volume 123, Issue 6, pp. 2488 - 2501
High-risk types of human papilloma virus (HPV) are increasingly associated with oropharyngeal squamous cell carcinoma (OPSCC). Strikingly, patients with... 
CHROMOSOMAL ALTERATIONS | MEDICINE, RESEARCH & EXPERIMENTAL | RETINOIC ACID | DNA METHYLATION | ONCOGENIC HUMAN-PAPILLOMAVIRUS | PROMOTER METHYLATION | EPIGENETIC INACTIVATION | TONSILLAR CANCER | POSITIVE HEAD | TUMOR-SUPPRESSOR | HIGH VIRAL LOAD | Human papillomavirus 16 - physiology | Oligonucleotide Array Sequence Analysis | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - virology | Humans | Gene Expression Regulation, Neoplastic | Oropharyngeal Neoplasms - mortality | Transcriptome | Case-Control Studies | DNA Methylation | Carcinoma, Squamous Cell - mortality | Papillomavirus Infections - virology | Receptors, AMPA - genetics | Promoter Regions, Genetic | Oropharyngeal Neoplasms - genetics | Kaplan-Meier Estimate | Proportional Hazards Models | GATA4 Transcription Factor - genetics | Oropharyngeal Neoplasms - virology | Papillomavirus Infections - mortality | Retinal Dehydrogenase - genetics | Transcription Factors - genetics | Sequence Analysis, DNA | Homeodomain Proteins - genetics | Papillomavirus Infections - genetics | Host-Pathogen Interactions | Disease-Free Survival | CpG Islands | HeLa Cells | Human papillomavirus 16 - genetics | Complications and side effects | Squamous cell carcinoma | Care and treatment | Causes of | Physiological aspects | Genetic aspects | Diagnosis | Research | Methylation | Papillomavirus infections | Cluster analysis | Disease | Decision making | Genes | Values | Principal components analysis | Patients | Ethics | Human papillomavirus | DNA methylation | Software | Behavior | Genetic testing | Cervical cancer
Journal Article
International Journal of Cancer, ISSN 0020-7136, 06/2017, Volume 140, Issue 12, pp. 2748 - 2757
Journal Article
Cancer, ISSN 0008-543X, 11/2017, Volume 123, Issue 22, pp. 4382 - 4390
Journal Article
International Journal of Cancer, ISSN 0020-7136, 04/2018, Volume 142, Issue 7, pp. 1361 - 1368
Treatment of patients with neck lymph node metastasis of squamous cell carcinoma (SCC) from unknown primary tumor (NSCCUP) is challenging due to the risk of... 
head and neck cancer | human papillomavirus | multiplex serology | survival | lymph node metastasis | HEAD | ONCOLOGY | EARLY PROTEINS | RISK | CANCER | Head and Neck Neoplasms - secondary | Prognosis | Humans | Middle Aged | Male | Papillomavirus Infections - diagnosis | Carcinoma, Squamous Cell - diagnosis | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - mortality | Antibodies, Viral - analysis | Sensitivity and Specificity | Aged, 80 and over | Adult | Female | Papillomavirus Infections - complications | Biomarkers, Tumor - analysis | Neoplasms, Unknown Primary - virology | Kaplan-Meier Estimate | Neoplasms, Unknown Primary - mortality | Papillomavirus Infections - mortality | Disease-Free Survival | Carcinoma, Squamous Cell - secondary | Head and Neck Neoplasms - diagnosis | Papillomaviridae | Aged | Head and Neck Neoplasms - mortality | Neoplasms, Unknown Primary - pathology | Proteins | Viral antibodies | Medical research | Squamous cell carcinoma | Care and treatment | RNA | Medicine, Experimental | Antibodies | Diagnosis | Metastasis | Toxicity | INK4a protein | mRNA | Lymph nodes | Metastases | Human papillomavirus | Bioindicators | Neck | Localization | Deoxyribonucleic acid--DNA | Lymphatic system | Immunoglobulins | p16 Protein | Oropharynx | Patients | Survival | Sensitivity | Medical prognosis | Biomarkers | Diagnostic systems | Tumors | Lymph | Index Medicus
Journal Article
Cancer Treatment Reviews, ISSN 0305-7372, 2015, Volume 42, pp. 24 - 29
Highlights • In the era of de-escalation trials, the identification of HPV-driven OPSCC is essential. • HPV-DNA or p16 IHC are the most used tests to define... 
Hematology, Oncology and Palliative Medicine | Human papillomavirus | p16INK4a immunohistochemistry | Head and neck squamous cell carcinoma | HPV DNA | Serology | Oropharyngeal carcinoma | In situ hybridization | E6 mRNA | P16 | immunohistochemistry | HUMAN-PAPILLOMAVIRUS HPV | CERVICAL-CANCER | TONSILLAR CARCINOMAS | HIGH VIRAL LOAD | NECK-CANCER | HUMAN-PAPILLOMAVIRUS-16 DNA | TREATMENT DE-ESCALATION | PHASE-III TRIAL | p16(INK4a) immunohistochemistry | RETINOBLASTOMA PROTEIN | ONCOLOGY | ACTIVE HUMAN-PAPILLOMAVIRUS | Immunohistochemistry | Oropharyngeal Neoplasms - therapy | Smoking - adverse effects | Tumor Suppressor Protein p53 - biosynthesis | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - virology | Humans | DNA, Viral - analysis | Cyclin D1 | Antibodies, Viral - blood | Papillomaviridae - genetics | Papillomavirus Infections - diagnosis | Retinoblastoma Protein - biosynthesis | Papillomaviridae - immunology | Cyclin-Dependent Kinase Inhibitor p16 - analysis | In Situ Hybridization | Polymerase Chain Reaction | Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis | Papillomavirus E7 Proteins - biosynthesis | Oncogenes | Diagnosis, Differential | Oropharyngeal Neoplasms - genetics | Carcinoma, Squamous Cell - therapy | Oropharyngeal Neoplasms - virology | Papillomaviridae - isolation & purification | Alcohol Drinking - adverse effects | Oncogene Proteins, Viral - biosynthesis | Papillomaviridae - pathogenicity | Carcinoma, Squamous Cell - etiology | Repressor Proteins - biosynthesis | Oropharyngeal Neoplasms - etiology | Biomarkers | Neoplasm Proteins - analysis | DNA, Neoplasm - genetics | Cell Transformation, Viral | Papillomavirus infections | Squamous cell carcinoma | Index Medicus
Journal Article
Head & Neck, ISSN 1043-3074, 12/2017, Volume 39, Issue 12, pp. 2397 - 2405
Background: PIK3CA alterations have been shown to be a frequent event in oropharyngeal squamous cell cancer (SCC), especially in human papillomavirus... 
protein kinase B (AKT) | tissue microarray | human papillomavirus | oropharyngeal squamous cell carcinoma | lymph node metastasis | SURGERY | HEAD | RISK | SMOKING | HUMAN-PAPILLOMAVIRUS | COMBINATION | NECK-CANCER | MTOR | PIK3CA | OTORHINOLARYNGOLOGY | BIOLOGY | MUTATIONS | Immunohistochemistry | Multivariate Analysis | Up-Regulation | Class I Phosphatidylinositol 3-Kinases - genetics | Head and Neck Neoplasms - virology | Prognosis | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Carcinoma, Squamous Cell - virology | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Carcinoma, Squamous Cell - surgery | Male | Oropharyngeal Neoplasms - pathology | Squamous Cell Carcinoma of Head and Neck | Adult | Female | Retrospective Studies | PTEN Phosphohydrolase - genetics | Oropharyngeal Neoplasms - genetics | Papillomavirus Infections - complications | Risk Assessment | Kaplan-Meier Estimate | Oropharyngeal Neoplasms - virology | Papillomavirus Infections - mortality | Disease Progression | Head and Neck Neoplasms - pathology | Disease-Free Survival | Oropharyngeal Neoplasms - surgery | Analysis of Variance | Survival Analysis | Head and Neck Neoplasms - genetics | Aged | Biopsy, Needle | Head and Neck Neoplasms - surgery | Cohort Studies | Squamous cell carcinoma | Phosphatases | RNA | Analysis | Genetic research | Development and progression | Papillomavirus infections | Protein kinases | TOR protein | Tensin | AKT protein | Drug delivery | Rapamycin | Drug development | Kinases | Ribonucleic acid--RNA | 1-Phosphatidylinositol 3-kinase | Survival analysis | Human papillomavirus | DNA microarrays | PTEN protein | Deoxyribonucleic acid--DNA | Tumors
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 2012, Volume 2, p. 36
Human papillomavirus (HPV) infection is well established as an etiological agent responsible for a number of pathologies affecting the stratified epithelia of... 
Epigenome | Genome | OPSCC | HNSCC | Transcriptome | HPV | epigenome
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0170091
Although the prevalence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) is increasing in developed countries and becoming a... 
UNITED-STATES | POPULATION | HPV PREVALENCE | RISK-FACTORS | MULTIDISCIPLINARY SCIENCES | OROPHARYNGEAL CANCER | HEALTHY-INDIVIDUALS | SQUAMOUS-CELL CARCINOMA | SEXUAL-BEHAVIORS | HUMAN-IMMUNODEFICIENCY-VIRUS | NATURAL-HISTORY | Prevalence | Humans | Papillomavirus Infections - epidemiology | Risk Factors | Male | Multiplex Polymerase Chain Reaction | Papillomaviridae - genetics | Young Adult | Mouth Diseases - epidemiology | Adult | Italy - epidemiology | Surveys and Questionnaires | Papillomavirus Infections - etiology | Human papillomavirus 16 - genetics | Complications and side effects | Squamous cell carcinoma | Care and treatment | Analysis | Sexual behavior | Youth | Teenagers | Papillomavirus infections | Prevalence studies (Epidemiology) | Developed countries | Drug abuse | Neurosciences | Mucosa | Vaccination | Sex | Colleges & universities | Containers | Alcohol | Infections | Gender | Risk factors | Tonsillitis | Confidence intervals | Sexually transmitted diseases | Demographics | Human papillomavirus | Questionnaires | Technicians | Sampling | Deoxyribonucleic acid--DNA | Medical personnel | Medical research | Immunization | Young adults | Risk groups | Inflammation | Risk analysis | Studies | Tobacco | Genotyping | Oral infection | Determinants | Adults | Head & neck cancer | Deoxyribonucleic acid | DNA
Journal Article
International Journal of Cancer, ISSN 0020-7136, 07/2016, Volume 139, Issue 1, pp. 85 - 98
Journal Article