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Cancer Discovery, ISSN 2159-8274, 01/2014, Volume 4, Issue 1, pp. 80 - 93
Journal Article
01/2016, ISBN 1339808765
About 50% of metastatic melanomas harbor BRAF V600 mutations, most commonly a V600E substitution, which constitutively hyper-activate the MAPK pathway and... 
Cellular biology | Molecular biology | Bioinformatics
Dissertation
Cancer Discovery, ISSN 2159-8274, 01/2018, Volume 8, Issue 1, pp. 74 - 93
Journal Article
Journal Article
Cell Discovery, ISSN 2056-5968, 09/2016, Volume 2, Issue 1, pp. 16028 - 16028
A prominent mechanism of acquired resistance to BRAF inhibitors in BRAF(V600)-mutant melanoma is associated with the upregulation of receptor tyrosine kinases.... 
melanoma | phospho-proteomics | Drug resistance | EMT | BRAF inhibition | TARGETED THERAPY | ACQUIRED-RESISTANCE | MALIGNANT-MELANOMA | CANCER STEM-CELLS | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | LUNG-CANCER | MOLECULAR CLASSIFICATION | GENE-EXPRESSION | GROWTH-FACTOR | C-JUN
Journal Article
Cancer cell, ISSN 1535-6108, 2/2015, Volume 27, Issue 2, pp. 240 - 256
Combined BRAF and MEK targeted therapy improves upon BRAF inhibitor (BRAFi) therapy but is still beset by acquired resistance. We show that melanomas acquire... 
Journal Article
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