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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 37, pp. 15324 - 15329
Inflammation plays a key role in the pathogenesis of obesity. Chronic overfeeding leads to macrophage infiltration in the adipose tissue, resulting in... 
Adipose tissues | Obesity | Cytokines | Insulin resistance | Mice | Gene expression regulation | Triglycerides | Inflammation | Adipocytes | Macrophages | APOPTOSIS | ACTIVATION | INTERLEUKIN-18 | MICE DEFICIENT | CASPASE-1 | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | CRYSTALS | IL-1-BETA | EXPRESSION | ADIPOSE-TISSUE | Inflammasomes - metabolism | Fatty Liver - pathology | NLR Family, Pyrin Domain-Containing 3 Protein | Cholesterol - blood | Humans | Fatty Liver - complications | Caspase 1 - metabolism | Male | Adipocytes - drug effects | Obesity - blood | Cytoskeletal Proteins - deficiency | Dietary Fats - pharmacology | Dietary Fats - administration & dosage | Cytoskeletal Proteins - metabolism | Hyperinsulinism - complications | Macrophages - pathology | Obesity - complications | Adipose Tissue - pathology | Fatty Liver - prevention & control | Insulin Resistance | Adipocytes - pathology | Obesity - metabolism | Cell Movement - drug effects | Hyperinsulinism - pathology | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Adipocytes - metabolism | CARD Signaling Adaptor Proteins | Triglycerides - blood | Macrophages - drug effects | Glucose Clamp Technique | Energy Metabolism - drug effects | Hypertrophy | Physiological aspects | Research | Gene expression | Leptin | Biological Sciences | crystals | expression | interleukin-18 | mice deficient | il-1-beta | apoptosis | sensitivity | adipose-tissue | activation | caspase-1
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2015, Volume 112, Issue 32, pp. 10038 - 10043
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits... 
Immunohistochemistry | Up-Regulation | Body Weight | Cell Proliferation | Biological Markers | Male | Mucus | Colony Count, Microbial | Journal Article | Antioxidants | Sulfides | Anti-Bacterial Agents | Microbiota | Ki-67 Antigen | Cell Death | Heme | Colon | Feces | Intestinal Mucosa | Down-Regulation | Mice, Inbred C57BL | Epithelial Cells | Animals | Cell Cycle | Diet | Models, Biological | Research Support, Non-U.S. Gov't | Mucolysis | (Tri)sulfides | Red meat | Mucus barrier | Colorectal cancer | colorectal cancer | MUCIN | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | red meat | mucus barrier | (tri)sulfides | mucolysis | COLORECTAL-CANCER | CALCIUM | FAT | MICE | INHIBITOR | CYTOTOXICITY | EXPRESSION | Cell Cycle - genetics | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Colon - drug effects | Microbiota - drug effects | Body Weight - drug effects | Ki-67 Antigen - metabolism | Mucus - drug effects | Intestinal Mucosa - drug effects | Feces - microbiology | Heme - pharmacology | Mucus - metabolism | Sulfides - metabolism | Cell Death - drug effects | Biomarkers - metabolism | Colon - pathology | Epithelial Cells - pathology | Up-Regulation - genetics | Antioxidants - pharmacology | Intestinal Mucosa - microbiology | Down-Regulation - drug effects | Down-Regulation - genetics | Up-Regulation - drug effects | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Colon - microbiology | Cell Cycle - drug effects | Intestinal Mucosa - pathology | Cell proliferation | Colon cancer | Epithelial cells | Physiological aspects | Observations | Health aspects | Biological Sciences | susceptibility | expression | bacterial | inhibitor | mucin | fat | colorectal-cancer | mice | cytotoxicity
Journal Article
Diabetologia, ISSN 0012-186X, 2018, Volume 61, Issue 4, pp. 942 - 953
Recent studies have identified intracellular metabolism as a fundamental determinant of macrophage function. In obesity, proinflammatory macrophages accumulate... 
Immunometabolism | Adipose tissue | Medicine & Public Health | Human Physiology | Oxidative phosphorylation | Metabolic Diseases | Internal Medicine | Inflammation | Glycolysis obesity | Macrophages | CELLS | LOCALIZATION | ADIPOCYTES | NECROSIS-FACTOR-ALPHA | Immuno metabolism | CIRCULATING LEVELS | INSULIN-RESISTANCE | FUNCTIONAL POLARIZATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | CHEMOKINE | HIF-1-ALPHA | Myeloid Cells - cytology | Activation, Metabolic | Cytokines - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Gene Expression Regulation | Insulin Resistance | Adipose Tissue - cytology | Male | Gene Expression Profiling | Mice, Knockout | Obesity - metabolism | Macrophages - metabolism | Phenotype | Animals | Adipocytes - metabolism | Oxygen - chemistry | Glycolysis | Mice | Adipose tissues | Lactates | Obesity | Glucose metabolism | Analysis | Leptin | Insulin resistance | Metabolic rate | Energy metabolism | CD14 antigen | Cell activation | Bone marrow | Oxidation | Enzyme-linked immunosorbent assay | Hypoxia-inducible factors | Explants | Cytokines | Diabetes mellitus | Metabolism | Gene expression | Insulin | DNA microarrays | Metabolic activation | Hypoxia | Lactic acid | Intracellular | Peritoneum | Nutrition, Metabolism and Genomics | Chair Nutrition Metabolism and Genomics | HNE Voeding, Metabolisme en Genomics | VLAG | Voeding, Metabolisme en Genomica | HNE Nutrition, Metabolism and Genomics
Journal Article
American Journal of Physiology-Gastrointestinal and Liver Physiology, ISSN 0193-1857, 12/2013, Volume 305, Issue 12, pp. G900 - G910
Journal Article
CELL METABOLISM, ISSN 1550-4131, 12/2010, Volume 12, Issue 6, pp. 580 - 592
Dietary saturated fat is linked to numerous chronic diseases, including cardiovascular disease. Here we study the role of the lipoprotein lipase inhibitor... 
ACTIVATION | OBESITY | LOW-DENSITY LIPOPROTEINS | INDUCE | HYPERLIPIDEMIA | ENDOCRINOLOGY & METABOLISM | LIPASE | ENDOPLASMIC-RETICULUM STRESS | ANGIOPOIETIN-LIKE PROTEIN-4 | ACCUMULATION | CELL | CELL BIOLOGY
Journal Article
Journal Article
Diabetologia, ISSN 0012-186X, 2017, Volume 60, Issue 7, pp. 1304 - 1313
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2018, Volume 115, Issue 30, pp. 7789 - 7794
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2018, Volume 13, Issue 8, p. e0201929
Journal Article
Gastroenterology, ISSN 0016-5085, 12/2018, Volume 155, Issue 6, pp. 1951 - 1966.e26
Journal Article