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1. Full Text Human Positron Emission Tomography Neuroimaging
by Hooker, Jacob M and Carson, Richard E
Annual review of biomedical engineering, ISSN 1523-9829, 6/2019, Volume 21, Issue 1, pp. 551 - 581
Neuroimaging with positron emission tomography (PET) is the most powerful tool for understanding pharmacology, neurochemistry, and pathology in the living... 
radiotracer | positron emission tomography | brain | imaging | radiochemistry | tracer kinetic modeling | Neuroimaging | Brain | Usage | Medical examination | PET imaging | Methods
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2. Full Text Adamantane/Cucurbituril: A Potential Pretargeted Imaging Strategy in Immuno-PET
by Strebl, Martin G and Yang, Jane and Isaacs, Lyle and Hooker, Jacob M
Molecular Imaging, ISSN 1535-3508, 10/2018, Volume 17, p. 1536012118799838
Positron emission tomography (PET) imaging with biological macromolecules greatly expands the possibilities of molecular imaging. There are, however, practical... 
bioconjugation | cucurbituril | antibody | imaging | PET | ANTIBODIES | IN-VIVO CHEMISTRY | RADIOIMMUNOTHERAPY | BIOCHEMICAL RESEARCH METHODS | DELIVERY | THERAPY | ASSEMBLIES | BIOTIN | MICE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | ANTIGEN | Adamantane - pharmacology | Antibodies - metabolism | Macrocyclic Compounds - chemistry | Mice, Inbred C57BL | Hydroxamic Acids - chemistry | Male | Positron-Emission Tomography | Rats, Sprague-Dawley | Brain - metabolism | Tissue Distribution | Animals | Adamantane - chemistry | Hydroxamic Acids - pharmacology | Adamantane - analogs & derivatives | Computed tomography | Imaging | Macromolecules | Positron emission | Antibodies | Tomography | Exploration | Conjugation | Kinetics | Supramolecular compounds | Positron emission tomography
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3. Full Text Bridging the gaps in 18 F PET tracer development
by Campbell, Michael G and Mercier, Joel and Genicot, Christophe and Gouverneur, Véronique and Hooker, Jacob M and Ritter, Tobias
Nature Chemistry, ISSN 1755-4330, 12/2016, Volume 9, Issue 1, pp. 1 - 3
Drug Discovery - methods | Technology, Pharmaceutical - methods | Radioactive Tracers | Radiopharmaceuticals - chemistry | Fluorine Radioisotopes | Positron-Emission Tomography - methods
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4. Full Text Direct11CN-Labeling of Unprotected Peptides via Palladium-Mediated Sequential Cross-Coupling Reactions
by Zhao, Wenjun and Lee, Hong Geun and Buchwald, Stephen L and Hooker, Jacob M
Journal of the American Chemical Society, ISSN 0002-7863, 05/2017, Volume 139, Issue 21, pp. 7152 - 7155
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5. Full Text Cyanation of arylboronic acids in aqueous solutions
by Ma, Longle and Placzek, Michael S and Hooker, Jacob M and Vasdev, Neil and Liang, Steven H
Chemical Communications, ISSN 1359-7345, 2017, Volume 53, Issue 49, pp. 6597 - 6600
A copper-mediated C-11-cyanation method employing arylboronic acids and [C-11]HCN has been developed. This method was applied to the radiochemical synthesis of... 
BORONIC ACIDS | POSITRON-EMISSION-TOMOGRAPHY | RADIOPHARMACEUTICALS | C-11 | RADIOSYNTHESIS | COMPLEXES | RECEPTOR | EFFICIENT | CHEMISTRY, MULTIDISCIPLINARY | PET | CYANIDE | Synthesis | Aqueous solutions | Accessibility | Aromatic compounds | Precursors | Halides | Radiochemistry
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6. Reply
by Elena Herranz and Jacob M Hooker and David Izquierdo-Garcia and Marco L Loggia and Caterina Mainero
Annals of Neurology, ISSN 0364-5134, 02/2017, Volume 81, Issue 2, p. 324
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7. Reply
by Elena Herranz and Jacob M Hooker and David Izquierdo-Garcia and Marco L Loggia and Caterina Mainero
Annals of Neurology, ISSN 0364-5134, 02/2017, Volume 81, Issue 2, p. 324
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8. Full Text Corrigendum: Concerted nucleophilic aromatic substitution with 19F and 18F
by Neumann, Constanze N and Hooker, Jacob M and Ritter, Tobias
Nature, ISSN 0028-0836, 10/2016, Volume 538, Issue 7624, p. 274
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9. Full Text Erratum: Corrigendum: Concerted nucleophilic aromatic substitution with 19F− and 18F
by Neumann, Constanze N and Hooker, Jacob M and Ritter, Tobias
Nature, ISSN 0028-0836, 10/2016, Volume 538, Issue 7624, pp. 274 - 274
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10. Full Text Concerted nucleophilic aromatic substitution with (19)F(-) and (18)F(-)
by Neumann, Constanze N and Hooker, Jacob M and Ritter, Tobias
Nature, ISSN 0028-0836, 06/2016, Volume 534, Issue 7607, p. 369
Nucleophilic aromatic substitution (SNAr) is widely used by organic chemists to functionalize aromatic molecules, and it is the most commonly used method to... 
Imidazolines - chemistry | Halogenation | Phenols - chemistry | Positron-Emission Tomography | Fluorine Radioisotopes - chemistry | Carbon - chemistry | Fluorine - chemistry | Electrons | Substitution reactions | Observations | Nucleophilic reactions
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11. Full Text Neuroinflammation: Brain on Fire?
by Hooker, Jacob M
ACS Chemical Neuroscience, ISSN 1948-7193, 04/2016, Volume 7, Issue 4, pp. 415 - 415
Inflammation - pathology | Inflammation - metabolism | Brain - immunology | Humans | Inflammation - physiopathology
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12. Full Text Concerted nucleophilic aromatic substitution with 19F- and 18F
by Neumann, Constanze N and Hooker, Jacob M and Ritter, Tobias
Nature, ISSN 0028-0836, 05/2016, Volume 534, Issue 7607, pp. 369 - 373
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13. Full Text [11C]Cyanation of arylboronic acids in aqueous solutionsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7cc02886e
by Ma, Longle and Placzek, Michael S and Hooker, Jacob M and Vasdev, Neil and Liang, Steven H
ISSN 1359-7345, 6/2017, Volume 53, Issue 49, pp. 6597 - 66
A copper-mediated 11 C-cyanation method employing arylboronic acids and [ 11 C]HCN has been developed. This method was applied to the radiochemical synthesis... 
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14. Full Text Concerted nucleophilic aromatic substitution with ^sup 19^F^sup -^ and ^sup 18^F^sup -
by Constanze N Neumann and Jacob M Hooker and Tobias Ritter
Nature, ISSN 0028-0836, 06/2016, Volume 534, Issue 7607, p. 369
Nucleophilic aromatic substitution (S^sub N^Ar) is widely used by organic chemists to functionalize aromatic molecules, and it is the most commonly used method... 
Organic chemistry | Phenols | Chemical reactions | Fluorides
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15. Full Text Site-selective 18 F fluorination of unactivated C-H bonds mediated by a manganese porphyrin
by Liu, Wei and Huang, Xiongyi and Placzek, Michael S and Krska, Shane W and McQuade, Paul and Hooker, Jacob M and Groves, John T
Chemical science, ISSN 2041-6520, 02/2018, Volume 9, Issue 5, p. 1168
The first direct C-H F fluorination reaction of unactivated aliphatic sites using no-carrier-added [ F]fluoride is reported. Under the influence of a manganese... 
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16. Full Text Nickel-Mediated Oxidative Fluorination for PET with Aqueous [18F] Fluoride
by Lee, Eunsung and Hooker, Jacob M and Ritter, Tobias
Journal of the American Chemical Society, ISSN 0002-7863, 10/2012, Volume 134, Issue 42, pp. 17456 - 17458
A one-step oxidative fluorination for carbon–fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which... 
CHEMISTRY, MULTIDISCIPLINARY | POSITRON-EMISSION-TOMOGRAPHY | Nickel - chemistry | Oxidation-Reduction | Organometallic Compounds - chemical synthesis | Water - chemistry | Organometallic Compounds - chemistry | Molecular Structure | Positron-Emission Tomography | Fluorine Radioisotopes | Fluorine - chemistry
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17. Full Text Direct 11 CN-Labeling of Unprotected Peptides via Palladium-Mediated Sequential Cross-Coupling Reactions
by Zhao, Wenjun and Lee, Hong Geun and Buchwald, Stephen L and Hooker, Jacob M and Massachusetts General Hospital, Boston, MA (United States)
Journal of the American Chemical Society, ISSN 0002-7863, 05/2017, Volume 139, Issue 21, p. 7152
A practical procedure for CN-labeling of unprotected peptides has been developed. The method was shown to be highly chemoselective for cysteine over other... 
Chemistry
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18. Full Text Beyond the Amyloid Hypothesis of Alzheimer's Disease: Tau Pathology Takes Center Stage
by Lindsley, Craig W and Hooker, Jacob M
ACS Chemical Neuroscience, ISSN 1948-7193, 11/2018, Volume 9, Issue 11, pp. 2519 - 2519
NEUROSCIENCES | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY
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19. Full Text Site-selective 18 F fluorination of unactivated C–H bonds mediated by a manganese porphyrin
by Liu, Wei and Huang, Xiongyi and Placzek, Michael S and Krska, Shane W and McQuade, Paul and Hooker, Jacob M and Groves, John T and Univ. of Virginia, Charlottesville, VA (United States) and Energy Frontier Research Centers (EFRC) (United States). Center for Catalytic Hydrocarbon Functionalization (CCHF)
Chemical Science, ISSN 2041-6520, 12/2017, Volume 9, Issue 5
The first direct C–H 18F fluorination reaction of unactivated aliphatic sites using no-carrier-added [18F]fluoride is reported. Under the influence of a... 
INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY | RADIOLOGY AND NUCLEAR MEDICINE
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20. Full Text Targeted Fluorination with the Fluoride Ion by Manganese-Catalyzed Decarboxylation
by Huang, Xiongyi and Liu, Wei and Hooker, Jacob M and Groves, John T and Energy Frontier Research Centers (EFRC) (United States). Center for Catalytic Hydrocarbon Functionalization (CCHF)
Angewandte Chemie (International Edition), ISSN 1433-7851, 03/2015, Volume 54, Issue 17
We describe the first catalytic decarboxylative fluorination reaction based on the nucleophilic fluoride ion. The reported method allows the facile replacement... 
INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY | catalysis (homogeneous), catalysis (heterogeneous), bio-inspired, hydrogen and fuel cells, materials and chemistry by design, synthesis (novel materials)
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