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Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2014, Volume 57, Issue 20, pp. 8238 - 8248
Journal Article
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2011, Volume 11, Issue 4, pp. 450 - 466
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2015, Volume 43, Issue 2, pp. 182 - 189
Evaluation of drug-drug interaction (DDI) involving circulating inhibitory metabolites of perpetrator drugs has recently drawn more attention from regulatory... 
IN-VITRO | WARFARIN | KINETICS | HUMANS | PHARMACOLOGY & PHARMACY | PLASMA-PROTEIN BINDING | DESETHYLAMIODARONE | DISCOVERY | DIALYSIS | Cytochrome P-450 CYP2D6 Inhibitors - chemistry | Liver - enzymology | Cytochrome P-450 CYP2D6 Inhibitors - metabolism | Expert Systems | Humans | Middle Aged | Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics | Male | Cytochrome P-450 CYP2C9 Inhibitors - chemistry | Amiodarone - blood | Anti-Arrhythmia Agents - metabolism | Amiodarone - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Drug Interactions | Liver - drug effects | Amiodarone - pharmacokinetics | Computer Simulation | Cytochrome P-450 CYP3A Inhibitors - chemistry | Cytochrome P-450 CYP2C9 Inhibitors - metabolism | Adult | Female | Cytochrome P-450 CYP2C9 Inhibitors - blood | Reproducibility of Results | Cytochrome P-450 CYP2D6 Inhibitors - pharmacokinetics | Cytochrome P-450 CYP3A Inhibitors - blood | Administration, Oral | Liver - metabolism | Amiodarone - antagonists & inhibitors | Anti-Arrhythmia Agents - chemistry | Anti-Arrhythmia Agents - pharmacokinetics | Anti-Arrhythmia Agents - administration & dosage | Amiodarone - analogs & derivatives | Amiodarone - metabolism | Cytochrome P-450 CYP3A Inhibitors - metabolism | Models, Biological | Biotransformation - drug effects | Cytochrome P-450 CYP2D6 Inhibitors - blood | Infusions, Intravenous | Cytochrome P-450 CYP2C9 Inhibitors - pharmacokinetics
Journal Article
CLINICAL PHARMACOLOGY & THERAPEUTICS, ISSN 0009-9236, 01/2017, Volume 101, Issue 1, pp. 22 - 24
Current trends in pronounced late-stage attrition rates of promising drug candidates are a pressing concern for patients, providers, and other stakeholders... 
PHARMACOLOGY & PHARMACY
Journal Article
Xenobiotica, ISSN 0049-8254, 12/2019, Volume 49, Issue 12, pp. 1423 - 1433
Several physiologically-based pharmacokinetic (PBPK) models have been reported for intravenous (IV) and subcutaneous (SC) injections, but there has been a... 
pharmacokinetics | computational simulation | Physiologically based pharmacokinetic model | protein therapeutics | intramuscular injections | MACROMOLECULES | MUSCLE | BIOAVAILABILITY | DISPOSITION | PBPK MODEL | CHARACTERIZE | TRANSPORT | METABOLISM | PHARMACOLOGY & PHARMACY | TOXICOLOGY | ABSORPTION | MONOCLONAL-ANTIBODIES
Journal Article
EXPERT OPINION ON DRUG DISCOVERY, ISSN 1746-0441, 2019, Volume 14, Issue 3, pp. 221 - 230
Introduction: The PK optimization of drug candidates is one of the most resource-intensive tasks in pharmaceutical research and development. With the... 
DESIGN | ADME | RISK | half-life | dose projection | MOLECULES | PLASMA-PROTEIN-BINDING | METABOLISM | PHARMACOKINETICS | lipophilicity | PREDICTIONS | PHARMACOLOGY & PHARMACY | PATIENT | INHIBITORS | metabolite identification | medicinal chemistry
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 03/2019, Volume 108, Issue 3, pp. 1296 - 1302
Equilibrium dialysis has been widely used for the measurement of the fraction of unbound drug ( ) in plasma, but it suffers from the accuracy and reliability... 
drug-drug interactions | PPB | α-acid glycoprotein | highly bound drugs | equilibrium dialysis | plasma protein binding | serum albumin | bidirectional equilibrium dialysis | fraction of unbound | alpha-acid glycoprotein | CHEMISTRY, MEDICINAL | ITRACONAZOLE | CHEMISTRY, MULTIDISCIPLINARY | PLASMA-PROTEIN-BINDING | TISSUE BINDING | PHARMACOLOGY & PHARMACY
Journal Article
Journal Article
NATURE MATERIALS, ISSN 1476-1122, 05/2019, Volume 18, Issue 5, pp. 418 - 422
At the recent Artificial Intelligence Applications in Biopharma Summit in Boston, USA, a panel of scientists from industry who work at the interface of machine... 
PHYSICS, CONDENSED MATTER | DOMAIN | PHYSICS, APPLIED | DEEP | MATERIALS SCIENCE, MULTIDISCIPLINARY | APPLICABILITY | CHEMISTRY, PHYSICAL | TOXICITY | RANDOM FOREST | PREDICTION | Artificial intelligence | Machine learning | Pharmaceuticals
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 01/2017, Volume 101, Issue 1, pp. 22 - 24
Current trends in pronounced late‐stage attrition rates of promising drug candidates are a pressing concern for patients, providers, and other stakeholders... 
Time Factors | Humans | Drug Design | Pharmacology, Clinical - trends | Drug Approval | Goals | Delivery of Health Care - trends | Clinical pharmacology | Medical care | Technology application | Management | United States
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2015, Volume 43, Issue 2, pp. 284 - 288
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 07/2019, Volume 106, Issue 1, pp. 228 - 237
For in vitro to in vivo extrapolation (IVIVE) of brain distribution of drugs that are transported at the human blood–brain barrier (BBB), it is important to... 
HEPATIC EXPRESSION | LIVER-TISSUE | CELLS | IN-VITRO | WHITE-MATTER | RAT | RESISTANCE PROTEIN BCRP/ABCG2 | QUANTIFICATION | PHARMACOLOGY & PHARMACY | CEREBRAL-CORTEX | P-GLYCOPROTEIN
Journal Article