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2016, Topics in Medicinal Chemistry, ISBN 3319399241, Volume 18
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art... 
Neurochemistry | Proteins | Chemistry | Medicinal chemistry | Molecular biology | Medical biochemistry
Web Resource
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2019, Volume 62, Issue 17, pp. 7589 - 7602
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2017, Volume 60, Issue 17, pp. 7233 - 7243
Journal Article
2016, Topics in Medicinal Chemistry, ISBN 3319399241, Volume 18
Web Resource
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2017, Volume 60, Issue 17, pp. 7233 - 7243
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 09/2019, Volume 62, Issue 17, pp. 7589 - 7602
Transient receptor potential canonical (TRPC) channels are highly homologous, nonselective cation channels that form many homo- and heterotetrameric channels.... 
CATION CHANNELS | ACTIVATION | CHEMISTRY, MEDICINAL | INHIBITION | SMALL-MOLECULE | (-)-ENGLERIN | BIOLOGICAL EVALUATION | CRYO-EM | CAPACITATIVE CA2+ ENTRY | CORTICAL-LESIONS | EXPRESSION
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 03/2019, Volume 29, Issue 6, p. 791
The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying... 
Proteins | Medical colleges | Urea | Pharmacy | Drugstores | Potassium channels | G proteins
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2019, Volume 29, Issue 2, pp. 155 - 159
The transient receptor potential cation channel 5 (TRPC5) has been previously shown to affect podocyte survival in the kidney. As such, inhibitors of TRPC5 are... 
TRPC5 | Inhibitor | Chronic kidney disease | Transient receptor potential cation channel 5 | AC1903 | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | CHANNELS
Journal Article
2016, Topics in Medicinal Chemistry, ISBN 3319399241, Volume 18
eBook
ACS Chemical Neuroscience, 02/2013, Volume 4, Issue 2, pp. 211 - 213
Journal Article
ACS CHEMICAL NEUROSCIENCE, ISSN 1948-7193, 02/2013, Volume 4, Issue 2, pp. 211 - 213
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 2676 - 2676
Journal Article
RSC Drug Discovery Series, ISSN 2041-3203, 2017, Volume 2017-, Issue 56, pp. 175 - 193
Journal Article
Expert Opinion on Therapeutic Patents, ISSN 1354-3776, 10/2016, Volume 26, Issue 10, pp. 1115 - 1128
Introduction: The bone morphogenetic protein (BMP) is a critical signaling pathway and plays a diverse role in embryonic pattern formation and is implicated in... 
ALK | inhibitors | small molecule | Bone morphogenetic protein | BMP | activin receptor-like kinase | OSTEOBLAST | CHEMISTRY, MEDICINAL | INTRINSIC PONTINE GLIOMA | DORSOMORPHIN | RECEPTOR | CANCER | ROLES | GROWTH | PHARMACOLOGY & PHARMACY | DIFFERENTIATION | HIGH-GRADE GLIOMA | FIBRODYSPLASIA OSSIFICANS PROGRESSIVA
Journal Article
Journal of medicinal chemistry, 04/2019
ROMK (Kir1.1) is a member of the inwardly-rectifying family of potassium (Kir) channels. It is primarily expressed in two regions of the kidney, the cortical... 
Journal Article
CURRENT TOPICS IN MEDICINAL CHEMISTRY, ISSN 1568-0266, 07/2009, Volume 9, Issue 10, pp. 949 - 963
This article describes recent advances in the development and biological evaluation of small molecule mGluR4 positive allosteric modulators (PAMs), and, to a... 
CNS DISORDERS | allosteric | PHCCC | METABOTROPIC GLUTAMATE-RECEPTOR | CHEMISTRY, MEDICINAL | Parkinson's disease | ANTAGONIST | BASAL GANGLIA | SYNAPTIC-TRANSMISSION | PROTEIN-COUPLED RECEPTORS | PHARMACOLOGICAL ACTIVATION | RAT MODEL | DISCOVERY | IN-VIVO | Metabotropic | dopamine | mGluR4 | positive allosteric modulator | glutamate | Allosteric | Dopamine | Positive allosteric modulator | Glutamate
Journal Article
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