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1. Full Text Cytokines in Autoimmune Uveitis
by Horai, Reiko and Caspi, Rachel R
Journal of Interferon & Cytokine Research, ISSN 1079-9907, 10/2011, Volume 31, Issue 10, pp. 733 - 744
Autoimmune uveitis is a complex group of sight-threatening diseases that arise without a known infectious trigger. The disorder is often associated with... 
Reviews | TGF-BETA | EFFECTOR MECHANISMS | IFN-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | BEHCETS-DISEASE | IMMUNOLOGY | CELL BIOLOGY | GROWTH-FACTOR-BETA | INTERFERON-GAMMA | REGULATORY T-CELLS | OCULAR AUTOIMMUNITY | TH17 CELLS | Th1 Cells - pathology | Uveitis - therapy | Humans | Autoimmune Diseases - immunology | Th1 Cells - immunology | Animals | Uveitis - immunology | Autoimmune Diseases - therapy | Th17 Cells - immunology | Autoimmune Diseases - pathology | Uveitis - pathology | Cytokines - immunology | Disease Models, Animal | Th17 Cells - pathology | Care and treatment | Immune response | Cytokines | Uveitis | Physiological aspects | Research | Health aspects | Risk factors
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2. Full Text Microbiome and Autoimmune Uveitis
by Horai, R and Caspi, RR
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 02/2019, Volume 10, p. 232
Commensal microbes affect all aspects of immune development and homeostasis in health and disease. Increasing evidence points to the notion that the gut... 
PROTECTION | gut | GUT MICROBIOTA | IMMUNOLOGY | autoreactive T cells | autoimmune uveitis | commensal microbiota | retina | INFLAMMATION | DISEASE | T-CELLS | ANTIGEN | AXIS
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3. Full Text Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site
by Horai, Reiko and Zárate-Bladés, Carlos R and Dillenburg-Pilla, Patricia and Chen, Jun and Kielczewski, Jennifer L and Silver, Phyllis B and Jittayasothorn, Yingyos and Chan, Chi-Chao and Yamane, Hidehiro and Honda, Kenya and Caspi, Rachel R
Immunity, ISSN 1074-7613, 08/2015, Volume 43, Issue 2, pp. 343 - 353
Activated retina-specific T cells that have acquired the ability to break through the blood-retinal barrier are thought to be causally involved in autoimmune... 
IMMUNE-SYSTEM | RECOGNITION | INFLAMMATION | DISEASE | UVEITIS | GUT MICROBIOTA | INDUCTION | IMMUNOLOGY | TH17 | EXPRESSION | RETINOID-BINDING PROTEIN | Autoimmunity | Eye Proteins - immunology | Retina - immunology | Intestines - immunology | Retinol-Binding Proteins - metabolism | Retinol-Binding Proteins - genetics | Eye Proteins - genetics | Disease Models, Animal | Blood-Retinal Barrier - immunology | Microbiota - immunology | Receptors, Antigen, T-Cell - metabolism | Lymphocyte Activation | Cells, Cultured | Immune Tolerance | Antigens, Bacterial - administration & dosage | Mice, Inbred Strains | Mice, Knockout | Animals | Intestines - microbiology | Eye Proteins - metabolism | Uveitis - immunology | Autoantigens - immunology | T-Lymphocytes - immunology | Uveitis - microbiology | Retinol-Binding Proteins - immunology | Ophthalmology | Microbiota (Symbiotic organisms) | T cells | Analysis | Blindness | Antigens | Medical research | Lymphatic system | Disease | Laboratories | T cell receptors | Histology | Genotype & phenotype | Microorganisms | Lymphocytes | Software | Age | Immune system
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4. Full Text IL-17 Production from Activated T Cells Is Required for the Spontaneous Development of Destructive Arthritis in Mice Deficient in IL-1 Receptor Antagonist
by Susumu Nakae and Shinobu Saijo and Reiko Horai and Katsuko Sudo and Shigeo Mori and Yoichiro Iwakura
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2003, Volume 100, Issue 10, pp. 5986 - 5990
IL-17 is a T cell-derived, proinflammatory cytokine that is suspected to be involved in the development of various inflammatory diseases. Although there are... 
T lymphocytes | Autoimmunity | Molecules | Biological Sciences | Receptors | Cytokines | Developmental biology | Rheumatoid arthritis | Cultured cells | Arthritis | Lymph nodes | RHEUMATOID-ARTHRITIS | OX40 | COLLAGEN-INDUCED ARTHRITIS | INTERLEUKIN-17 | MULTIDISCIPLINARY SCIENCES | CD40 LIGAND | ANTIBODY | INDUCTION | SUPPRESSION | EXPRESSION | ANTIGEN | Sialoglycoproteins - genetics | Gene Expression Regulation - immunology | Lymphocyte Activation | Tumor Necrosis Factors | Interleukin-17 - genetics | Male | Interleukin-17 - biosynthesis | Interleukin-17 - deficiency | Interleukin-1 - pharmacology | Membrane Glycoproteins - genetics | Mice, Knockout | Arthritis, Rheumatoid - genetics | Animals | Sialoglycoproteins - physiology | CD40 Ligand - genetics | Female | Interleukin 1 Receptor Antagonist Protein | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Arthritis, Rheumatoid - immunology | Crosses, Genetic | Disease Models, Animal | Sialoglycoproteins - deficiency | Inflammation | Research | Mediators
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5. Full Text Use of Optical Coherence Tomography and Electroretinography to Evaluate Retinal Pathology in a Mouse Model of Autoimmune Uveitis
by Chen, Jun and Qian, Haohua and Horai, Reiko and Chan, Chi-Chao and Caspi, Rachel R
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e63904
Experimental autoimmune uveoretinitis (EAU) in mice is a model for human autoimmune uveitis. Longitudinal follow-up is only possible by non-invasive... 
SYSTEM | MICE | UVEORETINITIS | MACULAR EDEMA | MULTIDISCIPLINARY SCIENCES | DISEASE | Electroretinography | Autoimmune Diseases - physiopathology | Tomography, Optical Coherence | Retina - physiopathology | Animals | Time Factors | Mice | Autoimmune Diseases - pathology | Fundus Oculi | Retina - pathology | Uveitis - physiopathology | Uveitis - pathology | Disease Models, Animal | Tomography | Usage | Models | Comparative analysis | Uveitis | Glaucoma | Disease | Laboratories | Retina | Horizontal cells | Visual perception | Immunology | Imaging | Lesions | Experimental autoimmune uveoretinitis | Quantitative analysis | Edema | Antigens | Medical imaging | Histology | Electroretinograms | Studies | Pathology | Optical Coherence Tomography | Coherence | In vivo methods and tests
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6. Full Text STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection
by St. Leger, Anthony J and Hansen, Anna M and Karauzum, Hatice and Horai, Reiko and Yu, Cheng-Rong and Laurence, Arian and Mayer-Barber, Katrin D and Silver, Phyllis and Villasmil, Rafael and Egwuagu, Charles and Datta, Sandip K and Caspi, Rachel R
Journal of Experimental Medicine, ISSN 0022-1007, 04/2018, Volume 215, Issue 4, pp. 1079 - 1090
Appropriate regulation of IL-17 production in the host can mean the difference between effective control of pathogens and uncontrolled inflammation that causes... 
Phosphorylation | Signal Transduction | Staphylococcus aureus - physiology | Eye Infections - pathology | Mice, Inbred C57BL | Interleukin-17 - biosynthesis | Immunity, Innate | Interleukins - metabolism | Mice, Knockout | Animals | Promyelocytic Leukemia Zinc Finger Protein - metabolism | Mucous Membrane - immunology | T-Lymphocytes - metabolism | Th17 Cells - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Immunologic Memory | Eye Infections - immunology | Receptors, Antigen, T-Cell, alpha-beta - metabolism | Thymus Gland - metabolism | Mucous Membrane - microbiology | STAT3 Transcription Factor - metabolism | CD8 antigen | Leukemia | Mucosa | Helper cells | Stat3 protein | Infections | Lymphocytes T | Interleukin 1 receptors | Zinc | Interleukin 17 | CD4 antigen | T-cell receptor | Promyeloid leukemia | Signaling | Control | Lymphocytes | Interleukin 1 | Zinc finger proteins | 312 | 311 | 319
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7. Full Text Altered Development of CD8 + T Cell Lineages in Mice Deficient for the Tec Kinases Itk and Rlk
by Broussard, Christine and Fleischecker, Christine and Horai, Reiko and Chetana, Madeva and Venegas, Ana M and Sharp, Leslie L and Hedrick, Stephen M and Fowlkes, B.J and Schwartzberg, Pamela L
Immunity, ISSN 1074-7613, 2006, Volume 25, Issue 1, pp. 93 - 104
Mutations affecting the Tec kinases Itk and Rlk decrease T cell receptor-induced Ca mobilization and Erk kinase activation and impair both positive and... 
DEVBIO | SIGNALING | CELLIMMUNO | HEMATOPOIETIC-CELLS | DOUBLE-POSITIVE THYMOCYTES | COMMITMENT | PROTEIN | HISTOCOMPATIBILITY ANTIGEN | NEGATIVE SELECTION | FAMILY KINASES | RECEPTOR | IMMUNOLOGY | CLASS-I MOLECULES | CUTTING EDGE | CD8-Positive T-Lymphocytes - cytology | Signal Transduction | Protein-Tyrosine Kinases - metabolism | Thymus Gland - cytology | Protein-Tyrosine Kinases - classification | Protein-Tyrosine Kinases - deficiency | CD8-Positive T-Lymphocytes - enzymology | Mice, Knockout | Cell Lineage | Phenotype | Protein-Tyrosine Kinases - genetics | Animals | Time Factors | Thymus Gland - immunology | Cell Differentiation | Mice | CD8-Positive T-Lymphocytes - immunology | Histocompatibility Antigens - metabolism | Thymus Gland - metabolism | Organ Culture Techniques | Flow cytometry | Peptides | Lymphocytes | Bone marrow | T cell receptors | Kinases | Immune system
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8. Full Text Comparative Analysis of Induced vs. Spontaneous Models of Autoimmune Uveitis Targeting the Interphotoreceptor Retinoid Binding Protein
by Chen, Jun and Qian, Haohua and Horai, Reiko and Chan, Chi-Chao and Falick, Yishay and Caspi, Rachel R
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e72161
Animal models of autoimmunity to the retina mimic specific features of human uveitis, but no model by itself reproduces the full spectrum of human disease. We... 
LIPOTEICHOIC ACID | RAT | IRBP | UVEORETINITIS EAU | MULTIDISCIPLINARY SCIENCES | DISEASE | SUSCEPTIBILITY | MICE | MECHANISMS | ENDOTOXIN-INDUCED UVEITIS | TH1 | Eye Proteins - immunology | Autoimmune Diseases - physiopathology | Humans | Mice, 129 Strain | Mutation, Missense | Retinol-Binding Proteins - metabolism | Retinol-Binding Proteins - genetics | Eye Proteins - genetics | Autoimmune Diseases - pathology | Disease Models, Animal | Electroretinography | Mice, Inbred C57BL | Retina - physiopathology | Autoimmune Diseases - immunology | Mice, Knockout | Animals | Eye Proteins - metabolism | Uveitis - immunology | Mice | Photic Stimulation | Fundus Oculi | Retina - pathology | Uveitis - physiopathology | Uveitis - pathology | Retinol-Binding Proteins - immunology | Autoimmunity | Medical research | Uveitis | Medicine, Experimental | Models | Genetic engineering | T cells | Comparative analysis | Epidemiology | Protein binding | Animal models | Laboratories | Retina | Visual perception | T-cell receptor | Immunology | Lymphocytes | Quality | Rodents | Tomography | Physiology | Degeneration | Experimental autoimmune uveoretinitis | Antigens | Immunization | Medical imaging | Transgenic mice | Visual signals | Inflammation | T cell receptors | Experimental autoimmune uveitis | Whooping cough | Pathology | Optical Coherence Tomography | Retinal degeneration | AIRE protein | Interphotoreceptor retinoid-binding protein
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9. Full Text Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis
by Matsuki, Taizo and Nakae, Susumu and Sudo, Katsuko and Horai, Reiko and Iwakura, Yoichiro
International Immunology, ISSN 0953-8178, 02/2006, Volume 18, Issue 2, pp. 399 - 407
IL-1 is a pro-inflammatory cytokine that plays an important role in inflammation and host responses to infection. We have previously shown that imbalances in... 
Autoimmunity | Cytokines | Dendritic cells | T cells | Knockout mouse | TNF RECEPTOR | DEFICIENT MICE | IMMUNOLOGY | PERTUSSIS TOXIN | FACTOR-ALPHA | TUMOR-NECROSIS-FACTOR | dendritic cells | IL-1 RECEPTOR ANTAGONIST | autoimmunity | MULTIPLE-SCLEROSIS | cytokines | CENTRAL-NERVOUS-SYSTEM | DEPENDENT ANTIBODY-PRODUCTION | knockout mouse | TRANSGENIC MICE | Amino Acid Sequence | Receptors, Interleukin-1 - immunology | Mice, Inbred C57BL | Encephalomyelitis, Autoimmune, Experimental - immunology | Molecular Sequence Data | Myelin-Oligodendrocyte Glycoprotein | Male | Epitopes | Lymphocyte Activation - immunology | Myelin-Associated Glycoprotein - immunology | Animals | Sialoglycoproteins - physiology | Interleukin-1 - physiology | Myelin Proteins | Female | Interleukin 1 Receptor Antagonist Protein | T-Lymphocytes - immunology | Mice
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10. Full Text Cutting edge: NKT cells constitutively express IL-23 receptor and RORγt and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion
by Rachitskaya, Aleksandra V and Hansen, Anna M and Horai, Reiko and Li, Zhuqing and Villasmil, Rafael and Luger, R. Dro and Nussenblatt, Robert B and Caspi, Rachel R
Journal of Immunology, ISSN 0022-1767, 04/2008, Volume 180, Issue 8, pp. 5167 - 5171
Th17 cells require IL-6 and TGF beta for lineage commitment and IL-23 for maintenance. Unexpectedly, naive IL-6(-/-) splenocytes stimulated with anti-CD3 and... 
PATHWAYS | POPULATION | IMMUNOLOGY | INFLAMMATION | T(H)17 | GROWTH
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11. Full Text AS101 ameliorates experimental autoimmune uveitis by regulating Th1 and Th17 responses and inducing Treg cells
by Bing, So Jin and Shemesh, Itay and Chong, Wai Po and Horai, Reiko and Jittayasothorn, Yingyos and Silver, Phyllis B and Sredni, Benjamin and Caspi, Rachel R
Journal of Autoimmunity, ISSN 0896-8411, 06/2019, Volume 100, pp. 52 - 61
AS101 is an organotellurium compound with multifaceted immunoregulatory properties that is remarkable for its lack of toxicity. We tested the therapeutic... 
AS101 | Th17 cell | Experimental autoimmune uveitis | Regulatory T cell | Antigens | Analysis | Uveitis | Bone morphogenetic proteins | Development and progression | Cell differentiation | T cells | Transforming growth factors
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12. Full Text Requirements for Selection of Conventional and Innate T Lymphocyte Lineages
by Horai, Reiko and Mueller, Kristen L and Handon, Robin A and Cannons, Jennifer L and Anderson, Stacie M and Kirby, Martha R and Schwartzberg, Pamela L
Immunity, ISSN 1074-7613, 2007, Volume 27, Issue 5, pp. 775 - 785
Mice deficient in the Tec kinase Itk develop a large population of CD8 T cells with properties, including expression of memory markers, rapid production of... 
CELLIMMUNO | HEMATOPOIETIC-CELLS | POSITIVE SELECTION | CD4(+)CD8(+) THYMOCYTES | THYMIC SELECTION | NEGATIVE SELECTION | PERIPHERAL HOMEOSTASIS | IMMUNOLOGY | NF-KAPPA-B | NKT-CELL-DEVELOPMENT | TEC FAMILY KINASES | CUTTING EDGE | CD8-Positive T-Lymphocytes - cytology | Receptor Protein-Tyrosine Kinases - immunology | Thymus Gland - cytology | Intracellular Signaling Peptides and Proteins - immunology | CD28 Antigens - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | CD28 Antigens - metabolism | Cell Differentiation - immunology | Animals | Flow Cytometry | T-Lymphocytes - cytology | Signaling Lymphocytic Activation Molecule Associated Protein | Precursor Cells, T-Lymphoid - cytology | T-Lymphocytes - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Precursor Cells, T-Lymphoid - immunology | Cell Lineage - immunology | T cells | Genomics | Kinases | Lymphocytes | T cell receptors
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13. Full Text NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity
by Arima-Yoshida, Fumiko and Manabe, Toshiya and Nakazawa, Takanobu and Komai, Shoji and Sudo, Katsuko and Iwakura, Yoichiro and Fukaya, Masahiro and Delawary, Mina and Yamamoto, Tadashi and Kiyama, Yuji and Goto, June and Ebine, Kazumi and Horai, Reiko and Umemori, Hisashi and Watabe, Ayako M and Tezuka, Tohru and Watanabe, Masahiko
The EMBO Journal, ISSN 0261-4189, 06/2006, Volume 25, Issue 12, pp. 2867 - 2877
Phosphorylation of neural proteins in response to a diverse array of external stimuli is one of the main mechanisms underlying dynamic changes in neural... 
amygdala | synaptic plasticity | tyrosine phosphorylation | NMDA receptor | fear learning | Amygdala | Tyrosine phosphorylation | Fear learning | Synaptic plasticity | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRAFFICKING | SUBUNIT COMPOSITION | CELL BIOLOGY | ORGANIZATION | NMDA-RECEPTOR | MEMORY | SYNAPSES | CHANNELS | LONG-TERM POTENTIATION | EXPRESSION | Phosphorylation | Receptors, N-Methyl-D-Aspartate - metabolism | Amygdala - cytology | Fear - physiology | Mutation - genetics | Synaptic Transmission | Phosphotyrosine - metabolism | Protein Transport | Amygdala - ultrastructure | Learning - physiology | Animals | Synapses - metabolism | Neuronal Plasticity | Tetany | Conditioning, Classical | Mice | Amygdala - physiology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Receptors, N-Methyl-D-Aspartate - ultrastructure | Proteins | Fear & phobias | Brain | Neurons | Rodents | Mutation | Animal cognition
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