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Journal Article
Lancet, The, ISSN 0140-6736, 2014, Volume 383, Issue 9911, pp. 60 - 68
Summary Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to LDL receptors, leading to their degradation. Genetics studies have shown that... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | DENSITY-LIPOPROTEIN CHOLESTEROL | DOUBLE-STRANDED-RNA | PLASMA-CHOLESTEROL | METAANALYSIS | CARDIOVASCULAR-DISEASE | MONOCLONAL-ANTIBODY | HYPERCHOLESTEROLEMIA | STATINS | AMG 145 | ATORVASTATIN | Single-Blind Method | Serine Endopeptidases - biosynthesis | Humans | Middle Aged | RNA, Small Interfering - pharmacology | RNA, Small Interfering - adverse effects | Cholesterol, LDL - drug effects | Male | Healthy Volunteers | Proprotein Convertases - genetics | Dose-Response Relationship, Drug | Proprotein Convertases - biosynthesis | RNA Interference | Serine Endopeptidases - blood | Serine Endopeptidases - genetics | Adult | Cholesterol, LDL - blood | Female | Proprotein Convertases - blood | RNA, Small Interfering - administration & dosage | Genetic Therapy - adverse effects | Genetic Therapy - methods | Proprotein Convertase 9 | Enzymes | Research | Gene mutations | Properties | Gene expression | Identification and classification | Medical research | RNA | Low density lipoproteins | Anticholesteremic agents | Clinical trials | Aluminum compounds | Coronary heart disease | Cholesterol | Hypercholesterolemia | Analysis | Medicine, Experimental | Product development | Trans fatty acids | Blood proteins | Studies | Heart | Nanoparticles | Plasma | Nutrition research | Cardiovascular disease | Lipids | Mutation | Drug dosages | Statins
Journal Article
by Yun, Jeong H and Lamb, Andrew and Chase, Robert and Singh, D and Singh, Dave and Parker, Margaret M and Saferali, Aabida and Vestbo, J and Vestbo, Jørgen and Tal-Singer, R and Tal-Singer, Ruth and Castaldi, Peter J and Silverman, E and Silverman, Edwin K and Hersh, Craig and Hersh, Craig P and Crapo, James D and Make, Barry J and Make, B and Regan, Elizabeth A and Beaty, Terri and Begum, Ferdouse and Busch, Robert and Cho, Michael and DeMeo, Dawn L and Boueiz, Adel R and Foreman, Marilyn G and Halper-Stromberg, Eitan and Hansel, Nadia N and Hardin, Megan E and Hayden, Lystra P and Hetmanski, Jacqueline and Hobbs, Brian D and Hokanson, John E and Laird, Nan and Lange, Christoph and Lutz, Sharon M and McDonald, Merry-Lynn and Qiao, Dandi and Santorico, Stephanie and Wan, Emily S and Won, Sungho and Al Qaisi, Mustafa and Coxson, H and Coxson, Harvey O and Gray, Teresa and Han, MeiLan K and Hoffman, Eric A and Humphries, Stephen and Jacobson, Francine L and Judy, Philip F and Kazerooni, Ella A and Kazerooni, Ella and Kluiber, Alex and Lynch, David A and Newell, John D and Newell, John and Ross, James C and San Jose Estepar, Raul and Schroeder, Joyce and Sieren, Jered and Stinson, Douglas and Stoel, Berend C and Tschirren, Juerg and Van Beek, Edwin and van Ginneken, Bram and van Rikxoort, Eva and Washko, George and Wilson, Carla G and Jensen, Robert and Everett, Douglas and Crooks, Jim and Moore, Camille and Strand, Matt and Hughes, John and Kinney, Gregory and Pratte, Katherine and Young, Kendra A and Curtis, Jeffrey L and Martinez, Carlos H and Pernicano, Perry G and Hanania, Nicola and Hanania, N and Alapat, Philip and Atik, Mustafa and Bandi, Venkata and Boriek, Aladin and Guntupalli, Kalpatha and Guy, Elizabeth and Nachiappan, Arun and Parulekar, Amit and Barr, R. Graham and Austin, John and D'Souza, Belinda and Pearson, Gregory D.N and Rozenshtein, Anna and Thomashow, Byron and MacIntyre, Neil and McAdams, H. Page and Washington, Lacey and ... and ECLIPSE Investigator and COPDGene Investigator and COPDGene and ECLIPSE Investigators
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 06/2018, Volume 141, Issue 6, pp. 2037 - 2047.e10
Journal Article
Journal Article
by Wan, Emily S and Castaldi, Peter J and Cho, Michael H and Hokanson, John E and Regan, Elizabeth A and Make, Barry J and Beaty, Terri H and Han, MeiLan K and Curtis, Jeffrey L and Curran-Everett, Douglas and Lynch, David A and DeMeo, Dawn L and Crapo, James D and Silverman, Edwin K and Lantz, Rochelle and Stepp, Lori and Melanson, Sandra and Klanderman, Barbara and Laird, Nan and Lange, Christoph and Santorico, Stephanie and McDonald, Merry-Lynn and Zhou, Jin and Mattheissen, Manuel and Hardin, Megan and Hetmanski, Jacqueline and Parker, Margaret and Murray, Tanda and Reilly, John and Coxson, Harvey and Judy, Philip and Hoffman, Eric and San Jose Estepar, Raul and Ross, James and Al Qaisi, Mustafa and Zach, Jordan and Kluiber, Alex and Sieren, Jered and Mann, Tanya and Richert, Deanna and McKenzie, Alexander and Akhavan, Jaleh and Stinson, Douglas and Jensen, Robert and Farzadegan, Homayoon and Meyerer, Stacey and Chandan, Shivam and Bragan, Samantha and Everett, Douglas and Williams, Andre and Wilson, Carla and Forssen, Anna and Powell, Amber and Piccoli, Joe and Sontag, Marci and Black-Shinn, Jennifer and Kinney, Gregory and Lutz, Sharon and Kazerooni, Ella and Hanania, Nicola and Alapat, Philip and Bandi, Venkata and Guntupalli, Kalpalatha and Guy, Elizabeth and Mallampalli, Antara and Trinh, Charles and Atik, Mustafa and Al-Azzawi, Hasan and Willis, Marc and Pinero, Susan and Fahr, Linda and Nachiappan, Arun and Bray, Collin and Frigini, L. Alexander and Farinas, Carlos and Katz, David and Freytes, Jose and Marie Marciel, Anne and Hersh, Craig and Washko, George and Jacobson, Francine and Hatabu, Hiroto and Clarke, Peter and Gill, Ritu and Hunsaker, Andetta and Trotman-Dickenson, Beatrice and Madan, Rachna and Barr, R. Graham and Thomashow, Byron and Austin, John and D'Souza, Belinda and MacIntyre, Neil and Washington, Lacey and McAdams, H. Page and Rosiello, Richard and Bresnahan, Timothy and Bradley, Joseph and Kuong, Sharon and Meller, Steven and Roland, Suzanne and ... and COPDGene Investigators
Respiratory Research, ISSN 1465-9921, 08/2014, Volume 15, Issue 1, pp. 89 - 89
Journal Article
by Kim, Victor and Davey, Adam and Comellas, Alejandro P and Han, Meilan K and Washko, George and Martinez, Carlos H and Lynch, David and Lee, Jin H and Silverman, Edwin K and Crapo, James D and Make, Barry J and Criner, Gerard J and Farzadegan, Homayoon and Bragan, Samantha and Cayetano, Stacey and Curtis, Jeffrey and Kazerooni, Ella and Hanania, Nicola and Alapat, Philip and Bandi, Venkata and Guntupalli, Kalpalatha and Guy, Elizabeth and Mallampalli, Antara and Trinh, Charles and Atik, Mustafa and Al-Azzawi, Hasan and Willis, Marc and Pinero, Susan and Fahr, Linda and Nachiappan, Arun and Bray, Collin and Frigini, L. Alexander and Farinas, Carlos and Katz, David and Freytes, Jose and Marciel, Anne Marie and DeMeo, Dawn and Hersh, Craig and Jacobson, Francine and Hatabu, Hiroto and Clarke, Peter and Gill, Ritu and Hunsaker, Andetta and Trotman-Dickenson, Beatrice and Madan, Rachna and Barr, R. Graham and Thomashow, Byron and Austin, John and D'Souza, Belinda and MacIntyre, Neil and Washington, Lacey and McAdams, H. Page and Rosiello, Richard and Bresnahan, Timothy and Bradley, Joseph and Kuong, Sharon and Meller, Steven and Roland, Suzanne and McEvoy, Charlene and Tashjian, Joseph and Wise, Robert and Hansel, Nadia and Brown, Robert and Diette, Gregory and Horton, Karen and Casaburi, Richard and Porszasz, Janos and Fischer, Hans and Budoff, Matt and Rambod, Mehdi and Sharafkhaneh, Amir and Kamal, Hirani and Darvishi, Roham and Niewoehner, Dennis and Anderson, Quentin and Rice, Kathryn and Caine, Audrey and Foreman, Marilyn and Westney, Gloria and Berkowitz, Eugene and Bowler, Russell and Schroeder, Joyce and Hale, Valerie and Armstrong, John and Dyer, Debra and Chung, Jonathan and Cox, Christian and Marchetti, Nathaniel and Satti, Aditi and Mamary, A. James and Steiner, Robert and Dass, Chandra and Cone, Libby and Bailey, William and Dransfield, Mark and Wells, Michael and Bhatt, Surya and Nath, Hrudaya and Singh, Satinder and Ramsdell, Joe and ... and COPDGene Investigators and COPDGene® Investigators and The COPDGene® Investigators
Respiratory Research, ISSN 1465-9921, 04/2014, Volume 15, Issue 1, pp. 52 - 52
Journal Article