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Cell, ISSN 0092-8674, 09/2013, Volume 155, Issue 1, p. 188
Summary Mitochondria are key organelles in the maintenance of cellular energy metabolism and integrity. Here, we show that mitochondria number decrease but... 
Journal Article
Neuron, ISSN 0896-6273, 05/2019, Volume 102, Issue 3, pp. 514 - 516
The paraventricular hypothalamus (PVH) plays a pivotal role in regulating energy balance, though circuit mechanisms remain obscure. In this issue of , identify... 
NEURONS | NEUROSCIENCES | HYPOTHALAMUS | CIRCUIT | Medical colleges | Neurons | Neurophysiology | Energy balance | Energy | Animal behavior | Homeostasis | Hypothalamus | Feeding
Journal Article
Cell, ISSN 0092-8674, 09/2013, Volume 155, Issue 1, p. 228
Summary The powerful regulation of bone mass exerted by the brain suggests the existence of bone-derived signals modulating this regulation or other functions... 
Journal Article
Trends in Cell Biology, ISSN 0962-8924, 06/2017, Volume 27, Issue 6, p. 391
Despite the well-known role of chronic mitochondrial dysfunction in the pathophysiology of the brain, the impact of acute impairment of mitochondrial activity... 
Studies | Learning | Brain | Mitochondria | Cannabinoids | Memory | Cognitive ability | Marijuana | Impact analysis
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2017, Volume 127, Issue 11, p. 3918
Journal Article
Journal Article
Cell, ISSN 0092-8674, 09/2015, Volume 163, Issue 1, pp. 26 - 27
Zeng et al. reveal that the lipolytic effect of the hormone leptin is mediated by sympathetic nerve fibers that directly “envelope” white adipocytes. Local... 
INNERVATION | NEURONS | WHITE ADIPOSE-TISSUE | OBESE GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Adipose Tissue, White - metabolism | Animals | Humans | Leptin - metabolism | Lipolysis | Leptin | Obesity | Neurophysiology
Journal Article
Cerebral Cortex, ISSN 1047-3211, 06/2019, Volume 29, Issue 6, pp. 2716 - 2727
Abstract Current findings suggest that accumulation of amyloid-β (Aβ) and hyperphosphorylated tau in the brain disrupt synaptic function in... 
high-voltage spindles | NUCLEUS BASALIS | FUNCTIONAL CONNECTIVITY | EPILEPTIC ACTIVITY | TgF344-AD | NEUROSCIENCES | theta oscillation | sensory processing | THETA OSCILLATIONS | AUDITORY-EVOKED POTENTIALS | CHOLINERGIC NEURONS | MOUSE MODEL | A-BETA | GAMMA OSCILLATIONS | BASAL FOREBRAIN | Alzheimer's disease
Journal Article
Fertility and Sterility, ISSN 0015-0282, 02/2019, Volume 111, Issue 2, pp. 197 - 204
Mitochondria play a central role in the regulation of energy metabolism in oocytes and preimplantation embryos, where the number and morphology of mitochondria... 
Aging | oocyte | mitochondrial unfolded protein response | CLPP | mitochondria | ACTIVATION | UNCOUPLING PROTEINS | UBIQUITIN | OBSTETRICS & GYNECOLOGY | LONGEVITY | PARKIN | PINK1 | REPRODUCTIVE BIOLOGY | MTDNA | DNA CONTENT | IN-VITRO FERTILIZATION
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2019, Volume 116, Issue 3, p. 104
Journal Article
Cell Metabolism, ISSN 1550-4131, 06/2018, Volume 27, Issue 6, pp. 1168 - 1175
Viral vectors have been shown to be potent and versatile tools for genome editing. In the present Minireview, we focus on lentiviruses and adeno-associated... 
STEM-CELLS | INTEGRATION SITE SELECTION | SPINAL MUSCULAR-ATROPHY | MEDIATED GENE DELIVERY | ADENOASSOCIATED VIRUS | ER-STRESS | ENDOCRINOLOGY & METABOLISM | LEPTIN RESISTANCE | EXPRESSION | LENTIVIRAL VECTORS | HYPOTHALAMUS | CELL BIOLOGY | Physiological aspects | Homeostasis | Medical colleges | Brain | Genetic vectors
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 04/2018, Volume 24, Issue 4, pp. 333 - 334
Melanocortin receptors play crucial roles in multiple physiological processes. Melanocortin receptor 4 (MC4R) is expressed in key brain regions, and gene... 
MEDICINE, RESEARCH & EXPERIMENTAL | OBESITY | ENERGY HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY
Journal Article
Cell Stem Cell, ISSN 1934-5909, 05/2018, Volume 22, Issue 5, pp. 615 - 616
Several methods for making hypothalamic-like neurons (iHTNs) from human or mouse induced pluripotent stem cells (iPSCs) with varying efficiencies exist. In... 
PLURIPOTENT STEM-CELLS | OBESITY | DIFFERENTIATION | DEFICIENCY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Obesity | Animals | Neurons | Humans | Cell Differentiation | Mice | Induced Pluripotent Stem Cells
Journal Article
Cerebral cortex (New York, N.Y. : 1991), ISSN 1047-3211, 03/2019
We previously observed an association between mode of delivery and brain mitochondrial mechanisms in pups. We also showed that mitochondrial processes impact... 
Journal Article
Cell Reports, ISSN 2211-1247, 03/2019, Volume 26, Issue 11, pp. 2849 - 2858.e4
We found that exposure of adult animals to calorie-dense foods rapidly abolished expression of mitofusin 2 (Mfn2), a gene promoting mitochondrial fusion and... 
white adipocyte | mitofusin | mitochondria | obesity | C/EBP-ALPHA | MAMMALIAN HOMOLOGS | FUSION | MEMBRANE | DYNAMICS | PPAR-GAMMA | MFN2 | DEGRADATION | ADIPOGENESIS | MITOCHONDRIAL FISSION | CELL BIOLOGY
Journal Article
Yale Journal of Biology and Medicine, ISSN 0044-0086, 09/2017, Volume 90, Issue 3, pp. 493 - 498
Comparative Medicine is typically defined as a discipline which relates and leverages the biological similarities and differences among animal species to... 
Veterinarians | Animal models | One health | Translation | Comparative medicine | Animals | Humans | Biomedical Research - methods | Medicine - methods | Translational Medical Research - methods | Animals, Laboratory
Journal Article
Trends in Cell Biology, ISSN 0962-8924, 2017, Volume 27, Issue 6, pp. 391 - 392
Despite the well-known role of chronic mitochondrial dysfunction in the pathophysiology of the brain, the impact of acute impairment of mitochondrial activity... 
Pathology | learning | memory | cannabinoid receptor 1 | brain | mitochondria | RECEPTORS | CELL BIOLOGY | Animals | Energy Metabolism | Signal Transduction | Models, Biological | Humans | Cognition | Mitochondria - metabolism | Cannabinoids - metabolism | Medical colleges | Neurophysiology
Journal Article