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1. Full Text Hepatocellular Carcinoma : Translational Precision Medicine Approaches
by Hoshida, Yujin
10/2019, ISBN 3030215393, 365
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2. Full Text Abstract SY36-02: Heterogeneity in molecular subtype of hepatocellular carcinoma
by Hoshida, Yujin
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. SY36-02 - SY36-02
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3. Full Text Nearest template prediction: A single-sample-based flexible class prediction with confidence assessment
by Hoshida, Yujin
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, pp. e15543 - e15543
Gene-expression signature-based disease classification and clinical outcome prediction has not been widely introduced in clinical medicine as initially... 
BREAST-CANCER | HEPATOCELLULAR-CARCINOMA | PROFILES | BIOLOGY | GENE-EXPRESSION | MICROARRAYS | OUTCOMES | SIGNATURE | DISCOVERY | STATISTICAL-ANALYSIS | Acute Disease | Computational Biology - methods | Reproducibility of Results | Oligonucleotide Array Sequence Analysis - methods | Humans | Leukemia, Myeloid - genetics | Gene Expression Regulation, Neoplastic | Rats | Gene Expression Profiling - methods | Gene Expression Regulation, Leukemic | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Algorithms | Animals | Breast Neoplasms - genetics | Liver Cirrhosis - genetics | Cluster Analysis | Genes | Analysis | Medical devices | Decision making | Leukemia | Genomics | Genomes | Breast cancer | Metastasis | Gene expression | Optimization | Datasets | Studies | DNA microarrays | Mathematical analysis | S gene | Clinical medicine | Methods | Index Medicus
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4. Full Text Is hepatocellular cancer the same disease in alcoholic and non-alcoholic fatty liver diseases?
by Goossens, Nicolas and Hoshida, Yujin
Gastroenterology, ISSN 0016-5085, 6/2016, Volume 150, Issue 8, pp. 1710 - 1717
PNPLA3 | single nucleotide polymorphism | risk factor | prognosis | non-alcoholic steatohepatitis
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5. Full Text Dose and duration of aspirin use to reduce incidental hepatocellular carcinoma
by Fujiwara, Naoto and Singal, Amit G and Hoshida, Yujin
Hepatology, ISSN 0270-9139, 06/2019
Hepatocellular carcinoma (HCC) incidence in the U.S. is increasing in specific subgroups of patients such as white men with hepatitis C and Hispanics with... 
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6. Full Text Aspirin: Does it Have a Role for Chemoprevention of Hepatocellular Carcinoma?
by Marquardt, Patrick and Hoshida, Yujin and Singal, Amit G
Gastroenterology, ISSN 0016-5085, 04/2019, Volume 156, Issue 5, pp. 1530 - 1531
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7. Full Text Generic chemoprevention of hepatocellular carcinoma
: Generic hepatocellular carcinoma chemoprevention
by Athuluri-Divakar, Sai Krishna and Hoshida, Yujin
Annals of the New York Academy of Sciences, ISSN 0077-8923, 03/2019, Volume 1440, Issue 1, pp. 23 - 35
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8. Full Text Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum
by Yamauchi, Mai and Morikawa, Teppei and Kuchiba, Aya and Imamura, Yu and Qian, Zhi Rong and Nishihara, Reiko and Liao, Xiaoyun and Waldron, Levi and Hoshida, Yujin and Huttenhower, Curtis and Chan, Andrew T and Giovannucci, Edward and Fuchs, Charles and Ogino, Shuji
Gut, ISSN 0017-5749, 06/2012, Volume 61, Issue 6, pp. 847 - 854
ObjectiveColorectal cancer is typically classified into proximal colon, distal colon and rectal cancer. Tumour genetic and epigenetic features differ by tumour... 
ISLAND METHYLATOR PHENOTYPE | COLON-CANCER | POPULATION-BASED SAMPLE | DNA METHYLATION | LINE-1 HYPOMETHYLATION | BRAF MUTATION | MICROSATELLITE INSTABILITY | BODY-MASS INDEX | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | P-GLYCOPROTEIN | ras Proteins - genetics | Colonic Neoplasms - genetics | Microsatellite Instability | Proto-Oncogene Proteins p21(ras) | Cecal Neoplasms - pathology | Colorectal Neoplasms - genetics | Humans | Long Interspersed Nucleotide Elements - genetics | Male | Colonic Neoplasms - metabolism | Sigmoid Neoplasms - genetics | Rectal Neoplasms - genetics | Female | Rectal Neoplasms - pathology | Colorectal Neoplasms - metabolism | Cecal Neoplasms - genetics | Mutation Rate | Proto-Oncogene Proteins - genetics | DNA Methylation - genetics | Mutation - genetics | Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | CpG Islands - genetics | Aged | Rectal Neoplasms - metabolism | DNA, Neoplasm - genetics | Colorectal Neoplasms - pathology | Sigmoid Neoplasms - pathology | Development and progression | Genetic aspects | Colon (Anatomy) | Research | Gene mutations | Colorectal cancer | Medical personnel | Studies | Hypotheses | Hospitals | Biopsy | Rodents | Epigenetics | Mutation | Data bases | Tumors | Index Medicus | Abridged Index Medicus
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9. Full Text Addressing the challenges of hepatitis c cure and persistent risk of hepatocellular carcinoma
by Baumert, Thomas F and Hoshida, Yujin
Viruses, ISSN 1999-4915, 05/2019, Volume 11, Issue 5, p. 441
Chronic hepatitis C virus (HCV) infection is a major cause of liver disease and hepatocellular carcinoma (HCC)-the second leading, and rising, cause of death... 
VIROLOGY | n/a
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10. Full Text Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma
by Fuchs, Bryan C and Hoshida, Yujin and Fujii, Tsutomu and Wei, Lan and Yamada, Suguru and Lauwers, Gregory Y and McGinn, Christopher M and DePeralta, Danielle K and Chen, Xintong and Kuroda, Toshihiko and Lanuti, Michael and Schmitt, Anthony D and Gupta, Supriya and Crenshaw, Andrew and Onofrio, Robert and Taylor, Bradley and Winckler, Wendy and Bardeesy, Nabeel and Caravan, Peter and Golub, Todd R and Tanabe, Kenneth K
Hepatology, ISSN 0270-9139, 04/2014, Volume 59, Issue 4, pp. 1577 - 1590
Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer‐related mortality in the United States. Because of the lack of viable treatment... 
FUNCTIONAL POLYMORPHISM | HEPATIC STELLATE CELLS | MODELS | GENE-EXPRESSION | TARGETS | RISK | MECHANISMS | CYP2E1 | GASTROENTEROLOGY & HEPATOLOGY | ERLOTINIB | HEPATOCARCINOGENESIS | Erlotinib Hydrochloride | Prognosis | Rats, Wistar | Carcinoma, Hepatocellular - prevention & control | Humans | Transcriptome | Hepatic Stellate Cells - metabolism | Receptor, Epidermal Growth Factor - drug effects | Hepatocytes - pathology | Male | Receptor, Epidermal Growth Factor - metabolism | Diethylnitrosamine - adverse effects | Liver Neoplasms - pathology | Phosphorylation - drug effects | Liver Cirrhosis - genetics | Hepatic Stellate Cells - pathology | Hepatocytes - drug effects | Disease Models, Animal | Hepatic Stellate Cells - drug effects | Liver Neoplasms - prevention & control | Liver Cirrhosis - etiology | Liver Cirrhosis - prevention & control | Carbon Tetrachloride - adverse effects | Cells, Cultured | Bile Ducts - physiopathology | Rats | Mice, Inbred Strains | Disease Progression | Animals | Quinazolines - therapeutic use | Carcinoma, Hepatocellular - pathology | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Ligation - adverse effects | Quinazolines - pharmacology | Liver cancer | Epidermal growth factor | Rodents | Mortality | Hepatology | Gene expression | Liver cirrhosis | Index Medicus
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11. Full Text DNA methylation‐based prognosis and epidrivers in hepatocellular carcinoma
by Villanueva, Augusto and Portela, Anna and Sayols, Sergi and Battiston, Carlo and Hoshida, Yujin and Méndez‐González, Jesús and Imbeaud, Sandrine and Letouzé, Eric and Hernandez‐Gea, Virginia and Cornella, Helena and Pinyol, Roser and Solé, Manel and Fuster, Josep and Zucman‐Rossi, Jessica and Mazzaferro, Vincenzo and Esteller, Manel and Llovet, Josep M and HEPTROMIC Consortium
Hepatology, ISSN 0270-9139, 06/2015, Volume 61, Issue 6, pp. 1945 - 1956
Epigenetic deregulation has emerged as a driver in human malignancies. There is no clear understanding of the epigenetic alterations in hepatocellular... 
SURVIVAL | GENE-EXPRESSION | NEUROBLASTOMA | GASTROENTEROLOGY & HEPATOLOGY | CANCER | Carcinoma, Hepatocellular - mortality | Prognosis | Liver Neoplasms - genetics | Carcinoma, Hepatocellular - diagnosis | Humans | Male | Liver Neoplasms - mortality | Case-Control Studies | DNA Methylation | Liver Neoplasms - diagnosis | Spain - epidemiology | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - metabolism | Female | Italy - epidemiology | Aged | Genome, Human | Carcinoma, Hepatocellular - metabolism | Liver cancer | Genes | Medical prognosis | Mortality | DNA methylation | Epigenetics | Deoxyribonucleic acid--DNA | Tumors | Index Medicus | Metilació | Epigènesi | DNA | Càncer de fetge | Pronòstic mèdic | Epigenesis | ADN | Methylation
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12. Full Text Lin28 promotes transformation and is associated with advanced human malignancies
by O'Sullivan, Maureen and Phillips, Letha A and Viswanathan, Srinivas R and Daley, George Q and Llovet, Josep M and Einhorn, William and Toffanin, Sara and Hughes, Timothy P and Lockhart, Victoria L and Powers, John T and Mermel, Craig H and Meyerson, Matthew and Shah, Samar P and Sorensen, Poul H and Radich, Jerald and Hoshida, Yujin and Lu, Jun and Azam, Mohammad and Ng, Tony L and Beroukhim, Rameen and Teixeira, Jose and Mullighan, Charles G and Golub, Todd R and Tanwar, Pradeep S
Nature Genetics, ISSN 1061-4036, 07/2009, Volume 41, Issue 7, pp. 843 - 848
Multiple members of the let-7 family of miRNAs are often repressed in human cancers, thereby promoting oncogenesis by derepressing targets such as HMGA2, K-Ras... 
LUNG-CANCER | STEM-CELLS | METASTASIS | GENETICS & HEREDITY | GENE-EXPRESSION | LET-7 | HUMAN HEPATOCELLULAR-CARCINOMA | CELL-DIFFERENTIATION | MICRORNA EXPRESSION | EPITHELIAL OVARIAN-CANCER | WILMS-TUMOR | RNA-Binding Proteins - genetics | Animals | Liver Neoplasms - genetics | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Carcinoma, Hepatocellular - genetics | Humans | Gene Expression Regulation, Neoplastic | Cell Line, Tumor | Mice | MicroRNAs - genetics | DNA-Binding Proteins - genetics | Physiological aspects | Genetic aspects | Research | Binding proteins | Gene expression | Cancer | Proteins | Medical research | Tissue | Disease | Stem cells | Kidney diseases | Cervical cancer | Tumors | Index Medicus
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13. Full Text Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma
by Hoshida, Yujin and Villanueva, Augusto and Kobayashi, Masahiro and Peix, Judit and Chiang, Derek Y and Camargo, Amy and Gupta, Supriya and Moore, Jamie and Wrobel, Matthew J and Lerner, Jim and Reich, Michael and Chan, Jennifer A and Glickman, Jonathan N and Ikeda, Kenji and Hashimoto, Masaji and Watanabe, Goro and Daidone, Maria G and Roayaie, Sasan and Schwartz, Myron and Thung, Swan and Salvesen, Helga B and Gabriel, Stacey and Mazzaferro, Vincenzo and Bruix, Jordi and Friedman, Scott L and Kumada, Hiromitsu and Llovet, Josep M and Golub, Todd R
The New England Journal of Medicine, ISSN 0028-4793, 11/2008, Volume 359, Issue 19, pp. 1995 - 2004
The authors have established a method for the analysis of gene expression in tissue specimens preserved in formaldehyde. The expression profile of tissue... 
LIVER-CANCER | MEDICINE, GENERAL & INTERNAL | INTERFERON | MANAGEMENT | RESECTION | PREVENTION | TUMOR | RANDOMIZED-TRIAL | RISK | RECURRENCE | Multivariate Analysis | Carcinoma, Hepatocellular - mortality | Genome-Wide Association Study | Liver - pathology | Prognosis | Liver Neoplasms - genetics | Oligonucleotide Array Sequence Analysis - methods | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Gene Expression Profiling - methods | Male | Tissue Fixation - methods | Liver Neoplasms - mortality | Feasibility Studies | Paraffin Embedding - methods | Carcinoma, Hepatocellular - genetics | Carcinoma, Hepatocellular - pathology | Polymerase Chain Reaction | Survival Analysis | Female | Liver Neoplasms - pathology | Neoplasm Recurrence, Local - genetics | Aged | Causes of | Hepatoma | Diagnosis | Gene expression | Analysis | Risk factors | Liver cancer | Hospitals | Surgery | Liver cirrhosis | Methods | Tumors | Index Medicus | Abridged Index Medicus
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14. Full Text SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression
by Ding, Zhihu and Wu, Chang-Jiun and Chu, Gerald C and Xiao, Yonghong and Ho, Dennis and Zhang, Jingfang and Perry, Samuel R and Labrot, Emma S and Wu, Xiaoqiu and Lis, Rosina and Hoshida, Yujin and Hiller, David and Hu, Baoli and Jiang, Shan and Zheng, Hongwu and Stegh, Alexander H and Scott, Kenneth L and Signoretti, Sabina and Bardeesy, Nabeel and Wang, Y. Alan and Hill, David E and Golub, Todd R and Stampfer, Meir J and Wong, Wing H and Loda, Massimo and Mucci, Lorelei and Chin, Lynda and Depinho, Ronald A
Nature, ISSN 0028-0836, 02/2011, Volume 470, Issue 7333, pp. 269 - 276
Effective clinical management of prostate cancer (PCA) has been challenged by significant intratumoural heterogeneity on the genomic and pathological levels... 
INACTIVATION | APOPTOSIS | SMAD4 | OSTEOPONTIN | TGF-BETA | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PTEN | DIFFERENTIATION | PHYSICIANS HEALTH | EXPRESSION | Osteopontin - genetics | Cyclin D1 - metabolism | Cell Proliferation | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Male | Gene Expression Profiling | Osteopontin - metabolism | Prostatic Neoplasms - diagnosis | Prostate - metabolism | Bone Morphogenetic Proteins - metabolism | Prostatic Neoplasms - genetics | Lung Neoplasms - secondary | Smad4 Protein - genetics | Neoplasm Invasiveness - pathology | Genes, Tumor Suppressor - physiology | Prostate-Specific Antigen - metabolism | Transforming Growth Factor beta | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | PTEN Phosphohydrolase - deficiency | Mice, Transgenic | Penetrance | Lymphatic Metastasis | Smad4 Protein - metabolism | Disease Progression | Neoplasm Metastasis - genetics | Animals | Cyclin D1 - genetics | Models, Biological | Neoplasm Metastasis - pathology | Mice | Smad4 Protein - deficiency | Neoplasm Invasiveness - genetics | Adenocarcinoma | Care and treatment | Genetic aspects | Prostate cancer | Proteins | Genotype & phenotype | Cell cycle | Apoptosis | Tumors | Index Medicus
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15. Full Text Molecular epidemiology of hepatocellular carcinoma
by Hoshida, Yujin
Clinical Liver Disease, ISSN 2046-2484, 12/2012, Volume 1, Issue 6, pp. 177 - 179
Watch a video presentation of this article Watch the interview with the author Answer questions and earn CME 
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