PLoS Genetics, ISSN 1553-7390, 07/2012, Volume 8, Issue 7, p. e1002784
We provide here a comparative genome analysis of ten strains within the Pseudomonas fluorescens group including seven new genomic sequences. These strains...
CHLORORAPHIS O6 | PHENYLACETIC ACID | GENETICS & HEREDITY | FLUORESCENS PF-5 | SECONDARY METABOLITE | GAMMA-AMINOBUTYRIC-ACID | BIOLOGICAL-CONTROL | BIOCONTROL STRAIN | SYRINGAE PV. SYRINGAE | III SECRETION SYSTEM | ANTIBIOTIC PRODUCTION | Repetitive Sequences, Nucleic Acid - genetics | Genome, Bacterial | Multigene Family | Bacterial Proteins - genetics | Plant Diseases - microbiology | Plants - microbiology | Phylogeny | Pseudomonas fluorescens - metabolism | Insecta - genetics | Pseudomonas fluorescens - genetics | Sequence Analysis, DNA | Genetic Heterogeneity | Genetic Variation | Bacteriocins - genetics | Animals | Host-Pathogen Interactions - genetics | Plants - genetics | Bacterial Toxins - genetics | Plant Diseases - genetics | Resorcinols - metabolism | Quantitative genetics | Epigenetic inheritance | Genomics | Physiological aspects | Genetic aspects | Research | Pseudomonas | Bacterial genetics | Biological diversity | Plant diseases | Crop diseases | Microbiology
CHLORORAPHIS O6 | PHENYLACETIC ACID | GENETICS & HEREDITY | FLUORESCENS PF-5 | SECONDARY METABOLITE | GAMMA-AMINOBUTYRIC-ACID | BIOLOGICAL-CONTROL | BIOCONTROL STRAIN | SYRINGAE PV. SYRINGAE | III SECRETION SYSTEM | ANTIBIOTIC PRODUCTION | Repetitive Sequences, Nucleic Acid - genetics | Genome, Bacterial | Multigene Family | Bacterial Proteins - genetics | Plant Diseases - microbiology | Plants - microbiology | Phylogeny | Pseudomonas fluorescens - metabolism | Insecta - genetics | Pseudomonas fluorescens - genetics | Sequence Analysis, DNA | Genetic Heterogeneity | Genetic Variation | Bacteriocins - genetics | Animals | Host-Pathogen Interactions - genetics | Plants - genetics | Bacterial Toxins - genetics | Plant Diseases - genetics | Resorcinols - metabolism | Quantitative genetics | Epigenetic inheritance | Genomics | Physiological aspects | Genetic aspects | Research | Pseudomonas | Bacterial genetics | Biological diversity | Plant diseases | Crop diseases | Microbiology
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 12/2015, Volume 9, Issue 12, p. e0004264
Background A vaccine targeting Plasmodium vivax will be an essential component of any comprehensive malaria elimination program, but major gaps in our...
APICAL MEMBRANE ANTIGEN-1 | HUMORAL IMMUNE-RESPONSES | DUFFY BINDING-PROTEIN | DETERGENT-RESISTANT MICRODOMAINS | TRANSMISSION-BLOCKING VACCINE | NATURALLY ACQUIRED ANTIBODIES | MONTANIDE ISA 51 | MALARIA PARASITES | PROTECTIVE EFFICACY | PARASITOLOGY | TROPICAL MEDICINE | SURFACE PROTEIN-3 | Merozoites - immunology | Antigens, Protozoan - immunology | Age Factors | Cambodia | Gene Library | Antibodies, Protozoan - immunology | Malaria, Vivax - parasitology | Humans | Plasmodium vivax - genetics | Male | Vaccines, Synthetic - immunology | Protozoan Proteins - genetics | Plasmodium vivax - immunology | Animals | Recombinant Proteins - immunology | HEK293 Cells | Malaria Vaccines - immunology | Protein Binding | Antigens, Protozoan - genetics | Malaria, Vivax - prevention & control | Protein Interaction Domains and Motifs | Erythrocytes - parasitology | Merozoites - chemistry | Protozoan Proteins - immunology | Plasmodium vivax | Innovations | Forecasts and trends | Genetic aspects | Drug discovery | Vaccines | Observations | Properties | Recombinant molecules | Protein-protein interactions | Proteins | Studies | Antigens | Plasma | Candidates | Malaria | Pathogenesis | Laboratories | Mortality | Libraries | Blood
APICAL MEMBRANE ANTIGEN-1 | HUMORAL IMMUNE-RESPONSES | DUFFY BINDING-PROTEIN | DETERGENT-RESISTANT MICRODOMAINS | TRANSMISSION-BLOCKING VACCINE | NATURALLY ACQUIRED ANTIBODIES | MONTANIDE ISA 51 | MALARIA PARASITES | PROTECTIVE EFFICACY | PARASITOLOGY | TROPICAL MEDICINE | SURFACE PROTEIN-3 | Merozoites - immunology | Antigens, Protozoan - immunology | Age Factors | Cambodia | Gene Library | Antibodies, Protozoan - immunology | Malaria, Vivax - parasitology | Humans | Plasmodium vivax - genetics | Male | Vaccines, Synthetic - immunology | Protozoan Proteins - genetics | Plasmodium vivax - immunology | Animals | Recombinant Proteins - immunology | HEK293 Cells | Malaria Vaccines - immunology | Protein Binding | Antigens, Protozoan - genetics | Malaria, Vivax - prevention & control | Protein Interaction Domains and Motifs | Erythrocytes - parasitology | Merozoites - chemistry | Protozoan Proteins - immunology | Plasmodium vivax | Innovations | Forecasts and trends | Genetic aspects | Drug discovery | Vaccines | Observations | Properties | Recombinant molecules | Protein-protein interactions | Proteins | Studies | Antigens | Plasma | Candidates | Malaria | Pathogenesis | Laboratories | Mortality | Libraries | Blood
Journal Article
eLife, ISSN 2050-084X, 09/2017, Volume 6
The study of antigenic targets of naturally-acquired immunity is essential to identify and prioritize antigens for further functional characterization. We...
FUNCTIONAL ANTIBODIES | INVASION | FALCIPARUM-MALARIA | FORCE | IMMUNE-RESPONSES | BIOLOGY | MEROZOITE ANTIGENS | INFECTION | SERUM | ANTIBODY-RESPONSES | P. VIVAX | Papua New Guinea | Antigens, Protozoan - immunology | Immunoglobulin G - blood | Humans | Child, Preschool | Infant | Recombinant Proteins - genetics | Protozoan Proteins - genetics | Plasmodium vivax - immunology | Antibodies, Protozoan - blood | Recombinant Proteins - immunology | Antigens, Protozoan - genetics | Malaria, Vivax - prevention & control | Malaria Vaccines - isolation & purification | Protozoan Proteins - immunology | Antigens | Immunoglobulins | Candidates | Malaria | Immunoglobulin G | Infections | Biology | Vaccines | Parasites | Epidemiology | Studies | Proteins | Infectious diseases | Algorithms | Children
FUNCTIONAL ANTIBODIES | INVASION | FALCIPARUM-MALARIA | FORCE | IMMUNE-RESPONSES | BIOLOGY | MEROZOITE ANTIGENS | INFECTION | SERUM | ANTIBODY-RESPONSES | P. VIVAX | Papua New Guinea | Antigens, Protozoan - immunology | Immunoglobulin G - blood | Humans | Child, Preschool | Infant | Recombinant Proteins - genetics | Protozoan Proteins - genetics | Plasmodium vivax - immunology | Antibodies, Protozoan - blood | Recombinant Proteins - immunology | Antigens, Protozoan - genetics | Malaria, Vivax - prevention & control | Malaria Vaccines - isolation & purification | Protozoan Proteins - immunology | Antigens | Immunoglobulins | Candidates | Malaria | Immunoglobulin G | Infections | Biology | Vaccines | Parasites | Epidemiology | Studies | Proteins | Infectious diseases | Algorithms | Children
Journal Article
Nature Communications, ISSN 2041-1723, 02/2016, Volume 7, Issue 1, p. 10507
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say),...
ORGANIZATION | RESPONSES | PROTEIN | HEME | GENE | SEQUENCES | EVOLUTIONARY ANALYSES | PATHWAY | MULTIDISCIPLINARY SCIENCES | ANAPLASMA-PHAGOCYTOPHILUM INFECTION | CATTLE TICK | Anaplasma phagocytophilum | Ixodes - genetics | Animals | Genomics | Ligand-Gated Ion Channels - genetics | Xenopus laevis | Genome - genetics | Arachnid Vectors - genetics | Gene Expression Profiling | Lyme Disease - transmission | Oocytes
ORGANIZATION | RESPONSES | PROTEIN | HEME | GENE | SEQUENCES | EVOLUTIONARY ANALYSES | PATHWAY | MULTIDISCIPLINARY SCIENCES | ANAPLASMA-PHAGOCYTOPHILUM INFECTION | CATTLE TICK | Anaplasma phagocytophilum | Ixodes - genetics | Animals | Genomics | Ligand-Gated Ion Channels - genetics | Xenopus laevis | Genome - genetics | Arachnid Vectors - genetics | Gene Expression Profiling | Lyme Disease - transmission | Oocytes
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 2016, Volume 10, Issue 5, p. e0004639
Background Elimination of Plasmodium vivax malaria would be greatly facilitated by the development of an effective vaccine. A comprehensive and systematic...
MALARIA TRANSMISSION INTENSITY | PARASITES | SURFACE PROTEIN | IMMUNE-RESPONSES | ACQUISITION | PREVENTION | INFECTION | NEW-GUINEAN CHILDREN | PARASITOLOGY | TROPICAL MEDICINE | P. FALCIPARUM | REVEALS | Antigens, Protozoan - immunology | Humans | Malaria, Vivax - epidemiology | Middle Aged | Plasmodium vivax - genetics | Infant | Peptide Library | Young Adult | Antibodies, Protozoan - blood | Adult | Antigens, Protozoan - blood | Female | Protozoan Proteins - chemistry | Malaria, Vivax - prevention & control | Child | Papua New Guinea - epidemiology | Plasmodium vivax - chemistry | Merozoites - immunology | Antibodies, Protozoan - immunology | Malaria, Vivax - parasitology | Biomarkers - blood | Immunity, Innate | Drug Discovery | Plasmodium vivax - immunology | Animals | High-Throughput Screening Assays | Protozoan Proteins - isolation & purification | Adolescent | Malaria, Vivax - immunology | Melanesia - epidemiology | Merozoites - chemistry | Protozoan Proteins - immunology | Cohort Studies | Malaria vaccine | Parasite antigens | Research | Proteins | Studies | Antigens | Medical research | Immunoglobulins | Candidates | Malaria | Funding | Mortality | Libraries | Infections | Plasmodium vivax | Malària
MALARIA TRANSMISSION INTENSITY | PARASITES | SURFACE PROTEIN | IMMUNE-RESPONSES | ACQUISITION | PREVENTION | INFECTION | NEW-GUINEAN CHILDREN | PARASITOLOGY | TROPICAL MEDICINE | P. FALCIPARUM | REVEALS | Antigens, Protozoan - immunology | Humans | Malaria, Vivax - epidemiology | Middle Aged | Plasmodium vivax - genetics | Infant | Peptide Library | Young Adult | Antibodies, Protozoan - blood | Adult | Antigens, Protozoan - blood | Female | Protozoan Proteins - chemistry | Malaria, Vivax - prevention & control | Child | Papua New Guinea - epidemiology | Plasmodium vivax - chemistry | Merozoites - immunology | Antibodies, Protozoan - immunology | Malaria, Vivax - parasitology | Biomarkers - blood | Immunity, Innate | Drug Discovery | Plasmodium vivax - immunology | Animals | High-Throughput Screening Assays | Protozoan Proteins - isolation & purification | Adolescent | Malaria, Vivax - immunology | Melanesia - epidemiology | Merozoites - chemistry | Protozoan Proteins - immunology | Cohort Studies | Malaria vaccine | Parasite antigens | Research | Proteins | Studies | Antigens | Medical research | Immunoglobulins | Candidates | Malaria | Funding | Mortality | Libraries | Infections | Plasmodium vivax | Malària
Journal Article
BMC Genomics, ISSN 1471-2164, 12/2012, Volume 13, Issue 1, pp. 698 - 698
Background: The genera Aspergillus and Penicillium include some of the most beneficial as well as the most harmful fungal species such as the...
PROTEIN | ALIGNMENT | DNA-SEQUENCE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PODOSPORA-ANSERINA | PHYLOGENETIC ANALYSIS | STRUCTURAL-ANALYSIS | GENETICS & HEREDITY | HOMING ENDONUCLEASES | FILAMENTOUS FUNGI | NEUROSPORA-CRASSA | SPLICING ACTIVITY | Introns - genetics | Molecular Sequence Annotation | Genome, Mitochondrial - genetics | Phylogeny | Mutagenesis, Insertional - genetics | Genes, Mitochondrial - genetics | Penicillium - genetics | Genome Size - genetics | Base Sequence | Plasmids - genetics | Aspergillus - genetics | Genetic Variation - genetics | Sequence Analysis | Genes, Fungal - genetics | Evolution, Molecular | Measurement | Aspergillus | Usage | Penicillium | Physiological aspects | Genomes | Genetic aspects | Nucleotide sequencing | Research | DNA sequencing | RNA | Genes | Genomics | Antifungal agents | Population genetics | RNA polymerases | Proteins | Analysis | DNA | Fungi | Genetics | Mitochondrial DNA | Pathogens | Homing behavior | Introns | rRNA | Conservation | Ribosomal subunits | homing endonuclease | Mitochondria | Plasmids | Evolution | genomics
PROTEIN | ALIGNMENT | DNA-SEQUENCE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PODOSPORA-ANSERINA | PHYLOGENETIC ANALYSIS | STRUCTURAL-ANALYSIS | GENETICS & HEREDITY | HOMING ENDONUCLEASES | FILAMENTOUS FUNGI | NEUROSPORA-CRASSA | SPLICING ACTIVITY | Introns - genetics | Molecular Sequence Annotation | Genome, Mitochondrial - genetics | Phylogeny | Mutagenesis, Insertional - genetics | Genes, Mitochondrial - genetics | Penicillium - genetics | Genome Size - genetics | Base Sequence | Plasmids - genetics | Aspergillus - genetics | Genetic Variation - genetics | Sequence Analysis | Genes, Fungal - genetics | Evolution, Molecular | Measurement | Aspergillus | Usage | Penicillium | Physiological aspects | Genomes | Genetic aspects | Nucleotide sequencing | Research | DNA sequencing | RNA | Genes | Genomics | Antifungal agents | Population genetics | RNA polymerases | Proteins | Analysis | DNA | Fungi | Genetics | Mitochondrial DNA | Pathogens | Homing behavior | Introns | rRNA | Conservation | Ribosomal subunits | homing endonuclease | Mitochondria | Plasmids | Evolution | genomics
Journal Article
PLOS NEGLECTED TROPICAL DISEASES, ISSN 1935-2735, 09/2019, Volume 13, Issue 9, p. e0007222
Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been...
INFECTIONS | PFMDR1 COPY NUMBER | GENOMIC ANALYSIS | RESISTANCE | MALARIA | DIVERSITY | NEGATIVE INDIVIDUALS | PARASITOLOGY | TROPICAL MEDICINE | Genomics | Genomes | Nucleotide sequencing | Health aspects | Epidemiology | Protein binding | DNA sequencing | Laboratories | Funding | Copy number | Genes | Erythrocytes | Heterozygotes | Infections | Parasites | Gene sequencing | Proteins | Duffy antigen | Red blood cells | Reproduction (copying) | Bioinformatics | Public health | Supervision | Antigens | Malaria | Nucleotide sequence | College campuses | Polymerase chain reaction | Infectious diseases | Samples | DNA | Diagnostic systems | Mutation | Binding sites | Chemokines
INFECTIONS | PFMDR1 COPY NUMBER | GENOMIC ANALYSIS | RESISTANCE | MALARIA | DIVERSITY | NEGATIVE INDIVIDUALS | PARASITOLOGY | TROPICAL MEDICINE | Genomics | Genomes | Nucleotide sequencing | Health aspects | Epidemiology | Protein binding | DNA sequencing | Laboratories | Funding | Copy number | Genes | Erythrocytes | Heterozygotes | Infections | Parasites | Gene sequencing | Proteins | Duffy antigen | Red blood cells | Reproduction (copying) | Bioinformatics | Public health | Supervision | Antigens | Malaria | Nucleotide sequence | College campuses | Polymerase chain reaction | Infectious diseases | Samples | DNA | Diagnostic systems | Mutation | Binding sites | Chemokines
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2016, Volume 113, Issue 22, pp. 6271 - 6276
The ability of the malaria parasite to invade erythrocytes is dependent on the expression of the Duffy blood group antigen on erythrocytes. Consequently,...
DNA expansion | Plasmodium vivax | Duffy-binding protein | Duffy blood group antigen | CHEMOKINES DARC | FALCIPARUM | MULTIDISCIPLINARY SCIENCES | ERYTHROCYTE INVASION | BLOOD-GROUP | GENE | RESISTANCE | MALARIA PARASITE | NEGATIVE INDIVIDUALS | NUTRIENT-UPTAKE | ANTIGEN | Africa - epidemiology | Malaria, Vivax - genetics | Malaria, Vivax - parasitology | Humans | Malaria, Vivax - epidemiology | Plasmodium vivax - genetics | Saimiri | Mutation - genetics | Protozoan Proteins - genetics | DNA Copy Number Variations | Animals | Erythrocytes - pathology | Protein Binding | Antigens, Protozoan - genetics | Duffy Blood-Group System - genetics | Erythrocytes - parasitology | Real-Time Polymerase Chain Reaction | Malaria, Vivax - pathology | Receptors, Cell Surface - genetics | Biological Sciences
DNA expansion | Plasmodium vivax | Duffy-binding protein | Duffy blood group antigen | CHEMOKINES DARC | FALCIPARUM | MULTIDISCIPLINARY SCIENCES | ERYTHROCYTE INVASION | BLOOD-GROUP | GENE | RESISTANCE | MALARIA PARASITE | NEGATIVE INDIVIDUALS | NUTRIENT-UPTAKE | ANTIGEN | Africa - epidemiology | Malaria, Vivax - genetics | Malaria, Vivax - parasitology | Humans | Malaria, Vivax - epidemiology | Plasmodium vivax - genetics | Saimiri | Mutation - genetics | Protozoan Proteins - genetics | DNA Copy Number Variations | Animals | Erythrocytes - pathology | Protein Binding | Antigens, Protozoan - genetics | Duffy Blood-Group System - genetics | Erythrocytes - parasitology | Real-Time Polymerase Chain Reaction | Malaria, Vivax - pathology | Receptors, Cell Surface - genetics | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e33016
Background: Neisseria meningitidis serogroup B has been predominant in Brazil, but no broadly effective vaccine is available to prevent endemic meningococcal...
STRAINS | VACCINE CANDIDATE | SAO-PAULO | PROTEIN | NADA | MULTIDISCIPLINARY SCIENCES | FACTOR-H | DIVERSITY | PORA | IDENTIFICATION | MENINGOCOCCAL DISEASE | Geography | Meningococcal Infections - genetics | Meningococcal Infections - epidemiology | Genes, Bacterial - genetics | Humans | Molecular Sequence Data | Neisseria meningitidis, Serogroup B - genetics | Meningococcal Infections - microbiology | Phylogeny | Biodiversity | Multilocus Sequence Typing | Neisseria meningitidis, Serogroup B - isolation & purification | Genetic Variation | Likelihood Functions | Molecular Epidemiology | Time Factors | Bacterial Typing Techniques | Base Sequence | Neisseria meningitidis, Serogroup B - classification | Brazil - epidemiology | Meningitis | Vaccines | Epidemiology | Analysis | Epidemics | Antigens | Laboratories | Outer membrane proteins | Genetic diversity | Membrane proteins | Proteins | Infectious diseases | Immunology | Surveillance | Multilocus sequence typing | Meningococcal disease | meningococcal disease | outer membrane proteins | Typing
STRAINS | VACCINE CANDIDATE | SAO-PAULO | PROTEIN | NADA | MULTIDISCIPLINARY SCIENCES | FACTOR-H | DIVERSITY | PORA | IDENTIFICATION | MENINGOCOCCAL DISEASE | Geography | Meningococcal Infections - genetics | Meningococcal Infections - epidemiology | Genes, Bacterial - genetics | Humans | Molecular Sequence Data | Neisseria meningitidis, Serogroup B - genetics | Meningococcal Infections - microbiology | Phylogeny | Biodiversity | Multilocus Sequence Typing | Neisseria meningitidis, Serogroup B - isolation & purification | Genetic Variation | Likelihood Functions | Molecular Epidemiology | Time Factors | Bacterial Typing Techniques | Base Sequence | Neisseria meningitidis, Serogroup B - classification | Brazil - epidemiology | Meningitis | Vaccines | Epidemiology | Analysis | Epidemics | Antigens | Laboratories | Outer membrane proteins | Genetic diversity | Membrane proteins | Proteins | Infectious diseases | Immunology | Surveillance | Multilocus sequence typing | Meningococcal disease | meningococcal disease | outer membrane proteins | Typing
Journal Article