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1. Full Text Edoxaban versus Warfarin in Patients with Atrial Fibrillation
by Giugliano, Robert P and Ruff, Christian T and Braunwald, Eugene and Murphy, Sabina A and Wiviott, Stephen D and Halperin, Jonathan L and Waldo, Albert L and Ezekowitz, Michael D and Weitz, Jeffrey I and Špinar, Jindřich and Ruzyllo, Witold and Ruda, Mikhail and Koretsune, Yukihiro and Betcher, Joshua and Shi, Minggao and Grip, Laura T and Patel, Indravadan and Patel, Shirali P and Hanyok, James J and Mercuri, Michele and Antman, Elliott M and ENGAGE AF-TIMI 48 Investigators
The New England Journal of Medicine, ISSN 0028-4793, 11/2013, Volume 369, Issue 22, pp. 2093 - 2104
Edoxaban, an oral factor Xa inhibitor, was noninferior to warfarin in the prevention of stroke or systemic embolism in patients with atrial fibrillation. There... 
STROKE | MEDICINE, GENERAL & INTERNAL | METAANALYSIS | PHARMACOKINETICS | SAFETY | ORAL ANTICOAGULANTS | PREVENTION | GENERATION | FACTOR XA INHIBITOR | Stroke - prevention & control | Embolism - prevention & control | Double-Blind Method | Follow-Up Studies | Atrial Fibrillation - drug therapy | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Atrial Fibrillation - complications | Kaplan-Meier Estimate | Warfarin - adverse effects | Anticoagulants - therapeutic use | Male | Thiazoles - therapeutic use | Anticoagulants - adverse effects | Thiazoles - adverse effects | Warfarin - therapeutic use | Pyridines - adverse effects | Cardiovascular Diseases - mortality | Adult | Female | Aged | Hemorrhage - chemically induced | Pyridines - therapeutic use | Warfarin | Anticoagulants (Medicine) | Research | Comparative analysis | Drug therapy | Atrial fibrillation | Fees & charges | Cardiac arrhythmia | Stroke | Heart attacks | Risk groups | Glycoproteins | Patients | Bleeding | Embolism | Manuscripts | Fibrillation | Motivation | Death | Thromboembolism | Drug dosages | Pharmaceuticals | Anticoagulants | Cardiovascular Diseases | Enoxaparin | Hemorrhage | Life Sciences | Atrial Fibrillation
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2. Full Text Edoxaban for the Prevention of Thromboembolism in Patients With Atrial Fibrillation and Bioprosthetic Valves
by Carnicelli, Anthony P and De Caterina, Raffaele and Halperin, Jonathan L and Renda, Giulia and Ruff, Christian T and Trevisan, Marco and Nordio, Francesco and Mercuri, Michele F and Antman, Elliott and Giugliano, Robert P and ENGAGE AF-TIMI 48 Investigators
Circulation, ISSN 0009-7322, 03/2017, Volume 135, Issue 13, pp. 1273 - 1275
bioprosthetic valve | atrial fibrillation | edoxaban | anticoagulation | warfarin | CARDIAC & CARDIOVASCULAR SYSTEMS | PERIPHERAL VASCULAR DISEASE | Heart Valve Prosthesis Implantation - instrumentation | Anticoagulants - administration & dosage | Humans | Stroke - diagnosis | Warfarin - adverse effects | Thiazoles - administration & dosage | Warfarin - administration & dosage | Thiazoles - adverse effects | Factor Xa Inhibitors - administration & dosage | Thromboembolism - diagnosis | Pyridines - adverse effects | Thromboembolism - prevention & control | Atrial Fibrillation - diagnosis | Stroke - prevention & control | Pyridines - administration & dosage | Atrial Fibrillation - drug therapy | Risk Factors | Atrial Fibrillation - complications | Heart Valve Prosthesis - adverse effects | Bioprosthesis - adverse effects | Treatment Outcome | Thromboembolism - etiology | Anticoagulants - adverse effects | Atrial Fibrillation - blood | Stroke - blood | Stroke - etiology | Thromboembolism - blood | Blood Coagulation - drug effects | Heart Valve Prosthesis Implantation - adverse effects | Factor Xa Inhibitors - adverse effects | Hemorrhage - chemically induced
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3. Full Text Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events: Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)
by Rost, Natalia S and Giugliano, Robert P and Ruff, Christian T and Murphy, Sabina A and Crompton, Andrea E and Norden, Andrew D and Silverman, Scott and Singhal, Aneesh B and Nicolau, José C and SomaRaju, Bhupathi and Mercuri, Michele F and Antman, Elliott M and Braunwald, Eugene and ENGAGE AF-TIMI 48 Investigators
Stroke, ISSN 0039-2499, 08/2016, Volume 47, Issue 8, pp. 2075 - 2082
BACKGROUND AND PURPOSE—Patients with atrial fibrillation and previous ischemic stroke (IS)/transient ischemic attack (TIA) are at high risk of recurrent... 
clinical trial | atrial fibrillation | risk factors | stroke | PREDICTING STROKE | METAANALYSIS | RIVAROXABAN | PREVENTION | PERIPHERAL VASCULAR DISEASE | CLINICAL NEUROLOGY | hemorrhage | Recurrence | Stroke - prevention & control | Double-Blind Method | Atrial Fibrillation - drug therapy | Humans | Middle Aged | Anticoagulants - therapeutic use | Male | Treatment Outcome | Brain Ischemia - prevention & control | Secondary Prevention | Stroke - drug therapy | Thiazoles - therapeutic use | Warfarin - therapeutic use | Brain Ischemia - drug therapy | Female | Aged | Atrial Fibrillation - prevention & control | Pyridines - therapeutic use
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4. Full Text Stroke and Mortality Risk in Patients With Various Patterns of Atrial Fibrillation: Results From the ENGAGE AF-TIMI 48 Trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48)
by Link, Mark S and Giugliano, Robert P and Ruff, Christian T and Scirica, Benjamin M and Huikuri, Heikke and Oto, Ali and Crompton, Andrea E and Murphy, Sabina A and Lanz, Hans and Mercuri, Michele F and Antman, Elliott M and Braunwald, Eugene and ENGAGE AF-TIMI 48 Investigators
Circulation: Arrhythmia and Electrophysiology, ISSN 1941-3149, 01/2017, Volume 10, Issue 1, pp. e004267 - e004267
BACKGROUND—Whether the pattern of atrial fibrillation (AF) modifies the risk/benefit of anticoagulation is controversial. In ENGAGE AF-TIMI 48 trial (Effective... 
Stroke | Thromboembolism | Atrial fibrillation | Mortality | Bleeding | PERSISTENT | CARDIAC & CARDIOVASCULAR SYSTEMS | bleeding | thromboembolism | MANAGEMENT | AMERICAN-COLLEGE | EDOXABAN | stroke | atrial fibrillation | WARFARIN | mortality | ASSOCIATION TASK-FORCE | UPDATE | Stroke - prevention & control | Humans | Risk Factors | Atrial Fibrillation - complications | Anticoagulants - therapeutic use | Male | Treatment Outcome | Thromboembolism - etiology | Thromboembolism - mortality | Thiazoles - therapeutic use | Atrial Fibrillation - physiopathology | Warfarin - therapeutic use | Factor Xa Inhibitors - therapeutic use | Stroke - etiology | Thromboembolism - prevention & control | Atrial Fibrillation - mortality | Female | Aged | Hemorrhage - chemically induced | Stroke - mortality | Pyridines - therapeutic use
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5. Full Text Cardioversion of Atrial Fibrillation in ENGAGE AF‐TIMI 48
by Plitt, Anna and Ezekowitz, Michael D and De Caterina, Raffaele and Nordio, Francesco and Peterson, Nancy and Giugliano, Robert P and ENGAGE AF-TIMI 48 Investigators
Clinical Cardiology, ISSN 0160-9289, 06/2016, Volume 39, Issue 6, pp. 345 - 346
CARDIAC & CARDIOVASCULAR SYSTEMS | Humans | Stroke - diagnosis | Warfarin - adverse effects | Male | Thiazoles - therapeutic use | Electric Countershock - adverse effects | Thiazoles - adverse effects | Warfarin - therapeutic use | Pyridines - adverse effects | Time Factors | Female | Atrial Fibrillation - diagnosis | Pyridines - therapeutic use | Stroke - prevention & control | Double-Blind Method | Atrial Fibrillation - therapy | Risk Factors | Atrial Fibrillation - complications | Anticoagulants - therapeutic use | Treatment Outcome | Combined Modality Therapy | Anticoagulants - adverse effects | International Normalized Ratio | Atrial Flutter - complications | Factor Xa Inhibitors - therapeutic use | Stroke - etiology | Atrial Flutter - diagnosis | Atrial Flutter - therapy | Factor Xa Inhibitors - adverse effects | Aged | Hemorrhage - chemically induced | Atrial fibrillation
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6. Full Text Cerebrovascular Events in 21 105 Patients With Atrial Fibrillation Randomized to Edoxaban Versus Warfarin: Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48
by Giugliano, Robert P and Ruff, Christian T and Rost, Natalia S and Silverman, Scott and Wiviott, Stephen D and Lowe, Cheryl and Deenadayalu, Naveen and Murphy, Sabina A and Grip, Laura T and Betcher, Joshua M and Duggal, Anil and Dave, Jay and Shi, Minggao and Mercuri, Michele and Antman, Elliott M and Braunwald, Eugene and ENGAGE AF-TIMI 48 Investigators
Stroke, ISSN 0039-2499, 08/2014, Volume 45, Issue 8, pp. 2372 - 2378
BACKGROUND AND PURPOSE—The once-daily oral factor Xa inhibitor, edoxaban, is as effective as warfarin in preventing stroke and systemic embolism while... 
atrial fibrillation | cerebral hemorrhage | anticoagulant | stroke | METAANALYSIS | PREVENTION | INTENSITY | CLINICAL NEUROLOGY | THERAPY | INHIBITION | DABIGATRAN | ORAL ANTICOAGULANTS | PERIPHERAL VASCULAR DISEASE | Pyridines - administration & dosage | Anticoagulants - administration & dosage | Double-Blind Method | Atrial Fibrillation - drug therapy | Humans | Middle Aged | Warfarin - adverse effects | Anticoagulants - therapeutic use | Male | Thiazoles - administration & dosage | Treatment Outcome | Thiazoles - therapeutic use | Anticoagulants - adverse effects | Warfarin - administration & dosage | Thiazoles - adverse effects | Warfarin - therapeutic use | Dose-Response Relationship, Drug | Pyridines - adverse effects | Stroke - chemically induced | Female | Aged | Pyridines - therapeutic use
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