X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
biochemistry & molecular biology (201) 201
animals (198) 198
rats (120) 120
humans (116) 116
3',5'-cyclic-amp phosphodiesterases - metabolism (78) 78
cyclic nucleotide phosphodiesterases, type 4 (75) 75
index medicus (71) 71
phosphorylation (71) 71
cell biology (68) 68
cyclic amp - metabolism (65) 65
male (61) 61
rolipram (57) 57
mice (54) 54
molecular sequence data (53) 53
signal transduction (51) 51
amino acid sequence (48) 48
adenylate cyclase (46) 46
activation (45) 45
kinetics (44) 44
camp (41) 41
phosphodiesterase (39) 39
adenylyl cyclases - metabolism (37) 37
cyclic amp-dependent protein kinases - metabolism (37) 37
camp-specific phosphodiesterase (36) 36
cell line (35) 35
liver - enzymology (34) 34
beta-arrestin (33) 33
cells, cultured (33) 33
expression (33) 33
phosphodiesterase inhibitors - pharmacology (33) 33
protein-kinase-a (33) 33
molecular-cloning (32) 32
gtp-binding proteins - metabolism (31) 31
insulin (31) 31
cos cells (30) 30
isoenzymes - metabolism (30) 30
protein-kinase (30) 30
cyclic-nucleotide phosphodiesterases (29) 29
3',5'-cyclic-amp phosphodiesterases - genetics (28) 28
cyclic amp (28) 28
rats, inbred strains (28) 28
liver (27) 27
map kinase (27) 27
pde4 (27) 27
glucagon - pharmacology (26) 26
liver - drug effects (26) 26
cells (25) 25
cyclic nucleotide phosphodiesterases, type 4 - metabolism (25) 25
hepatocytes (25) 25
identification (25) 25
membrane association (25) 25
pharmacology & pharmacy (24) 24
protein binding (24) 24
transfection (24) 24
dependent protein-kinase (23) 23
enzyme activation (23) 23
glucagon (23) 23
3',5'-cyclic-amp phosphodiesterases - antagonists & inhibitors (22) 22
amp-specific phosphodiesterase (22) 22
gene (22) 22
nucleotide phosphodiesterases (22) 22
receptor (22) 22
base sequence (21) 21
biophysics (21) 21
cell membrane - enzymology (21) 21
colforsin - pharmacology (21) 21
cyclic nucleotide phosphodiesterases, type 3 (21) 21
plasma membranes (21) 21
beta-arrestins (20) 20
cercopithecus aethiops (20) 20
rolipram - pharmacology (20) 20
cyclic-amp phosphodiesterase (19) 19
family (19) 19
rolipram inhibition (19) 19
3',5'-cyclic-amp phosphodiesterases - chemistry (18) 18
article (18) 18
binding (18) 18
cell membrane - metabolism (18) 18
enzyme activation - drug effects (18) 18
insulin - pharmacology (18) 18
isoproterenol - pharmacology (18) 18
liver - metabolism (18) 18
liver plasma-membranes (18) 18
isoenzymes - genetics (17) 17
rats, sprague-dawley (17) 17
cyclic nucleotide phosphodiesterases, type 4 - genetics (16) 16
cyclic-amp (16) 16
drosophila-melanogaster (16) 16
inhibition (16) 16
phosphoric diester hydrolases - metabolism (16) 16
arrestins - metabolism (15) 15
binding sites (15) 15
catalytic domain (15) 15
cell membrane - drug effects (15) 15
models, molecular (15) 15
n-terminal domain (15) 15
proteins (15) 15
guanine nucleotide-binding protein (14) 14
hek293 cells (14) 14
multidisciplinary sciences (14) 14
more...
Library Location Library Location
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Trends in Biochemical Sciences, ISSN 0968-0004, 02/2010, Volume 35, Issue 2, pp. 91 - 100
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2010, Volume 159, Issue 4, pp. 842 - 855
Background and purpose:  Apremilast is an orally administered phosphodiesterase-4 inhibitor, currently in phase 2 clinical studies of psoriasis and other... 
immunopharmacology | anti-inflammatory drugs | PDE inhibitor | chemokines | inflammation | skin pharmacology | anti‐inflammatory drugs | Skin pharmacology | Inflammation | Anti-inflammatory drugs | Immunopharmacology | Chemokines | TRANSCRIPTION FACTORS | DIFFERENTIAL EXPRESSION | ELEMENT-BINDING PROTEIN | NECROSIS-FACTOR-ALPHA | PERITONEAL-MACROPHAGES | PDE4 INHIBITORS | OBSTRUCTIVE PULMONARY-DISEASE | CYCLIC-AMP PHOSPHODIESTERASE | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | PLAQUE-TYPE PSORIASIS | Humans | Middle Aged | Thalidomide - pharmacology | RNA, Messenger - metabolism | Zymosan - metabolism | Thalidomide - analogs & derivatives | Ultraviolet Rays | Psoriasis - pathology | Time Factors | U937 Cells | Anti-Inflammatory Agents - administration & dosage | Skin Transplantation | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cytokines - genetics | Keratinocytes - enzymology | Disease Models, Animal | Psoriasis - immunology | Leukocytes, Mononuclear - drug effects | Psoriasis - drug therapy | Administration, Oral | Anti-Inflammatory Agents - pharmacology | Thalidomide - administration & dosage | Skin - enzymology | Keratinocytes - immunology | Killer Cells, Natural - enzymology | Keratinocytes - drug effects | Lipopolysaccharides - pharmacology | Killer Cells, Natural - drug effects | Mice | Transplantation, Heterologous | Dose-Response Relationship, Drug | Psoriasis - genetics | Enterotoxins - immunology | Leukocytes, Mononuclear - immunology | Inflammation Mediators - metabolism | Phosphodiesterase 4 Inhibitors | Killer Cells, Natural - immunology | Adult | Skin - pathology | Skin - immunology | Severity of Illness Index | Cytokines - metabolism | Phosphodiesterase Inhibitors - pharmacology | Mice, SCID | Gene Expression Regulation - drug effects | Phosphodiesterase Inhibitors - administration & dosage | Animals | Skin - radiation effects | Leukocytes, Mononuclear - enzymology | Cell Proliferation - drug effects | Psoriasis - enzymology | Skin - drug effects | Psoriasis | Tumor necrosis factor-TNF | Rodents | Research Papers
Journal Article
CELLULAR SIGNALLING, ISSN 0898-6568, 03/2015, Volume 27, Issue 3, pp. A1 - A2
Journal Article
DRUG DISCOVERY TODAY, ISSN 1359-6446, 11/2005, Volume 10, Issue 22, pp. 1503 - 1519
Cyclic AMP (CAMP) is a key second messenger in all cells. It is compartmentalized within cells and its levels are controlled, as a result of spatially discrete... 
PROTEIN-KINASE-A | TRANSMEMBRANE CONDUCTANCE REGULATOR | CAMP-SPECIFIC PHOSPHODIESTERASE | INHIBITOR SELECTIVITY | MAP KINASE | N-TERMINAL DOMAIN | PHARMACOLOGY & PHARMACY | AMP-SPECIFIC PHOSPHODIESTERASE | KAPPA-B | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | MONOCYTIC CELLS
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 3 - 4
In this issue of , Arozarena et al. describe that the oncogenic BRAF Val600Glu mutant, which occurs in about half of melanomas, downregulates the... 
ONCOLOGY | GROWTH | CELL BIOLOGY
Journal Article
Circulation Research, ISSN 0009-7330, 04/2007, Volume 100, Issue 7, pp. 950 - 966
Journal Article
Journal Article
Nature Neuroscience, ISSN 1097-6256, 03/2010, Volume 13, Issue 3, pp. 327 - 332
Journal Article
Circulation Research, ISSN 0009-7330, 10/2008, Volume 103, Issue 8, pp. 836 - 844
Protein kinase A (PKA) is a key regulatory enzyme that, on activation by cAMP, modulates a wide variety of cellular functions. PKA isoforms type I and type II... 
Compartmentalization | Protein kinase A | Adrenergic stimulation | Compartmentation | Prostaglandin | CAMP | compartmentation | CAMP DIFFUSION | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | ANCHORING PROTEINS | compartmentalization | prostaglandin | CARDIAC MYOCYTES | PKA | SUBUNITS | cAMP | PROSTAGLANDIN-E1 | adrenergic stimulation | PERIPHERAL VASCULAR DISEASE | protein kinase A | ISCHEMIC PIG-HEART | RECEPTORS | HEMATOLOGY | REVEALS | Phosphorylation | Cricetulus | Fluorescence Recovery After Photobleaching | Receptors, G-Protein-Coupled - metabolism | Receptors, G-Protein-Coupled - agonists | Recombinant Fusion Proteins - metabolism | Myocytes, Cardiac - enzymology | Transfection | Cyclic AMP-Dependent Protein Kinase Type I - genetics | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Fluorescence Resonance Energy Transfer | Cyclic AMP-Dependent Protein Kinase Type I - metabolism | Cyclic AMP-Dependent Protein Kinase Type II - metabolism | Cyclic AMP - metabolism | A Kinase Anchor Proteins - metabolism | CHO Cells | Animals, Newborn | Calcium-Binding Proteins - metabolism | Cricetinae | Phosphoric Diester Hydrolases - metabolism | Rats | Rats, Sprague-Dawley | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Biosensing Techniques | Cyclic AMP-Dependent Protein Kinase Type II - genetics | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Troponin I - metabolism
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2017, Volume 474, Issue 4, pp. 597 - 609
Cyclic AMP (cAMP)-specific phosphodiesterase-4 (PDE4) enzymes underpin compartmentalised cAMP signalling by localising to distinct signalling complexes. PDE4... 
CELLS | SIGNALING PATHWAYS | ACTIVATION | CAMP-SPECIFIC PHOSPHODIESTERASE | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | A-MEDIATED PHOSPHORYLATION | BETA-ARRESTIN | BINDING-SITES | ROLIPRAM INHIBITION | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | Intracellular Signaling Peptides and Proteins - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Intracellular Signaling Peptides and Proteins - genetics | 1-Alkyl-2-acetylglycerophosphocholine Esterase - chemistry | Protein-Serine-Threonine Kinases - metabolism | Gene Expression | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Recombinant Proteins - chemistry | Ubiquitin-Conjugating Enzymes - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Ubiquitin-Conjugating Enzymes - metabolism | Molecular Docking Simulation | Protein-Serine-Threonine Kinases - chemistry | src-Family Kinases - genetics | COS Cells | Mitogen-Activated Protein Kinase 1 - metabolism | Microtubule-Associated Proteins - chemistry | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | beta-Arrestins - metabolism | Cercopithecus aethiops | Ubiquitin-Conjugating Enzymes - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | 1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics | HEK293 Cells | src-Family Kinases - metabolism | Protein Interaction Domains and Motifs | Mitogen-Activated Protein Kinase 3 - chemistry | beta-Arrestins - chemistry | Cyclic AMP-Dependent Protein Kinases - metabolism | Recombinant Proteins - metabolism | Catalytic Domain | Protein Structure, Secondary | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - genetics | Amino Acid Motifs | 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism | beta-Arrestins - genetics | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | src-Family Kinases - chemistry | protein–protein interactions | cAMP | cyclic nucleotide phosphodiesterases
Journal Article
JOURNAL OF BIOCHEMISTRY, ISSN 0021-924X, 07/2019, Volume 166, Issue 1, pp. 97 - 106
Phosphodiesterases (PDEs) shape local cAMP gradients to underpin the specificity of receptor function. Key to this process is the highly defined nature of the... 
DESIGN | ACTIVATED PROTEIN-KINASE | NEUROTROPHIN RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | P38 MAPK | PHOSPHODIESTERASE-4 PDE4 | INFLAMMATION | cyclic-AMP | p75-NTR | PDE4A | phosphodiesterase | INHIBITOR | EXPRESSION | extracellular matrix | CAMP | COPD | Regular Papers
Journal Article