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1. Full Text Safety and efficacy of the peptide-based therapeutic vaccine for HIV-1, Vacc-4x: A phase 2 randomised, double-blind, placebo-controlled trial
by Pollard, Richard B and Rockstroh, Jürgen K and Pantaleo, Giuseppe and Asmuth, David M and Peters, Barry and Lazzarin, Adriano and Garcia, Felipe and Ellefsen, Kim and Podzamczer, Daniel and Van Lunzen, Jan and Arastéh, Keikawus and Schürmann, Dirk and Clotet, Bonaventura and Hardy, W David and Mitsuyasu, Ronald and Moyle, Graeme and Plettenberg, Andreas and Fisher, Martin and Fätkenheuer, Gerd and Fischl, Margaret and Taiwo, Babafemi and Baksaas, Ingebjørg and Jolliffe, Darren and Persson, Stefan and Jelmert, Øyvind and Hovden, Arnt-Ove and Sommerfelt, Maja A and Wendel-Hansen, Vidar and Sørensen, Birger and SP – Sveriges Tekniska Forskningsinstitut
The Lancet Infectious Diseases, ISSN 1473-3099, 2014, Volume 14, Issue 4, pp. 291 - 300
Background: Present combination antiretroviral therapy (cART) alone does not cure HIV infection and requires lifelong drug treatment. The potential role of HIV... 
IMMUNIZATION | INFECTIOUS DISEASES | IMMUNOGENICITY | T-CELL RESPONSES | REPLICATION | COLONY-STIMULATING FACTOR | TREATMENT INTERRUPTIONS | I TRIAL | HIV-1-INFECTED INDIVIDUALS | ANTIRETROVIRAL THERAPY | INFECTED PATIENTS | Anti-Retroviral Agents - therapeutic use | Cell Proliferation | Double-Blind Method | Humans | Middle Aged | AIDS Vaccines - immunology | Immunotherapy, Active | Male | AIDS Vaccines - therapeutic use | CD4 Lymphocyte Count | Withholding Treatment | CD4-Positive T-Lymphocytes - physiology | AIDS Vaccines - adverse effects | CD8-Positive T-Lymphocytes - physiology | Viral Load | Young Adult | HIV Infections - immunology | Time Factors | Adult | Female | HIV Infections - drug therapy | Highly active antiretroviral therapy | Antiviral agents | AIDS vaccines | Peptides | Clinical trials | Cross infection | Nosocomial infections | HIV (Viruses) | Drug therapy | Human immunodeficiency virus--HIV | Naturvetenskap | Natural Sciences
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2. Full Text A novel peptide-based vaccine candidate with protective efficacy against influenza A in a mouse model
by Herrera-Rodriguez, José and Meijerhof, Tjarko and Niesters, Hubert G and Stjernholm, Grete and Hovden, Arnt-Ove and Sørensen, Birger and Ökvist, Mats and Sommerfelt, Maja A and Huckriede, Anke
Virology, ISSN 0042-6822, 02/2018, Volume 515, pp. 21 - 28
Current influenza vaccines mainly induce antibody responses to the variable hemagglutinin proteins of the virus strains included in the vaccine. Instead, a... 
Cell mediated immunity | Peptides | Influenza | Universal vaccine | Humoral immunity | TRIAL | RESPONSES | IMMUNITY | VIRUS | SAFETY | T-CELL EPITOPES | VIROLOGY
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3. Full Text Expression of ESE-3 Isoforms in Immunogenic and Tolerogenic Human Monocyte-Derived Dendritic Cells
by Sprater, Florian and Hovden, Arnt-Ove and Appel, Silke
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e49577
Dendritic cells (DC) are the only hematopoietic cells expressing the epithelial specific Ets transcription factor ESE-3. Here we analyzed presence and quantity... 
ACTIVATION | EPITHELIUM | ETS TRANSCRIPTION FACTOR | MULTIDISCIPLINARY SCIENCES | AIRWAY INFLAMMATION | DIFFERENTIATION | ARTHRITIS | NF-KAPPA-B | CANCER | BINDING | FAMILY | Flow Cytometry - methods | Immunotherapy - methods | Transcription Factors - chemistry | Exons | Monocytes - cytology | Humans | Gene Expression Regulation | Immunoblotting - methods | Polymerase Chain Reaction - methods | Immunohistochemistry - methods | Transcription Factors - metabolism | Phenotype | Cell Nucleus - metabolism | Immune System | Models, Biological | Protein Isoforms | Dendritic Cells - cytology | Models, Genetic | Proto-Oncogene Proteins c-ets - metabolism | HeLa Cells | Dendritic cells | Analysis | Immune response | ETS protein | Alternative splicing | Antigens | Phosphorylation | Transcription factors | Populations | Cytokines | Albinism | Laboratories | Arthritis | Gene expression | Kinases | Blood | Ovarian cancer | Hemopoiesis | Monocytes | Immunology | Immunogenicity | Isoforms | Prostate cancer
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4. Full Text A case for preART-adjusted endpoints in HIV therapeutic vaccine trials
by Huang, Yunda and Zhang, Lily and Jolliffe, Darren and Hovden, Arnt-Ove and Ökvist, Mats and Pantaleo, Giuseppe and Sommerfelt, Maja A
Vaccine, ISSN 0264-410X, 2016, Volume 34, Issue 10, pp. 1282 - 1288
Highlights • preART values were significantly predictive of CD4 counts and VL during ATI. • preART-adjusted endpoints led to more powerful statistical analyses... 
Allergy and Immunology | Fold-change | Missing data | HIV-infected | preART | Analytical treatment interruption | Statistical power | PreART | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNIZATION | SAFETY | CLINICAL-TRIALS | ANTIRETROVIRAL THERAPY | IMMUNOLOGY | HIV-1 | Anti-Retroviral Agents - therapeutic use | Double-Blind Method | Humans | Middle Aged | Male | AIDS Vaccines - therapeutic use | CD4 Lymphocyte Count | Viral Load | Young Adult | Endpoint Determination | HIV Infections - therapy | Adult | Female | Clinical trials | Vaccines | HIV (Viruses) | Health aspects | Analysis | Immunization | Estimates | Human immunodeficiency virus--HIV | Bias
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5. Full Text Correlation of Antibody Responses to a Peptide Antigen gp120-C5501–512/gp41732–744 with HIV Disease Progression
by Sørensen, Birger and Sommerfelt, Maja A and Stjernholm, Grete and Smith, Peter Lawrence and Ökvist, Mats and Hovden, Arnt-Ove and Hoddevik, Gunnar and Redfield, Robert and Ustina, Valentina and Jelmert, Øyvind and Zeldis, Jerome and Dalgleish, Angus
AIDS Research and Human Retroviruses, ISSN 0889-2229, 06/2017, Volume 33, Issue 6, pp. 558 - 566
Antibodies to the carboxy-terminal constant (C5) region 5 of the HIV-1 envelope glycoprotein gp120 have previously been associated with slow disease... 
Immunology | antibody | HIV pathogenesis | immune response | immune activation | HIV envelope glycoproteins | Binding | Antigens | Correlation | Similarity | Peptides | Glycoprotein gp41 | Pathogenesis | Cross-reactivity | Glycoprotein | Antibodies | Glycoproteins | Arthritis | Patients | Peptide mapping | Suppressors | CD4 antigen | Rheumatoid arthritis | Human immunodeficiency virus--HIV | Histocompatibility antigen HLA | Inhibition | Glycoprotein gp120 | Anchoring
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6. Effect of the Modification of p24 Peptide Antigen on Dendritic Cell Uptake and T Cell Activation
by Smith, Peter L and Norgate, Kirstie J and Hegarty, Eve and Gregeda, Nathalie and Heelas, Edward and Sommerfelt, Maja and Lange, Tonnes and Hovden, Arnt-Ove and Sorenson, Birger and Dalgleish, Angus G and Bodman-Smith, Mark
Current HIV Research, ISSN 1570-162X, 01/2017, Volume 15, Issue 1, pp. 3 - 14
Background: Vacc-4x is a candidate therapeutic vaccine consisting of 4 modified peptides based on conserved regions of HIV-1 p24 super(Gag). Vacc4x has been... 
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7. Full Text The bacterial preparation OK432 induces IL-12p70 secretion in human dendritic cells in a TLR3 dependent manner
by Hovden, Arnt-Ove and Karlsen, Marie and Jonsson, Roland and Appel, Silke
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e31217
Dendritic cells (DC) used in therapeutic cancer immunotherapy have to be able to stimulate T cells resulting in an immune response that can efficiently target... 
TOLL-LIKE RECEPTOR-4 | ACID | ANTICANCER | IMMUNOTHERAPY | OK-432 | BIOLOGY | STREPTOCOCCAL PREPARATION | LIGAND | MATURATION | CANCER | CYTOTOXIC T-LYMPHOCYTES | Humans | Toll-Like Receptor 3 - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Gene Knockdown Techniques | Dose-Response Relationship, Drug | Chloroquine - pharmacology | Dendritic Cells - secretion | Signal Transduction - drug effects | Myeloid Differentiation Factor 88 - antagonists & inhibitors | Dendritic Cells - drug effects | Ligands | Picibanil - pharmacology | Toll-Like Receptor 4 - antagonists & inhibitors | Interleukin-12 - secretion | Myeloid Differentiation Factor 88 - metabolism | Streptococcus pyogenes - chemistry | Interleukin-12 - biosynthesis | RNA - metabolism | RNA, Small Interfering - metabolism | Care and treatment | Dendritic cells | Immunotherapy | Ribonuclease | T cells | Health aspects | Cancer | Immune response | Cytokines | Peptides | Laboratories | Secretion | Proteinase | Interleukin 12 | Stimulation | Lymphocytes T | Pattern recognition | TLR3 protein | Signaling | Chlamydia | Lymphocytes | Toll-like receptors | Bacteria | Immune system
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8. Full Text Correlation of Antibody Responses to a Peptide Antigen gp120-C5 501-512 /gp41 732-744 with HIV Disease Progression
by Sørensen, Birger and Sommerfelt, Maja A and Stjernholm, Grete and Smith, Peter Lawrence and Ökvist, Mats and Hovden, Arnt-Ove and Hoddevik, Gunnar and Redfield, Robert and Ustina, Valentina and Jelmert, Øyvind and Zeldis, Jerome and Dalgleish, Angus
AIDS research and human retroviruses, 06/2017, Volume 33, Issue 6, p. 558
Antibodies to the carboxy-terminal constant (C5) region 5 of the HIV-1 envelope glycoprotein gp120 have previously been associated with slow disease... 
HIV Antibodies - blood | HIV Envelope Protein gp120 - immunology | HIV Infections - immunology | HIV Antigens - immunology | HIV Envelope Protein gp41 - immunology | Humans | Antibody Formation | Disease Progression | Cohort Studies
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9. Full Text Cell-Mediated Immune Predictors of Vaccine Effect on Viral Load and CD4 Count in a Phase 2 Therapeutic HIV-1 Vaccine Clinical Trial
by Huang, Yunda and Pantaleo, Giuseppe and Tapia, Gonzalo and Sanchez, Brittany and Zhang, Lily and Trondsen, Monica and Hovden, Arnt-Ove and Pollard, Richard and Rockstroh, Jürgen and Ökvist, Mats and Sommerfelt, Maja A
EBioMedicine, ISSN 2352-3964, 10/2017, Volume 24, Issue C, pp. 195 - 204
In a placebo-controlled trial of the peptide-based therapeutic HIV-1 p24 vaccine candidate Vacc-4x, participants on combination antiretroviral therapy (cART)... 
Analytical treatment interruption (ATI) | Immune predictors | CD4 | HIV | Therapeutic vaccine | Viral load | MEDICINE, RESEARCH & EXPERIMENTAL | VIRUS-INFECTION | PROTECTION | EFFICACY | RESPONSES | IMMUNIZATION | VACC-4X | IMMUNOTHERAPY | DNA | DOUBLE-BLIND | INTERRUPTION | Tumor Necrosis Factor-alpha - metabolism | AIDS Vaccines - pharmacology | CD4-Positive T-Lymphocytes - cytology | Humans | Middle Aged | Male | Treatment Outcome | CD4 Lymphocyte Count | Young Adult | HIV Infections - immunology | HIV-1 - immunology | HIV-1 - physiology | Adult | Female | HIV Infections - drug therapy | Cell Proliferation - drug effects | AIDS Vaccines - administration & dosage | Viral Load - drug effects | Immunity, Cellular | Interleukin-6 - metabolism | CD4-Positive T-Lymphocytes - drug effects
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10. Effect of the modification of p24 peptide antigen on dendritic cell uptake and T cell activation
by Smith, Peter L and Norgate, Kirstie J and Hegarty, Eve and Gregeda, Nathalie and Heelas, Edward and Sommerfelt, Maja and Lange, Tönnes and Hovden, Arnt-Ove and Sørenson, Birger and Dalgleish, Angus G and Bodman-Smith, Mark
Current HIV Research, ISSN 1570-162X, 01/2017, Volume 15, Issue 1, pp. 3 - 14
Background: Vacc-4x is a candidate therapeutic vaccine consisting of 4 modified peptides based on conserved regions of HIV-1 p24(Gag). Vacc4x has been shown to... 
Human immunodeficiency virus | Epitope | Therapeutic vaccine | Peptide | Human leukocyte antigen | T cell | therapeutic vaccine | INFECTIOUS DISEASES | peptide | COLONY-STIMULATING FACTOR | human leukocyte antigen | GAG P24-LIKE PEPTIDES | THERAPEUTIC IMMUNIZATION | ANTIRETROVIRAL THERAPY | IMMUNOLOGY | PERFORIN EXPRESSION | AMINO-ACID | HIV-INFECTION | VIROLOGY | PHASE-I TRIAL | PRESENTING CELLS | DOUBLE-BLIND | epitope | Recombinant Proteins - metabolism | HIV Core Protein p24 - immunology | Lymphocyte Activation | Coculture Techniques | Dendritic Cells - immunology | Humans | Interferon-gamma - secretion | Cells, Cultured | Enzyme-Linked Immunospot Assay | Recombinant Proteins - genetics | Microscopy, Confocal | Flow Cytometry | HIV Core Protein p24 - genetics | Recombinant Proteins - immunology | HIV Core Protein p24 - metabolism | T-Lymphocytes - immunology
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11. Full Text Safety and efficacy of the peptide-based therapeutic vaccine for HIV-1, Vacc-4×: a phase 2 randomised, double-blind, placebo-controlled trial
by Pollard, Richard B, MD and Rockstroh, Jürgen K, MD and Pantaleo, Giuseppe, MD and Asmuth, David M, MD and Peters, Barry, MD and Lazzarin, Adriano, Prof and Garcia, Felipe, MD and Ellefsen, Kim, MSc and Podzamczer, Daniel, MD and van Lunzen, Jan, MD and Arastéh, Keikawus, MD and Schürmann, Dirk, MD and Clotet, Bonaventura, MD and Hardy, W David, MD and Mitsuyasu, Ronald, MD and Moyle, Graeme, MD and Plettenberg, Andreas, MD and Fisher, Martin, MD and Fätkenheuer, Gerd, MD and Fischl, Margaret, MD and Taiwo, Babafemi, MD and Baksaas, Ingebjørg, PhD and Jolliffe, Darren, MSc and Persson, Stefan, PhD and Jelmert, Øyvind, MSc and Hovden, Arnt-Ove, PhD and Sommerfelt, Maja A, PhD and Wendel-Hansen, Vidar, Dr and Sørensen, Birger, MSc
Lancet Infectious Diseases, The, ISSN 1473-3099, 2014, Volume 14, Issue 4, pp. 291 - 300
Summary Background Present combination antiretroviral therapy (cART) alone does not cure HIV infection and requires lifelong drug treatment. The potential role... 
Infectious Disease
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12. Full Text Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses
by Hovden, Arnt-Ove and Karlsen, Marie and Jonsson, Roland and Aarstad, Hans J and Appel, Silke
BMC Immunology, ISSN 1471-2172, 01/2011, Volume 12, Issue 1, pp. 2 - 2
Background: Design of tumour specific immunotherapies using the patients' own dendritic cells (DC) is a fast advancing scientific field. The functional... 
PHASE-III TRIAL | MIGRATION | CAPACITY | MELANOMA | OK-432 | VACCINATION | GENERATION | IMMUNOLOGY | PROSTAGLANDIN E-2 | CANCER VACCINES | Chemokines - secretion | Monocytes - cytology | Humans | Fluorescence | Chemotaxis - drug effects | Immunity - drug effects | Dendritic Cells - secretion | Phenotype | CD40 Antigens - metabolism | Cell Differentiation - drug effects | Lymphocyte Activation - drug effects | T-Lymphocytes - drug effects | Inflammation Mediators - metabolism | Dendritic Cells - drug effects | T-Lymphocytes - immunology | Cell Membrane - metabolism | Dendritic Cells - cytology | Picibanil - pharmacology | Interleukin-12 - secretion | Cell Membrane - drug effects | Usage | Care and treatment | Dendritic cells | Immunotherapy | Physiological aspects | Research | T cells | Cancer | Studies | Good Manufacturing Practice | Immune system
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13. Full Text Levels of Dendritic Cell Populations and Regulatory T Cells Vary Significantly Between Two Commonly Used Mouse Strains
by Vogelsang, Petra and Hovden, Arnt‐Ove and Jonsson, Roland and Appel, Silke
Scandinavian Journal of Immunology, ISSN 0300-9475, 12/2009, Volume 70, Issue 6, pp. 541 - 546
Dendritic cells (DC) are a heterogeneous group of professional antigen‐presenting cells (APC) involved in both initiating immune responses and maintaining... 
IFN | IMMUNITY | THYMUS | SPLEEN | SUBTYPES | IMMUNOLOGY | EXPRESSION | Spleen - immunology | Dendritic Cells - immunology | Humans | Mice, Inbred C57BL | Spleen - cytology | Blood Cell Count | T-Lymphocytes, Regulatory - immunology | Animals | T-Lymphocytes, Regulatory - cytology | Female | Dendritic Cells - cytology | Mice | Mice, Inbred BALB C | Genetic Variation - immunology
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14. Full Text Influenza: the virus and prophylaxis with inactivated influenza vaccine in “at risk” groups, including COPD patients
by Hovden, Arnt-Ove and Cox, Rebecca Jane and Haaheim, Lars Reinhardt
International Journal of Chronic Obstructive Pulmonary Disease, ISSN 1176-9106, 9/2007, Volume 2, Issue 3, pp. 229 - 240
Influenza is a major respiratory pathogen, which exerts a huge human and economic toll on society. Influenza is a vaccine preventable disease, however, the... 
influenza | vaccine | Review | immune response | efficacy | COPD
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15. Full Text The humoral immune response and protective efficacy of vaccination with inactivated split and whole influenza virus vaccines in BALB/c mice
by Cox, Rebecca Jane and Hovden, Arnt-Ove and Brokstad, Karl Albert and Szyszko, Ewa and Madhun, Abdullah Sami and Haaheim, Lars Reinhardt
Vaccine, ISSN 0264-410X, 2006, Volume 24, Issue 44, pp. 6585 - 6587
Recently the urgency of developing a pandemic influenza vaccine has lead to the re-evaluation of the use of whole virus vaccine. We have compared the humoral... 
Whole virus vaccine | Immune response | Mouse | Split virus vaccine | Influenza vaccine | MEDICINE, RESEARCH & EXPERIMENTAL | influenza vaccine | ADULTS | IGG | A/DUCK/SINGAPORE/97 H5N3 VACCINE | ANTIBODY | SERUM | INDUCTION | IMMUNOLOGY | whole virus vaccine | mouse | IMMUNIZATION | immune response | split virus vaccine | VIROSOMES | VETERINARY SCIENCES | INFECTION | MF59-ADJUVANTED INFLUENZA | Orthomyxoviridae Infections - prevention & control | Antibody-Producing Cells - drug effects | Influenza Vaccines - administration & dosage | Immunoglobulin G - blood | Orthomyxoviridae - growth & development | Antibodies, Viral - blood | Orthomyxoviridae - immunology | Vaccines, Inactivated - immunology | Animals | Antibody-Producing Cells - immunology | Influenza Vaccines - immunology | Immunoglobulin G - biosynthesis | Vaccines, Inactivated - administration & dosage | Antibody Formation - drug effects | Mice | Mice, Inbred BALB C | Orthomyxoviridae - drug effects | Orthomyxoviridae Infections - immunology | Disease Models, Animal | Influenza vaccines | Vaccination | Influenza | Medical research | Antigens | Cytokines | Nose | Cytotoxicity | Infections | Vaccines | Immune system
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16. Full Text Influenza: The virus and prophylaxis with inactivated influenza vaccine in "at risk" groups, including COPD patients
by Hovden, Arnt-Ove and Cox, Rebecca Jane and Haaheim, Lars Reinhardt
International Journal of COPD, ISSN 1176-9106, 2007, Volume 2, Issue 3, pp. 229 - 240
Influenza is a major respiratory pathogen, which exerts a huge human and economic toll on society. Influenza is a vaccine preventable disease, however, the... 
Efficacy | Vaccine | Immune response | Influenza | COPD | Humans | Influenza B virus - pathogenicity | Influenza, Human - epidemiology | Pulmonary Disease, Chronic Obstructive - physiopathology | Health Expenditures | Contraindications | Norway - epidemiology | Influenza A virus - pathogenicity | Influenza Vaccines - therapeutic use | Influenza, Human - virology | Influenza B virus - drug effects | Influenza, Human - drug therapy | Vaccines, Inactivated - therapeutic use | Influenza A virus - drug effects | Influenza, Human - prevention & control
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17. Full Text A pilot study of the immune response to whole inactivated avian influenza H7N1 virus vaccine in mice
by Hovden, Arnt‐Ove and Brokstad, Karl A and Major, Diane and Wood, John and Haaheim, Lars R and Cox, Rebecca J
Influenza and Other Respiratory Viruses, ISSN 1750-2640, 01/2009, Volume 3, Issue 1, pp. 21 - 28
Background  Highly pathogenic avian influenza (HPAI) outbreaks in domestic poultry bring humans into close contact with new influenza subtypes and represent a... 
mice | Influenza H7N1 | whole virus vaccine | Mice | Whole virus vaccine | INFECTIOUS DISEASES | RESPIRATORY-TRACT | RANDOMIZED-TRIAL | LETHAL CHALLENGE | H5N1 INFLUENZA | CANDIDATE VACCINES | A VIRUS | HEALTHY-ADULTS | VIROLOGY | RECEPTOR SPECIFICITY | MF59-ADJUVANTED INFLUENZA | PANDEMIC PREPAREDNESS | Orthomyxoviridae Infections - prevention & control | Bone Marrow - immunology | Spleen - immunology | Poultry | Influenza A virus - isolation & purification | Influenza in Birds - epidemiology | Antibodies, Viral - blood | Immunoglobulin M - immunology | Pilot Projects | Vaccines, Inactivated - immunology | Animals | Antibody-Producing Cells - immunology | Immunization, Secondary | Influenza Vaccines - immunology | Disease Outbreaks | Immunoglobulin G - immunology | Immunoglobulin A - immunology | Influenza in Birds - virology | Female | Influenza A virus - immunology | Italy - epidemiology | Mice, Inbred BALB C | Original
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