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ISSN 0039-2499, 2018
Background and Purpose: Observational studies have reported increased risk of ischemic stroke among individuals with low serum 25-hydroxyvitamin D (S-25OHD)... 
polymorphisms, single nucleotide | 25-hydroxyvitamin D | vitamin D | random allocation | stroke
Journal Article
Journal Article
European journal of human genetics : EJHG, ISSN 1018-4813, 06/2017, Volume 25, Issue 7, p. 854
Logistic regression is often used instead of Cox regression to analyse genome-wide association studies (GWAS) of single-nucleotide polymorphisms (SNPs) and... 
Logistic Models | Data Interpretation, Statistical | Polymorphism, Single Nucleotide | Genome-Wide Association Study - methods | Genome-Wide Association Study - standards | Humans
Journal Article
ISSN 0021-9150, 2018
Importance: Human genetic studies have indicated that plasma lipoprotein(a) [Lp(a)] is causally associated with the risk of coronary heart disease (CHD), but... 
Journal Article
Journal Article
ISSN 1061-4036, 2017
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic... 
Journal Article
Nature Genetics, ISSN 1061-4036, 2017, Volume 49, Issue 9, p. 1385
Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10(-8)) at the time of... 
genetics | cardiovascular diseases | genome-wide association studies | sequence annotation | Kardiologi | Medicinsk genetik | Basic Medicine | Medical Genetics | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin
Journal Article
by Malik, Rainer and Chauhan, Ganesh and Traylor, Matthew Stephen and Sargurupremraj, Muralidharan and Okada, Yukinori and Mishra, Aniket and Rutten-Jacobs, Loes Carola and Giese, Anne-Katrin and van der Laan, Sander W and Gretarsdottir, Solveig and Anderson, Christopher D and Chong, Michael and Adams, Hieab HH and Ago, Tetsuro and Almgren, Peter and Amouyel, Philippe and Ay, Hakan and Bartz, Traci M and Benavente, Oscar R and Bevan, Steve and Boncoraglio, Giorgio B and Brown, Robert D and Butterworth, Adam S and Carrera, Caty and Carty, Cara L and Chasman, Daniel I and Chen, Wei-Min and Cole, John W and Correa, Adolfo and Cotlarciuc, Ioana and Cruchaga, Carlos and Danesh, John and de Bakker, Paul IW and DeStefano, Anita L and den Hoed, Marcel and Duan, Qing and Engelter, Stefan T and Falcone, Guido J and Gottesman, Rebecca F and Grewal, Raji P and Gudnason, Vilmundur and Gustafsson, Stefan and Haessler, Jeffrey and Harris, Tamara B and Hassan, Ahamad and Havulinna, Aki S and Heckbert, Susan R and Holliday, Elizabeth G and Howard, George and Hsu, Fang-Chi and Hyacinth, Hyacinth I and Ikram, M Arfan and Ingelsson, Erik and Irvin, Marguerite R and Jian, Xueqiu and Jiménez-Conde, Jordi and Johnson, Julie A and Jukema, J Wouter and Kanai, Masahiro and Keene, Keith L and Kissela, Brett M and Kleindorfer, Dawn O and Kooperberg, Charles and Kubo, Michiaki and Lange, Leslie A and Langefeld, Carl D and Langenberg, Claudia and Launer, Lenore J and Lee, Jin-Moo and Lemmens, Robin and Leys, Didier and Lewis, Cathryn M and Lin, Wei-Yu and Lindgren, Arne G and Lorentzen, Erik and Magnusson, Patrik K and Maguire, Jane and Manichaikul, Ani and McArdle, Patrick F and Meschia, James F and Mitchell, Braxton D and Mosley, Thomas H and Nalls, Michael A and Ninomiya, Toshiharu and O'Donnell, Martin J and Psaty, Bruce M and Pulit, Sara L and Rannikmäe, Kristiina and Reiner, Alexander P and Rexrode, Kathryn M and Rice, Kenneth and Rich, Stephen S and Ridker, Paul M and Rost, Natalia S and Rothwell, Peter M and Rotter, Jerome I and Rundek, Tatjana and Sacco, Ralph L and Sakaue, Saori and Sale, Michele M and ... and Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap and Göteborgs universitet and Gothenburg University and Institute of Biomedicine, Department of Pathology and Core Facilities, Bioinformatics and Sahlgrenska Academy and Institutionen för biomedicin, avdelningen för patologi and Sahlgrenska akademin and Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Nature Genetics, ISSN 1061-4036, 2018, Volume 50, Issue D, Munich, Germany. [Chauhan, Ganesh] Indian Inst Sci, Ctr Brain Res, Bangalore, Karnataka, India. [Chauhan, Ganesh; Sargurupremraj, Muralidharan; Mishra, Aniket; Tzourio, Christophe; Debette, [Traylor, Matthew; Rutten-Jacobs, Loes; Markus, Hugh S.] Univ Cambridge, Div Clin Neurosci, Stroke [Sargurupremraj, Muralidharan; Mishra, Aniket; Debette, Stephanie] Bordeaux Univ Hosp, Inst [Okada, Yukinori; Kanai, Masahiro; Kamatani, Yoichiro] RIKEN Ctr Integrat Med Sci, Lab Stat Anal, [Okada, Yukinori; Kanai, Masahiro; Sakaue, Saori] Osaka Univ, Grad Sch Med, Dept Stat Genet, Osaka, [Okada, Yukinori] Osaka Univ, Immunol Frontier Res Ctr WPI IFReC, Lab Stat Immunol, Suita, Osaka, [Giese, Anne-Katrin; Rost, Natalia S.] Harvard Med Sch, MGH, Dept Neurol, Boston, MA USA. [van der Laan, Sander W.] Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Lab Expt Cardiol,Dept [Gretarsdottir, Solveig; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Stefansson, Kari] DeCODE Genet [Anderson, Christopher D.; Rosand, Jonathan] MGH, Ctr Genom Med, Boston, MA USA. [Anderson, Christopher D.; Ay, Hakan; Rost, Natalia S.; Rosand, Jonathan] MGH, J Philip Kistler Stroke [Anderson, Christopher D.; Rosand, Jonathan] Broad Inst, Program Med & Populat Genet, Cambridge, p. 524
Journal Article
by Mahajan, Anubha and Wessel, Jennifer and Willems, Sara M and Zhao, Wei and Robertson, Neil R and Chu, Audrey Y and Gan, Wei and Kitajima, Hidetoshi and Taliun, Daniel and Rayner, N William and Guo, Xiuqing and Lu, Yingchang and Li, Man and Jensen, Richard A and Hu, Yao and Huo, Shaofeng and Lohman, Kurt K and Zhang, Weihua and Cook, James P and Prins, Bram Peter and Flannick, Jason and Grarup, Niels and Trubetskoy, Vassily Vladimirovich and Kravic, Jasmina and Kim, Young Jin and Rybin, Denis V and Yaghootkar, Hanieh and Müller-Nurasyid, Martina and Meidtner, Karina and Li-Gao, Ruifang and Varga, Tibor V and Marten, Jonathan and Li, Jin and Smith, Albert Vernon and An, Ping and Ligthart, Symen and Gustafsson, Stefan and Malerba, Giovanni and Demirkan, Ayse and Tajes, Juan Fernandez and Steinthorsdottir, Valgerdur and Wuttke, Matthias and Lecoeur, Cécile and Preuss, Michael and Bielak, Lawrence F and Graff, Marielisa and Highland, Heather M and Justice, Anne E and Liu, Dajiang J and Marouli, Eirini and Peloso, Gina Marie and Warren, Helen R and ExomeBP Consortium and MAGIC Consortium and GIANT Consortium and Afaq, Saima and Afzal, Shoaib and Ahlqvist, Emma and Almgren, Peter and Amin, Najaf and Bang, Lia B and Bertoni, Alain G and Bombieri, Cristina and Bork-Jensen, Jette and Brandslund, Ivan and Brody, Jennifer A and Burtt, Noël P and Canouil, Mickaël and Chen, Yii-Der Ida and Cho, Yoon Shin and Christensen, Cramer and Eastwood, Sophie V and Eckardt, Kai-Uwe and Fischer, Krista and Gambaro, Giovanni and Giedraitis, Vilmantas and Grove, Megan L and de Haan, Hugoline G and Hackinger, Sophie and Hai, Yang and Han, Sohee and Tybjærg-Hansen, Anne and Hivert, Marie-France and Isomaa, Bo and Jäger, Susanne and Jørgensen, Marit E and Jørgensen, Torben and Käräjämäki, Annemari and Kim, Bong-Jo and Kim, Sung Soo and Koistinen, Heikki A and Kovacs, Peter and Kriebel, Jennifer and Kronenberg, Florian and Läll, Kristi and Lange, Leslie A and Lee, Jung-Jin and Lehne, Benjamin and Li, Huaixing and Lin, Keng-Hung and ... and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Geriatrik and Kardiovaskulär epidemiologi and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi and Institutionen för folkhälso- och vårdvetenskap
Nature Genetics, ISSN 1061-4036, 2018, Volume 50, Issue 4, p. 559
Identification of coding variant associations for complex diseases offers a direct route to biological insight, but is dependent on appropriate inference... 
ExomeBP Consortium | MAGIC Consortium | GIANT Consortium | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 03/2017, Volume 49, Issue 3, pp. 403 - 415
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic,... 
Journal Article | genome-wide association studies | hypertension | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2017, Volume 49, Issue 12, pp. 1758 - 1766
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 02/2017, Volume 69, Issue 7, p. 823
BACKGROUND: Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show... 
expression quantitative trait loci | genetics | genome-wide association | single nucleotide polymorphism | cholesteryl ester transfer protein | Journal Article | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 10/2016, Volume 48, Issue 10, pp. 1151 - 1161
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and... 
HEART | RISK-FACTORS | PLASMA-LEVELS | CARDIOVASCULAR-DISEASE | GENE-CENTRIC ARRAY | AGING RESEARCH | LOCI | IDENTIFICATION | CHARGE | GENOME-WIDE ASSOCIATION | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
by Marouli, E and Graff, M and Medina-Gomez, C and Lo, K.S and Wood, A.R and Kjaer, T.R and Fine, R.S and Lu, Y and Schurmann, C and Highland, H.M and Rueger, S and Thorleifsson, G and Justice, A.E and Lamparter, D and Stirrups, K.E and Turcot, V and Young, K.L and Winkler, T.W and Esko, T and Karaderi, T and Locke, A.E and Masca, N.G and Ng, M.C and Mudgal, P and Rivas, M.A and Vedantam, S and Mahajan, A and Guo, X and Abecasis, G and Aben, K.K and Adair, L.S and Alam, D.S and Albrecht, E and Allin, K.H and Allison, M and Amouyel, P and Appel, E.V and Arveiler, D and Asselbergs, F.W and Auer, P.L and Balkau, B and Banas, B and Bang, L.E and Benn, M and Bergmann, S and Bielak, L.F and Bluher, M and Boeing, H and Boerwinkle, E and Boger, C.A and Bonnycastle, L.L and Bork-Jensen, J and Bots, M.L and Bottinger, E.P and Bowden, D.W and Brandslund, I and Breen, G and Brilliant, M.H and Broer, L and Burt, A.A and Butterworth, A.S and Carey, D.J and Caulfield, M.J and Chambers, J.C and Chasman, D.I and Chen, Y.I and Chowdhury, R and Christensen, C and Chu, A.Y and Cocca, M and Collins, F.S and Cook, J.P and Corley, J and Galbany, J.C and Cox, A.J and Cuellar-Partida, G and Danesh, J and Davies, G and Bakker, P.I. de and Borst, G.J. de and Denus, S. de and Groot, M.C. de and Mutsert, R. de and Deary, I.J and Dedoussis, G and Demerath, E.W and Hollander, A.I. den and Dennis, J.G and Angelantonio, E. Di and nos, F and Du, M and Dunning, A.M and Easton, D.F and Ebeling, T and Edwards, T.L and Ellinor, P.T and Elliott, P and Evangelou, E and Farmaki, A.E and Faul, J.D and ... and Global Lipids Genetics Consortium and EpiHealth: Epidemiology for Health and Genetisk och molekylär epidemiologi and ExomeBP Consortium and Lunds universitet and The EPIC-InterAct Consortium and EPIC-CVD Consortium and Lund University and CHD Exome+ Consortium and GoT2D Genes Consortium and MAGIC Investigators and ReproGen Consortium and Genetic and Molecular Epidemiology and EXODIAB: Excellence in Diabetes Research in Sweden and T2D-Genes Consortium
Nature, ISSN 0028-0836, 2017, Volume 542, Issue 7640, pp. 186 - 190
Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so... 
development | genetic association study | Medicinsk genetik | Basic Medicine | Medical Genetics | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
ISSN 2047-4873, 2017
$\textbf{Aims}$ Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A$_{2}$ (Lp-PLA$_{2}$), has not reduced risk of cardiovascular disease... 
human genetics | coronary heart disease | darapladib | target validation | lipoprotein-associated phospholipase A2
Journal Article
by Fuchsberger, Christian and Flannick, Jason and Teslovich, Tanya M and Mahajan, Anubha and Agarwala, Vineeta and Gaulton, Kyle J and Ma, Clement and Fontanillas, Pierre and Moutsianas, Loukas and McCarthy, Davis J and Rivas, Manuel A and Perry, John Richard and Sim, Xueling and Blackwell, Thomas W and Robertson, Neil R and Rayner, N William and Cingolani, Pablo and Locke, Adam E and Tajes, Juan Fernandez and Highland, Heather M and Dupuis, Josee and Chines, Peter S and Lindgren, Cecilia M and Hartl, Christopher and Jackson, Anne U and Chen, Han and Huyghe, Jeroen R and van de Bunt, Martijn and Pearson, Richard D and Kumar, Ashish and Müller-Nurasyid, Martina and Grarup, Niels and Stringham, Heather M and Gamazon, Eric R and Lee, Jaehoon and Chen, Yuhui and Scott, Robert and Below, Jennifer E and Chen, Peng and Huang, Jinyan and Go, Min Jin and Stitzel, Michael L and Pasko, Dorota and Parker, Stephen CJ and Varga, Tibor V and Green, Todd and Beer, Nicola L and Day-Williams, Aaron G and Ferreira, Teresa and Fingerlin, Tasha and Horikoshi, Momoko and Hu, Cheng and Huh, Iksoo and Ikram, Mohammad Kamran and Kim, Bong-Jo and Kim, Yongkang and Kim, Young Jin and Kwon, Min-Seok and Lee, Juyoung and Lee, Selyeong and Lin, Keng-Han and Maxwell, Taylor J and Nagai, Yoshihiko and Wang, Xu and Welch, Ryan P and Yoon, Joon and Zhang, Weihua and Barzilai, Nir and Voight, Benjamin F and Han, Bok-Ghee and Jenkinson, Christopher P and Kuulasmaa, Teemu and Kuusisto, Johanna and Manning, Alisa and Ng, Maggie CY and Palmer, Nicholette D and Balkau, Beverley and Stančáková, Alena and Abboud, Hanna E and Boeing, Heiner and Giedraitis, Vilmantas and Prabhakaran, Dorairaj and Gottesman, Omri and Scott, James and Carey, Jason and Kwan, Phoenix and Grant, George and Smith, Joshua D and Neale, Benjamin M and Purcell, Shaun and Butterworth, Adam Stuart and Howson, Joanna McCammond and Lee, Heung Man and Lu, Yingchang and Kwak, Soo-Heon and Zhao, Wei and Danesh, John and Lam, Vincent KL and Park, Kyong Soo and Saleheen, Danish and ... and Cardiovascular Research - Hypertension and Kardiovaskulär forskning - hypertoni and Genomics, Diabetes and Endocrinology and Diabetes - Islet Patophysiology and EpiHealth: Epidemiology for Health and Genomik, diabetes och endokrinologi and Internal Medicine - Epidemiology and Diabetiska komplikationer and GoT2D Consortium and Genetisk och molekylär epidemiologi and Lunds universitet and Lund University and Diabetes - öpatofysiologi and Internmedicin - epidemiologi and Genetic and Molecular Epidemiology and EXODIAB: Excellence in Diabetes Research in Sweden and Diabetic Complications and T2D-Genes Consortium
Nature, ISSN 0028-0836, 2016, Volume 536, Issue 7614, p. 41
Journal Article
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