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1. Full Text Genome-wide association study identifies 112 new loci for body mass index in the Japanese population
by Akiyama, Masato and Okada, Yukinori and Kanai, Masahiro and Takahashi, Atsushi and Momozawa, Yukihide and Ikeda, Masashi and Iwata, Nakao and Ikegawa, Shiro and Hirata, Makoto and Matsuda, Koichi and Iwasaki, Motoki and Yamaji, Taiki and Sawada, Norie and Hachiya, Tsuyoshi and Tanno, Kozo and Shimizu, Atsushi and Hozawa, Atsushi and Minegishi, Naoko and Tsugane, Shoichiro and Yamamoto, Masayuki and Kubo, Michiaki and Kamatani, Yoichiro
Nature Genetics, ISSN 1061-4036, 10/2017, Volume 49, Issue 10, pp. 1458 - 1467
Obesity is a risk factor for a wide variety of health problems. In a genome-wide association study (GWAS) of body mass index (BMI) in Japanese people (n =... 
RHEUMATOID-ARTHRITIS | GENETIC-VARIATION | OBESITY | METAANALYSIS | VARIANTS | INSULIN-RESISTANCE | GENETICS & HEREDITY | RISK | FUNCTIONAL ANNOTATION | LD SCORE REGRESSION | HERITABILITY | Body Mass Index | Japan - epidemiology | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Comorbidity | Obesity - immunology | Diabetes Mellitus, Type 2 - genetics | Humans | Asian Continental Ancestry Group - genetics | Obesity - ethnology | Europe - epidemiology | Body Weight - genetics | Obesity - genetics | Diabetes Mellitus, Type 2 - ethnology | Lymphocyte Count | Polymorphism, Single Nucleotide | Body Weight - physiology | Quantitative trait loci | Obesity | Genome-wide association studies | Causes of | Genetic aspects | Health aspects | Japanese | Methods | CD19 antigen | Pathogenesis | Health problems | Body weight | Principal components analysis | Genomes | Males | Epidemiology | Loci | Risk factors | Studies | Body mass index | Body mass | Sexes | Lymphocytes | Cell number | Rheumatoid arthritis | Population | Insulin resistance | Health risk assessment | Index Medicus
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2. Population-based biobank participants' preferences for receiving genetic test results
by Yamamoto, Kayono and Hachiya, Tsuyoshi and Fukushima, Akimune and Nakaya, Naoki and Okayama, Akira and Tanno, Kozo and Aizawa, Fumie and Tokutomi, Tomoharu and Hozawa, Atsushi and Shimizu, Atsushi
Journal of Human Genetics, ISSN 1434-5161, 12/2017, Volume 62, Issue 12, pp. 1037 - 1048
There are ongoing debates on issues relating to returning individual research results (IRRs) and incidental findings (IFs) generated by genetic research in... 
INCIDENTAL FINDINGS | RETURN | EXOME | PROJECT | PROFESSIONALS | MISSION | PERSPECTIVES | KNOWLEDGE | GENETICS & HEREDITY | COHORT | ATTITUDES | Genetic Testing | Cross-Sectional Studies | Humans | Japan | Middle Aged | Incidental Findings | Male | Patient Preference | Disclosure | Young Adult | Biological Specimen Banks | Aged, 80 and over | Adult | Female | Surveys and Questionnaires | Aged | Cohort Studies | Communication
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3. Full Text The Tohoku Medical Megabank Project: Design and Mission
by Kuriyama, Shinichi and Yaegashi, Nobuo and Nagami, Fuji and Arai, Tomohiko and Kawaguchi, Yoshio and Osumi, Noriko and Sakaida, Masaki and Suzuki, Yoichi and Nakayama, Keiko and Hashizume, Hiroaki and Tamiya, Gen and Kawame, Hiroshi and Suzuki, Kichiya and Hozawa, Atsushi and Nakaya, Naoki and Kikuya, Masahiro and Metoki, Hirohito and Tsuji, Ichiro and Fuse, Nobuo and Kiyomoto, Hideyasu and Sugawara, Junichi and Tsuboi, Akito and Egawa, Shinichi and Ito, Kiyoshi and Chida, Koichi and Ishii, Tadashi and Tomita, Hiroaki and Taki, Yasuyuki and Minegishi, Naoko and Ishii, Naoto and Yasuda, Jun and Igarashi, Kazuhiko and Shimizu, Ritsuko and Nagasaki, Masao and Koshiba, Seizo and Kinoshita, Kengo and Ogishima, Soichi and Takai-Igarashi, Takako and Tominaga, Teiji and Tanabe, Osamu and Ohuchi, Noriaki and Shimosegawa, Toru and Kure, Shigeo and Tanaka, Hiroshi and Ito, Sadayoshi and Hitomi, Jiro and Tanno, Kozo and Nakamura, Motoyuki and Ogasawara, Kuniaki and Kobayashi, Seiichiro and Sakata, Kiyomi and Satoh, Mamoru and Shimizu, Atsushi and Sasaki, Makoto and Endo, Ryujin and Sobue, Kenji and Tohoku Medical Megabank Project Study Group, the and Yamamoto, Masayuki and Tohoku Med Megabank Project Study
Journal of Epidemiology, ISSN 0917-5040, 2016, Volume 26, Issue 9, pp. 493 - 511
The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast of the Tohoku region. The... 
the Great East Japan Earthquake | cohort study | genomic research | Tohoku Medical Megabank Project | biobank | The Great East Japan Earthquake | Biobank | Cohort study | Genomic research | NORTHEAST JAPAN | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | CEREBROVASCULAR DISEASES | ELECTRONIC HEALTH RECORDS | GREAT EAST JAPAN | ACUTE MYOCARDIAL-INFARCTION | DECOMPENSATED HEART-FAILURE | TSUNAMI | CARDIOVASCULAR-DISEASES | COMPLEX DISEASES | EARTHQUAKE | Prospective Studies | Disasters | Earthquakes | Humans | Japan | Disaster Medicine - organization & administration | Goals | Tsunamis | Studies | Genomes | the Great East Japan Earthquake; Tohoku Medical Megabank Project; cohort study; biobank; genomic research
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4. Full Text Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera
by Kabe, Yasuaki and Suematsu, Makoto and Sakamoto, Satoshi and Hirai, Miwa and Koike, Ikko and Hishiki, Takako and Matsuda, Atsushi and Hasegawa, Yuichi and Tsujita, Koji and Ono, Masayuki and Minegishi, Naoko and Hozawa, Atsushi and Murakami, Yoshinori and Kubo, Michiaki and Itonaga, Makoto and Handa, Hiroshi
Clinical Chemistry, ISSN 0009-9147, 10/2018, Volume 64, Issue 10, pp. 1463 - 1473
BACKGROUND: Although circulating exosomes in blood play crucial roles in cancer development and progression, difficulties in quantifying exosomes hamper their... 
CELLS | EXTRACELLULAR VESICLES | MARKERS | MEDICAL LABORATORY TECHNOLOGY | PROTEINS | CANCER | MODULATION | BEADS | Cell culture | Flow cytometry | CD9 antigen | Ovarian carcinoma | Surface antigens | Colorectal cancer | Antibodies | CD147 antigen | Exosomes | Ovarian cancer | Proteins | Carcinoembryonic antigen | Epidermal growth factor | Optical properties | Labeling | Growth factors | Enzyme-linked immunosorbent assay | Antigens | Immunoglobulins | CD63 antigen | Cloning | Breast cancer | Roles | Patients | ErbB-2 protein | Disk drives | Blood circulation | Linearity | MicroRNAs | Methods | Counting | Cancer
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5. Full Text Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus
by Hachiya, Tsuyoshi and Narita, Akira and Ohmomo, Hideki and Sutoh, Yoichi and Komaki, Shohei and Tanno, Kozo and Satoh, Mamoru and Sakata, Kiyomi and Hitomi, Jiro and Nakamura, Motoyuki and Ogasawara, Kuniaki and Yamamoto, Masayuki and Sasaki, Makoto and Hozawa, Atsushi and Shimizu, Atsushi
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 14162 - 10
Excessive sodium intake is a global risk factor for hypertension. Sodium effects on blood pressure vary from person to person; hence, high-risk group targeting... 
Statistical analysis | Sodium | Risk groups | Replication | Genomes | Blood pressure | Mathematical models | Genetic factors | Gene polymorphism
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6. Full Text Genome-wide meta-analysis in Japanese populations identifies novel variants at the TMC6-TMC8 and SIX3-SIX2 loci associated with HbA1c
by Hachiya, Tsuyoshi and Komaki, Shohei and Hasegawa, Yutaka and Ohmomo, Hideki and Tanno, Kozo and Hozawa, Atsushi and Tamiya, Gen and Yamamoto, Masayuki and Ogasawara, Kuniaki and Nakamura, Motoyuki and Hitomi, Jiro and Ishigaki, Yasushi and Sasaki, Makoto and Shimizu, Atsushi
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 1 - 11
Glycated haemoglobin (HbA1c) is widely used as a biomarker for the diagnosis of diabetes, for population-level screening, and for monitoring the glycaemic... 
Signal transduction | 14-3-3 protein | Molecular modelling | Diabetes mellitus | Hemoglobin | Association analysis | Glycosylation | Genomes | Heritability | Diabetes | Linoleic acid | Index Medicus
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7. Full Text Adjustment of cell-type composition minimizes systematic bias in blood DNA methylation profiles derived by DNA collection protocols
by Shiwa, Yuh and Hachiya, Tsuyoshi and Furukawa, Ryohei and Ohmomo, Hideki and Ono, Kanako and Kudo, Hisaaki and Hata, Jun and Hozawa, Atsushi and Iwasaki, Motoki and Matsuda, Koichi and Minegishi, Naoko and Satoh, Mamoru and Tanno, Kozo and Yamaji, Taiki and Wakai, Kenji and Hitomi, Jiro and Kiyohara, Yutaka and Kubo, Michiaki and Tanaka, Hideo and Tsugane, Shoichiro and Yamamoto, Masayuki and Sobue, Kenji and Shimizu, Atsushi
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, pp. e0147519 - e0147519
Differences in DNA collection protocols may be a potential confounder in epigenome-wide association studies (EWAS) using a large number of blood specimens from... 
STORAGE | GENETIC RISK | PERFORMANCE | PACKAGE | MULTIDISCIPLINARY SCIENCES | NORMALIZATION | BIOBANKS | SAMPLES | CANCER | EPIGENOME-WIDE ASSOCIATION | ARRAYS | Blood Specimen Collection - standards | Oligonucleotide Array Sequence Analysis - standards | Oligonucleotide Array Sequence Analysis - methods | Bias | Humans | Blood Cells - metabolism | Male | DNA - genetics | DNA - isolation & purification | DNA Methylation | Flow Cytometry | CpG Islands - genetics | Female | Genome-Wide Association Study - methods | Genome-Wide Association Study - standards | Blood Specimen Collection - methods | Physiological aspects | Genetic aspects | Research | DNA testing | Methylation | Methods | Statistical analysis | Adjustment | Blood cells | Cold storage | Preventive medicine | Blood | Disease prevention | Storage | Storage conditions | DNA methylation | Epigenetics | Collection | Deoxyribonucleic acid--DNA | CpG islands | Index Medicus | Deoxyribonucleic acid | DNA
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8. Full Text Attributable Fractions of Risk Factors for Cardiovascular Diseases
by Hozawa, Atsushi
Journal of Epidemiology, ISSN 0917-5040, 2011, Volume 21, Issue 2, pp. 81 - 86
Background: Cardiovascular disease (CVD) is a leading cause of death in Japan. To reduce the threat of CVD, it is important to identify its major risk factors.... 
cohort study | cardiovascular diseases | population attributable fraction | Cardiovascular diseases | Cohort study | Population attributable fraction | POPULATION | MIDDLE-AGE | CANCER | ALL-CAUSE MORTALITY | STROKE | CIGARETTE-SMOKING | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | JAPANESE | COHORT | HYPERTENSION | HIGH BLOOD-PRESSURE | Japan - epidemiology | Prevalence | Prospective Studies | Humans | Middle Aged | Risk Factors | Male | Smoking - epidemiology | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Adult | Female | Aged | Hypertension - epidemiology | Cardiovascular disease | Risk factors
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9. Full Text Slight increase in urinary albumin excretion within the normal range predicts incident hypertension in a community-based Japanese population: The Takahata study
by Hirayama, Atsushi and Konta, Tsuneo and Hozawa, Atsushi and Kawasaki, Ryo and Watanabe, Tetsu and Shibata, Yoko and Kayama, Takamasa and Fukao, Akira and Kubota, Isao
Hypertension Research, ISSN 0916-9636, 01/2015, Volume 38, Issue 1, pp. 56 - 60
Recent studies have suggested that urine albumin excretion in the high normal range predicts hypertension. However, the relationship between urinary albumin... 
blood pressure | urinary albumin | cohort study | ENDOTHELIAL DYSFUNCTION | RISK | LOW-GRADE ALBUMINURIA | BLOOD-PRESSURE | ALL-CAUSE | GENERAL-POPULATION | MICROALBUMINURIA | CARDIOVASCULAR MORTALITY | PERIPHERAL VASCULAR DISEASE | CHRONIC KIDNEY-DISEASE | ASSOCIATION | Japan - epidemiology | Humans | Middle Aged | Adult | Female | Male | Aged | Albuminuria | Hypertension - epidemiology | Hypertension - urine | Index Medicus
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10. Full Text Participants with Treated Hyperlipidemia may be More Health Conscious
by Hozawa, Atsushi and Okamura, Tomonori
Journal of Atherosclerosis and Thrombosis, ISSN 1340-3478, 2015
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11. Full Text Participants with Treated Hyperlipidemia may be More Health Conscious
by Atsushi Hozawa and Tomonori Okamura and School of Medicine and Division of Personalized Prevention and Epidemiology and Tohoku Medical Megabank Organization and Department of Preventive Medicine and Public Health and Tohoku University and Keio University
Journal of Atherosclerosis and Thrombosis, ISSN 1340-3478, 2015, Volume 22, Issue 10, pp. 1025 - 1026
[See article vol. 22 : 1030 - 1039] Hyperlipidemia is a well-known risk factor of coronary heart diseases, and the beneficial effect of hyperlipidemia... 
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12. Full Text Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals
by Nagasaki, Masao and Yasuda, Jun and Katsuoka, Fumiki and Nariai, Naoki and Kojima, Kaname and Kawai, Yosuke and Yamaguchi-Kabata, Yumi and Yokozawa, Junji and Danjoh, Inaho and Saito, Sakae and Sato, Yukuto and Mimori, Takahiro and Tsuda, Kaoru and Saito, Rumiko and Pan, Xiaoqing and Nishikawa, Satoshi and Ito, Shin and Kuroki, Yoko and Tanabe, Osamu and Fuse, Nobuo and Kuriyama, Shinichi and Kiyomoto, Hideyasu and Hozawa, Atsushi and Minegishi, Naoko and Engel, James Douglas and Kinoshita, Kengo and Kure, Shigeo and Yaegashi, Nobuo and Yamamoto, Masayuki and Tsuboi, Akito and Nagami, Fuji and Kawame, Hiroshi and Tomita, Hiroaki and Tsuji, Ichiro and Nakaya, Jun and Sugawara, Junichi and Suzuki, Kichiya and Kikuya, Masahiro and Abe, Michiaki and Nakaya, Naoki and Osumi, Noriko and Yamashita, Riu and Ogishima, Soichi and Takai, Takako and Tominaga, Teiji and Taki, Yasuyuki and Suzuki, Yoichi and ToMMo Japanese Reference Panel and ToMMo Japanese Reference Panel Project
Nature Communications, ISSN 2041-1723, 08/2015, Volume 6, Issue 1, pp. 8018 - 8018
The Tohoku Medical Megabank Organization reports the whole-genome sequences of 1,070 healthy Japanese individuals and construction of a Japanese population... 
GENE | MULTIDISCIPLINARY SCIENCES | RESOLUTION | DISEASE | LOCI | WIDE ASSOCIATION | SPECTRUM | HLA | EXPRESSION | HERITABILITY | REVEALS | Genetic Variation | Haplotypes | Genome, Human | Humans | Asian Continental Ancestry Group - genetics | Index Medicus
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13. Full Text Associations between Socioeconomic Status and the Prevalence and Treatment of Hypercholesterolemia in a General Japanese Population: NIPPON DATA2010
by Fujiyoshi, Naoko and Arima, Hisatomi and Satoh, Atsushi and Ojima, Toshiyuki and Nishi, Nobuo and Okuda, Nagako and Kadota, Aya and Ohkubo, Takayoshi and Hozawa, Atsushi and Nakaya, Naoki and Fujiyoshi, Akira and Okamura, Tomonori and Ueshima, Hirotsugu and Okayama, Akira and Miura, Katsuyuki and NIPPON DATA2010 Res Grp and NIPPON DATA2010 Research Group
Journal of Atherosclerosis and Thrombosis, ISSN 1340-3478, 2018, Volume 25, Issue 7, pp. 606 - 620
Aim: To investigate associations between socioeconomic status (SES) and the prevalence and treatment status of hypercholesterolemia in a general Japanese... 
Hypercholesterolemia | Socioeconomic status | Treatment | Japan | Risk factor | NUTRITION SURVEY | TOTAL CHOLESTEROL | SOCIAL-CONTROL | NATIONAL-HEALTH | MARITAL-STATUS | HIGHER BLOOD-PRESSURE | LESS EDUCATION | PERIPHERAL VASCULAR DISEASE | SEX-DIFFERENCES | CORONARY-HEART-DISEASE | CARDIOVASCULAR RISK-FACTORS | Japan - epidemiology | Multivariate Analysis | Prospective Studies | Cross-Sectional Studies | Humans | Menopause | Middle Aged | Risk Factors | Lipid Metabolism | Male | Social Class | Young Adult | Health Surveys | Aged, 80 and over | Adult | Female | Aged | Hypercholesterolemia - therapy | Odds Ratio | Hypercholesterolemia - epidemiology | Index Medicus | Original
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14. Full Text Prognosis of White-Coat and Masked Hypertension International Database of Home Blood Pressure in Relation to Cardiovascular Outcome
by Stergiou, George S and Asayama, Kei and Thijs, Lutgarde and Kollias, Anastasios and Niiranen, Teemu J and Hozawa, Atsushi and Boggia, Jose and Johansson, Jouni K and Ohkubo, Takayoshi and Tsuji, Ichiro and Jula, Antti M and Imai, Yutaka and Staessen, Jan A and Int Database Home Blood Pressure and International Database on HOme blood pressure in relation to Cardiovascular Outcome (IDHOCO) Investigators
Hypertension, ISSN 0194-911X, 04/2014, Volume 63, Issue 4, pp. 675 - 682
Home blood pressure monitoring is useful in detecting white-coat and masked hypertension and is recommended for patients with suspected or treated... 
meta-analysis | masked hypertension | cardiovascular diseases | white-coat hypertension | prognosis | home blood pressure monitoring | SELF-MEASUREMENT | METAANALYSIS | OHASAMA | TERM | EUROPEAN-SOCIETY | PREDICTION | INDIVIDUALS | GENERAL-POPULATION | STROKE RISK | OFFICE | PERIPHERAL VASCULAR DISEASE | Antihypertensive Agents - pharmacology | Prevalence | Prognosis | Follow-Up Studies | Humans | Middle Aged | Risk Factors | White Coat Hypertension - epidemiology | Male | Masked Hypertension - epidemiology | Treatment Outcome | Antihypertensive Agents - therapeutic use | Masked Hypertension - diagnosis | Cardiovascular Diseases - epidemiology | Masked Hypertension - drug therapy | Adult | Female | Aged | Blood Pressure - drug effects | Blood Pressure - physiology | White Coat Hypertension - diagnosis | White Coat Hypertension - drug therapy | Blood Pressure Monitoring, Ambulatory | Databases, Factual | Index Medicus
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15. Full Text Interethnic analyses of blood pressure loci in populations of East Asian and European descent
by Takeuchi, Fumihiko and Akiyama, Masato and Akiyama, Masato and Matoba, Nana and Matoba, Nana and Katsuya, Tomohiro and Nakatochi, Masahiro and Tabara, Yasuharu and Narita, Akira and Narita, Akira and Saw, Woei-Yuh and Moon, Sanghoon and Moon, Sanghoon and Spracklen, Cassandra N and Chai, Jin-Fang and Kim, Young-Jin and Kim, Young-Jin and Zhang, Liang and Wang, Chaolong and Wang, Chaolong and Li, Huaixing and Li, Honglan and Li, Honglan and Wu, Jer-Yuarn and Dorajoo, Rajkumar and Nierenberg, Jovia L and Wang, Ya Xing and Wang, Ya Xing and He, Jing and Bennett, Derrick A and Bennett, Derrick A and Takahashi, Atsushi and Takahashi, Atsushi and Momozawa, Yukihide and Momozawa, Yukihide and Hirata, Makoto and Hirata, Makoto and Matsuda, Koichi and Matsuda, Koichi and Rakugi, Hiromi and Nakashima, Eitaro and Isono, Masato and Shirota, Matsuyuki and Shirota, Matsuyuki and Hozawa, Atsushi and Ichihara, Sahoko and Matsubara, Tatsuaki and Matsubara, Tatsuaki and Yamamoto, Ken and Yamamoto, Ken and Kohara, Katsuhiko and Igase, Michiya and Han, Sohee and Han, Sohee and Gordon-Larsen, Penny and Gordon-Larsen, Penny and Huang, Wei and Lee, Nanette R and Lee, Nanette R and Adair, Linda S and Hwang, Mi Yeong and Hwang, Mi Yeong and Lee, Juyoung and Lee, Juyoung and Chee, Miao Li and Sabanayagam, Charumathi and Zhao, Wanting and Liu, Jianjun and Reilly, Dermot F and Sun, Liang and Sun, Liang and Huo, Shaofeng and Edwards, Todd L and Long, Jirong and Chang, Li-Ching and Chen, Chien-Hsiun and Chen, Chien-Hsiun and Yuan, Jian-Min and Yuan, Jian-Min and Koh, Woon-Puay and Koh, Woon-Puay and Friedlander, Yechiel and Kelly, Tanika N and Bin Wei, Wen and Xu, Liang and Xu, Liang and Cai, Hui and Cai, Hui and Xiang, Yong-Bing and Lin, Kuang and Lin, Kuang and Clarke, Robert and Clarke, Robert and Walters, Robin G and Millwood, Iona Y and Li, Liming and Li, Liming and Chambers, John C and Chambers, John C and Kooner, Jaspal S and ... and Int Genomics Blood Pressure and International Genomics of Blood Pressure (iGEN-BP) Consortium and The International Genomics of Blood Pressure (iGEN-BP) Consortium
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5052 - 16
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a... 
LINKAGE DISEQUILIBRIUM | METAANALYSIS | RARE VARIANTS | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | ARCHITECTURE | BODY-MASS INDEX | COMMON | FUNCTIONAL ANNOTATION | HERITABILITY | GENOME-WIDE ASSOCIATION | Linkage disequilibrium | Health risks | Blood pressure | Genomes | Gene loci | Cardiovascular diseases | Risk analysis | Minority & ethnic groups | Loci | Ethnic factors | Risk factors | Natural selection | Index Medicus
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