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1. Full Text Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach
by Floegel, Anna and Stefan, Norbert and Yu, Zhonghao and Mühlenbruch, Kristin and Drogan, Dagmar and Joost, Hans-Georg and Fritsche, Andreas and Häring, Hans-Ulrich and De Angelis, Martin Hrabě and Peters, Annette and Roden, Michael and Prehn, Cornelia and Wang-Sattler, Rui and Illig, Thomas and Schulze, Matthias B and Adamski, Jerzy and Boeing, Heiner and Pischon, Tobias
Diabetes (New York, N.Y.), ISSN 0012-1797, 02/2013, Volume 62, Issue 2, pp. 639 - 648
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Glycine - blood | Metabolomics | Phosphatidylcholines - blood | Serum - metabolism | Humans | Middle Aged | Insulin Resistance | Male | Risk | Biomarkers - blood | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Sphingomyelins - blood | Hexoses - blood | Adult | Female | Phenylalanine - blood | Insulin Secretion | Type 2 diabetes | Risk factors (Health) | Metabolites | Physiological aspects | Research | Health aspects | Risk factors | Index Medicus | Abridged Index Medicus | Genetics | Genomes | Proteomics
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2. Full Text Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease
by Finan, Brian and Clemmensen, Christoffer and Zhu, Zhimeng and Stemmer, Kerstin and Gauthier, Karine and Müller, Luisa and De Angelis, Meri and Moreth, Kristin and Neff, Frauke and Perez-Tilve, Diego and Fischer, Katrin and Lutter, Dominik and Sánchez-Garrido, Miguel A and Liu, Peng and Tuckermann, Jan and Malehmir, Mohsen and Healy, Marc E and Weber, Achim and Heikenwalder, Mathias and Jastroch, Martin and Kleinert, Maximilian and Jall, Sigrid and Brandt, Sara and Flamant, Frédéric and Schramm, Karl-Werner and Biebermann, Heike and Döring, Yvonne and Weber, Christian and Habegger, Kirk M and Keuper, Michaela and Gelfanov, Vasily and Liu, Fa and Köhrle, Josef and Rozman, Jan and Fuchs, Helmut and Gailus-Durner, Valerie and Hrabě de Angelis, Martin and Hofmann, Susanna M and Yang, Bin and Tschöp, Matthias H and DiMarchi, Richard and Müller, Timo D
Cell (Cambridge), ISSN 0092-8674, 10/2016, Volume 167, Issue 3, pp. 843 - 857.e14
conjugate | co-agonist | thyroid hormone | polypharmacology | glucagon | dyslipidemia | NASH | obesity | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Triiodothyronine - adverse effects | Obesity - drug therapy | Body Weight - drug effects | Metabolic Diseases - drug therapy | Molecular Targeted Therapy | Hyperglycemia - drug therapy | Bone and Bones - drug effects | Drug Delivery Systems | Liver - drug effects | Triiodothyronine - drug effects | Glucagon - chemistry | Disease Models, Animal | Triiodothyronine - pharmacology | Atherosclerosis - drug therapy | Liver - metabolism | Cholesterol - metabolism | Glucagon - pharmacology | Triiodothyronine - chemistry | Non-alcoholic Fatty Liver Disease - drug therapy | Drug Synergism | Animals | Glucagon - therapeutic use | Mice | Diabetes Mellitus, Type 2 - drug therapy | Chemical Engineering - methods | Glucagon - adverse effects | Drug Combinations | Type 2 diabetes | Physiological aspects | Glucagon | Health aspects | Atherosclerosis | Index Medicus | Life Sciences
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3. Full Text Epigenetic germline inheritance of diet-induced obesity and insulin resistance
by Huypens, Peter and Sass, Steffen and Wu, Moya and Dyckhoff, Daniela and Tschöp, Matthias and Theis, Fabian and Marschall, Susan and De Angelis, Martin Hrabě and Beckers, Johannes
Nature genetics, ISSN 1061-4036, 05/2016, Volume 48, Issue 5, pp. 497 - 499
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Inheritance Patterns | Genetic Predisposition to Disease | Animals | Fertilization in Vitro | Diet, High-Fat | Epigenesis, Genetic | Mice, Inbred C57BL | Insulin Resistance - genetics | Female | Male | Germ Cells | Obesity - genetics | Obesity | Epigenetic inheritance | Genetic susceptibility | Genetic research | Insulin resistance | Genetic aspects | Research | Observations | In vitro fertilization | Diet | Sperm | Epigenetics | Glucose | Insulin | Metabolic disorders | Index Medicus
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4. Full Text Fibroblast Growth Factor 21—Metabolic Role in Mice and Men
by Staiger, Harald and Keuper, Michaela and Berti, Lucia and Hrabě de Angelis, Martin and Häring, Hans-Ulrich
Endocrine reviews, ISSN 0163-769X, 10/2017, Volume 38, Issue 5, pp. 468 - 488
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Bone and Bones | Brain | Obesity | Signal Transduction | Humans | Fibroblast Growth Factors - genetics | Nutritional Physiological Phenomena | Lipid Metabolism | Fatty Liver | Animals | Metabolic Diseases - physiopathology | Glucose - metabolism | Diabetes Mellitus, Type 2 | Exercise - physiology | Mice | Adipose Tissue | Fibroblast Growth Factors - physiology | Fibroblast growth factor | Diabetes mellitus | Lipids | Pharmacology | Glucose | Metabolism | Glucose metabolism | Fibroblasts | Experimentation | Lipid metabolism | Growth factors | Diabetes mellitus (non-insulin dependent) | Metabolic disorders | Index Medicus
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5. Full Text A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
by Simon, Michelle M and Greenaway, Simon and White, Jacqueline K and Fuchs, Helmut and Gailus-Durner, Valérie and Wells, Sara and Sorg, Tania and Wong, Kim and Bedu, Elodie and Cartwright, Elizabeth J and Dacquin, Romain and Djebali, Sophia and Estabel, Jeanne and Graw, Jochen and Ingham, Neil J and Jackson, Ian J and Lengeling, Andreas and Mandillo, Silvia and Marve, Jacqueline and Meziane, Hamid and Preitner, Frédéric and Puk, Oliver and Roux, Michel and Adams, David J and Atkins, Sarah and Ayadi, Abdel and Becker, Lore and Blake, Andrew and Brooker, Debra and Cater, Heather and Champy, Marie-France and Combe, Roy and Danecek, Petr and Di Fenza, Armida and Gates, Hilary and Gerdin, Anna-Karin and Golini, Elisabetta and Hancock, John M and Hans, Wolfgang and Hölter, Sabine M and Hough, Tertius and Jurdic, Pierre and Keane, Thomas M and Morgan, Hugh and Müller, Werner and Neff, Frauke and Nicholson, George and Pasche, Bastian and Roberson, Laura-Anne and Rozman, Jan and Sanderson, Mark and Santos, Luis and Selloum, Mohammed and Shannon, Carl and Southwel, Anne and Tocchini-Valentini, Glauco P and Vancollie, Valerie E and Westerberg, Henrik and Wurst, Wolfgang and Zi, Min and Yalcin, Binnaz and Ramirez-Solis, Ramiro and Steel, Karen P and Mallon, Ann-Marie and De Angelis, Martin Hrabe and Herault, Yann and Brown, Steve D.M
Genome Biology, ISSN 1474-7596, 2013, Volume 14, Issue 7, pp. R82 - R82
Mouse phenotyping | Sequence variation | Gene knockout | C57BL/6 | Mouse inbred lines | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Eye - pathology | Spleen - immunology | Mice, Inbred C57BL | Genome - genetics | Hypersensitivity - immunology | INDEL Mutation - genetics | Male | Disease Resistance - immunology | Femur - diagnostic imaging | X-Ray Microtomography | Behavior, Animal | Phenotype | Animals | Maze Learning | Listeriosis - immunology | Killer Cells, Natural - immunology | Polymorphism, Single Nucleotide - genetics | Female | Listeriosis - microbiology | Index Medicus | Life Sciences | Genetics | Biochemistry, Molecular Biology | Genomics | mouse phenotyping | gene knockout | C57BL | 6 | sequence variation | Research
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6. Full Text Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors
by Gispert, S and Parganlija, D and Klinkenberg, M and se, S and Wittig, I and Mittelbronn, M and Grzmil, P and Koob, S and Hamann, A and Walter, M and Buchel, F and Adler, T and Angelis, M. Hrabe de and Busch, D.H and Zell, A and Reichert, A.S and Brandt, U and Osiewacz, H.D and Jenach, M and Auburger, G
Human molecular genetics, ISSN 0964-6906, 2013, Volume 22, Issue 24, pp. 4871 - 4887
Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | T-Lymphocyte Subsets - immunology | Molecular Chaperones - metabolism | Gonads - pathology | Male | Infertility - genetics | Hearing Loss - metabolism | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Cell Respiration - genetics | Mitochondria - genetics | Infertility - metabolism | Inflammation Mediators - metabolism | Female | Gene Order | Disease Models, Animal | DNA, Mitochondrial - metabolism | Endopeptidase Clp - genetics | Endopeptidase Clp - metabolism | Mitochondria - metabolism | Spleen - cytology | Mice, Knockout | Hearing Loss - genetics | Motor Activity - genetics | Gonads - metabolism | Phenotype | Animals | Growth Disorders - metabolism | Spleen - metabolism | T-Lymphocyte Subsets - metabolism | Mice | Mutation | Growth Disorders - genetics | Index Medicus | Animal models
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