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1. Standards of mouse model phenotyping
by Hrabé de Angelis, Martin and Chambon, Pierre and Brown, Stephen D. M
2006, 1. Aufl., ISBN 9783527310319, xxvi, 331
This is the first book in the field of mouse genetics to provide comprehensive and standardized methods for the characterization of laboratory mice. The editor... 
Phenotype | genetics | Transgenic mice | Mice, Transgenic | Mice | Mice as laboratory animals | Disease Models, Animal | Genetics
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2. Full Text Correction: From Dynamic Expression Patterns to Boundary Formation in the Presomitic Mesoderm
by Tiedemann, Hendrik B and Schneltzer, Elida and Zeiser, Stefan and Hoesel, Bastian and Beckers, Johannes and Przemeck, Gerhard K H and de Angelis, Martin HrabÄ›
PLoS computational biology, ISSN 1553-7358, 07/2019, Volume 15, Issue 7, p. e1007191
[This corrects the article DOI: 10.1371/journal.pcbi.1002586.]. 
Mesoderm
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3. Full Text Modeling coexistence of oscillation and Delta/Notch-mediated lateral inhibition in pancreas development and neurogenesis
by Tiedemann, Hendrik B and Schneltzer, Elida and Beckers, Johannes and Przemeck, Gerhard K.H and HrabÄ› de Angelis, Martin
Journal of Theoretical Biology, ISSN 0022-5193, 10/2017, Volume 430, pp. 32 - 44
During pancreas development, positive endocrine progenitors are specified by Delta/Notch (D/N) mediated lateral inhibition in the growing ducts. During... 
Neurog3 | Endocrine progenitor | Simulation | Pancreatogenesis | Cycling gene expression | PROGENITOR CELLS | ISLET DIFFERENTIATION | MOUSE | NOTCH | ORGANOGENESIS | MORPHOGENESIS | ENDOCRINE PROGENITORS | GROWTH | BIOLOGY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | GENE-EXPRESSION | LINEAGE | Basic Helix-Loop-Helix Transcription Factors - physiology | Nerve Tissue Proteins - physiology | Receptors, Notch - physiology | Neurogenesis | Cell Lineage | Feedback, Physiological | Animals | Pancreas - innervation | Gene Expression Regulation, Developmental | Models, Biological | Body Patterning | Mice | Pancreas - growth & development | Endocrine System - cytology | Transcription Factor HES-1 - physiology | Oscillometry | Models | Gene expression | Neurons | Analysis | Genes
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4. Full Text Prediction of glucose tolerance without an oral glucose tolerance test
by Babbar, Rohit and Heni, Martin and Peter, Andreas and de Angelis, Martin Hrabě and Häring, Hans-Ulrich and Fritsche, Andreas and Preissl, Hubert and Schölkopf, Bernhard and Wagner, Róbert
Frontiers in Endocrinology, ISSN 1664-2392, 03/2018, Volume 9, p. 82
Introduction: Impaired glucose tolerance (IGT) is diagnosed by a standardized oral glucose tolerance test (OGTT). However, the OGTT is laborious, and when not... 
Oral glucose tolerance test | Supervised machine learning | Machine learning classification | Classification | Prediction | Impaired glucose tolerance | Test-retest variability | Clinical study | clinical study | supervised machine learning | POPULATION | oral glucose tolerance test | CHOLESTEROL | impaired glucose tolerance | PREVALENCE | classification | machine learning classification | INSULIN SENSITIVITY | REPRODUCIBILITY | test-retest variability | RISK-FACTOR | ENDOCRINOLOGY & METABOLISM | prediction | CARDIOVASCULAR-DISEASE | IMPAIRED FASTING GLUCOSE | COMPLICATIONS | ASSOCIATION
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5. Full Text Schneller vom Labor zum Patienten
by HrabÄ› de Angelis, Martin
Info Diabetologie, ISSN 1865-5459, 06/2019, Volume 13, Issue 3, pp. 47 - 47
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6. Pharmacogenetics of oral antidiabetic therapy
by Ordelheide, Anna-Maria and Hrabě De Angelis, Martin and Häring, Hans-Ulrich and Staiger, Harald
Pharmacogenomics, ISSN 1462-2416, 04/2018, Volume 19, Issue 6, pp. 577 - 587
Type 2 diabetes prevalence is still on the rise worldwide. Antidiabetic drugs are widely prescribed to patients with Type 2 diabetes. Most patients start with... 
Type 2 diabetes | interindividual differences | OAD | oral antidiabetic drugs | T2D
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7. Full Text Erratum: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression
by Eden, Matthias and Meder, Benjamin and Völkers, Mirko and Poomvanicha, Montatip and Domes, Katrin and Branchereau, M and Marck, P and Will, Rainer and Bernt, Alexander and Rangrez, Ashraf and Busch, Matthias and Hrabě de Angelis, Martin and Heymes, Christophe and Rottbauer, Wolfgang and Most, Patrick and Hofmann, Franz and Frey, Norbert
Nature communications, ISSN 2041-1723, 05/2016, Volume 7, Issue 1, p. 11835
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8. Full Text Genomic characterization of mutant laboratory mouse strains by exome sequencing and annotation lift-over
by Derdak, Sophia and Sabrautzki, Sibylle and de Angelis, Martin HrabÄ› and Gut, Marta and Gut, Ivo G and Beltran, Sergi
BMC Genomics, ISSN 1471-2164, 05/2015, Volume 16, Issue 1, pp. 351 - 351
Background: Exome sequencing has become a popular method to evaluate undirected mutagenesis experiments in mice. However, the most suitable mouse strain for... 
Phenotype | Annotations | Mutagenesis | Exome sequencing | Mouse strains | Genomic variants | Sequence homology | ENU MUTAGENESIS | FORMAT | SPERMATOZOA | ALIGNMENT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MUTATION | GENETICS & HEREDITY | MICE | WIDE | TOOL | Exome - genetics | Animals | Laboratories | Molecular Sequence Annotation | Female | Male | Mice | Mutation | Genomics - methods | Sequence Analysis, DNA - methods | Gene mutations | Identification and classification | Innovations | Analysis | Genes | Biotechnology industry | Index Medicus
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9. Full Text Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe β-Cell Loss in Munich Ins2C95S Mutant Mice
by Nadja Herbach and Birgit Rathkolb and Elisabeth Kemter and Lisa Pichl and Matthias Klaften and Martin Hrabé de Angelis and Philippe A. Halban and Eckhard Wolf and Bernhard Aigner and Ruediger Wanke
Diabetes, ISSN 0012-1797, 05/2007, Volume 56, Issue 5, pp. 1268 - 1276
Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe β-Cell Loss in Munich Ins2 C95S Mutant Mice Nadja Herbach 1 ,... 
Diabetes Mellitus, Type 1 - epidemiology | Prevalence | Humans | Diabetes Mellitus, Type 1 - pathology | Diabetes Mellitus, Type 1 - genetics | Pancreas - pathology | Chromosome Mapping | Insulin - blood | Mice, Inbred C3H | DNA - genetics | Homozygote | Animals | Diabetes Mellitus, Type 1 - blood | Mice | Insulin-Secreting Cells - pathology | Blood Glucose - metabolism | Insulin - genetics | Genetic Carrier Screening
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10. Full Text Epigenetic germline inheritance of diet-induced obesity and insulin resistance
by Huypens, Peter and Sass, Steffen and Wu, Moya and Dyckhoff, Daniela and Tschöp, Matthias and Theis, Fabian and Marschall, Susan and De Angelis, Martin Hrabě and Beckers, Johannes
Nature Genetics, ISSN 1061-4036, 05/2016, Volume 48, Issue 5, pp. 497 - 499
There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the... 
Inheritance Patterns | Genetic Predisposition to Disease | Animals | Fertilization in Vitro | Diet, High-Fat | Epigenesis, Genetic | Mice, Inbred C57BL | Insulin Resistance - genetics | Female | Male | Germ Cells | Obesity - genetics | Obesity | Epigenetic inheritance | Genetic susceptibility | Genetic research | Insulin resistance | Genetic aspects | Research | Observations | In vitro fertilization | Diet | Sperm | Epigenetics | Glucose | Insulin | Metabolic disorders
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11. Full Text Expression of tas1 taste receptors in mammalian spermatozoa: Functional role of tas1r1 in regulating basal ca 2+ and camp concentrations in spermatozoa
by Meyer, Dorke and Voigt, Anja and Widmayer, Patricia and Borth, Heike and Huebner, Sandra and Breit, Andreas and Marschall, Susan and de Angelis, Martin Hrabé and Boehm, Ulrich and Meyerhof, Wolfgang and Gudermann, Thomas and Boekhoff, Ingrid
PLoS ONE, 02/2012, Volume 7, Issue 2
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12. Full Text Impact of Brain Fatty Acid Signaling on Peripheral Insulin Action in Mice
by Neschen, Susanne and Wu, Moya and Fuchs, Christiane and Kondofersky, Ivan and Theis, Fabian J and de Angelis, Martin Hrabě and Häring, Hans-Ulrich and Sartorius, Tina
Experimental and Clinical Endocrinology & Diabetes, ISSN 0947-7349, 11/2018
Abstract Aims and Methods Glucose homeostasis and energy balance are under control by peripheral and brain processes. Especially insulin signaling in the brain... 
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13. Full Text Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach
by Floegel, Anna and Stefan, Norbert and Yu, Zhonghao and Mühlenbruch, Kristin and Drogan, Dagmar and Joost, Hans-Georg and Fritsche, Andreas and Häring, Hans-Ulrich and De Angelis, Martin Hrabě and Peters, Annette and Roden, Michael and Prehn, Cornelia and Wang-Sattler, Rui and Illig, Thomas and Schulze, Matthias B and Adamski, Jerzy and Boeing, Heiner and Pischon, Tobias
Diabetes, ISSN 0012-1797, 02/2013, Volume 62, Issue 2, pp. 639 - 648
Metabolomic discovery of biomarkers of type 2 diabetes (T2D) risk may reveal etiological pathways and help to identify individuals at risk for disease. We... 
OXIDATION | AMINO-ACID-METABOLISM | FETUIN-A LEVELS | OBESITY | EPIC-GERMANY | KORA S4/F4 COHORT | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | NUTRITION (EPIC)-POTSDAM | DIETARY | MELLITUS | Glycine - blood | Metabolomics | Phosphatidylcholines - blood | Serum - metabolism | Humans | Middle Aged | Insulin Resistance | Male | Risk | Biomarkers - blood | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Sphingomyelins - blood | Hexoses - blood | Adult | Female | Phenylalanine - blood | Insulin Secretion | Type 2 diabetes | Risk factors (Health) | Metabolites | Physiological aspects | Research | Health aspects | Risk factors | Genetics | Genomes | Proteomics
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14. Full Text 04.17 TnfΔare/+: a multimorbidity model of spondyloarthropathies
by Denis, Maria C and Karagianni, Niki and Consortium, German Mouse Clinic and Fuchs, Helmut and Galius-Durner, Valerie and de Angelis, Martin HrabÄ› and Ntari, Lydia and Sakkou, Maria and Kollias, George
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2017, Volume 76, Issue Suppl 1, p. A49
BackgroundSpondyloarthropathies are a group of joint-related diseases with burden extending to multiple organs. Co-existing conditions have a major impact on... 
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15. Full Text Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides
by Benedikt Wefers and Melanie Meyer and Oskar Ortiz and Martin Hrabé de Angelis and Jens Hansen and Wolfgang Wurst and Ralf Kühn
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2013, Volume 110, Issue 10, pp. 3782 - 3787
The study of genetic disease mechanisms relies mostly on targeted mouse mutants that are derived from engineered embryonic stem (ES) cells. Nevertheless, the... 
Polymerase chain reaction | Disease models | Genetic vectors | Exons | DNA | Alleles | Genomes | Embryos | Genetic mutation | Pups | Knockin | Gene targeting | Knockout | Mouse genetics | knockout | EFFECTORS | knockin | MULTIDISCIPLINARY SCIENCES | gene targeting | mouse genetics | RAB38 | MICE | MUTATIONS | ZINC-FINGER NUCLEASES | GENOME | DISCOVERY | Oligodeoxyribonucleotides - administration & dosage | Humans | Genetic Diseases, Inborn - genetics | Molecular Sequence Data | Male | rab GTP-Binding Proteins - genetics | Mutation, Missense | Cleavage Stage, Ovum | Deoxyribonucleases - administration & dosage | Oligodeoxyribonucleotides - genetics | Base Sequence | HEK293 Cells | Germ-Line Mutation | Female | Disease Models, Animal | Amino Acid Sequence | Microinjections | Mice, Transgenic | Genetic Techniques | Sequence Homology, Nucleic Acid | Pregnancy | Deoxyribonucleases - genetics | Animals | Mutagenesis | Mice | Genetic Vectors | Embryonic development | Transcription factors | Oligodeoxynucleotides | Gene mutations | Physiological aspects | Genetic aspects | Research | Health aspects | Biological Sciences
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16. Full Text Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases
by Melanie Meyer and Martin Hrabé de Angelis and Wolfgang Wurst and Ralf Kühn and Pierre Chambon
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 34, pp. 15022 - 15026
Gene targeting by homologous recombination in embryonic stem cells is extensively used to generate specific mouse mutants. However, most mammalian species lack... 
Polymerase chain reaction | Zygotes | Gene targeting | Genetic vectors | DNA probes | DNA | Genomics | Homologous recombination | Fetus | Genetic loci | MICE | MAMMALIAN-CELLS | EXPRESSION | MULTIDISCIPLINARY SCIENCES | KNOCKOUT RATS | Embryonic Stem Cells - metabolism | Gene Targeting - methods | Zinc Fingers | RNA, Untranslated | Bacterial Proteins - genetics | Zygote - metabolism | Molecular Sequence Data | Mice, Transgenic | Endonucleases - metabolism | Mice, Knockout | DNA - genetics | Pregnancy | Proteins - genetics | Animals | Recombination, Genetic | Base Sequence | Female | Luminescent Proteins - genetics | Mice | Genetic Vectors | Genes, Reporter | Genetic recombination | Observations | homologous recombination | Embryo cells | Stem cells | genomics | Gene manipulation | Nuclease | Biological Sciences
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17. Full Text FMT-XCT: In vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography
by Ale, Angelique and Ermolayev, Vladimir and Herzog, Eva and Cohrs, Christian and De Angelis, Martin Hrabé and Ntziachristos, Vasilis
Nature Methods, ISSN 1548-7091, 06/2012, Volume 9, Issue 6, pp. 615 - 620
The development of hybrid optical tomography methods to improve imaging performance has been suggested over a decade ago and has been experimentally... 
LUNG-CANCER | DIFFUSE OPTICAL TOMOGRAPHY | MRI | PET/CT | BIOCHEMICAL RESEARCH METHODS | MODEL | REGULARIZATION | BREAST | Head and Neck Neoplasms - diagnostic imaging | Fluorescence | Tomography, Optical - methods | Tomography, X-Ray Computed - methods | Lung Neoplasms - pathology | Osteogenesis Imperfecta - diagnostic imaging | Image Processing, Computer-Assisted - methods | Equipment Design | Mammary Neoplasms, Experimental - diagnostic imaging | Head and Neck Neoplasms - pathology | Animals | Mammary Neoplasms, Experimental - pathology | Female | Lung Neoplasms - diagnostic imaging | Osteogenesis Imperfecta - pathology | Mice | Bone Remodeling | Disease Models, Animal | CT imaging | Usage | SPECT imaging | Diagnosis | Research | Cancer | Tomography | Scientific imaging | Optical measuring instruments
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18. Full Text Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease
by Finan, Brian and Clemmensen, Christoffer and Zhu, Zhimeng and Stemmer, Kerstin and Gauthier, Karine and Müller, Luisa and Müller, Timo D and De Angelis, Meri and Moreth, Kristin and Neff, Frauke and Perez-Tilve, Diego and Fischer, Katrin and Lutter, Dominik and Sánchez-Garrido, Miguel A and Liu, Fa and Liu, Peng and Tuckermann, Jan and Malehmir, Mohsen and Healy, Marc E and Weber, Christian and Weber, Achim and Heikenwalder, Mathias and Jastroch, Martin and Kleinert, Maximilian and Jall, Sigrid and Brandt, Sara and Flamant, Frédéric and Schramm, Karl-Werner and Biebermann, Heike and Döring, Yvonne and Habegger, Kirk M and Keuper, Michaela and Gelfanov, Vasily and Köhrle, Josef and Rozman, Jan and Fuchs, Helmut and Gailus-Durner, Valerie and Hrabě de Angelis, Martin and Hofmann, Susanna M and Yang, Bin and Tschöp, Matthias H and DiMarchi, Richard
Cell, ISSN 0092-8674, 10/2016, Volume 167, Issue 3, pp. 843 - 857.e14
Glucagon and thyroid hormone (T ) exhibit therapeutic potential for metabolic disease but also exhibit undesired effects. We achieved synergistic effects of... 
conjugate | co-agonist | thyroid hormone | polypharmacology | glucagon | dyslipidemia | NASH | obesity | BODY-WEIGHT | ACTIVATION | OBESITY | TRIIODOTHYRONINE | CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATHEROSCLEROSIS | RECEPTOR | GROWTH-FACTOR 21 | FGF21 | PROTECTS | CELL BIOLOGY | Triiodothyronine - adverse effects | Obesity - drug therapy | Body Weight - drug effects | Metabolic Diseases - drug therapy | Molecular Targeted Therapy | Hyperglycemia - drug therapy | Bone and Bones - drug effects | Drug Delivery Systems | Liver - drug effects | Triiodothyronine - drug effects | Glucagon - chemistry | Disease Models, Animal | Triiodothyronine - pharmacology | Atherosclerosis - drug therapy | Liver - metabolism | Cholesterol - metabolism | Glucagon - pharmacology | Triiodothyronine - chemistry | Non-alcoholic Fatty Liver Disease - drug therapy | Drug Synergism | Animals | Glucagon - therapeutic use | Mice | Diabetes Mellitus, Type 2 - drug therapy | Chemical Engineering - methods | Glucagon - adverse effects | Drug Combinations | Type 2 diabetes | Physiological aspects | Glucagon | Health aspects | Atherosclerosis | Life Sciences
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19. Full Text Genetics meets metabolomics: A genome-wide association study of metabolite profiles in human serum
by Gieger, Christian and Geistlinger, Ludwig and Altmaier, Elisabeth and