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Medicinal Chemistry, ISSN 1573-4064, 05/2018, Volume 14, Issue 3, pp. 281 - 292
Background: In the last decade, the concept of uncharged reactivators potentially able to penetrate the CNS has been introduced as an alternative to the... 
Organophosphate | Non-quaternary oximes | Anxiety | Quaternary oximes | Acetylcholinesterase | Neurotransmission | Oxime reactivators | organophosphate | EFFICIENT UNCHARGED REACTIVATORS | CHEMISTRY, MEDICINAL | neurotransmission | acetylcholinesterase | TOXICITY | HI-6 | BLOOD-BRAIN-BARRIER | quaternary oximes | non-quaternary oximes | PHOSPHYLATED CHOLINESTERASES | ALDOXIME | ACTING OXIME REACTIVATORS | NERVE AGENTS | oxime reactivators | PRALIDOXIME | INHIBITED HUMAN ACETYLCHOLINESTERASE | Antidotes - pharmacology | Antidotes - toxicity | Antidotes - chemical synthesis | Cholinesterase Reactivators - chemical synthesis | Cholinesterase Inhibitors - toxicity | Cholinesterase Reactivators - pharmacology | Rats | Sarin - toxicity | Organophosphate Poisoning - drug therapy | Cholinesterase Inhibitors - chemical synthesis | Oximes - chemical synthesis | Blood-Brain Barrier - drug effects | Paraoxon - toxicity | Animals | Oximes - toxicity | Cholinesterase Inhibitors - pharmacology | Butyrylcholinesterase - metabolism | Computer Simulation | Oximes - pharmacology | Cholinesterase Reactivators - toxicity | Mice | Organophosphates - toxicity | Oximes | Antidotes | Toxicity | Quaternary | Central nervous system | Affinity | Biocompatibility | Activation | Poisoning | Bioavailability | Physicochemical properties | Lipophilicity | Index Medicus
Journal Article
Journal Article
Molecules, ISSN 1420-3049, 06/2017, Volume 22, Issue 6, p. 1006
A novel series of 6-chlorotacrine-scutellarin hybrids was designed, synthesized and the biological activity as potential anti-Alzheimer’s agents was assessed.... 
Scutellarin | Enzyme inhibitor | 6-chlorotacrine | Alzheimer’s disease | Acetylcholinesterase | Butyrylcholinesterase | Antioxidants | Hybrids | Blood-brain barrier | Docking | Tacrine | Biological activity
Journal Article
Letters in Drug Design and Discovery, ISSN 1570-1808, 2018, Volume 15, Issue 8, pp. 822 - 827
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 5, p. 1103
Nerve agents and oxon forms of organophosphorus pesticides act as strong irreversible inhibitors of two cholinesterases in the human body: acetylcholinesterase... 
Oxime | Organophosphate | Acetylcholinesterase | Antidote | Butyrylcholinesterase | Paraoxon | organophosphate | butyrylcholinesterase | BIOCHEMISTRY & MOLECULAR BIOLOGY | acetylcholinesterase | ANTIDOTES | oxime | CHEMISTRY, MULTIDISCIPLINARY | INTOXICATION | PESTICIDES | NERVE AGENTS | IN-VITRO | antidote | OXIME-ASSISTED REACTIVATION | DIMETHANESULFONATE | paraoxon | CHOLINESTERASES | Antidotes - chemical synthesis | Cholinesterase Reactivators - chemical synthesis | Insecticides - chemistry | Cholinesterase Reactivators - pharmacology | Humans | Cholinesterase Inhibitors - chemistry | Obidoxime Chloride - pharmacology | Paraoxon - antagonists & inhibitors | Structure-Activity Relationship | Paraoxon - toxicity | Thermodynamics | Butyrylcholinesterase - chemistry | Protein Interaction Domains and Motifs | Erythrocytes - enzymology | Antidotes - pharmacology | Protein Structure, Secondary | Obidoxime Chloride - chemistry | Enzyme Assays | Acetylcholinesterase - chemistry | Oximes - chemical synthesis | Erythrocytes - drug effects | Insecticides - antagonists & inhibitors | Oximes - pharmacology | Protein Binding | Paraoxon - chemistry | Molecular Docking Simulation | Insecticides - toxicity | Oximes | Antidotes | Pesticides | Pyridinium | Activation | HI-6 | Rings (mathematics) | Organic chemistry | Anticholinergics | Obidoxime | Docking | Organophosphorus pesticides | Inhibition | Nerve agents
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2015, Volume 58, Issue 22, pp. 8985 - 9003
Journal Article
Chemistry & Biodiversity, ISSN 1612-1872, 01/2016, Volume 13, Issue 1, pp. 91 - 99
Journal Article
Molecules, ISSN 1420-3049, 04/2019, Volume 24, Issue 7, p. 1307
Twelve derivatives 1a-1m of the β-crinane-type alkaloid haemanthamine were developed. All the semisynthetic derivatives were studied for their inhibitory... 
docking studies | butyrylcholinesterase | Alzheimer’s disease | glycogen synthase kinase-3β inhibition | acetylcholinesterase | haemanthamine | Amaryllidaceae
Journal Article
ChemMedChem, ISSN 1860-7179, 06/2016, Volume 11, Issue 12, pp. 1264 - 1269
Novel indolotacrine analogues were designed, synthesized, and evaluated as potential drugs for the treatment of Alzheimer's disease. By using a... 
inhibitors | multitarget-directed ligands | cholinesterases | Alzheimer's disease | cytotoxicity | monoamine oxidase | MONOAMINE-OXIDASE | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | MULTIPOTENT | DONEPEZIL | CHOLINERGIC HYPOTHESIS | POTENTIAL TREATMENT | PHARMACOLOGY & PHARMACY | CHOLINESTERASE/MONOAMINE OXIDASE-INHIBITORS | PHARMACOLOGICAL EVALUATION | AGGREGATION | HYBRIDS | Cholinesterase Inhibitors - toxicity | Humans | Indoles - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Tacrine - therapeutic use | Monoamine Oxidase - chemistry | Indoles - metabolism | Cholinesterase Inhibitors - metabolism | Drug Design | Inhibitory Concentration 50 | Quinolines - toxicity | Tacrine - chemistry | Monoamine Oxidase Inhibitors - therapeutic use | Cell Survival - drug effects | Tacrine - metabolism | Quinolines - chemistry | Alzheimer Disease - drug therapy | Indoles - toxicity | Acetylcholinesterase - chemistry | Blood-Brain Barrier - metabolism | Hep G2 Cells | Quinolines - chemical synthesis | Quinolines - metabolism | Monoamine Oxidase Inhibitors - toxicity | Monoamine Oxidase Inhibitors - metabolism | Indoles - therapeutic use | Ligands | Quinolines - therapeutic use | Cholinesterase Inhibitors - therapeutic use | Indoles - chemistry | Acetylcholinesterase - metabolism | Monoamine Oxidase - metabolism | Tacrine - toxicity | Antioxidants | Monoamine oxidase | Permeability | Drug therapy | Analysis | Index Medicus
Journal Article
Molecules, ISSN 1420-3049, 07/2017, Volume 22, Issue 7, p. 1181
Alzheimer's disease is an age-related, neurodegenerative disorder, characterized by cognitive impairment and restrictions in activities of daily living. This... 
Argemone platyceras | Alkaloids | Acetylcholinesterase | Butyrylcholinesterase | Alzheimer's disease | Prolyl oligopeptidase | DRUG | butyrylcholinesterase | prolyl oligopeptidase | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | alkaloids | ENDOPEPTIDASE INHIBITOR | ISOQUINOLINE ALKALOIDS | acetylcholinesterase | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | QUATERNARY ALKALOIDS | TURKISH PLANTS | LINK | ACETYLCHOLINESTERASE INHIBITORS | Plant Extracts - chemistry | Alkaloids - pharmacology | Magnetic Resonance Spectroscopy - methods | Chromatography, Thin Layer - methods | Humans | Alkaloids - isolation & purification | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Enzyme Assays - methods | Cholinesterases - drug effects | Drug Discovery | Serine Endopeptidases - drug effects | Dose-Response Relationship, Drug | Enzyme Inhibitors - chemistry | Plant Roots - chemistry | Butyrylcholinesterase - drug effects | Inhibitory Concentration 50 | Argemone - chemistry | Alkaloids - chemistry | Nuclear magnetic resonance--NMR | Cognitive ability | Blood plasma | Spectrometry | Optical properties | Dementia disorders | Inhibition | Age | Columns (structural) | Recombinant | Activities of daily living | Chloroform | Ethanol | Neurodegenerative diseases | Medical treatment | Cholinesterase | Aluminum oxide | Oligopeptidase | Thin layer chromatography | Organic chemistry | Gasoline | Thin-layer chromatography | Optical rotation | Index Medicus | Alzheimer’s disease
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 250 - 262
Multi-target drug discovery is one of the most followed approaches in the active central nervous system (CNS) therapeutic area, especially in the search for... 
Neuroinflammation | Amyloid | Acetylcholinesterase | Alzheimer's disease | Multitarget compounds | DESIGN | CHEMISTRY, MEDICINAL | MULTITARGET DRUG DISCOVERY | NATURAL-PRODUCTS | NEURODEGENERATIVE DISEASES | POLYPHARMACOLOGY | BIOLOGICAL EVALUATION | AGENTS | ACETYLCHOLINESTERASE INHIBITORS | DERIVATIVES | AGGREGATION | Neuroprotective Agents - therapeutic use | Antioxidants - chemistry | Antioxidants - metabolism | Humans | Cholinesterase Inhibitors - chemistry | Stilbenes - chemistry | Molecular Targeted Therapy | Tacrine - therapeutic use | Tacrine - pharmacology | Neuroprotective Agents - pharmacology | Cholinesterase Inhibitors - metabolism | Liver - drug effects | Butyrylcholinesterase - metabolism | Drug Design | Tacrine - chemistry | Protein Aggregates - drug effects | Tacrine - metabolism | Neuroprotective Agents - chemistry | Alzheimer Disease - drug therapy | Rats | Antioxidants - pharmacology | Blood-Brain Barrier - metabolism | Antioxidants - therapeutic use | Peptide Fragments - chemistry | Animals | Cholinesterase Inhibitors - pharmacology | Alzheimer Disease - metabolism | Ligands | Amyloid beta-Peptides - chemistry | Cholinesterase Inhibitors - therapeutic use | Acetylcholinesterase - metabolism | Antioxidants | Analysis | Pharmacy | Resveratrol | Drugstores | Drug discovery | Permeability | Health aspects | Target marketing | Index Medicus
Journal Article
Molecules, ISSN 1420-3049, 07/2017, Volume 22, Issue 8, p. 1265
Tacrine (THA), the first clinically effective acetylcholinesterase (AChE) inhibitor and the first approved drug for the treatment of Alzheimer’s disease (AD),... 
Side effects | Inhibitors | Neurodegenerative diseases | Fragments | Amalgamation | Acetylcholinesterase | Huperzine A | Hepatotoxicity | Alzheimer's disease | Tacrine | 7-MEOTA | butyrylcholinesterase | Alzheimer’s disease | tacrine | 2-methoxyhuprine | acetylcholinesterase | huprine Y
Journal Article
Journal Article