Annals of Internal Medicine, ISSN 0003-4819, 10/2016, Volume 165, Issue 7, pp. 473 - 481
Background: Trends in the prevalence of chronic kidney disease (CKD) are important for health care policy and planning. Objective: To update trends in CKD...
MEDICINE, GENERAL & INTERNAL | NUTRITION EXAMINATION SURVEY | CREATININE | BLOOD-PRESSURE CONTROL | NATIONAL-HEALTH | US ADULTS | RISK | TEMPORAL TRENDS | HYPERTENSION | STAGE RENAL-DISEASE | PROGRESSION | United States - epidemiology | Glomerular Filtration Rate | Prevalence | Cross-Sectional Studies | Nutrition Surveys | Humans | Middle Aged | Male | Albuminuria | Renal Insufficiency, Chronic - epidemiology | Time Factors | Aged, 80 and over | Creatinine - blood | Adult | Female | Renal Insufficiency, Chronic - diagnosis | Aged | Medical policy | Kidney diseases | Analysis | Risk factors | Prevalence studies (Epidemiology)
MEDICINE, GENERAL & INTERNAL | NUTRITION EXAMINATION SURVEY | CREATININE | BLOOD-PRESSURE CONTROL | NATIONAL-HEALTH | US ADULTS | RISK | TEMPORAL TRENDS | HYPERTENSION | STAGE RENAL-DISEASE | PROGRESSION | United States - epidemiology | Glomerular Filtration Rate | Prevalence | Cross-Sectional Studies | Nutrition Surveys | Humans | Middle Aged | Male | Albuminuria | Renal Insufficiency, Chronic - epidemiology | Time Factors | Aged, 80 and over | Creatinine - blood | Adult | Female | Renal Insufficiency, Chronic - diagnosis | Aged | Medical policy | Kidney diseases | Analysis | Risk factors | Prevalence studies (Epidemiology)
Journal Article
Cancer and Metastasis Reviews, ISSN 0167-7659, 12/2016, Volume 35, Issue 4, pp. 575 - 588
Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660 women in the USA will be diagnosed with breast cancer in 2016. Breast...
Biomedicine, general | Targeted therapies | Biomedicine | Cancer Research | Oncology | Breast cancer | Drug resistance | Receptor tyrosine kinases | TRASTUZUMAB RESISTANCE | PROGNOSTIC VALUE | ESTROGEN-RECEPTOR | ANAPLASTIC LYMPHOMA KINASE | CELL LUNG-CANCER | NUCLEAR-LOCALIZATION | ONCOLOGY | EPIDERMAL-GROWTH-FACTOR | C-MET | GENE AMPLIFICATION | INTRACELLULAR DOMAIN | Breast Neoplasms - enzymology | Receptor, Epidermal Growth Factor - metabolism | Humans | Receptor, ErbB-2 - metabolism | Drug Resistance, Neoplasm | Female | Receptor Protein-Tyrosine Kinases - metabolism | Breast Neoplasms - drug therapy | Tyrosine | Medical colleges | DNA replication | Mortality | Phenols | Development and progression | Phosphotransferases
Biomedicine, general | Targeted therapies | Biomedicine | Cancer Research | Oncology | Breast cancer | Drug resistance | Receptor tyrosine kinases | TRASTUZUMAB RESISTANCE | PROGNOSTIC VALUE | ESTROGEN-RECEPTOR | ANAPLASTIC LYMPHOMA KINASE | CELL LUNG-CANCER | NUCLEAR-LOCALIZATION | ONCOLOGY | EPIDERMAL-GROWTH-FACTOR | C-MET | GENE AMPLIFICATION | INTRACELLULAR DOMAIN | Breast Neoplasms - enzymology | Receptor, Epidermal Growth Factor - metabolism | Humans | Receptor, ErbB-2 - metabolism | Drug Resistance, Neoplasm | Female | Receptor Protein-Tyrosine Kinases - metabolism | Breast Neoplasms - drug therapy | Tyrosine | Medical colleges | DNA replication | Mortality | Phenols | Development and progression | Phosphotransferases
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2017, Volume 23, Issue 14, pp. 3711 - 3720
Purpose: To explore whether a cross-talk exists between PARP inhibition and PD-L1/PD-1 immune checkpoint axis, and determine whether blockade of PD-L1/PD-1...
CELL LUNG-CANCER | BREAST-CANCER | OVEREXPRESSION | ACTIVATION | THERAPY | PEMBROLIZUMAB | ONCOLOGY | OVARIAN-CANCER | PROVIDES | COMBINATION | CHEMOTHERAPY | Tumor Microenvironment - drug effects | Poly (ADP-Ribose) Polymerase-1 - immunology | Breast Neoplasms - immunology | Humans | Poly(ADP-ribose) Polymerase Inhibitors - immunology | Lymphocytes, Tumor-Infiltrating - drug effects | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Breast Neoplasms - drug therapy | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Tumor Microenvironment - immunology | Xenograft Model Antitumor Assays | Immunosuppression | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Female | Mice | Gene Expression Regulation, Neoplastic - drug effects | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Cell culture | Flow cytometry | Biotechnology | Animal models | PD-1 protein | Immunoblotting | Lymphocytes T | Immunity | Anticancer properties | Lymphocytes | Xenografts | Tumor-infiltrating lymphocytes | Tumor cells | Poly(ADP-ribose) polymerase | Breast cancer | Tumor cell lines | Inhibitors | Immune checkpoint | Experimental design | PD-L1 protein | Cell lines | Breast | In vivo methods and tests | Tumors | Cancer
CELL LUNG-CANCER | BREAST-CANCER | OVEREXPRESSION | ACTIVATION | THERAPY | PEMBROLIZUMAB | ONCOLOGY | OVARIAN-CANCER | PROVIDES | COMBINATION | CHEMOTHERAPY | Tumor Microenvironment - drug effects | Poly (ADP-Ribose) Polymerase-1 - immunology | Breast Neoplasms - immunology | Humans | Poly(ADP-ribose) Polymerase Inhibitors - immunology | Lymphocytes, Tumor-Infiltrating - drug effects | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Breast Neoplasms - drug therapy | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Tumor Microenvironment - immunology | Xenograft Model Antitumor Assays | Immunosuppression | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Female | Mice | Gene Expression Regulation, Neoplastic - drug effects | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Cell culture | Flow cytometry | Biotechnology | Animal models | PD-1 protein | Immunoblotting | Lymphocytes T | Immunity | Anticancer properties | Lymphocytes | Xenografts | Tumor-infiltrating lymphocytes | Tumor cells | Poly(ADP-ribose) polymerase | Breast cancer | Tumor cell lines | Inhibitors | Immune checkpoint | Experimental design | PD-L1 protein | Cell lines | Breast | In vivo methods and tests | Tumors | Cancer
Journal Article
4.
Full Text
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
Nature Communications, ISSN 2041-1723, 08/2016, Volume 7, Issue 1, p. 12632
Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell death protein-1 (PD-1) leads to tumour-associated immune escape. Here...
EPITHELIAL-MESENCHYMAL TRANSITION | B7 FAMILY-MEMBER | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | N-LINKED GLYCANS | DEGRADATION | PROMOTES TUMORIGENESIS | PD-1 | CANCER | EXPRESSION | Phosphorylation | Breast Neoplasms - immunology | Humans | Antineoplastic Agents - therapeutic use | Lymphocyte Activation - immunology | Ubiquitination | beta-Transducin Repeat-Containing Proteins - metabolism | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Female | Antineoplastic Agents - pharmacology | Gefitinib | Breast - pathology | Tumor Escape - immunology | Programmed Cell Death 1 Receptor - metabolism | Epidermal Growth Factor - metabolism | Glycosylation | B7-H1 Antigen - immunology | Breast Neoplasms - drug therapy | Glycogen Synthase Kinase 3 beta - metabolism | Immunologic Surveillance - immunology | Xenograft Model Antitumor Assays | B7-H1 Antigen - metabolism | Animals | Breast Neoplasms - pathology | Quinazolines - therapeutic use | Protein Stability - drug effects | Cell Line, Tumor | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Quinazolines - pharmacology | Animal models | PD-1 protein | Lymphocytes T | Kinases | Inactivation | Immunity | Proteins | Signal transduction | Epidermal growth factor | Growth factors | Deactivation | Glycogen | Mortality | Glycogen synthase kinase 3 | Breast cancer | Immunosuppression | Cell death | PD-L1 protein | Ligands | Cancer | Tumors | Apoptosis
EPITHELIAL-MESENCHYMAL TRANSITION | B7 FAMILY-MEMBER | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | N-LINKED GLYCANS | DEGRADATION | PROMOTES TUMORIGENESIS | PD-1 | CANCER | EXPRESSION | Phosphorylation | Breast Neoplasms - immunology | Humans | Antineoplastic Agents - therapeutic use | Lymphocyte Activation - immunology | Ubiquitination | beta-Transducin Repeat-Containing Proteins - metabolism | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Female | Antineoplastic Agents - pharmacology | Gefitinib | Breast - pathology | Tumor Escape - immunology | Programmed Cell Death 1 Receptor - metabolism | Epidermal Growth Factor - metabolism | Glycosylation | B7-H1 Antigen - immunology | Breast Neoplasms - drug therapy | Glycogen Synthase Kinase 3 beta - metabolism | Immunologic Surveillance - immunology | Xenograft Model Antitumor Assays | B7-H1 Antigen - metabolism | Animals | Breast Neoplasms - pathology | Quinazolines - therapeutic use | Protein Stability - drug effects | Cell Line, Tumor | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Quinazolines - pharmacology | Animal models | PD-1 protein | Lymphocytes T | Kinases | Inactivation | Immunity | Proteins | Signal transduction | Epidermal growth factor | Growth factors | Deactivation | Glycogen | Mortality | Glycogen synthase kinase 3 | Breast cancer | Immunosuppression | Cell death | PD-L1 protein | Ligands | Cancer | Tumors | Apoptosis
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2011, Volume 13, Issue 3, pp. 317 - 323
The epithelial-mesenchymal transition (EMT) has recently been linked to stem cell phenotype(1,2). However, the molecular mechanism underlying EMT and...
WILD-TYPE P53 | ZEB1 | MUTATIONS | SPECTRUM | CANCER | EMT | CELL BIOLOGY | Entosis | Mitosis | Humans | Gene Expression Regulation, Neoplastic | Tumor Suppressor Protein p53 - metabolism | Aneuploidy | Stem Cells - cytology | Cytokinesis | Breast Neoplasms - metabolism | Cell Lineage | Genes, p53 | Microscopy, Fluorescence - methods | Epithelial-Mesenchymal Transition | Cell Line, Tumor | MicroRNAs - genetics | Physiological aspects | Tumor suppressor genes | MicroRNA | Research | Stem cells
WILD-TYPE P53 | ZEB1 | MUTATIONS | SPECTRUM | CANCER | EMT | CELL BIOLOGY | Entosis | Mitosis | Humans | Gene Expression Regulation, Neoplastic | Tumor Suppressor Protein p53 - metabolism | Aneuploidy | Stem Cells - cytology | Cytokinesis | Breast Neoplasms - metabolism | Cell Lineage | Genes, p53 | Microscopy, Fluorescence - methods | Epithelial-Mesenchymal Transition | Cell Line, Tumor | MicroRNAs - genetics | Physiological aspects | Tumor suppressor genes | MicroRNA | Research | Stem cells
Journal Article
Biogeosciences Discussions, ISSN 1810-6285, 01/2018, pp. 1 - 41
Abstract. Observations show that soil microorganisms can survive periods of aridity and recover rapidly after wetting events. This behavior can be explained by...
Journal Article
Cancer Cell, ISSN 1535-6108, 12/2016, Volume 30, Issue 6, pp. 925 - 939
Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current...
anti-CTLA4 | CSN5 | PD-L1 | deubiquitination | TNF-α | curcumin | CELLS | INHIBITION | ONCOLOGY | PHOSPHORYLATION | INFLAMMATION | KINASE | SUPERFAMILY | CTLA-4 | TNF-ALPHA | BLOCKADE | NF-KAPPA-B | CELL BIOLOGY | Neoplasms - metabolism | Tumor Necrosis Factor-alpha - metabolism | Neoplasm Transplantation | Humans | Curcumin - pharmacology | COP9 Signalosome Complex | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | B7-H1 Antigen - chemistry | B7-H1 Antigen - metabolism | Ubiquitination | Animals | Cell Line, Tumor | Female | Mice | Protein Stability | Peptide Hydrolases - metabolism | Ubiquitin | Medical colleges | T cells | Cell death | Immunotherapy | Tumors
anti-CTLA4 | CSN5 | PD-L1 | deubiquitination | TNF-α | curcumin | CELLS | INHIBITION | ONCOLOGY | PHOSPHORYLATION | INFLAMMATION | KINASE | SUPERFAMILY | CTLA-4 | TNF-ALPHA | BLOCKADE | NF-KAPPA-B | CELL BIOLOGY | Neoplasms - metabolism | Tumor Necrosis Factor-alpha - metabolism | Neoplasm Transplantation | Humans | Curcumin - pharmacology | COP9 Signalosome Complex | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | B7-H1 Antigen - chemistry | B7-H1 Antigen - metabolism | Ubiquitination | Animals | Cell Line, Tumor | Female | Mice | Protein Stability | Peptide Hydrolases - metabolism | Ubiquitin | Medical colleges | T cells | Cell death | Immunotherapy | Tumors
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Delivery and Specificity of CRISPR/Cas9 Genome Editing Technologies for Human Gene Therapy
Human Gene Therapy, ISSN 1043-0342, 07/2015, Volume 26, Issue 7, pp. 443 - 451
Genome editing using the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated 9 (Cas9) technology is revolutionizing the study...
Reviews | MEDICINE, RESEARCH & EXPERIMENTAL | HEPATITIS-B-VIRUS | DEFECTIVE LENTIVIRAL VECTORS | ADENOASSOCIATED VIRUS | NONDIVIDING CELLS | HUMAN-CELLS | ONE-STEP GENERATION | NUCLEASE SPECIFICITY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | OFF-TARGET CLEAVAGE | GENETICS & HEREDITY | CAS NUCLEASES | HEMATOPOIETIC STEM | Genetic Therapy - trends | Humans | CRISPR-Cas Systems | Clustered Regularly Interspaced Short Palindromic Repeats | Endonucleases | Bacterial Proteins
Reviews | MEDICINE, RESEARCH & EXPERIMENTAL | HEPATITIS-B-VIRUS | DEFECTIVE LENTIVIRAL VECTORS | ADENOASSOCIATED VIRUS | NONDIVIDING CELLS | HUMAN-CELLS | ONE-STEP GENERATION | NUCLEASE SPECIFICITY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | OFF-TARGET CLEAVAGE | GENETICS & HEREDITY | CAS NUCLEASES | HEMATOPOIETIC STEM | Genetic Therapy - trends | Humans | CRISPR-Cas Systems | Clustered Regularly Interspaced Short Palindromic Repeats | Endonucleases | Bacterial Proteins
Journal Article
Circulation, ISSN 0009-7322, 2015, Volume 131, Issue 18, pp. 1608 - 1639
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2019, Volume 294, Issue 43, pp. 15711 - 15723
Journal Article
Journal of the American Geriatrics Society, ISSN 0002-8614, 12/2019, Volume 67, Issue 12, pp. 2482 - 2489
OBJECTIVES Polypharmacy may affect frailty, a common and costly condition among older adults. Frailty prevalence is elevated among racial/ethnic minorities and...
aging health | frailty | epidemiology | cohort study | polypharmacy
aging health | frailty | epidemiology | cohort study | polypharmacy
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 12/2017, Volume 103, Issue 2, pp. 370 - 375
Context: Hypothalamic obesity, a treatment-resistant condition common to survivors of craniopharyngioma (CP), is strongly associated with a poor quality of...
ACTIVATION | FOOD-INTAKE | OPIOID ANTAGONISM | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | INCREASES | VASOPRESSIN | RECEPTOR | APPETITE | SURVIVORS | INSIGHTS | Pituitary Neoplasms - surgery | Neurosurgical Procedures - adverse effects | Obesity - drug therapy | Administration, Oral | Humans | Craniopharyngioma - complications | Male | Treatment Outcome | Hypothalamic Diseases - complications | Administration, Intranasal | Pituitary Neoplasms - complications | Craniopharyngioma - surgery | Oxytocin - administration & dosage | Hypothalamic Diseases - drug therapy | Obesity - etiology | Child | Naltrexone - administration & dosage | Carbohydrates | Obesity | Feeding behavior | Oxytocin | Hypothalamus | Naltrexone | Quality of life | Energy balance | Body mass index | Hunger | Body mass | Pituitary | Body size | Weight reduction | Neoplasia | Hyperphagia
ACTIVATION | FOOD-INTAKE | OPIOID ANTAGONISM | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | INCREASES | VASOPRESSIN | RECEPTOR | APPETITE | SURVIVORS | INSIGHTS | Pituitary Neoplasms - surgery | Neurosurgical Procedures - adverse effects | Obesity - drug therapy | Administration, Oral | Humans | Craniopharyngioma - complications | Male | Treatment Outcome | Hypothalamic Diseases - complications | Administration, Intranasal | Pituitary Neoplasms - complications | Craniopharyngioma - surgery | Oxytocin - administration & dosage | Hypothalamic Diseases - drug therapy | Obesity - etiology | Child | Naltrexone - administration & dosage | Carbohydrates | Obesity | Feeding behavior | Oxytocin | Hypothalamus | Naltrexone | Quality of life | Energy balance | Body mass index | Hunger | Body mass | Pituitary | Body size | Weight reduction | Neoplasia | Hyperphagia
Journal Article
Astrophysical Journal, Supplement Series, ISSN 0067-0049, 08/2013, Volume 207, Issue 2, pp. 24 - 23
We present a UV to mid-infrared multi-wavelength catalog in the CANDELS/GOODS-S field, combining the newly obtained CANDELS HST/WFC3 F105W, F125W, and F160W...
methods: data analysis | techniques: image processing | catalogs | galaxies: photometry | galaxies: high-redshift | STAR-FORMATION HISTORY | UV LUMINOSITY FUNCTION | GMASS ULTRADEEP SPECTROSCOPY | SIMILAR-TO 2 | HIGH-REDSHIFT GALAXIES | SPACE-TELESCOPE | SPECTRAL ENERGY-DISTRIBUTIONS | EXTRAGALACTIC LEGACY SURVEY | ASTRONOMY & ASTROPHYSICS | ORIGINS DEEP SURVEY | REST-FRAME ULTRAVIOLET | Mosaics | Star formation | Galaxies | Completeness | Spectral energy distribution | Apertures | Catalogs | Photometry | RED SHIFT | APERTURES | WAVELENGTHS | CATALOGS | ENERGY SPECTRA | ACCURACY | DATA ANALYSIS | IMAGE PROCESSING | ASTROPHYSICS, COSMOLOGY AND ASTRONOMY | COLOR | PHOTOMETRY | MASS | STARS | DETECTION | GALAXIES
methods: data analysis | techniques: image processing | catalogs | galaxies: photometry | galaxies: high-redshift | STAR-FORMATION HISTORY | UV LUMINOSITY FUNCTION | GMASS ULTRADEEP SPECTROSCOPY | SIMILAR-TO 2 | HIGH-REDSHIFT GALAXIES | SPACE-TELESCOPE | SPECTRAL ENERGY-DISTRIBUTIONS | EXTRAGALACTIC LEGACY SURVEY | ASTRONOMY & ASTROPHYSICS | ORIGINS DEEP SURVEY | REST-FRAME ULTRAVIOLET | Mosaics | Star formation | Galaxies | Completeness | Spectral energy distribution | Apertures | Catalogs | Photometry | RED SHIFT | APERTURES | WAVELENGTHS | CATALOGS | ENERGY SPECTRA | ACCURACY | DATA ANALYSIS | IMAGE PROCESSING | ASTROPHYSICS, COSMOLOGY AND ASTRONOMY | COLOR | PHOTOMETRY | MASS | STARS | DETECTION | GALAXIES
Journal Article