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Molecular Biology of the Cell, ISSN 1059-1524, 10/2019, p. mbc.E19-05-0284
The apical surface of the terminally differentiated mammalian urothelial umbrella cell is mechanically stable and highly impermeable, in part due its coverage... 
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 4541 - 4541
Abstract Inhibition of the endoplasmic reticulum (ER) stress response via blockade of inositol-requiring enzyme-1α (IRE-1α) is currently a promising... 
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2018, Volume 128, Issue 4
Myc activation is a primary oncogenic event in many human cancers; however, these transcription factors are difficult to inhibit pharmacologically, suggesting... 
Transcription factors | Chemotherapy | Oncology, Experimental | Physiological aspects | Genetic aspects | Research | Endoplasmic reticulum | Health aspects | Carcinogenesis | Nucleotidases | Proto-oncogenes | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 08/2012, Volume 109, Issue 34, p. 13739
allelic exclusion | natural antibodies | TN mice 
Allelomorphism | Immunology | Immunoglobulin G | Physiological aspects | B cells | Research | Health aspects
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. LB-336 - LB-336
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 4756 - 4756
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 05/2018, Volume 217, Issue 5, p. 1739
To relieve endoplasmic reticulum (ER) stress, IRE1 splices XBP1 messenger RNA (mRNA) or engages regulated IRE1-dependent decay (RIDD) of other mRNAs. Upon XBP1... 
Stresses | Phosphorylation | Immunoglobulins | Immunization | Switches | mRNA | Pharmacology | Ribonucleic acid--RNA | Stress | Lipopolysaccharides | Subtilase | Lymphocytes B | Toll-like receptors | Mice | Endoplasmic reticulum | Inducers
Journal Article
PLoS pathogens, ISSN 1553-7374, 04/2018, Volume 14, Issue 4, p. e1007027
[This corrects the article DOI: 10.1371/journal.ppat.1006596.]. 
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2014, Volume 124, Issue 6, pp. 2585 - 2598
Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We developed a murine CLL model... 
SELECTIVE-INHIBITION | MULTIPLE-MYELOMA | MEDICINE, RESEARCH & EXPERIMENTAL | IN-VITRO | UNFOLDED PROTEIN RESPONSE | TCL1 | MESSENGER-RNA | TRANSGENIC MOUSE | CHRONIC LYMPHOCYTIC-LEUKEMIA | ENDOPLASMIC-RETICULUM | TARGETING BTK | Endoribonucleases - genetics | Apoptosis - drug effects | Humans | Transcription Factors - deficiency | Endoribonucleases - antagonists & inhibitors | DNA-Binding Proteins - deficiency | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Enzyme Inhibitors - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Cell Survival - drug effects | DNA-Binding Proteins - antagonists & inhibitors | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - antagonists & inhibitors | Pyrimidines - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Mice, Knockout | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Cell Line, Tumor | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Care and treatment | Lymphocytic leukemia | Cancer cells | Development and progression | Genetic aspects | Cellular signal transduction | Gene expression | Leukemia | Rodents | Phenols | Kinases | Stress response | Drug dosages | Immune system | Apoptosis
Journal Article
PLoS Pathogens, ISSN 1553-7366, 08/2017, Volume 13, Issue 8, p. e1006596
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2019, Volume 62, Issue 11, pp. 5404 - 5413
Activation of the IRE-1/XBP-1 pathway has been linked to many human diseases. We report a novel fluorescent tricyclic chromenone inhibitor, D-F07, in which we... 
SELECTIVE-INHIBITION | SURVIVAL | XBP1 | CHEMISTRY, MEDICINAL | UNFOLDED PROTEIN RESPONSE | FLUOROPHORES | MESSENGER-RNA | PATHWAY | ER STRESS | IRE1-ALPHA | ENDOPLASMIC-RETICULUM STRESS
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2008, Volume 414, Issue Pt2, pp. 195 - 203
The apical surface of the mammalian urothelium is almost completely covered by two-dimensional protein crystals (known as urothelial plaques) of hexagonally... 
Journal Article
Nature Cell Biology, ISSN 1465-7392, 05/2017, Volume 19, Issue 6, pp. 698 - 710
The IRE1-XBP1 signalling pathway is part of a cellular programme that protects against endoplasmic reticulum (ER) stress, but also controls development and... 
HOMEOSTASIS | ER-STRESS | IN-VIVO | IRE1 | TRANSCRIPTION FACTOR XBP-1 | ENDOPLASMIC-RETICULUM STRESS | DIFFERENTIATION | MAMMALIAN-CELLS | UNFOLDED-PROTEIN-RESPONSE | TRANSLATIONAL CONTROL | CELL BIOLOGY | Transcription Factor CHOP - genetics | Protein Biosynthesis | Dendritic Cells - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | RNA, Messenger - metabolism | Respiratory Mucosa - pathology | Time Factors | Intestinal Mucosa - enzymology | Membrane Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Cell Survival | Membrane Proteins - genetics | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Respiratory Mucosa - enzymology | Activating Transcription Factor 4 - genetics | Genotype | Mice, Transgenic | RNA Stability | Unfolded Protein Response | Phenotype | Animals | Activating Transcription Factor 4 - metabolism | Dendritic Cells - enzymology | X-Box Binding Protein 1 - metabolism | Endoplasmic Reticulum Stress | Transcription Factor CHOP - metabolism | X-Box Binding Protein 1 - genetics | Apoptosis | Intestinal Mucosa - pathology | Regulators | Mucosa | Signal transduction | Alterations | Cell activation | Intestine | Immune system | Stresses | Spleen | Cell survival | Dendritic cells | mRNA turnover | Protein biosynthesis | JNK protein | Ribonucleic acid--RNA | Survival | Stress | Signaling | Lungs | Protein synthesis | Cell death | Decay | Shutdowns | Endonuclease | Endoplasmic reticulum
Journal Article
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