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Science, ISSN 0036-8075, 01/2017, Volume 355, Issue 6321, pp. 149 - 155
Journal Article
Cell, ISSN 0092-8674, 07/2017, Volume 170, Issue 3, pp. 470 - 482.e11
Voltage-gated sodium (Na ) channels initiate and propagate action potentials. Here, we present the cryo-EM structure of EeNa 1.4, the Na channel from electric... 
Nav1.4 | electromechanical coupling | Nav channels | structural biology | the beta-1 subunit | voltage-gated sodium channels | cryo-EM | fast inactivation | Na(v) channels | Na | Na(v)1.4 | channels | Cryo-EM | 1.4 | The beta-1 subunit | Fast inactivation | Electromechanical coupling | Structural biology | Voltage-gated sodium channels
Journal Article
Science, ISSN 0036-8075, 03/2019, Volume 363, Issue 6433, pp. 1309 - 1313
The voltage-gated sodium channel Nav1.2 is responsible for the initiation and propagation of action potentials in the central nervous system. We report the... 
Electric potential | Molecular structure | Channel gating | Central nervous system | Selectivity | Electron microscopy | Drug development | Channels | Neurological diseases | Resistance | Sodium | Sodium channels (voltage-gated) | Toxins | Conductance | Gating
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 9
Plasma membrane Ca2+-ATPases (PMCAs) are key regulators of global Ca2+ homeostasis and local intracellular Ca2+ dynamics. Recently, Neuroplastin (NPTN) and... 
PLANT | MECHANISM | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | RESOLUTION | SARCOLIPIN | BEAM-INDUCED MOTION | CALCIUM-PUMP | BINDING | CA-2+ PUMP | ATPASES | Calcium signalling | Regulators | Calcium (intracellular) | Calcium | Homeostasis | Magnesium | CD147 antigen | Adenosine triphosphatase | Calcium homeostasis | Calcium ions | Blood plasma | Ca2+-transporting ATPase
Journal Article
Nature, ISSN 0028-0836, 07/2019, Volume 572, Issue 7769, pp. 347 - 351
Journal Article
Nature, ISSN 0028-0836, 12/2019, Volume 576, Issue 7787, pp. 492 - 497
Journal Article
Science, ISSN 0036-8075, 08/2016, Volume 353, Issue 6302, pp. 904 - 911
How spliceosomes make the first cutIn eukaryotes, transcribed precursor mRNA includes noncoding sequences that must be spliced out. This is done by the... 
Proteins | Molecular structure | Splicing | Ribonucleic acids | Catalysts | Aluminum | Activation | Catalysis
Journal Article
Science, ISSN 0036-8075, 08/2016, Volume 353, Issue 6302, pp. 895 - 904
How spliceosomes make the first cutIn eukaryotes, transcribed precursor mRNA includes noncoding sequences that must be spliced out. This is done by the... 
Proteins | Splicing | Ribonucleic acids | Catalysts | Transesterification | Catalysis | Atomic structure | Gene sequencing
Journal Article
Science, ISSN 0036-8075, 08/2016, Volume 353, Issue 6302, p. 895
Each cycle of pre-messenger RNA splicing, carried out by the spliceosome, comprises two sequential transesterification reactions, which result in the removal... 
Genetic aspects | Spliceosomes | Brewer's yeast | Methods | RNA splicing
Journal Article
Cell, ISSN 0092-8674, 05/2019, Volume 177, Issue 6, p. 1495
The L-type voltage-gated Ca.sup.2+ (Ca.sub.v) channels are modulated by various compounds exemplified by 1,4-dihydropyridines (DHP), benzothiazepines (BTZ),... 
Hypertension | Calcium channels | Drug discovery | Molecular biology
Journal Article
Science, ISSN 0036-8075, 03/2019, Volume 363, Issue 6433, pp. 1309 - 1313
Journal Article
Cell, ISSN 0092-8674, 07/2017, Volume 170, Issue 3, p. 470
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.cell.2017.06.039... 
Medical colleges | Analysis | Eels
Journal Article
Cell, ISSN 0092-8674, 07/2017, Volume 170, Issue 3, pp. 470 - 482.e11
Journal Article
by Chi, XM and Gong, DS and Ren, K and Zhou, GW and Huang, GXY and Lei, JL and Zhou, Q and Yan, N
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 12/2019, Volume 116, Issue 51, pp. 25575 - 25582
The type 2 ryanodine receptor (RyR2) is responsible for releasing Ca2+ from the sarcoplasmic reticulum of cardiomyocytes, subsequently leading to muscle... 
ACTIVATION | type 2 ryanodine receptor | PROTEIN | MULTIDISCIPLINARY SCIENCES | SPONTANEOUS CA2+ RELEASE | allosteric regulation | BEAM-INDUCED MOTION | SARCOPLASMIC-RETICULUM | cryo-EM structures | SKELETAL-MUSCLE | CALCIUM-RELEASE CHANNEL | SELECTIVE BINDING | MUTATIONS | modulators | FKBP12.6 | Biological Sciences
Journal Article
Cell, ISSN 0092-8674, 05/2019, Volume 177, Issue 6, pp. 1495 - 1506.e12
Journal Article
Nature, 12/2019, Volume 576, Issue 7787, p. 492
Among the ten subtypes of mammalian voltage-gated calcium (Ca ) channels, Ca 3.1-Ca 3.3 constitute the T-type, or the low-voltage-activated, subfamily, the... 
Journal Article
Cell, 05/2019, Volume 177, Issue 6, p. 1495
The L-type voltage-gated Ca (Ca ) channels are modulated by various compounds exemplified by 1,4-dihydropyridines (DHP), benzothiazepines (BTZ), and... 
Journal Article
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