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Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 15
Chronic itch is a highly debilitating condition affecting about 10% of the general population. The relay of itch signals is under tight control by inhibitory... 
Receptors | Atopic dermatitis | Rodents | House dust | Dogs | Mice | Pharmacology | Drug delivery | Immunofluorescence | Dermatitis | Dorsal horn
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 07/2011, Volume 52, Issue 28, pp. 3543 - 3546
Selectfluor® is an easy to handle, air-stable and powerful electrophilic fluorination agent that can be used in a novel oxidative Mannich-type carbon–carbon... 
Oxidation | Selectfluor | Mannich reaction | Allylation | Nucleophilic addition | Selectfluor (R) | ALKENES | AMINES | CHEMISTRY, ORGANIC | FLUORINATION | SELECTFLUOR | Carbon-carbon composites | Construction | Amines | Tetrahedrons | Handles | Forming | Atmospherics | Bonding agents
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 07/2003, Volume 125, Issue 29, pp. 8706 - 8707
Journal Article
Alzheimer's Research and Therapy, ISSN 1758-9193, 2013, Volume 5, Issue 2, pp. 19 - 19
Introduction: Modulation of the gamma-secretase enzyme, which reduces the production of the amyloidogenic A beta(42) peptide while sparing the production of... 
PRESENILIN | CARBOXYL-TERMINAL FRAGMENT | ALZHEIMERS-DISEASE | NOTCH | TRANSMEMBRANE DOMAIN | BETA-PROTEIN | AMYLOID PRECURSOR PROTEIN | DIFFERENTIATION | CLEAVAGE | INHIBITOR | NEUROSCIENCES | CLINICAL NEUROLOGY | Enzymes | Plasma physics | Peptides | Analysis | Amyloid beta-protein | Models | Toy industry | Health aspects | Alzheimer's disease | Drug therapy
Journal Article
International Journal of Alzheimer's Disease, ISSN 2090-8024, 2012, Volume 2012, pp. 210756 - 10
The Amyloid Hypothesis states that the cascade of events associated with Alzheimer's disease (AD)-formation of amyloid plaques, neurofibrillary tangles,... 
Journal Article
ACS Symposium Series, ISSN 0097-6156, 2016, Volume 1239, pp. 271 - 280
Conference Proceeding
Journal of the American Chemical Society, ISSN 0002-7863, 10/2003, Volume 125, Issue 42, pp. 12836 - 12843
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2011, Volume 7, Issue 4, pp. S119 - S120
Journal Article
Organic Process Research & Development, ISSN 1083-6160, 06/2014, Volume 18, Issue 6, pp. 683 - 692
This work describes the demonstration of a kilogram-scale synthesis of a γ-secretase modulator from a plant-sterol-derived starting material. Key to developing... 
CHEMISTRY, ORGANIC | CHEMISTRY, APPLIED
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2003, Volume 125, Issue 42, pp. 12844 - 12849
Journal Article
Organic Process Research & Development, ISSN 1083-6160, 06/2014, Volume 18, Issue 6, pp. 676 - 682
The process development and production of two cycloartenol triterpenoid glycosides on a multikilogram scale are described. The two compounds were used as key... 
CHEMISTRY, ORGANIC | CIMICIFUGA | XYLOSIDE | OPTIMIZATION | ACTEIN | CHEMISTRY, APPLIED | CRUDE DRUG SHOMA
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2011, Volume 7, Issue 4, pp. S476 - S476
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2012, Volume 8, Issue 4, pp. P705 - P705
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2012, Volume 8, Issue 4, pp. P104 - P104
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 11/2012, Volume 3, Issue 11, pp. 908 - 913
The discovery of a new series of γ-secretase modulators is disclosed. Starting from a triterpene glycoside γ-secretase modulator that gave a very low... 
black cohosh | modulator | γ-secretase | amyloid β | Alzheimer's disease | CHEMISTRY, MEDICINAL | SAFETY | ALZHEIMERS-DISEASE | gamma-secretase | FLURBIPROFEN | amyloid beta | ALIGNMENT | PEPTIDE PRODUCTION | NSAIDS | HYPOTHESIS | INHIBITORS
Journal Article
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