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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 12/2013, Volume 110, Issue 51, pp. 20723 - 20728
Pancreatic ductal adenocarcinoma (PDA) represents an unmet therapeutic challenge. PDA is addicted to the activity of the mutated KRAS oncogene which is... 
Tumor cell line | Cell growth | Transfection | Cell lines | Small interfering RNA | Mice | Pancreatic neoplasms | Oncogenes | Tumors | Cancer | Gene therapy | Targeted therapy | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA, Small Interfering - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Cell Proliferation | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | ras Proteins - metabolism | Carcinoma, Pancreatic Ductal - genetics | Pancreatic Neoplasms - drug therapy | Female | Drug Evaluation, Preclinical | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pancreatic Neoplasms - pathology | RNA, Small Interfering - pharmacology | Gene Silencing | ras Proteins - antagonists & inhibitors | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Mice, SCID | Carcinoma, Pancreatic Ductal - pathology | Absorbable Implants | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Cell Line, Tumor | Mutation | Drug Delivery Systems - methods | Adenocarcinoma | Gene mutations | Pancreatic cancer | Physiological aspects | Genetic aspects | Research | Signal transduction | Survival analysis | Rodents | Oncology | Ribonucleic acid--RNA | Index Medicus | Biological Sciences | targeted therapy | gene therapy
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 01/2015, Volume 33, Issue 3, pp. 244 - 250
Journal Article
by Shitara, Kohei and Özgüroğlu, Mustafa and Bang, Yung-Jue and Di Bartolomeo, Maria and Mandalà, Mario and Ryu, Min-Hee and Fornaro, Lorenzo and Olesiński, Tomasz and Caglevic, Christian and Chung, Hyun C and Muro, Kei and Goekkurt, Eray and Mansoor, Wasat and McDermott, Raymond S and Shacham-Shmueli, Einat and Chen, Xinqun and Mayo, Carlos and Kang, S Peter and Ohtsu, Atsushi and Fuchs, Charles S and Lerzo, Guillermo and O'Connor, Juan Manuel and Mendez, Guillermo Ariel and Lynam, James and Tebbutt, Niall and Wong, Mark and Strickland, Andrew and Karapetis, Chris and Goldstein, David and Vasey, Paul and Van Laethem, Jean-Luc and Van Cutsem, Eric and Berry, Scott and Vincent, Mark and Muller, Bettina and Rey, Felipe and Zambrano, Angela and Guerra, Joaquin and Krogh, Merete and Baeksgaard, Lene and Yilmaz, Mette and Elme, Anneli and Magi, Andrus and Auvinen, Paivi and Alanko, Tuomo and Moehler, Markus and Kunzmann, Volker and Seufferlein, Thomas and Thuss-Patience, Peter and Hoehler, Thomas and Haag, Georg and Al-Batran, Salah-Eddin and Castro, Hugo and Lopez, Karla and Aguilar Vasquez, Mynor and Sandoval, Mario and Lam, Ka On and Cuffe, Sinead and Kelly, Cathy and Geva, Ravit and Hubert, Ayala and Beny, Alex and Brenner, Baruch and Giuseppe, Aprile and Falcone, Alfredo and Maiello, Evaristo and Passalacqua, Rodolfo and Montesarchio, Vincenzo and Hara, Hiroki and Chin, Keisho and Nishina, Tomohiro and Komatsu, Yoshito and Machida, Nozumo and Hironaka, Shuichi and Satoh, Taroh and Tamura, Takao and Sugimoto, Naotaoshi and Cho, Haruhiko and Omuro, Yashushi and Kato, Ken and Goto, Masahiro and Hyodo, Ichinosuke and Yoshida, Kazuhiro and Baba, Hideo and Esaki, Taito and Furuse, Junji and Wan Mohammed, Wan Zamaniah and Hernandez Hernandez, Carlos and Casas Garcia, Juan and Dominguez Andrade, Adriana and Clarke, Katriona and Hjortland, Geir and Glenjen, Nils and Kubiatowski, Tomasz and Jacek, Jassem and Wojtukiewicz, Marek and Lazarev, Sergey and Lancukhay, Yuri and Afanasayev, Sergey and Moiseyenko, Vladimir and ... and KEYNOTE-061 investigators and KEYNOTE-061 Investigators
The Lancet (British edition), ISSN 0140-6736, 07/2018, Volume 392, Issue 10142, pp. 123 - 133
Journal Article
Gynecologic oncology, ISSN 0090-8258, 02/2016, Volume 140, Issue 2, pp. 199 - 203
Journal Article
Case reports in oncology, ISSN 1662-6575, 01/2019, Volume 12, Issue 1, pp. 7 - 13
Pancreatic adenocarcinoma (PDAC) has a grim prognosis. Molecular and genomic analyses revealed that the striking majority of these tumors are driven by KRAS... 
Case Report | RET | Pancreatic adenocarcinoma | BRAF | KRAS | Targeted therapy | Lung cancer | Leukemia | Melanoma | Metastasis | Family medical history | Kinases | Patients | Cancer therapies | Abdomen | Consortia | Chemotherapy | Thyroid cancer | Pain | Pancreatic cancer | Biomarkers | Mutation | Tumors
Journal Article
by Koboldt, Daniel C and Fulton, Robert S and McLellan, Michael D and Schmidt, Heather and Kalicki-Veizer, Joelle and McMichael, Joshua F and Fulton, Lucinda L and Dooling, David J and Ding, Li and Mardis, Elaine R and Wilson, Richard K and Ally, Adrian and Balasundaram, Miruna and Butterfield, Yaron S. N and Carlsen, Rebecca and Carter, Candace and Chu, Andy and Chuah, Eric and Chun, Hye-Jung E and Coope, Robin J. N and Dhalla, Noreen and Guin, Ranabir and Hirst, Carrie and Hirst, Martin and Holt, Robert A and Lee, Darlene and Li, Haiyan I and Mayo, Michael and Moore, Richard A and Mungall, Andrew J and Pleasance, Erin and Robertson, A. Gordon and Schein, Jacqueline E and Shafiei, Arash and Sipahimalani, Payal and Slobodan, Jared R and Stoll, Dominik and Tam, Angela and Thiessen, Nina and Varhol, Richard J and Wye, Natasja and Zeng, Thomas and Zhao, Yongjun and Birol, Inanc and Jones, Steven J. M and Marra, Marco A and Cherniack, Andrew D and Saksena, Gordon and Onofrio, Robert C and Pho, Nam H and Carter, Scott L and Schumacher, Steven E and Tabak, Barbara and Hernandez, Bryan and Gentry, Jeff and Nguyen, Huy and Crenshaw, Andrew and Ardlie, Kristin and Beroukhim, Rameen and Winckler, Wendy and Getz, Gad and Gabriel, Stacey B and Meyerson, Matthew and Chin, Lynda and Kucherlapati, Raju and Hoadley, Katherine A and Auman, J. Todd and Fan, Cheng and Turman, Yidi J and Shi, Yan and Li, Ling and Topal, Michael D and He, Xiaping and Chao, Hann-Hsiang and Prat, Aleix and Silva, Grace O and Iglesia, Michael D and Zhao, Wei and Usary, Jerry and Berg, Jonathan S and Adams, Michael and Booker, Jessica and Wu, Junyuan and Gulabani, Anisha and Bodenheimer, Tom and Hoyle, Alan P and Simons, Janae V and Soloway, Matthew G and Mose, Lisle E and Jefferys, Stuart R and Balu, Saianand and Parker, Joel S and Hayes, D. Neil and Perou, Charles M and Malik, Simeen and Mahurkar, Swapna and Shen, Hui and Weisenberger, Daniel J and Triche Jr, Timothy and Lai, Phillip H and ... and The Cancer Genome Atlas Network and Canc Genome Atlas Network and Cancer Genome Atlas Network
Nature (London), ISSN 1476-4687, 09/2012, Volume 490, Issue 7418, pp. 61 - 70
We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | GATA3 Transcription Factor - genetics | Receptors, Estrogen - metabolism | Oligonucleotide Array Sequence Analysis | Genomics | Humans | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Gene Expression Profiling | Breast Neoplasms - metabolism | Ovarian Neoplasms - genetics | DNA Methylation | DNA Mutational Analysis | Female | Genes, BRCA1 | Genes, Neoplasm - genetics | Breast Neoplasms - classification | RNA, Messenger - genetics | Retinoblastoma Protein - metabolism | DNA Copy Number Variations - genetics | Genes, p53 - genetics | Mutation - genetics | Genetic Heterogeneity | Genome, Human - genetics | Phosphatidylinositol 3-Kinases - genetics | Exome - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Breast Neoplasms - pathology | Retinoblastoma Protein - genetics | Genes, erbB-2 - genetics | Proteomics | Protein Array Analysis | RNA, Neoplasm - genetics | MAP Kinase Kinase Kinase 1 - genetics | MicroRNAs - genetics | Breast tumors | Gene mutations | Oncology, Experimental | Genetic aspects | Research | Identification and classification | Cancer | Proteins | DNA methylation | Genetics | Breast cancer | Mutation | Index Medicus | Càncer de mama | Oncologia | Oncology | Gene expression | Expressió gènica | Genòmica
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 03/2016, Volume 113, Issue 13, pp. E1826 - E1834
Journal Article