X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Patent (734) 734
Journal Article (173) 173
Book Review (5) 5
Publication (4) 4
Book Chapter (2) 2
Conference Proceeding (1) 1
Dissertation (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
heterocyclic compounds (697) 697
chemistry (696) 696
metallurgy (696) 696
organic chemistry (696) 696
human necessities (679) 679
hygiene (679) 679
medical or veterinary science (679) 679
preparations for medical, dental, or toilet purposes (674) 674
specific therapeutic activity of chemical compounds ormedicinal preparations (619) 619
index medicus (80) 80
animals (66) 66
derivatives thereof (66) 66
nucleic acids (66) 66
nucleosides (66) 66
nucleotides (66) 66
sugars (66) 66
acyclic, carbocyclic or heterocyclic compounds containingelements other than carbon, hydrogen, halogen, oxygen, nitrogen,sulfur, selenium or tellurium (57) 57
humans (54) 54
chemistry, medicinal (46) 46
adhesives (42) 42
dyes (42) 42
lakes (42) 42
miscellaneous applications of materials (42) 42
miscellaneous compositions (42) 42
mordants (42) 42
natural resins (42) 42
organic dyes or closely-related compounds for producing dyes (42) 42
paints (42) 42
polishes (42) 42
rats (41) 41
chemistry, organic (40) 40
structure-activity relationship (33) 33
mice (25) 25
male (20) 20
potent (19) 19
carbazoles - pharmacology (17) 17
molecular structure (17) 17
discovery (16) 16
pyridazines - pharmacology (15) 15
rats, sprague-dawley (15) 15
receptors, histamine h3 - metabolism (14) 14
antagonists (12) 12
stereoisomerism (12) 12
cep-26401 (11) 11
models, molecular (11) 11
administration, oral (10) 10
carbazoles - chemical synthesis (10) 10
enzyme inhibitors - pharmacology (10) 10
histamine h (10) 10
pharmacology & pharmacy (10) 10
pyridazines - chemistry (10) 10
pyrrolidines - pharmacology (10) 10
carbazoles - chemistry (9) 9
drug design (9) 9
histamine (9) 9
histamine h3 antagonists - pharmacology (9) 9
inverse agonist (9) 9
pyridazines - chemical synthesis (9) 9
rat (9) 9
receptor (9) 9
sleep-wake (9) 9
cancer (8) 8
derivatives (8) 8
dose-response relationship, drug (8) 8
piperidines - pharmacology (8) 8
receptors, opioid, kappa - agonists (8) 8
vascular endothelial growth factor receptor-2 - antagonists & inhibitors (8) 8
alzheimers-disease (7) 7
biochemistry & molecular biology (7) 7
biological availability (7) 7
cells, cultured (7) 7
cloning (7) 7
cognitive disorders (7) 7
disease models, animal (7) 7
drug inverse agonism (7) 7
expression (7) 7
h-3 receptor (7) 7
histamine agonists - pharmacology (7) 7
histamine h3 receptor (7) 7
indole alkaloids (7) 7
nephrology (7) 7
nerve growth-factor (7) 7
pyridazinone (7) 7
urology & nephrology (7) 7
acyclic or carbocyclic compounds (6) 6
analysis (6) 6
dogs (6) 6
drug evaluation, preclinical (6) 6
female (6) 6
immunohistochemistry (6) 6
inhibitor (6) 6
mice, inbred c57bl (6) 6
piperidines - chemistry (6) 6
wakefulness - drug effects (6) 6
antineoplastic agents - pharmacology (5) 5
apoptosis (5) 5
binding sites (5) 5
blotting, western (5) 5
brain (5) 5
cho cells (5) 5
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (764) 764
French (185) 185
German (99) 99
Spanish (61) 61
Portuguese (36) 36
Chinese (35) 35
Norwegian (25) 25
Danish (16) 16
Russian (16) 16
Korean (9) 9
Czech (8) 8
Polish (8) 8
Slovak (7) 7
Hungarian (6) 6
Icelandic (6) 6
Bulgarian (5) 5
Slovenian (5) 5
Greek (4) 4
Croatian (3) 3
Finnish (3) 3
Swedish (3) 3
Ukrainian (3) 3
Serbian (2) 2
Turkish (2) 2
Japanese (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


LABORATORY INVESTIGATION, ISSN 0023-6837, 06/2015, Volume 95, Issue 6, pp. 697 - 697
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2011, Volume 21, Issue 20, pp. 6126 - 6130
Three series of novel 4,5-fused pyridazinones were synthesized as histamine H receptor antagonists. The 2,5,6,7-tetrahydrocyclopenta[ ]pyridazin-1-one and... 
Affinity | Fused | Pyridazinone | Histamine H3 | POTENT | CHEMISTRY, MEDICINAL | INHIBITION | COGNITIVE DISORDERS | LIGANDS | BRAIN HISTAMINE | CHEMISTRY, ORGANIC | DISCOVERY
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 02/2010, Volume 10, Issue 2, pp. 153 - 169
The H3 histamine receptor is expressed in many brain regions, including those involved in sleep/wake regulation and cognitive functions. Inhibition of the H3... 
Journal Article
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 02/2010, Volume 10, Issue 2, pp. 142 - 143
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2012, Volume 55, Issue 1, pp. 414 - 423
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2011, Volume 21, Issue 20, p. 6126
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 10/2011, Volume 21, Issue 20, pp. 6126 - 6130
Three series of novel 4,5-fused pyridazinones were synthesized as histamine H sub(3 receptor antagonists. The 2,5,6,7-tetrahydrocyclopenta[d]pyridazin-1-one 5q... 
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2012, Volume 22, Issue 12, p. 4198
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 01/2012, Volume 3, Issue 1, pp. 50 - 68
Journal Article
Applied Radiation and Isotopes, ISSN 0969-8043, 2012, Volume 70, Issue 3, pp. 512 - 514
Methods are presented to tritiate and characterize radioligand ( ). ► This paper addresses a useful compound to study the histamine-3 receptor. ► The compound... 
Pyridazin-3-one tritium | Tritium NMR | Histamine-3 receptor (H 3R) | Histamine-3 receptor (H | R | POTENT | NUCLEAR SCIENCE & TECHNOLOGY | Histamine-3 receptor (H3R) | ANTAGONISTS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | DISCOVERY | CHEMISTRY, INORGANIC & NUCLEAR
Journal Article
Applied Radiation and Isotopes, ISSN 0969-8043, 03/2012, Volume 70, Issue 3, p. 512
Display Omitted 
Histamine
Journal Article
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, ISSN 0969-8043, 03/2012, Volume 70, Issue 3, pp. 512 - 514
Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 01/2012, Volume 55, Issue 2, pp. 903 - 913
A substantial body of evidence supports the utility of antiangiogenesis inhibitors as a strategy to block or attenuate tumor-induced angiogenesis and... 
VEGF-R2 | CHEMISTRY, MEDICINAL | RECEPTOR TYROSINE KINASES | TIE-2 | EFFICACY | MODELS | IN-VIVO | TUMOR ANGIOGENESIS | DUAL INHIBITORS | CANCER | DISCOVERY | Neovascularization, Physiologic - drug effects | Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors | Indazoles - chemical synthesis | Humans | Macaca fascicularis | Biological Availability | Male | Carbazoles - chemical synthesis | Receptor, TIE-2 - chemistry | Structure-Activity Relationship | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Angiogenesis Inhibitors - chemical synthesis | Receptor, TIE-2 - antagonists & inhibitors | Recombinant Proteins - antagonists & inhibitors | Administration, Oral | Angiogenesis Inhibitors - pharmacology | Models, Molecular | Rats | Recombinant Proteins - chemistry | Angiogenesis Inhibitors - pharmacokinetics | Rats, Sprague-Dawley | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Indazoles - pharmacology | Xenograft Model Antitumor Assays | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Animals | Indazoles - pharmacokinetics | Mice, Nude | Carbazoles - pharmacokinetics | Mice | Carbazoles - pharmacology | Vascular Endothelial Growth Factor Receptor-3 - antagonists & inhibitors | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 07/2016, Volume 106, pp. 37 - 45
CEP-32215 is a new, potent, selective, and orally bioavailable inverse agonist of the histamine H sub(3) receptor (H sub(3)R) with drug-like properties. High... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2012, Volume 55, Issue 1, pp. 414 - 423
Previous studies have shown that (5-{4-[3-(R)-2-methylpyrrolin-1-yl-propoxy]phenyl}-2H-pyridazin-3-one) 2 had high affinity for both the human (hH(3)R K-i =... 
SYSTEM | CHEMISTRY, MEDICINAL | RAT | PHOSPHOLIPIDOSIS | MODELS | CLONING | BRAIN HISTAMINE | DISORDERS | AGONISTS | DISCOVERY
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 10/2011, Volume 21, Issue 20, pp. 6126 - 6130
Three series of novel 4,5-fused pyridazinones were synthesized as histamine H(3) receptor antagonists. The 2,5,6,7-tetrahydrocyclopenta[d]pyridazin-1-one 5q... 
Histamine H3 Antagonists - pharmacology | Animals | Humans | Rats | Pyridazines - pharmacokinetics | Structure-Activity Relationship | Pyridazines - pharmacology | Histamine H3 Antagonists - pharmacokinetics | Receptors, Histamine H3 - metabolism | Histamine H3 Antagonists - chemistry | Pyridazines - chemistry | Index Medicus
Journal Article
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.