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1. Full Text Interactions between cancer stem cells and their niche govern metastatic colonization
by Malanchi, Ilaria and Santamaria-Martínez, Albert and Susanto, Evelyn and Peng, Hong and Lehr, Hans-Anton and Delaloye, Jean-Francois and Huelsken, Joerg
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7379, pp. 85 - 91
Metastatic growth in distant organs is the major cause of cancer mortality. The development of metastasis is a multistage process with several rate-limiting... 
BREAST-CANCER | LONG-TERM | MAMMARY-TUMORS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | DISSEMINATION | BETA-CATENIN | IDENTIFICATION | EXPRESSION | TUMOR-INITIATING CELLS | PERIOSTIN-NULL MICE | Lung cancer | Stem cells | Cancer cells | Physiological aspects | Metastasis | Research | Properties | Experiments | Breast cancer
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2. Full Text Wnt/β-Catenin Is Essential for Intestinal Homeostasis and Maintenance of Intestinal Stem Cells
by Tea Fevr and Sylvie Robine and Daniel Louvard and Joerg Huelsken
Molecular and Cellular Biology, ISSN 0270-7306, 11/2007, Volume 27, Issue 21, pp. 7551 - 7559
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
COLON-CANCER | APC(MIN/+) MOUSE | CDNA MICROARRAY | EPITHELIUM | CRYPTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | C-MYC | DIFFERENTIATION | BETA-CATENIN | TUMORS | CELL BIOLOGY | Biomarkers - metabolism | Cell Proliferation | Intestinal Mucosa - ultrastructure | Signal Transduction | Down-Regulation | beta Catenin - deficiency | Homeostasis | Intestines - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Wnt Proteins - metabolism | beta Catenin - metabolism | Intestinal Mucosa - cytology | Intestines - ultrastructure | Cell Lineage | Animals | Mice, Mutant Strains | Cell Death | Transcription, Genetic | Cell Differentiation | Mice | Intestines - physiology | Intestines - cytology
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3. Full Text A Subset of Cancer-Associated Fibroblasts Determines Therapy Resistance
by Huelsken, Joerg and Hanahan, Douglas
Cell, ISSN 0092-8674, 02/2018, Volume 172, Issue 4, pp. 643 - 644
While functional heterogeneity of fibroblastic cells populating the tumor microenvironment is increasingly recognized, lack of definitive markers complicates... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | CELL BIOLOGY | Fibroblasts | Tumor Microenvironment | Signal Transduction | Carcinogenesis | Humans | Cancer-Associated Fibroblasts | Cancer
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4. Full Text SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas
by Hussenet, Thomas and Dali, Soraya and Exinger, Julien and Monga, Ben and Jost, Bernard and Dembelé, Doulaye and Martinet, Nadine and Thibault, Christelle and Huelsken, Joerg and Brambilla, Elisabeth and Du Manoir, Stanislas
PLoS ONE, ISSN 1932-6203, 01/2010, Volume 5, Issue 1, p. e8960
Squamous cell carcinoma (SCC) of the lung is a frequent and aggressive cancer type. Gene amplifications, a known activating mechanism of oncogenes, target the... 
CULLIN NEDDYLATION | BREAST-CANCER | SOLID TUMORS | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | GENE-EXPRESSION PROFILES | SCCRO DCUN1D1 | MODULE MAP | DIFFERENTIATION | RESPIRATORY EPITHELIUM | GENOME BROWSER | Lung Neoplasms - genetics | Chromosomes, Human, Pair 3 | SOXB1 Transcription Factors - genetics | Carcinoma, Squamous Cell - genetics | Humans | Squamous cell carcinoma | Analysis | Genes | Cytogenetics | Genetic aspects | Genetic transcription | Embryonic stem cells | Cancer | Coma | Cell culture | Deregulation | Transcription factors | Leukocyte migration | Epithelial cells | Gene regulation | Embryo cells | Stem cell transplantation | Genomes | Hybridization | Nuclei | Genotype & phenotype | Cell growth | Allografts | Telomerase | Lung carcinoma | Gene expression | Chromosome 3 | Esophagus | Amplification | Overexpression | Stem cells | Head & neck cancer | Cell migration | Tumors | Apoptosis
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5. Full Text β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
by Huelsken, Joerg and Vogel, Regina and Erdmann, Bettina and Cotsarelis, George and Birchmeier, Walter
Cell, ISSN 0092-8674, 2001, Volume 105, Issue 4, pp. 533 - 545
β-Catenin is an essential molecule in Wnt/wingless signaling, which controls decisive steps in embryogenesis. To study the role of β-catenin in skin... 
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6. Full Text The Wnt signalling pathway
by Huelsken, Joerg and Behrens, Juergen
Journal of Cell Science, ISSN 0021-9533, 11/2002, Volume 115, Issue 21, pp. 3977 - 3978
CELL BIOLOGY | Proto-Oncogene Proteins - metabolism | Animals | Humans | Zebrafish Proteins | Eukaryotic Cells - metabolism | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Wnt Proteins | Calcium Signaling - genetics
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7. Full Text Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory
by Grégoire Jeannet and Caroline Boudousquié and Noémie Gardiol and Joonsoo Kang and Joerg Huelsken and Werner Held and Douglas T. Fearon
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2010, Volume 107, Issue 21, pp. 9777 - 9782
Immune protection from intracellular pathogens depends on the generation of terminally differentiated effector and of multipotent memory precursor CD8 T cells,... 
T lymphocytes | Spleen | Antigens | Lymphocytic choriomeningitis virus | Splenocytes | Memory | T lymphoid precursor cells | Stem cells | Viruses | Infections | β-catenin | Memory precursor | Central memory | Lymphocytic choriomeningitis virus infection | γ-catenin | beta-catenin | STEM-CELLS | SECONDARY EXPANSION | PRECURSOR | lymphocytic choriomeningitis virus infection | MULTIDISCIPLINARY SCIENCES | SUBSETS | SIGNALS | gamma-catenin | RESPONSES | central memory | memory precursor | INFECTION | DIFFERENTIATION | EXPRESSION | Lymphocytic choriomeningitis virus - immunology | CD8-Positive T-Lymphocytes - cytology | Cell Proliferation | Signal Transduction | Mice, Inbred C57BL | Hepatocyte Nuclear Factor 1-alpha | gamma Catenin - metabolism | gamma Catenin - immunology | Wnt Proteins - metabolism | beta Catenin - metabolism | beta Catenin - immunology | Animals | T Cell Transcription Factor 1 - deficiency | CD8-Positive T-Lymphocytes - metabolism | Protein Binding | T Cell Transcription Factor 1 - immunology | Immunologic Memory | Mice | CD8-Positive T-Lymphocytes - immunology | Proteins | Viral meningitis | T cells | Health aspects | Biological Sciences
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8. Full Text Making the paper: genetic labelling reveals a role for hair follicle stem cells in skin cancer
by Huelsken, Joerg
Nature, ISSN 0028-0836, 04/2008, Volume 452, Issue 7187, p. xiii
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9. Full Text Inducibility of Drug-Metabolizing Enzymes by Xenobiotics in Mice with Liver-Specific Knockout of Ctnnb1
by Albert Braeuning and Riccardo Sanna and Joerg Huelsken and Michael Schwarz
Drug Metabolism and Disposition, ISSN 0090-9556, 05/2009, Volume 37, Issue 5, pp. 1138 - 1145
Basal as well as xenobiotic-induced expression of the main enzymes from phase I and phase II of drug metabolism is confined to the perivenous areas of the... 
CYTOCHROME-P450 EXPRESSION | PATHWAY | HA-RAS | QUANTIFICATION | ZONATION | ZONAL GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | INDUCTION | BETA-CATENIN | MOUSE HEPATOCYTES | TUMORS | Immunohistochemistry | Phenobarbital - pharmacology | Liver - enzymology | Male | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Hepatocytes - metabolism | Xenobiotics - pharmacology | Liver - drug effects | Enzyme Induction - drug effects | Female | NF-E2-Related Factor 2 - genetics | Hepatocytes - drug effects | Liver - metabolism | Receptors, Aryl Hydrocarbon - genetics | Receptors, Steroid - drug effects | Receptors, Aryl Hydrocarbon - drug effects | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | beta Catenin - genetics | Mice, Knockout | Transcription Factors - metabolism | Pharmaceutical Preparations - metabolism | Animals | Receptors, Steroid - genetics | NF-E2-Related Factor 2 - metabolism | Mice | Pyridines - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism
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10. Full Text HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer
by Ordóñez-Morán, Paloma and Dafflon, Caroline and Imajo, Masamichi and Nishida, Eisuke and Huelsken, Joerg
Cancer Cell, ISSN 1535-6108, 12/2015, Volume 28, Issue 6, pp. 815 - 829
Hierarchical organization of tissues relies on stem cells, which either self-renew or produce committed progenitors predestined for lineage differentiation.... 
β-catenin | cancer stem cells | MYC | retinoids | Retinoids | Cancer stem cells | INTESTINAL EPITHELIUM | HOMEOSTASIS | RETINOIC ACID | PROTEIN | ONCOLOGY | PATHWAY | GENE-EXPRESSION | RECEPTOR | PROLIFERATION | BETA-CATENIN | CELL BIOLOGY | Intestinal Mucosa - metabolism | Cell Proliferation | Neoplastic Stem Cells - drug effects | Colorectal Neoplasms - genetics | Homeodomain Proteins - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Phosphoproteins - metabolism | Neoplasm Metastasis | Transfection | Neoplastic Stem Cells - metabolism | RNA Interference | Time Factors | Cell Transformation, Neoplastic - genetics | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Neoplastic Stem Cells - pathology | Female | Antineoplastic Agents - pharmacology | Cell Differentiation | Tumor Cells, Cultured | Colorectal Neoplasms - metabolism | Caco-2 Cells | Tissue Culture Techniques | HCT116 Cells | Mice, Inbred C57BL | Mice, Transgenic | Phosphoproteins - genetics | Cell Transformation, Neoplastic - metabolism | Homeodomain Proteins - genetics | HT29 Cells | Feedback, Physiological | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Aged | Cell Transformation, Neoplastic - pathology | Colorectal Neoplasms - pathology | Retinoids - pharmacology | Intestinal Mucosa - pathology | Development and progression | Developmental biology | Colorectal cancer | Stem cells | Prevention | Resveratrol | Transplantation | Metastasis | Cancer
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11. Full Text Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature
: Single-Cell RNA-Seq-Based Stem Cell Identification
by Schwalie, Petra C and Ordóñez-Morán, Paloma and Huelsken, Joerg and Deplancke, Bart
STEM CELLS, ISSN 1066-5099, 12/2017, Volume 35, Issue 12, pp. 2390 - 2402
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12. Full Text Cross‐Tissue Identification of Somatic Stem and Progenitor Cells Using a Single‐Cell RNA‐Sequencing Derived Gene Signature
by Schwalie, Petra C and Ordóñez‐Morán, Paloma and Huelsken, Joerg and Deplancke, Bart
STEM CELLS, ISSN 1066-5099, 12/2017, Volume 35, Issue 12, pp. 2390 - 2402
A long‐standing question in biology is whether multipotent somatic stem and progenitor cells (SSPCs) feature molecular properties that could guide their... 
Somatic stem cells | Self‐renewal | Progenitor cells | Genomics | Stem/progenitor cells | Self-renewal | POPULATION | TRANSCRIPTOME | Stem | CELL & TISSUE ENGINEERING | CELL BIOLOGY | HETEROGENEITY | IN-VITRO | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | RATHER | DIFFERENTIATION | HEMATOLOGY | EXPRESSION | SEQ | REVEALS | PLASTICITY | RNA | Cell differentiation | Analysis | Genes | Stem cells | Tissue engineering | Epidermis | Exploration | Population studies | Gene expression | Ribonucleic acid--RNA | Biological activity | Gene sequencing | Regeneration | Hierarchies | Organoids | Intestine | Computer applications | Cells (biology) | Tumorigenesis | Pancreas | Cancer | Resolution
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13. Full Text Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis
by Khurana, Satish and Schouteden, Sarah and Manesia, Javed K and Santamaria-Martínez, Albert and Huelsken, Joerg and Lacy-Hulbert, Adam and Verfaillie, Catherine M
Nature Communications, ISSN 2041-1723, 12/2016, Volume 7, Issue 1, p. 13500
Integrins play an important role in haematopoietic stem cell (HSC) maintenance in the bone marrow niche. Here, we demonstrate that Periostin (Postn) via... 
PROGENITOR CELLS | CANCER CELLS | PATHWAY | MULTIDISCIPLINARY SCIENCES | BONE-MARROW NICHE | KINASE INHIBITOR P27(KIP1) | DNA-DAMAGE | SELF-RENEWAL | EXPRESSION | ALPHA-V INTEGRINS | ADHESION RECEPTORS
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14. Full Text To the Editor
by Huelsken, Joerg and Held, Werner
European Journal of Immunology, ISSN 0014-2980, 12/2009, Volume 39, Issue 12, pp. 3582 - 3583
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15. Full Text Tissue-specific stem cells: friend or foe?
by Huelsken, Joerg
Cell Research, ISSN 1001-0602, 03/2009, Volume 19, Issue 3, pp. 279 - 281
CATENIN | MAINTENANCE | MARKER | CANCER | LGR5 | CELL BIOLOGY | Biomarkers - metabolism | Animals | Cell Proliferation | Humans | Neoplastic Stem Cells - pathology | Cell Differentiation | Mice | Stem Cells - cytology | Organ Specificity
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16. Full Text Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice
by Joerg Huelsken and Regina Vogel and Volker Brinkmann and Bettina Erdmann and Carmen Birchmeier and Walter Birchmeier
The Journal of Cell Biology, ISSN 0021-9525, 2/2000, Volume 148, Issue 3, pp. 567 - 578
The anterior-posterior axis of the mouse embryo is defined before formation of the primitive streak, and axis specification and subsequent anterior development... 
Ectoderm | Complementary DNA | Cell adhesion | Mesoderm | Embryonic cells | Embryos | Genetic mutation | Endoderm | Cells | Eggs | Anterior visceral endoderm | Wnt/wingless pathway | Plakoglobin | Armadillo | WNT SIGNALING PATHWAY | FUNCTIONAL INTERACTION | TRANSCRIPTION FACTOR LEF-1 | PRIMITIVE ENDODERM | E-CADHERIN | MOUSE EMBRYO | CELL BIOLOGY | EARLY XENOPUS EMBRYOS | anterior visceral endoderm | plakoglobin | SPEMANNS ORGANIZER | cell adhesion | armadillo | ALPHA-CATENIN | PREIMPLANTATION DEVELOPMENT | Lim1 gene | b-catenin | hex gene | anterior-posterior axis | cerberus-like gene | hesx1 gene
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17. Full Text Lrig1: a new master regulator of epithelial stem cells
by Ordóñez‐Morán, Paloma and Huelsken, Joerg
The EMBO Journal, ISSN 0261-4189, 05/2012, Volume 31, Issue 9, pp. 2064 - 2066
Work from Kim Jensen's lab recently published in NCB establishes the crucial role of Lrig1 in the control of intestinal homeostasis. 
ALPHA | CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Animals | Intestine, Small - cytology | Membrane Glycoproteins - metabolism | Humans | Glycoproteins - metabolism | Mice | Stem Cells - cytology | Intestine, Small - metabolism | Oncogene Proteins v-erbB - metabolism | Epithelial Cells - cytology | Homeostasis | Signal transduction | Small intestine | Stem cells | Have You Seen...?
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