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1. Full Text Sex differences in DNA methylation assessed by 450 K BeadChip in newborns
by Yousefi, P and Huen, K and Dave, V and Barcellos, L and Eskenazi, B and Holland, N
BMC GENOMICS, ISSN 1471-2164, 11/2015, Volume 16, Issue 908, p. 911
Background: DNA methylation is an important epigenetic mark that can potentially link early life exposures to adverse health outcomes later in life. Host... 
Gene ontology | POPULATION | EWAS | Cord blood | GENE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | Epigenetics | Birth cohort | Gender | AGE | Genome-Wide Association Study | Epigenomics | Epigenesis, Genetic - genetics | Humans | CpG Islands - genetics | Female | Male | DNA Methylation - genetics | Infant, Newborn | Infants (Newborn) | Epigenetic inheritance | Usage | Analysis | Research | Methylation | Biological markers | Health aspects
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2. Full Text In utero and childhood polybrominated diphenyl ether exposures and body mass at age 7 years: The CHAMACOS study
by Erkin-Cakmak, Ayca and Harley, Kim G and Chevrier, Jonathan and Bradman, Asa and Kogut, Katherine and Huen, Karen and Eskenazi, Brenda
Environmental Health Perspectives, ISSN 0091-6765, 2015, Volume 123, Issue 6, pp. 636 - 642
Background: Polybrominated diphenyl ethers (PBDEs) are lipophilic flame retardants that bioaccumulate in humans. Child serum PBDE concentrations in California... 
THYROID-HORMONE | PBDE MIXTURE | BIRTH-WEIGHT | OBESITY EPIDEMIC | ENVIRONMENTAL SCIENCES | ENDOCRINE DISRUPTORS | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | SERUM CONCENTRATIONS | BROMINATED FLAME RETARDANTS | TOXICOLOGY | DEVELOPMENTAL EXPOSURE | ASSOCIATION | POLYCHLORINATED-BIPHENYLS | Body Mass Index | Prenatal Exposure Delayed Effects - epidemiology | California - epidemiology | Humans | Male | Environmental Exposure | Maternal Exposure | Environmental Pollutants - blood | Pregnancy | Young Adult | Halogenated Diphenyl Ethers - blood | Flame Retardants - metabolism | Adolescent | Adult | Female | Child | Longitudinal Studies | Prenatal Exposure Delayed Effects - chemically induced | Environmental aspects | Obesity in children | Prenatal influences | Health aspects | Risk factors | Polybrominated biphenyls | Studies | Obesity | Health risk assessment | Womens health | Fire resistant materials | Index Medicus | Body size (biology) | Exposure | Children | Ethers | Serums | Age | Children's Health
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3. Full Text PON1 DNA methylation and neurobehavior in Mexican-American children with prenatal organophosphate exposure
by Huen, Karen and Solomon, Olivia and Kogut, Katherine and Eskenazi, Brenda and Holland, Nina
Environment International, ISSN 0160-4120, 12/2018, Volume 121, Issue Pt 1, pp. 31 - 40
is a multifunctional enzyme involved in oxidative stress and detoxification of some organophosphate (OP) pesticides. It has been associated with nervous system... 
Epigenetics | Cognition | PESTICIDE EXPOSURE | CHAMACOS | OXIDATIVE STRESS | ENZYME-ACTIVITY | ALZHEIMERS-DISEASE | SERUM | SPORADIC ALS | ENVIRONMENTAL SCIENCES | PARAOXONASE GENE POLYMORPHISMS | ILLUMINA 450K | AGRICULTURAL COMMUNITY | Phosphates | Epigenetic inheritance | Enzymes | Nervous system diseases | Gene expression | Autism | Pregnant women | DNA | Genetic research | Children | Methylation | Alzheimer's disease
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4. Full Text Association of prenatal urinary phthalate metabolite concentrations and childhood BMI and obesity
by Harley, Kim G and Berger, Kimberly and Rauch, Stephen and Kogut, Katherine and Claus Henn, Birgit and Calafat, Antonia M and Huen, Karen and Eskenazi, Brenda and Holland, Nina
Pediatric Research, ISSN 0031-3998, 09/2017, Volume 82, Issue 3, pp. 405 - 415
BACKGROUND: Although experiments in animals suggest that phthalates may have obesogenic effects, studies on prenatal exposure in children show inconsistent... 
IN-UTERO | GROWTH | ENVIRONMENTAL CHEMICALS | BODY-MASS INDEX | PPAR-GAMMA | PEDIATRICS | BISPHENOL-A | COHORT | ENDOCRINE DISRUPTING CHEMICALS | ADIPOGENESIS | EXPOSURE | Body Mass Index | Prenatal Exposure Delayed Effects | Humans | Child, Preschool | Male | Pregnancy | Young Adult | Phthalic Acids - urine | Obesity - urine | Obesity - epidemiology | Adolescent | Adult | Female | Child | Cohort Studies | Body mass index | Pediatrics | Obesity | Body fat | Metabolites | Health risk assessment
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5. Full Text Prenatal phthalate exposure and altered patterns of DNA methylation in cord blood
by Solomon, Olivia and Yousefi, Paul and Huen, Karen and Gunier, Robert B and Escudero‐Fung, Maria and Barcellos, Lisa F and Eskenazi, Brenda and Holland, Nina
Environmental and Molecular Mutagenesis, ISSN 0893-6692, 07/2017, Volume 58, Issue 6, pp. 398 - 410
Epigenetic changes such as DNA methylation may be a molecular mechanism through which environmental exposures affect health. Phthalates are known endocrine... 
in utero | exposure | 450K | phthalates | children | epigenetics | in utero exposure | METABOLITES | CHILDRENS ENVIRONMENTAL-HEALTH | IN-UTERO EXPOSURE | VALIDATION | IDENTIFICATION | BREAST | BRCA1 PROMOTER | ENVIRONMENTAL SCIENCES | 1ST TRIMESTER PHTHALATE | GENETICS & HEREDITY | GENE-EXPRESSION | BISPHENOL-A | TOXICOLOGY | Demography | Phthalic Acids - toxicity | Humans | Male | DNA Methylation - genetics | Fetal Blood - drug effects | Fetal Blood - metabolism | Maternal Exposure | Pregnancy | Prenatal Exposure Delayed Effects - genetics | Metabolome - drug effects | CpG Islands - genetics | Female | DNA Methylation - drug effects | Infant, Newborn | Endocrine disruptors | Epigenetic inheritance | Metabolites | Pregnant women | Analysis | DNA | Esters | Methylation | Neonates | Identification methods | Inflammatory response | Gestation | Blood | Cord blood | Fertility | DNA methylation | Prenatal experience | Deoxyribonucleic acid--DNA | CpG islands | Urine | BRCA1 protein | Health | Fetuses | Blood cells | Regional analysis | Breast cancer | Exposure | Inflammation | Intrauterine exposure | Phthalates | Side effects | Cancer
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6. Full Text Sex differences in DNA methylation assessed by 450K BeadChip in newborns
by Yousefi, Paul and Huen, Karen and Davé, Veronica and Barcellos, Lisa and Eskenazi, Brenda and Holland, Nina
BMC Genomics, 11/2015, Volume 16, Issue 1
Gene ontology | Epigenetics | Birth cohort | Gender | Cord blood | EWAS
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7. Full Text Effects of age, sex, and persistent organic pollutants on DNA methylation in children
by Huen, Karen and Yousefi, Paul and Bradman, Asa and Yan, Liying and Harley, Kim G and Kogut, Katherine and Eskenazi, Brenda and Holland, Nina
Environmental and Molecular Mutagenesis, ISSN 0893-6692, 04/2014, Volume 55, Issue 3, pp. 209 - 222
Epigenetic changes such as DNA methylation may be a molecular mechanism through which environmental exposures affect health. Methylation of Alu and long... 
DDE | DDT | PBDE | LINE‐1 | co‐exposure | Alu | epigenetics | LINE-1 | Co-exposure | Epigenetics | HUMAN-SERUM | IN-UTERO | PROMOTER METHYLATION | GASTRIC-CANCER RISK | co-exposure | POLYBROMINATED DIPHENYL ETHERS | BREAST-CANCER | ENVIRONMENTAL SCIENCES | MEXICAN-AMERICAN CHILDREN | GENETICS & HEREDITY | TOXICOLOGY | DICHLORODIPHENYLTRICHLOROETHANE DDT | CHAMACOS COHORT | POLYCHLORINATED-BIPHENYLS | Mexican Americans | Age Factors | Cell Count | Epigenesis, Genetic | Humans | Organic Chemicals - toxicity | Male | Maternal Exposure | DDT - toxicity | Halogenated Diphenyl Ethers - toxicity | Pregnancy | DNA Methylation | Long Interspersed Nucleotide Elements | Dichlorodiphenyl Dichloroethylene - toxicity | Sex Factors | Female | Environmental Pollutants - toxicity | Alu Elements | Child | Fetal Blood | Infant, Newborn | Cohort Studies | Sulfites | Pregnant women | Analysis | DNA | Genetic research | Children | Persistent organic pollutants | Methylation | Index Medicus
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8. Full Text Early-Life Home Environment and Obesity in a Mexican American Birth Cohort: The CHAMACOS Study
by Tindula, Gwen and Tindula, Gwen and Gunier, Robert B and Gunier, Robert B and Deardorff, Julianna and Deardorff, Julianna and Nabaglo, Kelly and Nabaglo, Kelly and Hubbard, Alan and Hubbard, Alan and Huen, Karen and Huen, Karen and Eskenazi, Brenda and Eskenazi, Brenda and Holland, Nina and Holland, Nina
Psychosomatic medicine, ISSN 0033-3174, 02/2019, Volume 81, Issue 2, pp. 209 - 219
Objective Little is known about the impact of the home environment on biomarkers of obesity, such as adipokines, in children. In this study, we examined the... 
adiponectin | CHAMACOS = Center for the Health Assessment of Mothers and Children of Salinas | children | BMI = body mass index | CES-D = Center for Epidemiological Studies Depression Scale | home environment | Mexican American | HOME = Home Observation for the Measurement of the Environment | FDR = false discovery rate | GEE = generalized estimating equation | leptin | HPA = hypothalamic-pituitary-adrenal | PSYCHIATRY | MATERNAL DEPRESSION | LONGITUDINAL DATA | PSYCHOLOGY | CHILDHOOD OVERWEIGHT | PSYCHOLOGY, MULTIDISCIPLINARY | SERUM-LEVELS | BODY-MASS INDEX | SOCIAL SUPPORT | STRESS | Psychological aspects | Mother and child | Mexican Americans | Obesity in children | Health aspects | Risk factors | Measurement | Learning environment | Hispanic Americans | Social factors | Mental depression | Hormones | Mothers | Adiponectin | Body mass index | Social interactions | Childhood obesity | Childhood | Questionnaires | Children | Biological markers | Age | Obesity | Maternal depression | Maternal support | Home environment | School environment | Childbirth & labor | Leptin | Symptoms | Social support | Original
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9. Full Text PON1 and Neurodevelopment in Children from the CHAMACOS Study Exposed to Organophosphate Pesticides in Utero
by Brenda Eskenazi and Karen Huen and Amy Marks and Kim G. Harley and Asa Bradman and Dana Boyd Barr and Nina Holland
Environmental Health Perspectives, ISSN 0091-6765, 12/2010, Volume 118, Issue 12, pp. 1775 - 1781
Background: Paraoxonase 1 (PONI) detoxifies oxon derivatives of some organophosphate (OP) pesticides, and its genetic polymorphisms influence enzyme activity... 
Pregnancy | Chemical hazards | Enzymes | Phosphoric acid esters | Enzyme activity | Pesticides | Premenstrual syndrome | Children | Mothers | Genotypes | Children's Health | Daps | Genetic susceptibility | Farmworker | PON1 | Paraoxonase | In utero exposure | Pervasive developmental disorder | Child behavior checklist | Organophos-phates | Biomarkers | Neurodevelopment | Mental development | Mexican americans | Child Behavior Checklist | ALZHEIMERS-DISEASE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | farmworker | neurodevelopment | children | pesticides | ARTERIAL ISCHEMIC-STROKE | PARAOXONASE GENE POLYMORPHISMS | genetic susceptibility | paraoxonase | ARYLESTERASE ACTIVITY | YOUNG-ADULTS | Mexican Americans | OXIDATIVE STRESS | ENZYME-ACTIVITY | biomarkers | pervasive developmental disorder | organophosphates | GULF-WAR VETERANS | SPORADIC ALS | ENVIRONMENTAL SCIENCES | RISK-FACTOR | in utero exposure | mental development | DAPs | Inactivation, Metabolic | Brain - embryology | Nutrition Surveys | Child Behavior Disorders - ethnology | Humans | Brain - enzymology | Child, Preschool | Infant | Brain - growth & development | Behavioral Symptoms - ethnology | Maternal Exposure - statistics & numerical data | Young Adult | Pesticides - urine | Adult | Female | Child Development - drug effects | Environmental Exposure - statistics & numerical data | Infant, Newborn | Organophosphorus Compounds - urine | Environmental Exposure - analysis | Aryldialkylphosphatase - genetics | Aryldialkylphosphatase - metabolism | Mexican Americans - ethnology | Adolescent | California - ethnology | Physiological aspects | Organophosphorus compounds | Child development | Health aspects | Risk factors | Pervasive developmental disorders | MDI | Health | Infants | Assessments | Organophosphates | Polymorphism | Research
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10. Full Text DNA methylation of LINE-1 and Alu repetitive elements in relation to sex hormones and pubertal timing in Mexican-American children
by Huen, Karen and Harley, Kim and Kogut, Katherine and Rauch, Stephen and Eskenazi, Brenda and Holland, Nina
Pediatric Research, ISSN 0031-3998, 06/2016, Volume 79, Issue 6, pp. 855 - 862
BACKGROUND: The molecular mechanisms linking environmental exposures to earlier pubertal development are not well characterized. Epigenetics may play an... 
MENARCHE | BOYS | BODY-MASS | PEDIATRICS | PERSISTENT ORGANIC POLLUTANTS | WIDE ASSOCIATION | BREAST DEVELOPMENT | GIRLS | ONSET | AGE | HYPOMETHYLATION | Puberty | Mexican Americans | Epigenomics | Luteinizing Hormone - blood | United States | Anthropometry | Epigenesis, Genetic | Humans | Hispanic Americans | Male | Gonadal Steroid Hormones - blood | Sequence Analysis, DNA | DNA Methylation | Long Interspersed Nucleotide Elements | Follicle Stimulating Hormone - blood | Female | Testosterone - blood | Hormones - blood | Alu Elements | Child | Longitudinal Studies | Infant, Newborn | Sexual Maturation | DNA methylation | Hormones | Hispanic American studies | Sexes | Children & youth
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11. Full Text Estimation of blood cellular heterogeneity in newborns and children for epigenome‐wide association studies
by Yousefi, Paul and Huen, Karen and Quach, Hong and Motwani, Girish and Hubbard, Alan and Eskenazi, Brenda and Holland, Nina and Schmezer, P
Environmental and Molecular Mutagenesis, ISSN 0893-6692, 12/2015, Volume 56, Issue 9, pp. 751 - 758
Confounding by cellular heterogeneity has become a major concern for epigenome‐wide association studies (EWAS) in peripheral blood samples from population and... 
minfi | differential cell count | 450K | birth cohort | epigenetics | Differential cell count | Epigenetics | Birth cohort | Minfi | ENVIRONMENTAL SCIENCES | SEX | GENETICS & HEREDITY | SITES | SMOKING | TOXICOLOGY | DIFFERENTIAL DNA METHYLATION | Genome-Wide Association Study | Blood Cell Count - methods | Age Factors | Epigenesis, Genetic | Humans | Male | Reference Values | DNA Methylation | Blood Cells - cytology | Female | Leukocyte Count - methods | Child | Longitudinal Studies | Blood Cells - physiology | Infant, Newborn | Cohort Studies | Infants (Newborn) | Epigenetic inheritance | Analysis | Leukemia | Blood | Erythrocytes | Index Medicus
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12. Full Text Age-Related Differences in miRNA Expression in Mexican-American Newborns and Children
by Huen, K and Lizarraga, D and Kogut, K and Eskenazi, B and Holland, N
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, ISSN 1660-4601, 02/2019, Volume 16, Issue 4, p. 524
Epigenetic mechanisms have emerged as an important pathway through which environmental exposures can affect health through the regulation of gene expression... 
ENVIRONMENTAL SCIENCES | ENVIRONMENTAL-HEALTH | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | DNA METHYLATION | SIGNATURES | miRNA | OPPORTUNITIES | SAMPLES | blood | age | EXPOSURE | MICRORNA
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