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1. Full Text GDNF gene is associated with tourette syndrome in a family study
by Huertas‐Fernández, Ismael and Gómez‐Garre, Pilar and Madruga‐Garrido, Marcos and Bernal‐Bernal, Inmaculada and Bonilla‐Toribio, Marta and Martín‐Rodríguez, Juan Francisco and Cáceres‐Redondo, María Teresa and Vargas‐González, Laura and Carrillo, Fátima and Pascual, Alberto and Tischfield, Jay A and King, Robert A and Heiman, Gary A and Mir, Pablo
Movement Disorders, ISSN 0885-3185, 07/2015, Volume 30, Issue 8, pp. 1115 - 1120
Background Tourette syndrome is a disorder characterized by persistent motor and vocal tics, and frequently accompanied by the comorbidities attention deficit... 
family‐based association analysis | Tourette syndrome | synaptic neurotransmission | family-based association analysis | NEUROTROPHIC FACTOR | BASAL GANGLIA | CLINICAL NEUROLOGY | OBSESSIVE-COMPULSIVE DISORDER | INDIVIDUALS | BRAIN-STEM PLASTICITY | GABAERGIC INTERNEURONS | MISSING HERITABILITY | LINKAGE | NEURON | GENOME-WIDE ASSOCIATION | Tourette Syndrome - genetics | Genetic Association Studies | Synaptic Transmission - genetics | United States | Humans | Middle Aged | Glial Cell Line-Derived Neurotrophic Factor - genetics | Male | Polymorphism, Genetic | Young Adult | Pedigree | Adolescent | Adult | Female | Child | Cohort Studies | Tourette's syndrome | Medical research | Genes | Attention-deficit hyperactivity disorder | Genetic research | Medicine, Experimental | Genetic aspects
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2. Full Text Clinical features and 123I-FP-CIT SPECT imaging in vascular parkinsonism and Parkinson's disease
by Benítez-Rivero, Sonia and Marín-Oyaga, Víctor A and García-Solís, David and Huertas-Fernández, Ismael and García-Gómez, Francisco J and Jesús, Silvia and Cáceres, María Teresa and Carrillo, Fátima and Ortiz, Ana M and Carballo, Manuel and Mir, Pablo
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 02/2013, Volume 84, Issue 2, pp. 122 - 129
Objectives To analyse the differences in the clinical features and characteristics of 123I-labelled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)... 
Dopamine Plasma Membrane Transport Proteins - metabolism | Brain - diagnostic imaging | Tomography, Emission-Computed, Single-Photon - methods | Iodine Radioisotopes | Parkinson Disease - diagnostic imaging | Humans | Middle Aged | Parkinson Disease, Secondary - diagnosis | Male | Cerebrovascular Disorders - metabolism | Functional Neuroimaging - methods | Case-Control Studies | Brain - metabolism | Tropanes | Cerebrovascular Disorders - diagnosis | Cerebrovascular Disorders - diagnostic imaging | Parkinson Disease - diagnosis | Parkinson Disease, Secondary - metabolism | Female | Aged | Parkinson Disease - metabolism | Functional Neuroimaging - statistics & numerical data | Parkinson Disease, Secondary - diagnostic imaging | Tomography, Emission-Computed, Single-Photon - statistics & numerical data
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3. Full Text Low serum uric acid levels in progressive supranuclear palsy
by Oropesa‐Ruiz, Juan Manuel and Huertas‐Fernández, Ismael and Jesús, Silvia and Cáceres‐Redondo, María Teresa and Vargas‐Gonzalez, Laura and Carrillo, Fátima and Carballo, Manuel and Gómez‐Garre, Pilar and Mir, Pablo
Movement Disorders, ISSN 0885-3185, 03/2016, Volume 31, Issue 3, pp. 402 - 405
ABSTRACT Introduction Uric acid is a natural antioxidant, and it has been shown that low levels of uric acid could be a risk factor for the development of PD.... 
antioxidants | uric acid | biomarkers | progressive supranuclear palsy | Antioxidants | Biomarkers | Uric acid | Progressive supranuclear palsy | OXIDATIVE STRESS | RISK | LONGITUDINAL DATA | PLASMA URATE | NEUROPROTECTION | CLINICAL NEUROLOGY | CEREBROSPINAL-FLUID URATE | MODELS | IDIOPATHIC PARKINSONS-DISEASE | Cross-Sectional Studies | Humans | Middle Aged | Risk Factors | Male | Supranuclear Palsy, Progressive - blood | Uric Acid - urine | Aged, 80 and over | Female | Multiple System Atrophy - blood | Aged | Parkinson Disease - metabolism | Uric Acid - blood | Parkinson Disease - blood | Supranuclear Palsy, Progressive - diagnosis | Analysis | Movement disorders
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4. Full Text Aberrant cortical associative plasticity associated with severe adult Tourette syndrome
by Martín‐Rodríguez, Juan Francisco and Ruiz‐Rodríguez, María Adilia and Palomar, Francisco J and Cáceres‐Redondo, María Teresa and Vargas, Laura and Porcacchia, Paolo and Gómez‐Crespo, Mercedes and Huertas‐Fernández, Ismael and Carrillo, Fátima and Madruga‐Garrido, Marcos and Mir, Pablo
Movement Disorders, ISSN 0885-3185, 03/2015, Volume 30, Issue 3, pp. 431 - 435
Background Recent studies have shown altered cortical plasticity in adult patients with Tourette syndrome. However, the clinical significance of this finding... 
paired associative stimulation | associative plasticity | motor cortex | transcranial magnetic stimulation | Tourette syndrome | Transcranial magnetic stimulation | Associative plasticity | Motor cortex | Paired associative stimulation | SYSTEM | ADHD | TIC SEVERITY | CLINICAL NEUROLOGY | CHILDREN | HUMAN MOTOR CORTEX | INHIBITION | EXCITABILITY | BRAIN-STEM PLASTICITY | DISORDER | SCALE | Transcranial Magnetic Stimulation | Young Adult | Neuronal Plasticity - physiology | Evoked Potentials, Motor - physiology | Tourette Syndrome - pathology | Humans | Middle Aged | Adult | Motor Cortex - physiopathology | Electromyography
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5. Full Text Lower levels of uric acid and striatal dopamine in non-tremor dominant Parkinson's disease subtype
by Huertas, Ismael and Jesús, Silvia and Lojo, José Antonio and García-Gómez, Francisco Javier and Cáceres-Redondo, María Teresa and Oropesa-Ruiz, Juan Manuel and Carrillo, Fátima and Vargas-Gonzalez, Laura and Rodríguez, Juan Francisco Martín and Gómez-Garre, Pilar and García-Solís, David and Mir, Pablo
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0174644
Parkinson's disease (PD) patients who present with tremor and maintain a predominance of tremor have a better prognosis. Similarly, PD patients with high... 
HETEROGENEITY | URATE | PREDICTOR | ATROPHY | MOTOR SUBTYPES | MULTIDISCIPLINARY SCIENCES | PATTERNS | ASSOCIATION | SPECT | PROGRESSION | Dopamine Plasma Membrane Transport Proteins - isolation & purification | Parkinson Disease - diagnostic imaging | Humans | Middle Aged | Male | Molecular Imaging - methods | Postural Balance - genetics | Parkinson Disease - physiopathology | Corpus Striatum - metabolism | Dopamine Plasma Membrane Transport Proteins - genetics | Gait - physiology | Neuropsychological Tests | Adult | Female | Postural Balance - physiology | Uric Acid - blood | Parkinson Disease - blood | Corpus Striatum - diagnostic imaging | Dopamine - metabolism | Gait - genetics | Parkinson's disease | Dopamine | Physiological aspects | Genetic aspects | Uric acid | Research | Diagnosis | Brain | Gait | Gout | Disorders | Cognitive ability | Nervous system | Rigidity | Males | Assaying | Genotype & phenotype | Archives & records | Autopsy | Neurodegeneration | Neostriatum | Longitudinal studies | Damage | Archives | Movement disorders | Stress concentration | Neurodegenerative diseases | Anemia | Single photon emission computed tomography | Studies | Neurology | Learning algorithms | Chemotherapy | Hospitals | Biomarkers | Neuroimaging | Drug abuse | Nuclear medicine | Oxidative stress | Animal models | Parkinsons disease | Atrophy | Lymphocytes | Rodents | Dementia disorders | Degeneration | Paralysis | Age | Autopsies | Akinesia | Neurons | Alcoholism | Diabetes mellitus | Health risks | Immunoproliferative diseases | Environmental factors | Standards | Medicine | Acids | Deterioration | Machine learning | Cancer
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6. Full Text Long-term levodopa/carbidopa intestinal gel in advanced Parkinson's disease
by Cáceres-Redondo, María T and Carrillo, Fátima and Lama, María J and Huertas-Fernández, Ismael and Vargas-González, Laura and Carballo, Manuel and Mir, Pablo
Journal of Neurology, ISSN 0340-5354, 2014, Volume 261, Issue 3, pp. 561 - 569
The short-term benefits of levodopa/carbidopa intestinal gel (LCIG) in patients with advanced Parkinson's disease (PD) are well documented, but the long-term... 
Long-term | LCIG | Advanced Parkinson's disease | NEUROPATHY | DEMENTIA | DUODENAL LEVODOPA INFUSION | EXPOSURE | CLINICAL NEUROLOGY | AGE | Antiparkinson Agents - pharmacology | Follow-Up Studies | Humans | Middle Aged | Male | Parkinson Disease - drug therapy | Gastrostomy - adverse effects | Carbidopa - pharmacology | Levodopa - administration & dosage | Cognition Disorders - etiology | Infusions, Parenteral - methods | Female | Carbidopa - administration & dosage | Cognitive Dysfunction - drug therapy | Severity of Illness Index | Levodopa - pharmacology | Parkinson Disease - complications | Cognition Disorders - physiopathology | Gels | Infusions, Parenteral - adverse effects | Treatment Outcome | Cognition Disorders - drug therapy | Cognitive Dysfunction - etiology | Cognitive Dysfunction - physiopathology | Parkinson Disease - physiopathology | Disease Progression | Neuropsychological Tests | Aged | Antiparkinson Agents - administration & dosage | Drug Combinations | Complications and side effects | Parkinson's disease | Patient outcomes | Dosage and administration | Research | Dopa | Drug therapy
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7. Full Text Lack of validation of variants associated with cervical dystonia risk: A GWAS replication study
by Gómez‐Garre, Pilar and Huertas‐Fernández, Ismael and Cáceres‐Redondo, María Teresa and Alonso‐Canovas, Araceli and Bernal‐Bernal, Inmaculada and Blanco‐Ollero, Alberto and Bonilla‐Toribio, Marta and Burguera, Juan Andrés and Carballo, Manuel and Carrillo, Fatima and José Catalán‐Alonso, M and Escamilla‐Sevilla, Francisco and Espinosa‐Rosso, Raul and Carmen Fernández‐Moreno, María and García‐Caldentey, Juan and García‐Moreno, José Manuel and Giacometti‐Silveira, Sandra and Gutiérrez‐García, Javier and Jesús‐Maestre, Silvia and López‐Valdés, Eva and Martínez‐Castrillo, Juan Carlos and Medialdea‐Natera, María Pilar and Méndez‐Lucena, Carolina and Mínguez‐Castellanos, Adolfo and Angel Moya, Miguel and Ochoa‐Sepulveda, Juan José and Ojea, Tomas and Rodríguez, Nuria and Rubio‐Agusti, Ignacio and Sillero‐Sánchez, Miriam and del Val, Javier and Vargas‐González, Laura and Mir, Pablo
Movement Disorders, ISSN 0885-3185, 12/2014, Volume 29, Issue 14, pp. 1825 - 1828
Background A recent genome‐wide association study (GWAS) has identified a putative association, not statistically confirmed, of cervical dystonia within... 
replication | cervical dystonia | GWAS | primary dystonia | association study | Association study | Primary dystonia | Replication | Cervical dystonia | CHANNEL | MUTATIONS | CLINICAL NEUROLOGY | Gene Frequency - genetics | Genetic Predisposition to Disease | Humans | Middle Aged | European Continental Ancestry Group | Genotype | Risk | Case-Control Studies | Dystonia - genetics | Age of Onset | Polymorphism, Single Nucleotide - genetics | Adult | Female | Aged | Genome-Wide Association Study - methods
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8. Full Text The use of botulinum toxin in the treatment of sialorrhea in parkinsonian disorders
by Gómez-Caravaca, María T and Gómez-Caravaca, María T and Cáceres-Redondo, María T and Cáceres-Redondo, María T and Huertas-Fernández, Ismael and Huertas-Fernández, Ismael and Vargas-González, Laura and Vargas-González, Laura and Carrillo, Fátima and Carrillo, Fátima and Carballo, Manuel and Carballo, Manuel and Mir, Pablo and Mir, Pablo
Neurological Sciences, ISSN 1590-1874, 2/2015, Volume 36, Issue 2, pp. 275 - 279
Drooling is a common symptom in parkinsonian disorders. Our aim was to assess the safety and effect of botulinum toxin when applied to parotid glands without... 
Neurology | Parkinsonian disorders | Medicine & Public Health | Neurosurgery | Psychiatry | Botulinum toxin | Neuroradiology | Parkinson’s disease | Sialorrhea | CRITERIA | DIAGNOSIS | Parkinson's disease | EFFICACY | SAFETY | AMYOTROPHIC-LATERAL-SCLEROSIS | NEUROSCIENCES | CLINICAL NEUROLOGY | TRIAL | DISEASE | DOUBLE-BLIND | INJECTIONS | Parotid Gland - drug effects | Parkinsonian Disorders - physiopathology | Follow-Up Studies | Humans | Male | Treatment Outcome | Botulinum Toxins, Type A - administration & dosage | Sialorrhea - drug therapy | Sialorrhea - physiopathology | Peripheral Nervous System Agents - administration & dosage | Time Factors | Parkinsonian Disorders - drug therapy | Peripheral Nervous System Agents - adverse effects | Female | Aged | Retrospective Studies | Botulinum Toxins, Type A - adverse effects
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9. Full Text Trait‐ and state‐dependent cortical inhibitory deficits in bipolar disorder
by Ruiz‐Veguilla, Miguel and Martín‐Rodríguez, Juan Francisco and Palomar, Francisco J and Porcacchia, Paolo and Álvarez de Toledo, Paloma and Perona‐Garcelán, Salvador and Rodríguez‐Testal, Juan Francisco and Huertas‐Fernández, Ismael and Mir, Pablo
Bipolar Disorders, ISSN 1398-5647, 05/2016, Volume 18, Issue 3, pp. 261 - 271
Objectives Euthymic patients with bipolar disorder (BD) have deficits in cortical inhibition. However, whether cortical inhibitory deficits are trait‐ or... 
longitudinal study | motor cortex | cortical inhibition | GABA receptors | transcallosal inhibition | short‐interval intracortical inhibition | Cortical inhibition | Short-interval intracortical inhibition | Motor cortex | Transcallosal inhibition | Longitudinal study | ABNORMALITIES | PSYCHIATRY | short-interval intracortical inhibition | SCHIZOPHRENIA | MECHANISMS | SMOKING | IMPULSIVITY | NEUROSCIENCES | CLINICAL NEUROLOGY | GABA(A) | TRANSCRANIAL MAGNETIC STIMULATION | INTERHEMISPHERIC INHIBITION | SYSTEMS | RATING-SCALE | Interneurons - physiology | Motor Activity - physiology | Character | Corpus Callosum - physiopathology | Humans | Middle Aged | Bipolar Disorder - physiopathology | Male | Bipolar Disorder - diagnosis | Bipolar Disorder - psychology | Cerebral Cortex - physiopathology | gamma-Aminobutyric Acid - physiology | Young Adult | Neural Inhibition - physiology | Transcranial Direct Current Stimulation | Adult | Female | Longitudinal Studies | Mania | GABA | Bipolar disorder | Analysis
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10. Full Text BDNF Val66Met polymorphism in primary adult‐onset dystonia: A case‐control study and meta‐analysis
by Gómez‐Garre, Pilar and Huertas‐Fernández, Ismael and Cáceres‐Redondo, María Teresa and Alonso‐Canovas, Araceli and Bernal‐Bernal, Inmaculada and Blanco‐Ollero, Alberto and Bonilla‐Toribio, Marta and Burguera, Juan Andrés and Carballo, Manuel and Carrillo, Fátima and Catalán‐Alonso, María José and Escamilla‐Sevilla, Francisco and Espinosa‐Rosso, Raúl and Fernández‐Moreno, María Carmen and García‐Caldentey, Juan and García‐Moreno, José Manuel and García‐Ruiz, Pedro José and Giacometti‐Silveira, Sandra and Gutiérrez‐García, Javier and Jesús, Silvia and López‐Valdés, Eva and Martínez‐Castrillo, Juan Carlos and Martínez‐Torres, Irene and Medialdea‐Natera, María Pilar and Méndez‐Lucena, Carolina and Mínguez‐Castellanos, Adolfo and Moya, Miguel and Ochoa‐Sepulveda, Juan José and Ojea, Tomás and Rodríguez, Nuria and Sillero‐Sánchez, Miriam and Vargas‐González, Laura and Mir, Pablo
Movement Disorders, ISSN 0885-3185, 07/2014, Volume 29, Issue 8, pp. 1083 - 1086
Background A polymorphism in brain‐derived neurotrophic factor (BDNF) (Val66Met) has been reported as a risk factor in primary dystonia. However, overall the... 
Primary dystonia | meta‐analysis | Val66Met | BDNF | association study | Association study | Meta-analysis | POPULATION | meta-analysis | CRANIAL-CERVICAL DYSTONIA | CLINICAL NEUROLOGY | NEUROTROPHIC FACTOR GENE | VA166MET POLYMORPHISM | COMMON POLYMORPHISM | DISEASE | ASSOCIATION | PLASTICITY | Brain-Derived Neurotrophic Factor - genetics | Dystonic Disorders - genetics | Genetic Predisposition to Disease - genetics | Genetic Association Studies | Gene Frequency | Humans | Middle Aged | Genotype | Male | Case-Control Studies | Polymorphism, Single Nucleotide - genetics | Adult | Female | Valine - genetics | Aged | Methionine - genetics
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11. Full Text Genetic association of sirtuin genes and Parkinson's disease
by Jesús, Silvia and Gómez-Garre, Pilar and Carrillo, Fátima and Cáceres-Redondo, María T and Huertas-Fernández, Ismael and Bernal-Bernal, Inmaculada and Bonilla-Toribio, Marta and Vargas-González, Laura and Carballo, Manuel and Mir, Pablo
Journal of Neurology, ISSN 0340-5354, 09/2013, Volume 260, Issue 9, pp. 2237 - 2241
Parkinson's disease (PD) is a neurodegenerative disease caused by both genetic and environmental factors. Sirtuins are highly-conserved, NAD-dependent class... 
Sirtuins | Parkinson's disease | Polymorphism | LONGEVITY | MODELS | PGC-1-ALPHA | MICE | MUTATIONS | DAMAGE | BRAIN | CLINICAL NEUROLOGY | PROTECTS | Genetic Predisposition to Disease - genetics | Humans | Middle Aged | Genotype | Polymorphism, Single Nucleotide | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Parkinson Disease - genetics | Sirtuins - genetics | Genetic aspects | MicroRNA | Single nucleotide polymorphisms | Health aspects | Risk factors | Animal models
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12. Full Text Abnormal sensorimotor integration correlates with cognitive profile in vascular parkinsonism
by Benítez-Rivero, Sonia and Palomar, Francisco J and Martín-Rodríguez, Juan F and de Toledo, Paloma Álvarez and Lama, María J and Huertas-Fernández, Ismael and Cáceres-Redondo, María T and Porcacchia, Paolo and Mir, Pablo
Journal of the Neurological Sciences, ISSN 0022-510X, 2016, Volume 377, pp. 161 - 166
Abstract Introduction Vascular parkinsonism is a syndrome that develops as a result of cerebrovascular disease. Although several studies on clinical features... 
Neurology | Long term potentiation | Parkinson's disease | Cognitive function | Vascular parkinsonism | Plasticity | Neurophysiology | LATENCY AFFERENT INHIBITION | CLINICAL-FEATURES | NEUROSCIENCES | CLINICAL NEUROLOGY | IMPAIRMENT | CIRCUITS | HUMAN MOTOR CORTEX | TRANSCRANIAL MAGNETIC STIMULATION | EXCITABILITY | FUNCTIONAL-EVALUATION | DISEASE | Cerebrovascular Disorders - physiopathology | Neural Inhibition | Humans | Afferent Pathways - physiopathology | Male | Cognition | Evoked Potentials, Somatosensory | Sensorimotor Cortex - physiopathology | Neuropsychological Tests | Transcranial Magnetic Stimulation | Evoked Potentials, Motor | Neuronal Plasticity | Median Nerve - physiopathology | Muscle, Skeletal - physiopathology | Parkinson Disease, Secondary - physiopathology | Parkinson Disease, Secondary - psychology | Aged, 80 and over | Female | Aged | Electromyography | Cerebrovascular Disorders - psychology | Medicine, Experimental | Medical research | Executives
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13. Full Text Low serum uric acid levels in progressive supranuclear palsy
: Uric Acid in PSP
by Oropesa-Ruiz, Juan Manuel and Huertas-Fernández, Ismael and Jesús, Silvia and Cáceres-Redondo, María Teresa and Vargas-Gonzalez, Laura and Carrillo, Fátima and Carballo, Manuel and Gómez-Garre, Pilar and Mir, Pablo
Movement Disorders, ISSN 0885-3185, 03/2016, Volume 31, Issue 3, pp. 402 - 405
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14. Full Text Systematic mutational analysis of FBXO7 in a Parkinson's disease population from southern Spain
by Gómez-Garre, Pilar and Jesús, Silvia and Carrillo, Fátima and Cáceres-Redondo, Maria Teresa and Huertas-Fernández, Ismael and Bernal-Bernal, Inmaculada and Bonilla-Toribio, Marta and Vargas-González, Laura and Carballo, Manuel and Mir, Pablo
Neurobiology of Aging, ISSN 0197-4580, 2014, Volume 35, Issue 3, pp. 727.e5 - 727.e7
Abstract Mutations in FBXO7 (PARK15) have been associated with a syndrome characterized by early-onset progressive parkinsonism with and without pyramidal... 
Neurology | Internal Medicine | Parkinsonism | Variants | Parkinson's disease | Early-onset | Mutational analysis | FBXO7 | Pyramidal signs | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | Spain - epidemiology | Humans | Age of Onset | Parkinson Disease - epidemiology | Mutation | Parkinson Disease - genetics | DNA Mutational Analysis - methods | F-Box Proteins - genetics
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15. Full Text Long-term levodopa/carbidopa intestinal gel in advanced Parkinson’s disease
by Cáceres-Redondo, María T and Carrillo, Fátima and Lama, María J and Huertas-Fernández, Ismael and Vargas-González, Laura and Carballo, Manuel and Mir, Pablo
Journal of Neurology, ISSN 0340-5354, 3/2014, Volume 261, Issue 3, pp. 561 - 569
The short-term benefits of levodopa/carbidopa intestinal gel (LCIG) in patients with advanced Parkinson’s disease (PD) are well documented, but the long-term... 
Neurology | Neurosciences | Medicine & Public Health | LCIG | Long-term | Neuroradiology | Advanced Parkinson’s disease
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