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Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 7538 - 13
Extracellular vesicles (EVs) are an important class of membrane-bound structures that have been widely investigated for their roles in intercellular... 
NECROSIS | MECHANISM | INFLAMMASOME ACTIVATION | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME | PYROPTOSIS | SECRETION | Regeneration | Monocytes | Intercellular signalling | Vesicles | Cell death | Centrifugation | Inflammation | Cell interactions | Exosomes | Apoptosis | Necrosis
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 10292 - 15
We developed a novel series of antimalarial compounds based on a 4-cyano-3-methylisoquinoline. Our lead compound MB14 achieved modest inhibition of the growth... 
INVASION | TRANSPORTER | MULTIDISCIPLINARY SCIENCES | MUTATION | RESISTANCE | DEPENDENT PROTEIN-KINASE | MALARIA PARASITE | CANDIDATE | CATION ATPASE PFATP4 | IDENTIFICATION | SPIROINDOLONE KAE609 | Malaria | Sodium | Antimalarial agents | Erythrocytes | Membrane permeability | Lysis | Genomes | Parasites | Permeability
Journal Article
Immunology and Cell Biology, ISSN 0818-9641, 01/2018, Volume 96, Issue 1, pp. 54 - 67
Host defense peptides (HDPs) are well‐characterized for their antimicrobial activities but also variously display potent immunomodulatory effects. Human... 
receptors | innate immunity | innate immune cells | cytokine induction | intracellular signaling | PI3K‐Akt signaling | Inflammation | immunology | human β‐defensin 3 | lipid binding | PI3K-Akt signaling | human β-defensin 3 | DENDRITIC CELLS | MAST-CELLS | RECEPTOR | CELL-PENETRATING PEPTIDES | ANTIMICROBIAL PEPTIDES | PLASMA-MEMBRANE | CELL BIOLOGY | EPITHELIAL-CELLS | HUMAN BETA-DEFENSIN-3 | human beta-defensin 3 | ANTIGEN-PRESENTING CELLS | NF-KAPPA-B | Tumor Necrosis Factors - genetics | beta-Defensins - genetics | Interleukin-6 - genetics | Signal Transduction | Anti-Infective Agents - metabolism | Immunomodulation | Humans | Cells, Cultured | Gene Expression Regulation | Tumor Necrosis Factors - metabolism | Type C Phospholipases - metabolism | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Immunity, Innate | Mutation - genetics | Protein Binding | Phosphatidylinositols - metabolism | beta-Defensins - metabolism | Monocytes - physiology | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | NF-κB protein | Cytokines | AKT protein | Kinases | Phospholipase C | Mammalian cells | 1-Phosphatidylinositol 3-kinase | Interleukin 6 | Leucocytes | Phospholipase | Signal transduction | Cell activation | Immunology | Defensins | Toll-like receptors | Tumor necrosis factor-TNF
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 05/2019, Volume 33, Issue 5, pp. 6470 - 6482
Defensins are an extensive family of host defense peptides found ubiquitously across plant and animal species. In addition to protecting against infection by... 
SYSTEM | NAD1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | cell permeabilization | anticancer | FAMILY | CELL BIOLOGY | X-ray crystallography | INHIBITION | innate immunity | GENE | BELL PEPPER | SEQUENCE | BIOLOGY | PLANT DEFENSIN | CATIONIC ANTIMICROBIAL PEPTIDES | antimicrobial peptide | EXPRESSION
Journal Article
Frontiers in immunology, ISSN 1664-3224, 2018, Volume 9, p. 2842
During the progression of necroptosis and pyroptosis, the plasma membrane will become permeabilized through the activation of mixed lineage kinase domain like... 
secondary necrosis | apoptosis | apoptotic cell disassembly | gasdermin | apoptotic bodies | DFNA5 | GSDME | CLEARANCE | MECHANISMS | PYROPTOSIS | IMMUNOLOGY | DYING CELLS | BODIES | Apoptotic proteins | Monocytes | Research | T cells | Necrosis
Journal Article
Journal of Extracellular Vesicles, ISSN 2001-3078, 12/2019, Volume 8, Issue 1, p. 1608786
Apoptosis is a form of programmed cell death that occurs throughout life as part of normal development as well as pathologic processes including chronic... 
apoptotic cell-derived extracellular vesicles | apoptotic bodies | Apoptosis | ACTIVATION | AUTOANTIGENS | MICROVESICLES | POPULATIONS | IDENTIFICATION | CELL BIOLOGY | EMERGING ROLE | CONTRACTION | EXOSOMES | BODIES | PROGRESSION
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2016, Volume 113, Issue 40, p. 11202
  Defensins are cationic antimicrobial peptides that serve as important components of host innate immune defenses, often by targeting cell membranes of... 
Mutagenesis | Peptides | Lipids | Bacteria | Crystal structure
Journal Article
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 10, p. e109596
Heparanase is a beta-D-endoglucuronidase that cleaves heparan sulfate (HS), facilitating degradation of the extracellular matrix (ECM) and the release of... 
ADHESION | TOLL-LIKE RECEPTOR-4 | ROLES | CELL-MIGRATION | MULTIDISCIPLINARY SCIENCES | LIPOPOLYSACCHARIDE | MAMMALIAN HEPARANASE | LUNG INJURY | DEGRADING ENZYME | EXPRESSION | T-CELLS | Leukocytes, Mononuclear - drug effects | Cytokines - metabolism | Heparitin Sulfate - pharmacology | Leukocytes, Mononuclear - secretion | Humans | Cytokines - secretion | Extracellular Space - drug effects | Glucuronidase - metabolism | Solubility | Heparitin Sulfate - metabolism | Toll-Like Receptor 4 - metabolism | Gene Expression Regulation - drug effects | Extracellular Space - metabolism | Animals | Signal Transduction - drug effects | Heparitin Sulfate - chemistry | Leukocytes, Mononuclear - cytology | Mice | Myeloid Differentiation Factor 88 - metabolism | Leukocyte migration | Leukocytes (mononuclear) | Cardiovascular disease | Arthritis | Biochemistry | Metastasis | Sulfates | Cell surface | Fragmentation | Metastases | Degradation | Interleukin 6 | Proteins | Angiogenesis | Splenocytes | Rodents | Atherosclerosis | Toll-like receptors | Peripheral blood mononuclear cells | Extracellular matrix | Biomolecules | Interleukin 8 | Immune system | Spleen | Heparan sulfate | NF-κB protein | Wound healing | Cytokines | Fragments | Inflammation | TLR4 protein | White blood cells | Tumor necrosis factor | Interleukin 10 | MyD88 protein | Sepsis | Diabetes | Sulfate | Cell migration | Chemokines | Monocyte chemoattractant protein 1 | Tumors
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 2019, Volume 26, Issue 5, pp. 781 - 793
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1962 - 10
Journal Article
Cellular and molecular life sciences : CMLS, 12/2018
To maintain physiological homeostasis, cell turnover occurs every day in the body via a form of programmed cell death called apoptosis. During apoptosis, cells... 
Journal Article