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JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2017, Volume 69, Issue 23, pp. 2876 - 2878
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2017, Volume 12, Issue 9, p. e0183747
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0168989
CIL-102 (1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone) is a well-known, major active agent of the alkaloid derivative of Camptotheca acuminata with... 
KINASE-ACTIVITY | BAICALEIN | INHIBITION | PROTEIN | MULTIDISCIPLINARY SCIENCES | CIL-102 | CYTOCHROME-C RELEASE | PROTEOMIC ANALYSIS | DERIVATIVES | CYTOTOXIC EVALUATION | HISTONE DEACETYLASE | Cell Survival - drug effects | Cell Proliferation | Apoptosis - drug effects | Humans | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Quinolines - pharmacology | p300-CBP Transcription Factors - metabolism | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Antineoplastic Agents - pharmacology | Colorectal Neoplasms - metabolism | Cytochrome c | Molecular mechanics | Analysis | Cancer cells | Cell cycle | Colorectal cancer | Research | Health aspects | Apoptosis | Cytochrome | Cdc2 protein | GTP-binding protein | Event-related potentials | Metastasis | Cancer therapies | Proteins | CREB-binding protein | Signal transduction | Cell growth | Surgery | Deoxyribonucleic acid--DNA | Health promotion | JNK protein | Cyclic AMP response element-binding protein | Caspase-8 | Phytochemicals | Hospitals | Molecular modelling | GADD45 protein | Viability | Biological properties | Phosphorylation | Colorectal carcinoma | DNA damage | Science | Activation | Kinases | Colon cancer | Cyclin B | Gastroenterology | Colon | Chronic illnesses | Cyclin-dependent kinases | Caspase | Biological activity | Medicine | Herbal medicine | Signaling | Cyclin-dependent kinase inhibitor p21 | Cell death | Medical prognosis | N-Terminus | Epigenetics | Cancer | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 03/2017, Volume 21, Issue 3, pp. 588 - 599
Erinacine A, a major active component of a diterpenoid derivative isolated from Hericium erinaceus mycelium, has been demonstrated to exert anticancer effects.... 
p70S6K | erinacine A | PI3K | PROF1 | ROS | mTOR | COFL1 | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | ACTIVATION | LIM-KINASE | COLON | HERICIUM-ERINACEUS | CELL BIOLOGY | GROWTH | MUSHROOM FRUITING BODIES | MICE | ACTIN CYTOSKELETON | EXTRACTS | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Phosphatidylinositol 3-Kinases - metabolism | Lim Kinases - metabolism | Actin Depolymerizing Factors - metabolism | rho-Associated Kinases - metabolism | Neoplasm Invasiveness - pathology | Female | Cell Death - drug effects | Proteomics - methods | Colorectal Neoplasms - metabolism | Diterpenes - pharmacology | Cell Survival - drug effects | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | HCT116 Cells | Animals | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Profilins - metabolism | Proteome - metabolism | Prevention | Cell death | Cancer cells | Colorectal cancer | Cancer | Kinases | Rodents | Cells | Proteomics | TOR protein | Cell proliferation | Phosphorylation | Toxicity | Colorectal carcinoma | Cytotoxicity | Activation | Metastasis | Experiments | Cell adhesion & migration | Anticancer properties | Proteins | Time dependence | Signal transduction | Cell cycle | Cofilin | Biocompatibility | Inhibition | Profilin | Aggressive behavior | Invasiveness | Mortality | 1-Phosphatidylinositol 3-kinase | Studies | Signaling | Phytochemicals | Medical prognosis | In vivo methods and tests | Viability | Apoptosis | Original
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2016, Volume 11, Issue 9, p. e0161767
Ultraviolet (UV) radiation, particularly ultraviolet A (UVA), is known to play a major role in photoaging of the human skin. Many studies have demonstrated... 
SIGNAL-TRANSDUCTION | ARTOCARPUS-HETEROPHYLLUS | ULTRAVIOLET-B IRRADIATION | HAIR FOLLICLE | HUMAN-SKIN | MULTIDISCIPLINARY SCIENCES | EPIDERMAL-GROWTH-FACTOR | HACAT KERATINOCYTES | MAPK PATHWAYS | MELANIN | HUMAN KERATINOCYTES | Cell Death - radiation effects | Skin - cytology | Humans | Skin Aging - drug effects | Skin Aging - radiation effects | Male | Enzyme Activation - drug effects | Enzyme Activation - radiation effects | Ultraviolet Rays - adverse effects | Animals | Fibroblasts - radiation effects | Fibroblasts - drug effects | Radiation-Protective Agents - pharmacology | Flavonoids - pharmacology | Mice | Mice, Inbred BALB C | Oxidative Stress - radiation effects | Cell Death - drug effects | Oxidative Stress - drug effects | Fibroblasts - metabolism | Mitogen-Activated Protein Kinases - metabolism | Antioxidants | Reactive oxygen species | Analysis | Radiation | Research | Protein kinases | Risk factors | Skin cancer | Oxidative stress | Phosphorylation | Hydrogen peroxide | Kinases | Damage prevention | Water loss | Rodents | Fibroblasts | Medical research | Free radicals | Dermatology | U.V. radiation | MAP kinase | Flow rates | Exposure | Fluorides | Community colleges | Blood flow | Medicine | Studies | Researchers | Protein kinase | Irradiation | Flow velocity | In vivo methods and tests | Skin | Topical application | Erythema | Viability | Radiation damage
Journal Article
Journal Article