PLoS Biology, ISSN 1544-9173, 11/2014, Volume 12, Issue 11, p. e1002005
Myriapods (e.g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but...
PHYLOGENY | EVOLUTION | PROTEIN | DNA METHYLATION | SEGMENT FORMATION | JUVENILE-HORMONE SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OLFACTORY RECEPTORS | BIOLOGY | DROSOPHILA | ODORANT-BINDING | FAMILY | Multigene Family | Protein Kinases - genetics | Arthropods - genetics | Selenoproteins - genetics | Circadian Rhythm Signaling Peptides and Proteins - genetics | Synteny | Male | Phylogeny | Sex Chromosomes | Transcription Factors - genetics | RNA, Untranslated - genetics | Hormones - genetics | Polymorphism, Genetic | DNA Methylation | Animals | Receptors, Odorant - genetics | Female | Genome, Mitochondrial | Genome | Evolution, Molecular | Genètica evolutiva | Genètica animal | Proteins | Scholarships & fellowships | Insects | Genes | Genomics | Project management | Colleges & universities | Phylogenetics | Genomes
PHYLOGENY | EVOLUTION | PROTEIN | DNA METHYLATION | SEGMENT FORMATION | JUVENILE-HORMONE SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OLFACTORY RECEPTORS | BIOLOGY | DROSOPHILA | ODORANT-BINDING | FAMILY | Multigene Family | Protein Kinases - genetics | Arthropods - genetics | Selenoproteins - genetics | Circadian Rhythm Signaling Peptides and Proteins - genetics | Synteny | Male | Phylogeny | Sex Chromosomes | Transcription Factors - genetics | RNA, Untranslated - genetics | Hormones - genetics | Polymorphism, Genetic | DNA Methylation | Animals | Receptors, Odorant - genetics | Female | Genome, Mitochondrial | Genome | Evolution, Molecular | Genètica evolutiva | Genètica animal | Proteins | Scholarships & fellowships | Insects | Genes | Genomics | Project management | Colleges & universities | Phylogenetics | Genomes
Journal Article
PLoS Biology, ISSN 1544-9173, 12/2010, Volume 8, Issue 12, p. e1000576
Virulence of complex pathogens in mammals is generally determined by multiple components of the pathogen interacting with the functional complexity and...
SIGNAL-TRANSDUCTION | TRYPTOPHAN | STRAINS | DEFENSE | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDOLEAMINE 2,3-DIOXYGENASE | BINDING PROTEINS | IN-VIVO | BIOLOGY | IDENTIFICATION | IIGP1 | Cell Membrane - parasitology | Toxoplasma - immunology | Phosphorylation | Protein-Serine-Threonine Kinases - physiology | Vacuoles - physiology | Virulence | Cell Membrane Permeability | Toxoplasma - physiology | Cell Membrane - physiology | Toxoplasma - pathogenicity | Polymorphism, Genetic | Cell Membrane - chemistry | Animals | GTP Phosphohydrolases - metabolism | Immune Evasion | Protozoan Proteins - metabolism | Vacuoles - chemistry | Protein-Serine-Threonine Kinases - immunology | Membrane Proteins - metabolism | Mice | Host-Parasite Interactions | Vacuoles - parasitology | Proteins | Infections | Parasites | Kinases | Rodents | Immune system
SIGNAL-TRANSDUCTION | TRYPTOPHAN | STRAINS | DEFENSE | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDOLEAMINE 2,3-DIOXYGENASE | BINDING PROTEINS | IN-VIVO | BIOLOGY | IDENTIFICATION | IIGP1 | Cell Membrane - parasitology | Toxoplasma - immunology | Phosphorylation | Protein-Serine-Threonine Kinases - physiology | Vacuoles - physiology | Virulence | Cell Membrane Permeability | Toxoplasma - physiology | Cell Membrane - physiology | Toxoplasma - pathogenicity | Polymorphism, Genetic | Cell Membrane - chemistry | Animals | GTP Phosphohydrolases - metabolism | Immune Evasion | Protozoan Proteins - metabolism | Vacuoles - chemistry | Protein-Serine-Threonine Kinases - immunology | Membrane Proteins - metabolism | Mice | Host-Parasite Interactions | Vacuoles - parasitology | Proteins | Infections | Parasites | Kinases | Rodents | Immune system
Journal Article
Current Opinion in Microbiology, ISSN 1369-5274, 2011, Volume 14, Issue 4, pp. 414 - 421
Highlights ► Up to 18 IRG proteins defend mice against Toxoplasma gondii and two Chlamydia species, but not against several other organisms. ► IRG proteins...
Pathology | CROHNS-DISEASE | P47 GTPASES | IFN-GAMMA | CHLAMYDIA-TRACHOMATIS | INTRACELLULAR PATHOGENS | MICROBIOLOGY | IMMUNITY-RELATED GTPASES | AUTOPHAGY | GTP-BINDING | HOST-RESISTANCE | CELLULAR-RESPONSE | Toxoplasma - immunology | Disease Resistance | GTP-Binding Proteins - immunology | Toxoplasmosis - immunology | Humans | Virulence | Phylogeny | GTP-Binding Proteins - genetics | Toxoplasma - pathogenicity | Animals | Vacuoles - metabolism | Mice | Host-Parasite Interactions | Immunity, Cellular | Intracellular Membranes - metabolism | Protein-Serine-Threonine Kinases - metabolism | GTP-Binding Proteins - metabolism | Proteins
Pathology | CROHNS-DISEASE | P47 GTPASES | IFN-GAMMA | CHLAMYDIA-TRACHOMATIS | INTRACELLULAR PATHOGENS | MICROBIOLOGY | IMMUNITY-RELATED GTPASES | AUTOPHAGY | GTP-BINDING | HOST-RESISTANCE | CELLULAR-RESPONSE | Toxoplasma - immunology | Disease Resistance | GTP-Binding Proteins - immunology | Toxoplasmosis - immunology | Humans | Virulence | Phylogeny | GTP-Binding Proteins - genetics | Toxoplasma - pathogenicity | Animals | Vacuoles - metabolism | Mice | Host-Parasite Interactions | Immunity, Cellular | Intracellular Membranes - metabolism | Protein-Serine-Threonine Kinases - metabolism | GTP-Binding Proteins - metabolism | Proteins
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2010, Volume 6, Issue 7
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2010, Volume 6, Issue 7
[...]induced lymphopenia seems also to arise following non-pathogenic immune stimuli since induction of experimental allergic encephalitis in Irgm1-deficient...
Proteins | Salmonella | Immunology | Rodents | Autophagy
Proteins | Salmonella | Immunology | Rodents | Autophagy
Journal Article
PLoS Pathogens, ISSN 1553-7366, 02/2009, Volume 5, Issue 2, p. e1000288
Toxoplasma gondii is a natural intracellular protozoal pathogen of mice and other small mammals. After infection, the parasite replicates freely in many cell...
APOPTOSIS | ACTIVATION | MICROBIOLOGY | AUTOPHAGY | ADAPTIVE IMMUNITY | INTERFERON | VIROLOGY | PROTOZOAN PARASITES | IN-VIVO | INFECTED MACROPHAGES | NF-KAPPA-B | PARASITOLOGY | HOST-RESISTANCE
APOPTOSIS | ACTIVATION | MICROBIOLOGY | AUTOPHAGY | ADAPTIVE IMMUNITY | INTERFERON | VIROLOGY | PROTOZOAN PARASITES | IN-VIVO | INFECTED MACROPHAGES | NF-KAPPA-B | PARASITOLOGY | HOST-RESISTANCE
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2013, Volume 288, Issue 16, p. 11504
Journal Article
Mammalian Genome, ISSN 0938-8990, 2/2011, Volume 22, Issue 1, pp. 43 - 54
The immunity-related GTPases (IRGs) belong to the family of large, interferon-inducible GTPases and constitute a cell-autonomous resistance system essential...
Life Sciences | Anatomy | Zoology | Cell Biology | CROHNS-DISEASE | P47 GTPASES | IFN-GAMMA | TRYPANOSOMA-CRUZI | BIOCHEMISTRY & MOLECULAR BIOLOGY | POPULATION BIOLOGY | NUCLEOTIDE-BINDING | INDUCIBLY EXPRESSED GTPASE | INTERFERON-GAMMA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | HOST-DEFENSE | TOXOPLASMA-GONDII | Mammals - virology | GTP Phosphohydrolases - immunology | Humans | Gene Expression Regulation | Mammals - microbiology | GTP Phosphohydrolases - chemistry | Host-Pathogen Interactions | Phagosomes - immunology | Animals | Mammals - immunology | GTP Phosphohydrolases - genetics | Mammals - parasitology | Mice | Proteins | Drug resistance in microorganisms | Pathogenic microorganisms | Parasitic diseases | Disease susceptibility | G proteins | Macrophages
Life Sciences | Anatomy | Zoology | Cell Biology | CROHNS-DISEASE | P47 GTPASES | IFN-GAMMA | TRYPANOSOMA-CRUZI | BIOCHEMISTRY & MOLECULAR BIOLOGY | POPULATION BIOLOGY | NUCLEOTIDE-BINDING | INDUCIBLY EXPRESSED GTPASE | INTERFERON-GAMMA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | HOST-DEFENSE | TOXOPLASMA-GONDII | Mammals - virology | GTP Phosphohydrolases - immunology | Humans | Gene Expression Regulation | Mammals - microbiology | GTP Phosphohydrolases - chemistry | Host-Pathogen Interactions | Phagosomes - immunology | Animals | Mammals - immunology | GTP Phosphohydrolases - genetics | Mammals - parasitology | Mice | Proteins | Drug resistance in microorganisms | Pathogenic microorganisms | Parasitic diseases | Disease susceptibility | G proteins | Macrophages
Journal Article
Cellular Microbiology, ISSN 1462-5814, 07/2010, Volume 12, Issue 7, pp. 939 - 961
Summary The immunity-related GTPases (IRGs) constitute an interferon-induced intracellular resistance mechanism in mice against Toxoplasma gondii. IRG proteins...
INTERFERON | P47 GTPASES | MICE DEFICIENT | IFN-GAMMA | CHLAMYDIA-TRACHOMATIS | INTRACELLULAR PATHOGENS | MICROBIOLOGY | ENDOPLASMIC-RETICULUM | IMMUNITY-RELATED GTPASE | CELLULAR-RESPONSE | HOST-RESISTANCE | CELL BIOLOGY | Immunohistochemistry | Toxoplasma - immunology | Cell Line | Vacuoles - enzymology | Animals | Electrophoresis, Polyacrylamide Gel | Mice | Vacuoles - parasitology | Blotting, Western | GTP-Binding Proteins - metabolism | Proteins | Phosphotransferases | G proteins | Signal transduction | Microtubules | Virulence | parasitophorous vacuole | Phagocytosis | Vacuoles | Guanosinetriphosphatase | Original articles
INTERFERON | P47 GTPASES | MICE DEFICIENT | IFN-GAMMA | CHLAMYDIA-TRACHOMATIS | INTRACELLULAR PATHOGENS | MICROBIOLOGY | ENDOPLASMIC-RETICULUM | IMMUNITY-RELATED GTPASE | CELLULAR-RESPONSE | HOST-RESISTANCE | CELL BIOLOGY | Immunohistochemistry | Toxoplasma - immunology | Cell Line | Vacuoles - enzymology | Animals | Electrophoresis, Polyacrylamide Gel | Mice | Vacuoles - parasitology | Blotting, Western | GTP-Binding Proteins - metabolism | Proteins | Phosphotransferases | G proteins | Signal transduction | Microtubules | Virulence | parasitophorous vacuole | Phagocytosis | Vacuoles | Guanosinetriphosphatase | Original articles
Journal Article
The EMBO Journal, ISSN 0261-4189, 10/2008, Volume 27, Issue 19, pp. 2495 - 2509
Members of the immunity‐related GTPase (IRG) family are interferon‐inducible resistance factors against a broad spectrum of intracellular pathogens including...
p47 GTPase | IRG‐47 | TGTP | IIGP | cell‐autonomous resistance | Cell-autonomous resistance | IRG-47 | PROTEIN | MICE DEFICIENT | RAS | CRYSTAL-STRUCTURE | IFN-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEOTIDE-BINDING | INDUCIBLY EXPRESSED GTPASE | CELL BIOLOGY | INTERFERON-GAMMA | ANTIVIRAL ACTIVITY | LRG-47 | cell-autonomous resistance | Toxoplasma - immunology | Cell Line | GTP-Binding Proteins - immunology | Fibroblasts - physiology | Interferons - immunology | GTP-Binding Proteins - genetics | Toxoplasma - pathogenicity | Two-Hybrid System Techniques | Animals | Immunity, Innate - physiology | Fibroblasts - cytology | Mice | Fibroblasts - microbiology | Proteins | Biomedical research | Immunology | Molecular biology | Binding sites
p47 GTPase | IRG‐47 | TGTP | IIGP | cell‐autonomous resistance | Cell-autonomous resistance | IRG-47 | PROTEIN | MICE DEFICIENT | RAS | CRYSTAL-STRUCTURE | IFN-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEOTIDE-BINDING | INDUCIBLY EXPRESSED GTPASE | CELL BIOLOGY | INTERFERON-GAMMA | ANTIVIRAL ACTIVITY | LRG-47 | cell-autonomous resistance | Toxoplasma - immunology | Cell Line | GTP-Binding Proteins - immunology | Fibroblasts - physiology | Interferons - immunology | GTP-Binding Proteins - genetics | Toxoplasma - pathogenicity | Two-Hybrid System Techniques | Animals | Immunity, Innate - physiology | Fibroblasts - cytology | Mice | Fibroblasts - microbiology | Proteins | Biomedical research | Immunology | Molecular biology | Binding sites
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2010, Volume 6, Issue 7, pp. 1 - 5
[...]induced lymphopenia seems also to arise following non-pathogenic immune stimuli since induction of experimental allergic encephalitis in Irgm1-deficient...
NATURAL-KILLER-CELLS | MICE DEFICIENT | IFN-GAMMA | SUSCEPTIBILITY | MICROBIOLOGY | VIROLOGY | INDUCIBLE GENES | TOXOPLASMA-GONDII | INFECTION | IMMUNITY-RELATED GTPASE | PARASITOLOGY | HOST-RESISTANCE | CELLULAR-RESPONSE | GTP-Binding Proteins - physiology | Animals | GTP-Binding Proteins - immunology | Mice, Inbred C57BL | Mice | Immunity | Host-Pathogen Interactions - immunology | Mice, Knockout | Proteins | Salmonella | Immunology | Autophagy | Rodents
NATURAL-KILLER-CELLS | MICE DEFICIENT | IFN-GAMMA | SUSCEPTIBILITY | MICROBIOLOGY | VIROLOGY | INDUCIBLE GENES | TOXOPLASMA-GONDII | INFECTION | IMMUNITY-RELATED GTPASE | PARASITOLOGY | HOST-RESISTANCE | CELLULAR-RESPONSE | GTP-Binding Proteins - physiology | Animals | GTP-Binding Proteins - immunology | Mice, Inbred C57BL | Mice | Immunity | Host-Pathogen Interactions - immunology | Mice, Knockout | Proteins | Salmonella | Immunology | Autophagy | Rodents
Journal Article
PLoS Pathogens, ISSN 1553-7366, 02/2009, Volume 5, Issue 2
Toxoplasma gondii is a natural intracellular protozoal pathogen of mice and other small mammals. After infection, the parasite replicates freely in many cell...
Toxoplasma | Physiological aspects | Research | Host-virus relationships | Guanosine triphosphatase | Interferon gamma | Proteins | Protozoa | Infections | Parasites | Rodents | Immune system
Toxoplasma | Physiological aspects | Research | Host-virus relationships | Guanosine triphosphatase | Interferon gamma | Proteins | Protozoa | Infections | Parasites | Rodents | Immune system
Journal Article
PLoS pathogens, ISSN 1553-7366, 02/2009, Volume 5, Issue 2, p. e1000288
Toxoplasma gondii is a natural intracellular protozoal pathogen of mice and other small mammals. After infection, the parasite replicates freely in many cell...
Microscopy, Phase-Contrast | GTP Phosphohydrolases - immunology | Necrosis - immunology | Autophagy - immunology | Necrosis - parasitology | Animals | Toxoplasma - genetics | Fibroblasts - parasitology | Toxoplasmosis, Animal - parasitology | Vacuoles - immunology | GTP Phosphohydrolases - genetics | Interferon-gamma - immunology | Fibroblasts - immunology | Mice | Vacuoles - parasitology | Toxoplasma - metabolism | Microscopy, Fluorescence
Microscopy, Phase-Contrast | GTP Phosphohydrolases - immunology | Necrosis - immunology | Autophagy - immunology | Necrosis - parasitology | Animals | Toxoplasma - genetics | Fibroblasts - parasitology | Toxoplasmosis, Animal - parasitology | Vacuoles - immunology | GTP Phosphohydrolases - genetics | Interferon-gamma - immunology | Fibroblasts - immunology | Mice | Vacuoles - parasitology | Toxoplasma - metabolism | Microscopy, Fluorescence
Journal Article
BMC Biology, 01/2016, Volume 14
Background The interferon-[gamma] (IFN-[gamma])-inducible immunity-related GTPase (IRG), Irgm1, plays an essential role in restraining activation of the IRG...
Proteins | Enzymes | Interferon | Parasites | Molecular biology
Proteins | Enzymes | Interferon | Parasites | Molecular biology
Journal Article
BMC Biology, ISSN 1741-7007, 2016, Volume 14, Issue 1, p. 33
BACKGROUND: The interferon-γ (IFN-γ)-inducible immunity-related GTPase (IRG), Irgm1, plays an essential role in restraining activation of the IRG pathogen...
Immunity-related GTPases, IRGs, Pathogen recognition, Irgm1, Irgm3, Lysosomes, Autophagy | Immunity-related GTPases | IRGs | Irgm1 | Lysosomes | Pathogen recognition | Autophagy | Irgm3 | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | P47 GTPASES | IFN-GAMMA | RESISTANCE GTPASES | MOUSE CELLS | BIOLOGY | CELL-AUTONOMOUS IMMUNITY | HOST-DEFENSE | TOXOPLASMA-GONDII | LRG-47 | T-LYMPHOCYTES | Cell Line | GTP-Binding Proteins - immunology | Infection - immunology | GTP Phosphohydrolases - immunology | GTP-Binding Proteins - analysis | Mice, Inbred C57BL | Immunity, Innate | GTP-Binding Proteins - genetics | Infection - genetics | Animals | Lysosomes - metabolism | GTP Phosphohydrolases - genetics | Gene Deletion | GTP Phosphohydrolases - analysis | Mice | Lysosomes - immunology
Immunity-related GTPases, IRGs, Pathogen recognition, Irgm1, Irgm3, Lysosomes, Autophagy | Immunity-related GTPases | IRGs | Irgm1 | Lysosomes | Pathogen recognition | Autophagy | Irgm3 | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | P47 GTPASES | IFN-GAMMA | RESISTANCE GTPASES | MOUSE CELLS | BIOLOGY | CELL-AUTONOMOUS IMMUNITY | HOST-DEFENSE | TOXOPLASMA-GONDII | LRG-47 | T-LYMPHOCYTES | Cell Line | GTP-Binding Proteins - immunology | Infection - immunology | GTP Phosphohydrolases - immunology | GTP-Binding Proteins - analysis | Mice, Inbred C57BL | Immunity, Innate | GTP-Binding Proteins - genetics | Infection - genetics | Animals | Lysosomes - metabolism | GTP Phosphohydrolases - genetics | Gene Deletion | GTP Phosphohydrolases - analysis | Mice | Lysosomes - immunology
Journal Article